Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes
Dottermusch M, Biabani A, Lempertz T, Schumann Y, Navolic J, Godbole S, Obrecht D, Frank S, Dorostkar M, Voß H, Schlüter H, Rutkowski S, Schüller U, Neumann J
NEURO-ONCOLOGY. 2024;26(5):935-949.

Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Dottermusch M, Ryba A, Ricklefs F, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann J, Schüller U
ACTA NEUROPATHOL. 2024;147(1):16.

A prognostic neural epigenetic signature in high-grade glioma
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller P, Sahm F, Menstel J, Zimmer D, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
NAT MED. 2024;30(6):1622-1635.

Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber T, Bonn S, Voß H, Neumann J, Silverbush D, Hovestadt V, Suvà M, Lamszus K, Gempt J, Westphal M, Heiland D, Hänzelmann S, Ricklefs F
ACTA NEUROPATHOL. 2024;147(1):21.

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
Godbole S, Voß H, Gocke A, Schlumbohm S, Schumann Y, Peng B, Mynarek M, Rutkowski S, Dottermusch M, Dorostkar M, Korshunov A, Mair T, Pfister S, Kwiatkowski M, Hotze M, Neumann P, Hartmann C, Weis J, Liesche-Starnecker F, Guan Y, Moritz M, Siebels B, Struve N, Schlüter H, Schüller U, Krisp C, Neumann J
NAT COMMUN. 2024;15(1):6237.

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar M, Takami T, Obrecht D, Takai K, Suwala A, Komori T, Godbole S, Wefers A, Otani R, Neumann J, Higuchi F, Schweizer L, Nakanishi Y, Monoranu C, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner V, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U
ACTA NEUROPATHOL. 2024;147(1):22.

Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas
Schüller U, Gocke A, Godbole S, Delbridge C, Thomas C, Neumann J
ACTA NEUROPATHOL. 2024;147(1):83.

Morphology-based molecular classification of spinal cord ependymomas using deep neural networks
Schumann Y, Dottermusch M, Schweizer L, Krech M, Lempertz T, Schüller U, Neumann P, Neumann J
BRAIN PATHOL. 2024;34(5):e13239.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Song F, Kovac V, Mohammadi B, Littau J, Scharfenberg F, Matamoros Angles A, Vanni I, Shafiq M, Orge L, Galliciotti G, Djakkani S, Linsenmeier L, Černilec M, Hartman K, Jung S, Tatzelt J, Neumann J, Damme M, Tschirner S, Lichtenthaler S, Ricklefs F, Sauvigny T, Schmitz M, Zerr I, Puig B, Tolosa E, Ferrer I, Magnus T, Rupnik M, Sepulveda-Falla D, Matschke J, Šmid L, Bresjanac M, Andreoletti O, Krasemann S, Foliaki S, Nonno R, Becker-Pauly C, Monzo C, Crozet C, Haigh C, Glatzel M, Curin Serbec V, Altmeppen H
ACTA NEUROPATHOL. 2024;148(1):2.

Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Stegat L, Eckhardt A, Gocke A, Neyazi S, Pohl L, Schmid S, Dottermusch M, Frank S, Pinnschmidt H, Herms J, Glatzel M, Snuderl M, Schweizer L, Thomas C, Neumann J, Dorostkar M, Schüller U, Wefers A
ACTA NEUROPATHOL. 2024;148(1):.

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
bioRxiv. 2023.

MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Göbel C, Godbole S, Schoof M, Holdhof D, Kresbach C, Loose C, Neumann J, Schüller U
ACTA NEUROPATHOL COM. 2023;11(1):174.

Direct 3D Sampling of the Embryonic Mouse Head: Layer-wise Nanosecond Infrared Laser (NIRL) Ablation from Scalp to Cortex for Spatially Resolved Proteomics
Navolić J, Moritz M, Voß H, Schlumbohm S, Schumann Y, Schlüter H, Neumann J, Hahn J
ANAL CHEM. 2023;95(47):17220-17227.

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures
Schoof M, Godbole S, Albert T, Dottermusch M, Walter C, Ballast A, Qin N, Olivera M, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter L, Epplen G, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach A, Eckhardt A, Münter D, Verma A, Struve N, Jones D, Remke M, Neumann J, Kerl K, Schüller U
NAT COMMUN. 2023;14(1):7717.

Robust classification using average correlations as features (ACF)
Schumann Y, Neumann J, Neumann P
BMC BIOINFORMATICS. 2023;24(1):.

Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
Bockmayr M, Harnisch K, Pohl L, Schweizer L, Mohme T, Körner M, Alawi M, Suwala A, Dorostkar M, Monoranu C, Hasselblatt M, Wefers A, Capper D, Hench J, Frank S, Richardson T, Tran I, Liu E, Snuderl M, Engertsberger L, Benesch M, von Deimling A, Obrecht D, Mynarek M, Rutkowski S, Glatzel M, Neumann J, Schüller U
NEURO-ONCOLOGY. 2022;24(10):1689-1699.

Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency featuring a high-grade atypical teratoid/rhabdoid tumour component
Dottermusch M, Schumann Y, Kordes U, Hasselblatt M, Neumann J
NEUROPATH APPL NEURO. 2022;48(3):e12777.

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC
Hasselblatt M, Thomas C, Federico A, Bens S, Hellström M, Casar-Borota O, Kordes U, Neumann J, Dottermusch M, Rodriguez F, Lo A, Cheng S, Hendson G, Hukin J, Hartmann C, Koch A, Capper D, Siebert R, Paulus W, Nemes K, Johann P, Frühwald M, Kool M
NEUROPATH APPL NEURO. 2022;48(4):e12797.

HarmonizR enables data harmonization across independent proteomic datasets with appropriate handling of missing values
Voß H, Schlumbohm S, Barwikowski P, Wurlitzer M, Dottermusch M, Neumann P, Schlüter H, Neumann J, Krisp C
NAT COMMUN. 2022;13(1):.

Molecular diagnostics helps to identify distinct subgroups of spinal astrocytomas
Biczok A, Strübing F, Eder J, Egensperger R, Schnell O, Zausinger S, Neumann J, Herms J, Tonn J, Dorostkar M
ACTA NEUROPATHOL COM. 2021;9(1):.

An atypical teratoid/rhabdoid tumor (AT/RT) with molecular features of pleomorphic xanthoastrocytoma (PXA) in a 62-year-old patient
Dottermusch M, Alomari A, Uksul N, Knappe U, Neumann J
Free Neuropathology. 2021;2:.

Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
Dottermusch M, Sumisławski P, Krevet J, Middelkamp M, Voß H, Siebels B, Bartsch H, Sotlar K, Meyer P, Frank S, Korshunov A, Glatzel M, Schüller U, Neumann J
ONCOGENESIS. 2021;10(11):78.

Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
Middelkamp M, Ruck L, Krisp C, Sumisławski P, Mohammadi B, Dottermusch M, Meister V, Küster L, Schlüter H, Windhorst S, Neumann J
ACTA NEUROPATHOL COM. 2021;9(1):185.

Correction to: Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(4):627.

Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(2):323-325.

The genetic landscape of choroid plexus tumors in children and adults
Thomas C, Soschinski P, Zwaig M, Oikonomopoulos S, Okonechnikov K, Pajtler K, Sill M, Schweizer L, Koch A, Neumann J, Schüller U, Sahm F, Rauschenbach L, Keyvani K, Proescholdt M, Riemenschneider M, Segewiß J, Ruckert C, Grauer O, Monoranu C, Lamszus K, Patrizi A, Kordes U, Siebert R, Kool M, Ragoussis J, Foulkes W, Paulus W, Rivera B, Hasselblatt M
NEURO-ONCOLOGY. 2021;23(4):650-660.

Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
Zin F, Cotter J, Haberler C, Dottermusch M, Neumann J, Schüller U, Schweizer L, Thomas C, Nemes K, Johann P, Kool M, Frühwald M, Paulus W, Judkins A, Hasselblatt M
BRAIN PATHOL. 2021;31(5):e12967.

Molecular characterization of histopathological ependymoma variants
Neumann J, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar M, Wefers A, Frank S, Monoranu C, Koch A, Witt H, Kool M, Pajtler K, Rutkowski S, Glatzel M, Schüller U
ACTA NEUROPATHOL. 2020;139(2):305-318.

TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma
Hellwig M, Lauffer M, Bockmayr M, Spohn M, Merk D, Harrison L, Ahlfeld J, Kitowski A, Neumann J, Ohli J, Holdhof D, Niesen J, Schoof M, Kool M, Kraus C, Zweier C, Holmberg D, Schüller U
ACTA NEUROPATHOL. 2019;137(4):657-673.

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
Merk D, Ohli J, Merk N, Thatikonda V, Morrissy S, Schoof M, Schmid S, Harrison L, Filser S, Ahlfeld J, Erkek S, Raithatha K, Andreska T, Weißhaar M, Launspach M, Neumann J, Shakarami M, Plenker D, Marra M, Li Y, Mungall A, Moore R, Ma Y, Jones S, Lutz B, Ertl-Wagner B, Rossi A, Wagener R, Siebert R, Jung A, Eberhart C, Lach B, Sendtner M, Pfister S, Taylor M, Chavez L, Kool M, Schüller U
DEV CELL. 2018;44(6):709-724.e6.

Medulloblastoma: experimental models and reality
Neumann J, Swartling F, Schüller U
ACTA NEUROPATHOL. 2017;134(5):679-689.

