2024

Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
Bay B, Fuh M, Rohde J, Worthmann A, Goßling A, Arnold N, Koester L, Lorenz T, Blaum C, Kirchhof P, Blankenberg S, Seiffert M, Brunner F, Waldeyer C, Heeren J
LIPIDS HEALTH DIS. 2024;23(1):197.

The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
Behler-Janbeck F, Baranowsky A, Schinke T, Jaeckstein M, Worthmann A, Fuh M, Gunasekaran K, Tiegs G, Amling M, Schinke T, Heeren J
FRONT ENDOCRINOL. 2024;15:1392418.

The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice
Benzi A, Heine M, Spinelli S, Salis A, Worthmann A, Diercks B, Astigiano C, Pérez Mato R, Memushaj A, Sturla L, Vellone V, Damonte G, Jaeckstein M, Koch-Nolte F, Mittrücker H, Guse A, De Flora A, Heeren J, Bruzzone S
FRONT ENDOCRINOL. 2024;14:1251351.

Time-resolved role of P2X4 and P2X7 during CD8+ T cell activation
Brock V, Lory N, Möckl F, Birus M, Stähler T, Woelk L, Jaeckstein M, Heeren J, Koch-Nolte F, Rissiek B, Mittrücker H, Guse A, Werner R, Diercks B
FRONT IMMUNOL. 2024;15:1258119.

Multimodal image-guided laser ablation system for precise 3D tissue sampling and subsequent analysis of biomolecules for cancer research
Hahn J, Moritz M, Walter A, Wieck T, Moustafa A, Mansour W, Harms C, Stenzel P, Heeren J, Haider M, Lange T, Schlüter H
2024. Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXII. Tárnok A, Houston J (eds.). 1. ed. Bellingham, Washington: SPIE , .

CD73-dependent generation of extracellular adenosine by vascular endothelial cells modulates de novo lipogenesis in adipose tissue
Jaeckstein M, Schulze I, Zajac M, Heine M, Mann O, Pfeifer A, Heeren J
FRONT IMMUNOL. 2024;14:1308456.

Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein M, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M
NATURE. 2024;625(7994):385-392.

EPAC1 enhances brown fat growth and beige adipogenesis
Reverte-Salisa L, Siddig S, Hildebrand S, Yao X, Zurkovic J, Jaeckstein M, Heeren J, Lezoualc'h F, Krahmer N, Pfeifer A
NAT CELL BIOL. 2024;26(1):113-123.

Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann A, Ridder J, Piel S, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer A, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz J, Kundu S, Fuh M, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich C, Schlüter H, Heeren J, Scheja L, Kubisch C, Schlein C
NAT COMMUN. 2024;15(1):45.

2023

Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice
Correia C, Præstholm S, Havelund J, Pedersen F, Siersbæk M, Ebbesen M, Gerhart-Hines Z, Heeren J, Brewer J, Larsen S, Blagoev B, Færgeman N, Grøntved L
ENDOCRINOLOGY. 2023;164(10):.

Live-cell imaging identifies cAMP microdomains regulating β-adrenoceptor-subtype-specific lipolytic responses in human white adipocytes
De Jong K, Ehret S, Heeren J, Nikolaev V
CELL REP. 2023;42(5):112433.

TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD
Liebold I, Meyer S, Heine M, Kuhl A, Witt J, Eissing L, Fischer A, Koop A, Kluwe J, Wiesch J, Wehmeyer M, Knippschild U, Scheja L, Heeren J, Bosurgi L, Worthmann A
CELLS-BASEL. 2023;12(3):.

The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue
Liebscher G, Vujic N, Schreiber R, Heine M, Krebiehl C, Duta-Mare M, Lamberti G, de Smet C, Hess M, Eichmann T, Hölzl S, Scheja L, Heeren J, Kratky D, Huber L
MOL METAB. 2023;71:101705.

Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa F, Schaltenberg N, Kumar Y, Lesker T, Steglich B, Liwinski T, Cortesi F, Frommann L, Diercks B, Bönisch F, Fischer A, Scognamiglio P, Pauly M, Casar C, Cohen Y, Pelczar P, Agalioti T, Delfs F, Worthmann A, Wahib R, Jagemann B, Mittrücker H, Kretz O, Guse A, Izbicki J, Lassen K, Strowig T, Schweizer M, Villablanca E, Elinav E, Huber S, Heeren J, Gagliani N
NAT IMMUNOL. 2023;24(9):1473-1486.

Lipidome Analysis of Oropharyngeal Tumor Tissues Using Nanosecond Infrared Laser (NIRL) Tissue Sampling and Subsequent Mass Spectrometry
Stadlhofer R, Moritz M, Fuh M, Heeren J, Zech H, Clauditz T, Schlüter H, Betz C, Eggert D, Böttcher A, Hahn J
INT J MOL SCI. 2023;24(9):.

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion
van Zwol W, Rimbert A, Wolters J, Smit M, Bloks V, Kloosterhuis N, Huijkman N, Koster M, Tharehalli U, de Neck S, Bournez C, Fuh M, Kuipers J, Rajan S, de Bruin A, Ginsberg H, van Westen G, Hussain M, Scheja L, Heeren J, Zimmerman P, van de Sluis B, Kuivenhoven J
HEPATOLOGY. 2023;78(5):1418-1432.

2022

Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice
Benzi A, Spinelli S, Sturla L, Heine M, Fischer A, Koch-Nolte F, Mittrücker H, Guse A, De Flora A, Heeren J, Bruzzone S
CELLS-BASEL. 2022;11(23):.

Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1
Dieckmann S, Strohmeyer A, Willershäuser M, Maurer S, Wurst W, Marschall S, de Angelis M, Kühn R, Worthmann A, Fuh M, Heeren J, Köhler N, Pauling J, Klingenspor M
AM J PHYSIOL-ENDOC M. 2022;322(2):E85-E100.

Lysosomal acid lipase promotes endothelial proliferation in cold-activated adipose tissue
Fischer A, Jaeckstein M, Heeren J
ADIPOCYTE. 2022;11(1):28-33.

