The brain is the most complex organ in the body. Approximately 100 billion neuronal connections are formed and maintained as we grow up and age, collectively determining the function of the nervous system. We explore the molecular and cellular composition, as well as the rules and mechanisms that shape and modify neuronal circuits during learning and behavior, along with their decline during disease and aging. Due of its dazzling complexity, we require cutting-edge technology and a multidisciplinary approach to unravel brain function.
We employ electrons and lasers to visualize subcellular structures and molecules in nerve cells, measure activity patterns in the brain, analyze changes in gene expression in specific neuronal and glial populations, and investigate the functions of certain proteins. We generate and study preclinical models of human neuroinflammatory, neurodegenerative, neurooncological, and neuropsychiatric diseases to gain insights into pathological processes and identify new biomarkers and therapeutic targets. Additionally, we develop machine learning approaches to discover hidden patterns in large datasets.
To make all of this possible, we support and train young scientists and clinician-scientists at all stages of their career to become critical and independent researchers.
In collaboration with partners from other disciplines such as immunology, psychology, physics and informatics, we develop interdisciplinary approaches to understand the brain from different perspectives. We believe that strong basic science powers new translational and clinical developments that generate a significant impact on our society.
Founded in 1987, the ZMNH is an internationally renowned research center of the University Medical Center Hamburg-Eppendorf (UKE), the medical faculty of the University of Hamburg. The UKE is one of the largest university medical centers in Germany and neuroscience is one of its main research focus areas.
As a dynamic institution, we are a fertile ground for a wide spectrum of neuroscience research. We have close ties with our local partners, and forged strong collaborations with researchers at the nearby University of Hamburg, the Centre for Structural Systems Biology, Fraunhofer ITMP ScreeningPort and the Hamburg University of Technology. The ZMNH is part of the
Since training and mentoring young scientists is one of our main priorities, all ZMNH graduate students are connected to the
The Hamburg Brain School connects the neuroscientific activities at the UKE from the molecular level to clinical research. It works in close collaboration with the UKE departments of neuroanatomy, neurophysiology, neuropathology, neurology and psychiatry, offering numerous opportunities for interaction with colleagues within our extended local scientific network. The Hamburg Brain School unites over 400 scientists and PhD students from 18 different institutes and clinics at UKE, including ZMNH.
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