In the Schinner lab, our primary objective is to comprehend the factors that underlie the development of genetic cardiomyopathies, specifically focusing on Arrhythmogenic Cardiomyopathy.
Through a series of targeted disease model systems that span from cell culture approaches to in vivo models, we strive to elucidate how mutations can result in arrhythmias, scaring of the heart, and eventual sudden cardiac death. Our research delves into the early processes leading to the pathological phenotype and assesses the therapeutic potential of protective and regenerative mechanisms.