Metabolic Turnover Studies to Quantify Energy Uptake by Thermogenic Adipose Tissues of Mice
Heine M, Corban C, Heeren J
2022. Brown Adipose Tissue. 1. ed. New York, NY: HUMANA PRESS INC, 107-118.

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann B, Haufs-Brusberg S, Puetz L, feickert m, Jaeckstein M, Hoffmann A, Zurkovic J, Heine M, Trautmann E, Müller C, Tönies A, Schlein C, Jafari A, Eltzsching H, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A
NATURE. 2022;609(7926):361–368.

A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids
Rohde J, Fuh M, Evangelakos I, Pauly M, Schaltenberg N, Siracusa F, Gagliani N, Tödter K, Heeren J, Worthmann A
METABOLITES. 2022;12(2):.

Novel Adipose Tissue Targets to Prevent and Treat Atherosclerosis
Scheja L, Heeren J
2022. Prevention and Treatment of Atherosclerosis. von Eckardstein A, Binder C (eds.). 1. ed. Cham: Springer, 289-310.

Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Schepanski S, Chini M, Sternemann V, Urbschat C, Thiele K, Sun T, Zhao Y, Poburski M, Woestemeier A, Thieme M, Zazara D, Alawi M, Fischer N, Heeren J, Vladimirov N, Woehler A, Puelles V, Bonn S, Gagliani N, Hanganu-Opatz I, Arck P
NAT COMMUN. 2022;13(1):.

Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients
Stürznickel J, Behler-Janbeck F, Baranowsky A, Schmidt T, Schwinge D, John C, Lohse A, Schramm C, Heeren J, Schinke T, Amling M
SCI REP-UK. 2022;12(1):.

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling
Thiemann E, Schwaerzer G, Evangelakos I, Fuh M, Jaeckstein M, Behrens J, Nilsson S, Kumari M, Scheja L, Pfeifer A, Heeren J, Heine M
FRONT PHYSIOL. 2022;13:.

Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans
Zickler M, Stanelle-Bertram S, Ehret S, Heinrich F, Lange P, Schaumburg B, Kouassi N, Beck S, Jaeckstein M, Mann O, Krasemann S, Schroeder M, Jarczak D, Nierhaus A, Kluge S, Peschka M, Schlüter H, Renné T, Pueschel K, Kloetgen A, Scheja L, Ondruschka B, Heeren J, Gabriel G
CELL METAB. 2022;34(1):1-2.

2021

Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?
Benzi A, Grozio A, Spinelli S, Sturla L, Guse A, De Flora A, Zocchi E, Heeren J, Bruzzone S
NUTRIENTS. 2021;13(11):.

CD38 downregulation modulates NAD+ and NADP(H) levels in thermogenic adipose tissues
Benzi A, Sturla L, Heine M, Fischer A, Spinelli S, Magnone M, Sociali G, Parodi A, Fenoglio D, Emionite L, Koch-Nolte F, Mittrücker H, Guse A, De Flora A, Zocchi E, Heeren J, Bruzzone S
BBA-MOL CELL BIOL L. 2021;1866(1):158819.

Nanoparticle-mediated targeting of autoantigen peptide to cross-presenting liver sinusoidal endothelial cells protects from CD8 T-cell-driven autoimmune cholangitis
Carambia A, Gottwick C, Schwinge D, Stein S, Digigow R, Şeleci M, Mungalpara D, Heine M, Schuran F, Corban C, Lohse A, Schramm C, Heeren J, Herkel J
IMMUNOLOGY. 2021;162(4):452-463.

Role of bile acids in inflammatory liver diseases
Evangelakos I, Heeren J, Verkade E, Kuipers F
SEMIN IMMUNOPATHOL. 2021;43(4):577-590.

Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality
Evangelakos I, Schwinge D, Worthmann A, John C, Roeder N, Pertzborn P, Behrens J, Schramm C, Scheja L, Heeren J
CELLS-BASEL. 2021;10(10):2656.

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
Fischer A, Jaeckstein M, Gottschling K, Heine M, Sass F, Mangels N, Schlein C, Worthmann A, Bruns O, Yuan Y, Zhu H, Chen O, Ittrich H, Nilsson S, Stefanicka P, Ukropec J, Balaz M, Dong H, Sun W, Reimer R, Scheja L, Heeren J
CELL METAB. 2021;33(3):547-564.e7.

Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation
Gu F, Krüger A, Roggenkamp H, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C L, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao J, Schetelig D, Werner R, Schröder K, Carty M, Bowie A, Huber S, Meier C, Mittrücker H, Heeren J, Krause K, Flügel A, Diercks B, Guse A
SCI SIGNAL. 2021;14(709):.

Isthmin 1 - a novel insulin-like adipokine
Heeren J, Scheja L
NAT REV ENDOCRINOL. 2021;17(12):709-710.

Metabolic-associated fatty liver disease and lipoprotein metabolism
Heeren J, Scheja L
MOL METAB. 2021;50:101238.

Comment on “Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes”
Rissiek B, Heeren J, Koch-Nolte F, Mittrücker H, Magnus T
J IMMUNOL. 2021;206(4):.

TFEB-deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
Sass F, Schlein C, Jaeckstein M, Pertzborn P, Schweizer M, Schinke T, Ballabio A, Scheja L, Heeren J, Fischer A
MOL METAB. 2021;47:101173.

Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice
Schaltenberg N, John C, Heine M, Haumann F, Rinninger F, Scheja L, Heeren J, Worthmann A
FRONT CARDIOVASC MED. 2021;8:628235.

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein C, Fischer A, Sass F, Worthmann A, Tödter K, Jaeckstein M, Behrens J, Lynes M, Kiebish M, Narain N, Bussberg V, Jespersen N, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng Y, Heeren J, Scheja L
CELL REP. 2021;34(2):108624.

Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice
Schuran F, Lommetz C, Steudter A, Ghallab A, Wieschendorf B, Schwinge D, Zuehlke S, Reinders J, Heeren J, Lohse A, Schramm C, Herkel J, Carambia A
CELL MOL GASTROENTER. 2021;11(2):371-388.

2020

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling
Asaro A, Carlo-Spiewok A, Malik A, Rothe M, Schipke C, Peters O, Heeren J, Willnow T
ALZHEIMERS DEMENT. 2020;16(9):1248-1258.

Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
Fischer A, Behrens J, Sass F, Schlein C, Heine M, Pertzborn P, Scheja L, Heeren J
J LIPID RES. 2020;61(11):1377-1389.

Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Fischer A, de Jong J, Sass F, Schlein C, Heeren J, Petrovic N
FRONT ENDOCRINOL. 2020;11:568682.

Therapeutic Targeting of Myeloperoxidase Attenuates NASH in Mice
Koop A, Thiele N, Steins D, Michaëlsson E, Wehmeyer M, Scheja L, Steglich B, Huber S, Schulze zur Wiesch J, Lohse A, Heeren J, Kluwe J
HEPATOL COMMUN. 2020;4(10):1441-1458.

Alterations of the bile microbiome in primary sclerosing cholangitis
Liwinski T, Zenouzi R, John C, Ehlken H, Rühlemann M, Bang C, Groth S, Lieb W, Kantowski M, Andersen N, Schachschal G, Karlsen T, Hov J, Rösch T, Lohse A, Heeren J, Franke A, Schramm C
GUT. 2020;69(4):665-672.

Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells
Meneses-Salas E, García-Melero A, Kanerva K, Blanco-Muñoz P, Morales-Paytuvi F, Bonjoch J, Casas J, Egert A, Beevi S, Jose J, Llorente-Cortés V, Rye K, Heeren J, Lu A, Pol A, Tebar F, Ikonen E, Grewal T, Enrich C, Rentero C
CELL MOL LIFE SCI. 2020;77(14):2839-2857.

Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey.
Müller-Wieland D, Altenburg C, Becher H, Burchard J, Frisch A, Gebhard J, Haas J, Harth V, Heeren J, Hengelbrock J, von Karais M, Knebel B, Kotzka J, Löwe B, Marx N, Pinnschmidt H, Preisser A, Rose M, Sawitzky-Rose B, Scheja L, Terschüren C, Töller M, Vettorazzi E, Wegscheider K
EXP CLIN ENDOCR DIAB. 2020;128(12):777-787.

Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature
Pauly M, Rohde J, John C, Evangelakos I, Koop A, Pertzborn P, Tödter K, Scheja L, Heeren J, Worthmann A
NUTRIENTS. 2020;12(10):.

A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism
Pradas-Juni M, Hansmeier N, Link J, Schmidt E, Larsen B, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer C, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus D, Kulkarni R, Zevnik B, Tröder S, Knippschild U, Edwards P, Lee R, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim T, Kornfeld J
NAT COMMUN. 2020;11(1):644.

The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues
Tian T, Heine M, Evangelakos I, Jaeckstein M, Schaltenberg N, Stähler T, Koch-Nolte F, Kumari M, Heeren J
PURINERG SIGNAL. 2020;16(4):529-542.

2019

Abscisic acid stimulates the release of insulin and of GLP-1 in the rat perfused pancreas and intestine
Booz V, Christiansen C, Kuhre R, Saltiel M, Sociali G, Schaltenberg N, Fischer A, Heeren J, Zocchi E, Holst J, Bruzzone S
DIABETES-METAB RES. 2019;35(2):e3102.

PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
Fischer A, Albers K, Schlein C, Sass F, Krott L, Schmale H, Gordts P, Scheja L, Heeren J
BBA-MOL BASIS DIS. 2019;1865(6):1592-1603.

Intact innervation is essential for diet-induced recruitment of brown adipose tissue
Fischer A, Schlein C, Cannon B, Heeren J, Nedergaard J
AM J PHYSIOL-ENDOC M. 2019;316(3):E487-E503.

Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation
Fliegert R, Heeren J, Koch-Nolte F, Nikolaev V, Lohr C, Meier C, Guse A
BIOCHEM SOC T. 2019;47(1):329-337.

Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis
Glaser F, John C, Engel B, Höh B, Weidemann S, Dieckhoff J, Stein S, Becker N, Casar C, Amrei Schuran F, Wieschendorf B, Preti M, Jessen F, Franke A, Carambia A, Lohse A, Ittrich H, Herkel J, Heeren J, Schramm C, Schwinge D
J HEPATOL. 2019;71(4):783-792.

Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong Z, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé G, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D
NAT COMMUN. 2019;10(1):3521.

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption
Johann K, Cremer A, Fischer A, Heine M, Pensado E, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley J, Backes H, Mittag J
CELL REP. 2019;27(11):3385-3400.e3.

Scanning transmission X-ray microscopy with efficient X-ray fluorescence detection (STXM-XRF) for biomedical applications in the soft and tender energy range
Lühl L, Andrianov K, Dierks H, Haidl A, Dehlinger A, Heine M, Heeren J, Nisius T, Wilhein T, Kanngießer B
J SYNCHROTRON RADIAT. 2019;26(Pt 2):430-438.

The endocrine function of adipose tissues in health and cardiometabolic disease
Scheja L, Heeren J
NAT REV ENDOCRINOL. 2019;15(9):507-524.

Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
Worthmann A, Schlein C, Berbée J, Rensen P, Heeren J, Bartelt A
NUTRIENTS. 2019;11(2):.

2018

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling
Bartelt A, Behler-Janbeck F, Beil F, Koehne T, Müller B, Schmidt T, Heine M, Ochs L, Yilmaz T, Dietrich M, Tuckermann J, Amling M, Herz J, Schinke T, Heeren J, Niemeier A
BONE RES. 2018;6:4.

Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet
Cairns R, Fischer A, Blanco-Munoz P, Alvarez-Guaita A, Meneses-Salas E, Egert A, Buechler C, Hoy A, Heeren J, Enrich C, Rentero C, Grewal T
PLOS ONE. 2018;13(8):e0201310.