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Neumann J, Wefers A, Lambo S, Bianchi E, Bockstaller M, Dorostkar M, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider M, Renner-Müller I, Merk D, Shakarami M, Sharma T, Chavez L, Glass R, Chan J, Taketo M, Neumann P, Kool M, Schüller U
NAT MED. 2017;23(10):1191-1202.

K27M midline gliomas display malignant progression by imaging and histology
Vettermann F, Neumann J, Suchorska B, Bartenstein P, Giese A, Dorostkar M, Albert N, Schüller U
NEUROPATH APPL NEURO. 2017;43(5):458-462.

Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium
Engel N, Neumann J, Ahlfeld J, Wefers A, Merk D, Ohli J, Schüller U
PLOS ONE. 2016;11(11):e0166690.

Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
Langenfurth A, Gu S, Bautze V, Zhang C, Neumann J, Schüller U, Stock K, Wolf S, Maier A, Mastrella G, Pak A, Cheng H, Kälin R, Holmbeck K, Strotmann J, Kettenmann H, Glass R
SCI REP-UK. 2016;6:32203.

Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients
Neumann J, Dorostkar M, Korshunov A, Mawrin C, Koch A, Giese A, Schüller U
J NEUROPATH EXP NEUR. 2016;75(5):408-14.

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin
Ochs S, Dorostkar M, Aramuni G, Schön C, Filser S, Pöschl J, Kremer A, Van Leuven F, Ovsepian S, Herms J
MOL PSYCHIATR. 2015;20(4):482-9.

Localization of SHH medulloblastoma in mice depends on the age at its initiation
Ohli J, Neumann J, Grammel D, Schüller U
ACTA NEUROPATHOL. 2015;130(2):307-9.

A 59-Year-Old Man with Two Cerebellar Lesions and Disturbed Cerebellar Morphology
Pöschl J, Berger F, Kretzschmar H, Schüller U
BRAIN PATHOL. 2015;25(6):790-1.

Histological subtype of medulloblastoma frequently changes upon recurrence
Pöschl J, Koch A, Schüller U
ACTA NEUROPATHOL. 2015;129(3):459-61.

Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue
Rachinger W, Stoecklein V, Terpolilli N, Haug A, Ertl L, Pöschl J, Schüller U, Schichor C, Thon N, Tonn J
J NUCL MED. 2015;56(3):347-53.

Loss of Smarc proteins impairs cerebellar development
Moreno N, Schmidt C, Ahlfeld J, Pöschl J, Dittmar S, Pfister S, Kool M, Kerl K, Schüller U
J NEUROSCI. 2014;34(40):13486-91.

Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma
Pöschl J, Bartels M, Ohli J, Bianchi E, Kuteykin-Teplyakov K, Grammel D, Ahlfeld J, Schüller U
ACTA NEUROPATHOL. 2014;127(4):605-7.

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts
Pöschl J, Stark S, Neumann P, Gröbner S, Kawauchi D, Jones D, Northcott P, Lichter P, Pfister S, Kool M, Schüller U
ACTA NEUROPATHOL. 2014;128(1):123-36.

Subgroup-specific localization of human medulloblastoma based on pre-operative MRI
Wefers A, Warmuth-Metz M, Pöschl J, von Bueren A, Monoranu C, Seelos K, Peraud A, Tonn J, Koch A, Pietsch T, Herold-Mende C, Mawrin C, Schouten-van Meeteren A, van Vuurden D, von Hoff K, Rutkowski S, Pfister S, Kool M, Schüller U
ACTA NEUROPATHOL. 2014;127(6):931-3.

Constitutive activation of β-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system
Pöschl J, Grammel D, Dorostkar M, Kretzschmar H, Schüller U
DEV BIOL. 2013;374(2):319-32.

Treatment of astrocytoma grade III with Photofrin II as a radiosensitizer. A case report
Schaffer M, Hofstetter A, Ertl-Wagner B, Batash R, Neumann J, Schaffer P
STRAHLENTHER ONKOL. 2013;189(11):972-6.

ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients
Adam S, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar H, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(6):788-97.

Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons.
Frick A, Grammel D, Schmidt F, Pöschl J, Priller M, Pagella P, von Bueren A, André O, Peraud A, Tonn J, Rutkowski S, Rutkowski S, Kretzschmar H, Schüller U
GLIA. 2012;60(5):820-832.

Letter to the editor
Schnell O, Pöschl J, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(5):724.

Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Pöschl J, Lorenz A, Hartmann W, von Bueren A, Kool M, Li S, Peraud A, Tonn J, Herms J, Xiang M, Rutkowski S, Kretzschmar H, Schüller U
ONCOGENE. 2011;30(47):4721-4730.

Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
Priller M, Pöschl J, Abrão L, von Bueren A, Cho Y, Rutkowski S, Kretzschmar H, Schüller U
CLIN CANCER RES. 2011;17(21):6791-801.

Letzte Aktualisierung aus dem FIS: 20.12.2024 - 23:32 Uhr