P10 - DNA Repair, hypoxia and genomic instability in metastatic prostate cancer: Mechanistic insights and treatment options DRAGOON Study

Christoph Oing & Wael Mansour
Mildred-Scheel Nachwuchszentrum, HaTriCS4 , Laboratory for Radiobiology & Experimental Radiooncology, University Medical Center Hamburg-Eppendorf

Dissemination of tumour cells and metastatic spread as well as cancer resistance to standard treatment are still the common cause of treatment failure and eventually death in prostate cancer patients. A better understanding of the biology of the above-mentioned features will lead to more effective cancer therapy options in prostate cancer. In the DRAGOON project, several high throughput techniques in various in vivo, in vitro and ex vivo models are being employed to investigate dissemination and metastasis as well as endocrine resistance in this context, by examining incurable prostate cancer at (i) an early (hormone-sensitive, node-positive) (subproject 1) and also (ii) a late (metastatic castration-resistant) (subproject 2) stage of metastatic disease, taking into account the complexity of advanced prostate cancer. Both subprojects aim to identify distinct signatures within the genome, transcriptome, epigenome and/or kinome, which contribute to prostate cancer dissemination, metastasis and progression to the castration resistant phenotype, which will assist in defining novel, biomarker-driven, personalized therapeutic strategies (subproject 3).

Grants: Mildred-Scheel Cancer Career Center, German Cancer Aid

Contact: w.mansour@uke.de