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity
Christoffersen C, Federspiel C, Borup A, Christensen P, Madsen A, Heine M, Nielsen C, Kjaer A, Holst B, Heeren J, Nielsen L
CELL REP. 2018;22(1):175-188.

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins
Fischer A, Albers K, Krott L, Hoffzimmer B, Heine M, Schmale H, Scheja L, Gordts P, Heeren J
MOL METAB. 2018;16:88-99.

Brown adipose tissue and lipid metabolism
Heeren J, Scheja L
CURR OPIN LIPIDOL. 2018;29(3):180-185.

Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
Heine M, Fischer A, Schlein C, Jung C, Straub L, Gottschling K, Mangels N, Yuan Y, Nilsson S, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J
CELL METAB. 2018;28(4):644-655.e4.

Regulation of immunometabolism in adipose tissue
Kumari M, Heeren J, Scheja L
SEMIN IMMUNOPATHOL. 2018;40(2):189-202.

FoxO transcription factors are required for hepatic HDL-cholesterol clearance
Lee S, Heine M, Schlein C, Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer A, Ginsberg H, Heeren J, Rinninger F, Haeusler R
J CLIN INVEST. 2018;128(4):1615-1626.

Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans
Oldoni F, van Capelleveen J, Dalila N, Wolters J, Heeren J, Sinke R, Hui D, Dallinga-Thie G, Frikke-Schmidt R, Hovingh K, van de Sluis B, Tybjærg-Hansen A, Kuivenhoven J
ARTERIOSCL THROM VAS. 2018;38(7):1440-1453.

Introduction to the special issue on dietary control of immunometabolism
Scheja L, Heeren J
SEMIN IMMUNOPATHOL. 2018;40(2):141-144.

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, Hammerschmidt P, Loureiro R, Kiefer C, Hansmeier N, Khani S, Bergami M, Heine M, Ntini E, Frommolt P, Zentis P, Ørom U, Heeren J, Blüher M, Bilban M, Kornfeld J
NAT COMMUN. 2018;9(1):3622.

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms
Treviño-Villarreal J, Reynolds J, Bartelt A, Langston P, MacArthur M, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace L, Mejia P, Trocha K, Kajitani G, Longchamp A, Harputlugil E, Gathungu R, Bird S, Bullock A, Figenshau R, Andriole G, Thompson A, Heeren J, Ozaki C, Kristal B, Fontana L, Mitchell J
JCI INSIGHT. 2018;3(21):.

Assessment of Uptake and Biodistribution of Radiolabeled Cholesterol in Mice Using Gavaged Recombinant Triglyceride-rich Lipoprotein Particles (rTRL)
Worthmann A, John C, Heeren J
BIO-PROTOCOL. 2018;8(13):e2916.

2017

AMPK Prevents Palmitic Acid-Induced Apoptosis and Lipid Accumulation in Cardiomyocytes
Adrian L, Lenski M, Tödter K, Heeren J, Böhm M, Laufs U
LIPIDS. 2017;52(9):737-750.

Differential effects of Calca-derived peptides in male mice with diet-induced obesity
Bartelt A, Jeschke A, Müller B, Gaziano I, Morales M, Yorgan T, Heckt T, Heine M, Gagel R, Emeson R, Amling M, Niemeier A, Heeren J, Schinke T, Keller J
PLOS ONE. 2017;12(6):e0180547.

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Bartelt A, John C, Schaltenberg N, Berbée J, Worthmann A, Cherradi M, Schlein C, Piepenburg J, Boon M, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson S, Fischer M, Wijers S, van Marken Lichtenbelt W, Scheja L, Rensen P, Heeren J
NAT COMMUN. 2017;8:Art. 15010.

Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase
Bartelt A, Koehne T, Tödter K, Reimer R, Müller B, Behler-Janbeck F, Heeren J, Scheja L, Niemeier A
INT J MOL SCI. 2017;18(6):1264.

Next-Generation optical imaging with short-wave infrared quantum dots
Bruns O, Bischof T, Harris D, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski F, Carr J, Rowlands C, Wilson M, Chen O, Wei H, Hwang G, Montana D, Coropceanu I, Achorn O, Kloepper J, Heeren J, So P, Fukumura D, Jensen K, Jain R, Bawendi M
NAT BIOMED ENG. 2017;1(4):UNSP 0056.

Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues
Chai C, Rivkin M, Berkovits L, Simerzin A, Zorde-Khvalevsky E, Rosenberg N, Klein S, Yaish D, Durst R, Shpitzen S, Udi S, Tam J, Heeren J, Worthmann A, Schramm C, Kluwe J, Ravid R, Hornstein E, Giladi H, Galun E
GASTROENTEROLOGY. 2017;153(5):1404-1415.

Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men
Iwen K, Backhaus J, Cassens M, Waltl M, Hedesan O, Merkel M, Heeren J, Sina C, Rademacher L, Windjäger A, Haug A, Kiefer F, Lehnert H, Schmid S
J CLIN ENDOCR METAB. 2017;102(11):4226-4234.

Quantitative and qualitative estimation of atherosclerotic plaque burden in vivo at 7T MRI using Gadospin F in comparison to en face preparation evaluated in ApoE KO mice
Jung C, Christiansen S, Kaul M, Koziolek E, Reimer R, Heeren J, Adam G, Heine M, Ittrich H
PLOS ONE. 2017;12(8):e0180407.

Disruption of the vacuolar-type H-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes
Kissing S, Rudnik S, Damme M, Lüllmann-Rauch R, Ichihara A, Kornak U, Eskelinen E, Jabs S, Heeren J, De Brabander J, Haas A, Saftig P
AUTOPHAGY. 2017;13(4):670-685.

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco D, Smith S, Tweet G, Humulock Z, Zrzavy T, Conde-Sanroman P, Gacias M, Weng Z, Chen H, Tjon E, Mazaheri F, Hartmann K, Madi A, Ulrich J, Glatzel M, Worthmann A, Heeren J, Budnik B, Lemere C, Ikezu T, Heppner F, Litvak V, Holtzman D, Lassmann H, Weiner H, Ochando J, Haass C, Butovsky O
IMMUNITY. 2017;47(3):566-581.e9.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue
Schugar R, Shih D, Warrier M, Helsley R, Burrows A, Ferguson D, Brown A, Gromovsky A, Heine M, Chatterjee A, Li L, Li X, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee R, Crooke R, Graham M, Morton R, Langefeld C, Das S, Rudel L, Zein N, McCullough A, Dasarathy S, Tang W, Erokwu B, Flask C, Laakso M, Civelek M, Naga Prasad S, Heeren J, Lusis A, Hazen S, Brown J
CELL REP. 2017;19(12):2451-2461.

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue (vol 19, pg 2451, 2017)
Schugar R, Shih D, Warrier M, Helsley R, Burrows A, Ferguson D, Brown A, Gromovsky A, Heine M, Chatterjee A, Li L, Li X, Wang Z, Willard B, Meng Y, Kim H, Che N, Pan C, Lee R, Crooke R, Graham M, Morton R, Langefeld C, Das S, Rudel L, Zein N, McCullough A, Dasarathy S, Tang W, Erokwu B, Flask C, Laakso M, Civelek M, Naga Prasad S, Heeren J, Lusis A, Hazen S, Brown J
CELL REP. 2017;20(1):279.

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann A, John C, Rühlemann M, Baguhl M, Heinsen F, Schaltenberg N, Heine M, Schlein C, Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul P, Heeren J
NAT MED. 2017;23(7):839-849.

2016

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Chen Y, Buyel J, Hanssen M, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, Schlein C, Froehlich H, Heeren J, Virtanen K, van Marken Lichtenbelt W, Pfeifer A
NAT COMMUN. 2016;7:11420.

Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect
Forny P, Schumann A, Mustedanagic M, Mathis D, Wulf M, Naegele N, Langhans C, Zhakupova A, Heeren J, Scheja L, Fingerhut R, Peters H, Hornemann T, Thony B, Koelker S, Burda P, Froese D, Devuyst O, Baumgartner M
J BIOL CHEM. 2016;291(39):20563-73.

Investigation of the anti-obesity effect of Pueraria montana var. lobata
Houriet J, Buhlmann E, Rudigier C, Kiehlmann E, Radtke J, Heeren J, Friedemann T, Schröder S, Wolfrum C, Wolfender J
PLANTA MED. 2016;81(S 01):S1-S381.

Quantitative Activity Measurements of Brown Adipose Tissue at 7 T Magnetic Resonance Imaging After Application of Triglyceride-Rich Lipoprotein 59Fe-Superparamagnetic Iron Oxide Nanoparticle: Intravenous Versus Intraperitoneal Approach
Jung C, Heine M, Freund B, Reimer R, Koziolek E, Kaul M, Kording F, Schumacher U, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H
INVEST RADIOL. 2016;51(3):194-202.

Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils
Kozik J, Trautmann T, Carambia A, Preti M, Lütgehetmann M, Krech T, Wiegard C, Heeren J, Herkel J
SCI REP-UK. 2016;6:28556.

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation
Krott L, Piscitelli F, Heine M, Borrino S, Scheja L, Silvestri C, Heeren J, Di Marzo V
J LIPID RES. 2016;57(3):464-73.

Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function
Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van T, Bartsch D, Brönneke H, Heine M, Hilpert H, Tarcitano E, Garinis G, Frommolt P, Heeren J, Mori M, Brüning J, Kornfeld J
NAT CELL BIOL. 2016;18(3):328-36.

Metabolic interplay between white, beige, brown adipocytes and the liver
Scheja L, Heeren J
J HEPATOL. 2016;64(5):1176-86.

Insulin Regulates Hepatic Triglyceride Secretion and Lipid Content via Signaling in the Brain
Scherer T, Lindtner C, O'Hare J, Hackl M, Zielinski E, Freudenthaler A, Baumgartner-Parzer S, Tödter K, Heeren J, Krššák M, Scheja L, Fürnsinn C, Buettner C
DIABETES. 2016;65(6):1511-20.

Implications of thermogenic adipose tissues for metabolic health
Schlein C, Heeren J
BEST PRACT RES CL EN. 2016;30(4):487-496.

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
Schlein C, Talukdar S, Heine M, Fischer A, Krott L, Nilsson S, Brenner M, Heeren J, Scheja L
CELL METAB. 2016;23(3):441-53.

Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis
Schröder T, Kucharczyk D, Bär F, Pagel R, Derer S, Jendrek S, Sünderhauf A, Brethack A, Hirose M, Möller S, Künstner A, Bischof J, Weyers I, Heeren J, Koczan D, Schmid S, Divanovic S, Giles D, Adamski J, Fellermann K, Lehnert H, Köhl J, Ibrahim S, Sina C
CELL METAB. 2016;5(4):283-95.

Utilizing immunoaffinity chromatography (IAC) cross-reactivity in GC-MS/MS exemplified at the measurement of prostaglandin E1 in human plasma using prostaglandin E2-specific IAC columns
Tsikas D, Suchy M, Tödter K, Heeren J, Scheja L
J CHROMATOGR B. 2016;1021:101-7.

2015

The distribution and degradation of radiolabeled superparamagnetic iron oxide nanoparticles and quantum dots in mice
Bargheer D, Giemsa A, Freund B, Heine M, Waurisch C, Stachowski G, Hickey S, Eychmüller A, Heeren J, Nielsen P
BEILSTEIN J NANOTECH. 2015;6:111-23.

The fate of a designed protein corona on nanoparticles in vitro and in vivo
Bargheer D, Nielsen J, Gébel G, Heine M, Salmen S, Stauber R, Weller H, Heeren J, Nielsen P
BEILSTEIN J NANOTECH. 2015;6:36-46.

Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
Baumeier C, Kaiser D, Heeren J, Scheja L, John C, Weise C, Eravci M, Lagerpusch M, Schulze G, Joost H, Schwenk R, Schürmann A
Biochim Biophys Acta. 2015;1851(5):566-76.

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée J, Boon M, Khedoe P, Bartelt A, Schlein C, Worthmann A, Kooijman S, Hoeke G, Mol I, John C, Jung C, Vazirpanah N, Brouwers L, Gordts P, Esko J, Hiemstra P, Havekes L, Scheja L, Heeren J, Rensen P
NAT COMMUN. 2015;6:6356.

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice
Carambia A, Freund B, Schwinge D, Bruns O, Salmen S, Ittrich H, Reimer R, Heine M, Huber S, Waurisch C, Eychmüller A, Wraith D, Korn T, Nielsen P, Weller H, Schramm C, Lüth S, Lohse A, Heeren J, Herkel J
J HEPATOL. 2015;62(6):1349-1356.

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
Dijk W, Heine M, Vergnes L, Boon M, Schaart G, Hesselink M, Reue K, van Marken Lichtenbelt W, Olivecrona G, Rensen P, Heeren J, Kersten S
ELIFE. 2015;4:.

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue
Hoffmann L, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer A, Stasch J, Bloch W, Friebe A, Heeren J, Pfeifer A
NAT COMMUN. 2015;6:Art. 7235.

Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control
Klünder S, Heeren J, Markmann S, Santer R, Braulke T, Pohl S
J LIPID RES. 2015;56(8):1625-32.

Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes
Lasrich D, Bartelt A, Grewal T, Heeren J
EXP CELL RES. 2015;337(1):94-102.

Diabetes prevalence in NZO females depends on estrogen action on liver fat content
Lubura M, Hesse D, Krämer M, Hallahan N, Schupp M, Loeffelholz C, Kriebel J, Rudovich N, Pfeiffer A, John C, Scheja L, Heeren J, Koliaki C, Roden M, Schürmann A
AM J PHYSIOL-ENDOC M. 2015;309(12):E968-E980.

Lrp1/LDL receptor play critical roles in mannose 6-phosphate-independent lysosomal enzyme targeting
Markmann S, Thelen M, Cornils K, Schweizer M, Brocke-Ahmadinejad N, Willnow T, Heeren J, Gieselmann V, Braulke T, Kollmann K
TRAFFIC. 2015.

Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner T, Bartelt A, Schlein C, Heeren J
PLOS ONE. 2015;10(12):.

2014

Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers K, Schlein C, Wenner K, Lohse P, Bartelt A, Heeren J, Santer R, Merkel M
ATHEROSCLEROSIS. 2014;233(1):97-103.

Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity
Bartelt A, Beil T, Müller B, Koehne T, Yorgan T, Heine M, Yilmaz T, Ruether W, Heeren J, Schinke T, Niemeier A
BONE. 2014;62:90-98.

Adipose tissue browning and metabolic health
Bartelt A, Heeren J
NAT REV ENDOCRINOL. 2014;10(1):24-36.

TGF-β-dependent induction of CD4⁺CD25⁺Foxp3⁺ Tregs by liver sinusoidal endothelial cells
Carambia A, Freund B, Schwinge D, Heine M, Laschtowitz A, Huber S, Wraith D, Korn T, Schramm C, Lohse A, Heeren J, Herkel J
J HEPATOL. 2014;61(3):594-9.

Dichloroacetate prevents restenosis in preclinical animal models of vessel injury
Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños J, Rakovic A, Spin J, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins R, Tsao P, Schrepfer S
NATURE. 2014;509(7502):641-644.

Selectins mediate small cell lung cancer systemic metastasis
Heidemann F, Schildt A, Schmid K, Bruns O, Riecken K, Jung C, Ittrich H, Wicklein D, Reimer R, Fehse B, Heeren J, Lüers G, Schumacher U, Heine M
PLOS ONE. 2014;9(4):e92327.

The cell-type specific uptake of polymer-coated or micelle-embedded QDs and SPIOs does not provoke an acute pro-inflammatory response in the liver
Heine M, Bartelt A, Bruns O, Bargheer D, Giemsa A, Freund B, Scheja L, Waurisch C, Eychmüller A, Reimer R, Weller H, Nielsen P, Heeren J
BEILSTEIN J NANOTECH. 2014;5:1432-1440.

A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids
John C, Werner P, Worthmann A, Wegner K, Tödter K, Scheja L, Rohn S, Heeren J, Fischer M
J CHROMATOGR A. 2014;1371:184-195.

Intraperitoneal Injection Improves the Uptake of Nanoparticle-Labeled High-Density Lipoprotein to Atherosclerotic Plaques Compared With Intravenous Injection: A Multimodal Imaging Study in ApoE Knockout Mice
Jung C, Kaul M, Bruns O, Dučić T, Freund B, Heine M, Reimer R, Meents A, Salmen S, Weller H, Nielsen P, Adam G, Heeren J, Ittrich H
CIRC-CARDIOVASC IMAG. 2014;7(2):303-11.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler N, Volz T, Bhadra O, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok J, Lohse A, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M
HEPATOLOGY. 2014.

Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries
Reverter M, Rentero C, Garcia-Melero A, Hoque M, Vilà de Muga S, Alvarez-Guaita A, Conway J, Wood P, Cairns R, Lykopoulou L, Grinberg D, Vilageliu L, Bosch M, Heeren J, Blasi J, Timpson P, Pol A, Tebar F, Murray R, Grewal T, Enrich C
CELL REP. 2014;7(3):883-897.

High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice
Rinninger F, Heine M, Singaraja R, Hayden M, Brundert M, Ramakrishnan R, Heeren J
J LIPID RES. 2014;55(9):1914-1924.

Synthesis of radioactively labelled CdSe/CdS/ZnS quantum dots for in vivo experiments
Stachowski G, Bauer C, Waurisch C, Bargheer D, Nielsen P, Heeren J, Hickey S, Eychmüller A
BEILSTEIN J NANOTECH. 2014;5:2383-2387.

2013

Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning
Bartelt A, John C, Cherradi M, Niemeier A, Tödter K, Heeren J, Scheja L
BBA-MOL CELL BIOL L. 2013;1831(5):934-42.

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain
Carlo A, Gustafsen C, Mastrobuoni G, Nielsen M, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, Kempa S, Petersen C, Willnow T
J NEUROSCI. 2013;33(1):358-70.

Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects
Donzelli S, Fischer G, King B, Niemann C, DuMond J, Heeren J, Wieboldt H, Baldus S, Gerloff C, Eschenhagen T, Carrier L, Böger R, Espey M
J PHARMACOL EXP THER. 2013;344(2):339-47.

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
Eissing L, Scherer T, Tödter K, Knippschild U, Greve J, Buurman W, Pinnschmidt H, Rensen S, Wolf A, Bartelt A, Heeren J, Buettner C, Scheja L
NAT COMMUN. 2013;4:1528.

Novel aspects of brown adipose tissue biology
Heeren J, Münzberg H
ENDOCRIN METAB CLIN. 2013;42(1):89-107.

TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection
Helk E, Bernin H, Ernst T, Ittrich H, Jacobs T, Heeren J, Tacke F, Tannich E, Lotter H
PLOS PATHOG. 2013;9(1):e1003096.

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
Kornfeld J, Baitzel C, Könner A, Nicholls H, Vogt M, Herrmanns K, Scheja L, Haumaitre C, Wolf A, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning J
NATURE. 2013;494(7435):111-5.

Inhibition of mitogen-activated protein kinase Erk1/2 promotes protein degradation of ATP binding cassette transporters A1 and G1 in CHO and HuH7 cells
Mulay V, Wood P, Manetsch M, Darabi M, Cairns R, Hoque M, Chan K, Reverter M, Alvarez-Guaita A, Rye K, Rentero C, Heeren J, Enrich C, Grewal T
PLOS ONE. 2013;8(4):e62667.

Increased expression of transthyretin in leptin-deficient ob/ob mice is not causative for their major phenotypic abnormalities.
Rendenbach C, Ganswindt S, Seitz S, Barvencik F, Hübner A, Baranowsky A, Streichert T, Niemeier A, Heeren J, Amling M, Bartelt A, Schinke T
J NEUROENDOCRINOL. 2013;25(1):14-22.

2012

The holy grail of metabolic disease: brown adipose tissue.
Bartelt A, Heeren J
CURR OPIN LIPIDOL. 2012;23(3):190-195.

A new, powerful player in lipoprotein metabolism: brown adipose tissue.
Bartelt A, Merkel M, Heeren J
J MOL MED. 2012;90(8):887-893.

A simple and widely applicable method to 59Fe-radiolabel monodisperse superparamagnetic iron oxide nanoparticles for in vivo quantification studies.
Freund B, Tromsdorf U, Bruns O, Heine M, Giemsa A, Bartelt A, Salmen S, Raabe N, Heeren J, Ittrich H, Reimer R, Hohenberg H, Schumacher U, Weller H, Nielsen P
ACS NANO. 2012;6(8):7318-7325.

Impaired LDL receptor-related protein 1 translocation correlates with improved dyslipidemia and atherosclerosis in apoE-deficient mice.
Gordts P, Bartelt A, Nilsson S, Annaert W, Christoffersen C, Nielsen L, Heeren J, Roebroek A
PLOS ONE. 2012;7(6):38330.

Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis.
Heeren J, Bruns O
CURR PHARM BIOTECHNO. 2012;13(2):365-372.

The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.
Jaschke A, Chung B, Hesse D, Kluge R, Zahn C, Moser M, Petzke K, Brigelius-Flohé R, Puchkov D, Koepsell H, Heeren J, Joost H, Schürmann A
HUM MOL GENET. 2012;21(14):3128-3142.

Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E.
Laatsch A, Panteli M, Sornsakrin M, Hoffzimmer B, Grewal T, Heeren J
PLOS ONE. 2012;7(1):29385.

Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5.
Makrypidi G, Damme M, Müller-Loennies S, Trusch M, Schmidt B, Schlüter H, Heeren J, Lübke T, Saftig P, Braulke T
MOL CELL BIOL. 2012;32(4):774-782.

The role of apolipoprotein E in bone metabolism.
Niemeier A, Schinke T, Heeren J, Amling M
BONE. 2012;50(2):518-524.

Triacylglycerol-rich lipoproteins protect lipoprotein lipase from inactivation by ANGPTL3 and ANGPTL4.
Nilsson S, Anderson F, Ericsson M, Larsson M, Makoveichuk E, Lookene A, Heeren J, Olivecrona G
Biochim Biophys Acta. 2012;1821(10):1370-1378.

The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module.
van Rahden V, Brand K, Najm J, Heeren J, Heeren J, Braulke T, Kutsche K, Kutsche K
HUM MOL GENET. 2012;21(23):5019-5038.

2011

Brown adipose tissue activity controls triglyceride clearance.
Bartelt A, Bruns O, Reimer R, Hohenberg H, Ittrich H, Peldschus K, Kaul M, Tromsdorf U, Weller H, Waurisch C, Eychmüller A, Gordts P, Rinninger F, Brügelmann K, Freund B, Nielsen P, Merkel M, Heeren J
NAT MED. 2011;17(2):200-205.

Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.
Bartelt A, Orlando P, Mele C, Ligresti A, Tödter K, Scheja L, Heeren J, Di Marzo V
DIABETOLOGIA. 2011;54(11):2900-2910.

Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells.
Brundert M, Heeren J, Merkel M, Carambia A, Herkel J, Groitl P, Dobner T, Ramakrishnan R, Moore K, Rinninger F
J LIPID RES. 2011;52(4):745-758.

PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.
Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett R
J CELL SCI. 2011;124(2):280-291.

[Energy, brown adipose tissue, obesity].
Merkel M, Heeren J
DEUT MED WOCHENSCHR. 2011;136(11):548-550.

Apolipoprotein A-V; a potent triglyceride reducer.
Nilsson S, Heeren J, Olivecrona G, Merkel M
ATHEROSCLEROSIS. 2011;219(1):15-21.

Short-term activation of liver X receptors inhibits osteoblasts but long-term activation does not have an impact on murine bone in vivo.
Prawitt J, Beil F, Marshall R, Bartelt A, Rüther W, Heeren J, Amling M, Staels B, Niemeier A
BONE. 2011;48(2):339-346.

Role for LAMP-2 in endosomal cholesterol transport.
Schneede A, Schmidt C, Hölttä-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J, Sandhoff K, Ikonen E, Saftig P, Eskelinen E
J CELL MOL MED. 2011;15(2):280-295.

Ras/mitogen-activated protein kinase (MAPK) signaling modulates protein stability and cell surface expression of scavenger receptor SR-BI.
Wood P, Mulay V, Darabi M, Chan K, Heeren J, Pol A, Lambert G, Rye K, Enrich C, Grewal T
J BIOL CHEM. 2011;286(26):23077-23092.

2010

Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity.
Bartelt A, Beil F, Schinke T, Röser K, Ruether W, Heeren J, Niemeier A
BONE. 2010;47(4):736-745.

Hypertriglyceridemia in obese subjects: caused by reduced apolipoprotein A5 plasma levels?
Heeren J, Merkel M
ATHEROSCLEROSIS. 2010;212(2):386-387.

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export.
Kjolby M, Andersen O, Breiderhoff T, Fjorback A, Pedersen K, Madsen P, Jansen P, Heeren J, Willnow T, Nykjaer A
CELL METAB. 2010;12(3):213-223.

Phosphorylation of sterol regulatory element-binding protein (SREBP)-1a links growth hormone action to lipid metabolism in hepatocytes.
Kotzka J, Knebel B, Avci H, Jacob S, Nitzgen U, Jockenhovel F, Heeren J, Haas J, Muller-Wieland D
ATHEROSCLEROSIS. 2010;213(1):156-165.

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Linsel-Nitschke P, Heeren J, Aherrahrou Z, Bruse P, Gieger C, Illig T, Prokisch H, Heim K, Doering A, Peters A, Meitinger T, Wichmann H, Hinney A, Reinehr T, Roth C, Ortlepp J, Soufi M, Sattler A, Schaefer J, Stark K, Hengstenberg C, Schaefer A, Schreiber S, Kronenberg F, Samani N, Schunkert H, Erdmann J
ATHEROSCLEROSIS. 2010;208(1):183-189.

2009

European Lipoprotein Club: report of the 31st ELC Annual Conference, Tutzing, 8-11 September 2008.
Bernini F, Freeman D, Groen A, Heeren J, Kalopissis A, Kronenberg F, Lindstedt K, Parini P, Schuster G, Anne T, Dij v, Willems K, von Eckardstein A
ATHEROSCLEROSIS. 2009;205(1):41-47.

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.
Bruns O, Ittrich H, Peldschus K, Kaul M, Tromsdorf U, Lauterwasser J, Nikolic M, Mollwitz B, Merkel M, Bigall N, Sapra S, Reimer R, Hohenberg H, Weller H, Eychmüller A, Adam G, Beisiegel U, Heeren J
NAT NANOTECHNOL. 2009;4(3):193-201.

Receptor-Mediated Endocytosis and Intracellular Trafficking of Lipoproteins
Heeren J, Beisiegel U
2009. Cellular Lipid Metabolism. Springer Verlag Berlin Heidelberg: 213-237.

Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance.
Laatsch A, Merkel M, Talmud P, Grewal T, Beisiegel U, Heeren J
ATHEROSCLEROSIS. 2009;204(1):105-111.

2008

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding.
Dorfmeister B, Zeng W, Dichlberger A, Nilsson S, Schaap F, Hubacek J, Merkel M, Cooper J, Lookene A, Putt W, Whittall R, Lee P, Lins L, Delsaux N, Nierman M, Kuivenhoven J, Kastelein J, Vrablik M, Olivecrona G, Schneider W, Heeren J, Humphries S, Talmud P
ARTERIOSCL THROM VAS. 2008;28(10):1866-1871.

Duck hepatitis B virus requires cholesterol for endosomal escape during virus entry.
Funk A, Mouna M, Hohenberg H, Heeren J, Reimer R, Lambert C, Prange R, Sirma H
J VIROL. 2008;82(21):10532-10542.

European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007.
Hofker M, Bernini F, von Eckardstein A, Freeman D, Heeren J, Karpe F, Kalopissis A, Kronenberg F, Kuipers F, Lindstedt K, Parini P, Schuster G, Dijk v, Willems K
ATHEROSCLEROSIS. 2008;197(1):471-479.

Apoprotein A-V: An important regulator of triglyceride metabolism
Kluger M, Heeren J, Merkel M
J INHERIT METAB DIS. 2008;31(2):281-8.

Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function.
Niemeier A, Niedzielska D, Secer R, Schilling A, Merkel M, Enrich C, Rensen P, Heeren J
BONE. 2008;43(2):230-237.

Characterization of lipid metabolism in insulin-sensitive adipocytes differentiated from immortalized human mesenchymal stem cells.
Prawitt J, Niemeier A, Kassem M, Beisiegel U, Heeren J
EXP CELL RES. 2008;314(4):814-824.

Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells.
Rellin L, Heeren J, Beisiegel U
BBA-MOL CELL BIOL L. 2008;1781(5):232-238.

Liver TAG transiently decreases while PL n-3 and n-6 fatty acids are persistently elevated in insulin resistant mice.
Scheja L, Tödter K, Mohr R, Niederfellner G, Michael M, Meissner A, Schoettler A, Pospisil H, Beisiegel U, Heeren J
LIPIDS. 2008;43(11):1039-1051.

2007

Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor.
Loeffler B, Heeren J, Blaeser M, Radner H, Kayser D, Aydin B, Merkel M
J LIPID RES. 2007;48(2):288-298.

Letzte Aktualisierung aus dem FIS: 21.12.2024 - 04:11 Uhr