2024

Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation
Adolph J, Fleischhack G, Tschirner S, Rink L, Dittes C, Mikasch R, Dammann P, Mynarek M, Obrecht-Sturm D, Rutkowski S, Bison B, Warmuth-Metz M, Pietsch T, Pfister S, Pajtler K, Milde T, Kortmann R, Dietzsch S, Timmermann B, Tippelt S
CANCERS. 2024;16(11):.

Classification of Brain Tumors by Nanopore Sequencing of Cell-Free DNA from Cerebrospinal Fluid
Afflerbach A, Rohrandt C, Brändl B, Sönksen M, Hench J, Frank S, Börnigen D, Alawi M, Mynarek M, Winkler B, Ricklefs F, Synowitz M, Dührsen L, Rutkowski S, Wefers A, Müller F, Schoof M, Schüller U
CLIN CHEM. 2024;70(1):250-260.

The German sickle cell disease registry reveals a surprising risk of acute splenic sequestration and an increased transfusion requirement in patients with compound heterozygous sickle cell disease HbS/β-thalassaemia and no or low HbA expression
Allard P, Tagliaferri L, Weru V, Cario H, Lobitz S, Grosse R, Bleeke M, Oevermann L, Hakimeh D, Jarisch A, Kopp-Schneider A, Kulozik A, Kunz J
EUR J HAEMATOL. 2024;113(4):501-509.

Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
Anastasopoulou S, Swann G, Andres-Jensen L, Attarbaschi A, Barzilai-Birenboim S, Erdelyi D, Escherich G, Hamadeh L, Harila A, Lopez-Lopez E, McGowan S, Möricke A, Putti C, Sagi J, Schmiegelow K, Ullrich N, van der Sluis I, Wahid Q, Winick N, Sramkova L, Zalcberg Y, Zapotocka E, Bhojwani D, Halsey C
BRIT J HAEMATOL. 2024;205(4):1450-1459.

Correction: Bailey et al. Clinical Trials in High-Risk Medulloblastoma: Evolution of the SIOP-Europe HR-MB Trial. Cancers 2022, 14, 374
Bailey S, André N, Gandola L, Massimino M, Wheatley K, Gates S, Homer V, Rutkowski S, Clifford S
CANCERS. 2024;16(6):.

Overview of Neuro-Ophthalmic Findings in Leukodystrophies
Bettinger C, Dulz S, Atiskova Y, Guerreiro H, Schön G, Guder P, Maier S, Denecke J, Bley A
J CLIN MED. 2024;13(17):.

Molecular refinement of pilocytic astrocytoma in adult patients
Bode H, Kresbach C, Holdhof D, Dorostkar M, Harter P, Hench J, Frank S, Suwala A, Schweizer L, Eckhardt A, Neyazi S, Bockmayr M, Wefers A, Schüller U
NEUROPATH APPL NEURO. 2024;50(1):e12949.

Survival in primary hemophagocytic lymphohistiocytosis, 2016 to 2021: etoposide is better than its reputation
Böhm S, Wustrau K, Pachlopnik Schmid J, Prader S, Ahlman M, Yacobovich J, Beier R, Speckmann C, Behnisch W, Ifversen M, Jordan M, Marsh R, Naumann-Bartsch N, Mauz-Koerholz C, Honig M, Schulz A, Malinowska I, Hines M, Nichols K, Gil-Herrera J, Talano J, Crooks B, Formankova R, Jorch N, Bakhtiar S, Kühnle I, Streiter M, Nathrath M, Russo A, Duerken M, Lang P, Lindemans C, Henter J, Lehmberg K, Ehl S
BLOOD. 2024;143(10):872-881.

40-Year-old man with two asynchronous spinal cord tumors
Bschorer M, Dottermusch M, Matschke J, Gempt J, Schüller U, Mohme M
BRAIN PATHOL. 2024;34(6):e13309.

No clear benefit of preventive cranial radiotherapy in childhood Philadelphia-positive acute lymphoblastic leukemia: a retrospective analysis of the EsPhALL2010 study
Conter V, Valsecchi M, De Lorenzo P, Gandemer V, Heyman M, Saha V, Diaz P, Li C, Attarbaschi A, Escherich G, Stary J, Schrappe M, Pieters R, Cario G, Biondi A
HAEMATOLOGICA. 2024;109(11):3766-3770.

Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial
Corbacioglu S, Lode H, Ellinger S, Zeman F, Suttorp M, Escherich G, Bochennek K, Gruhn B, Lang P, Rohde M, Debatin K, Steinbach D, Beilken A, Ladenstein R, Spachtholz R, Heiss P, Hellwig D, Tröger A, Koller M, Menhart K, Riemenschneider M, Zoubaa S, Kietz S, Jakob M, Sommer G, Heise T, Hundsdörfer P, Kühnle I, Dilloo D, Schönberger S, Schwabe G, von Luettichau I, Graf N, Schlegel P, Frühwald M, Jorch N, Paulussen M, Schneider D, Metzler M, Leipold A, Nathrath M, Imschweiler T, Christiansen H, Schmid I, Crazzolara R, Niktoreh N, Cario G, Faber J, Demmert M, Babor F, Fröhlich B, Bielack S, Bernig T, Greil J, Eggert A, Simon T, Foell J
LANCET ONCOL. 2024;25(7):922-932.

Overview of current European practice for the management of patients with intracranial germ cell tumours
Diezi M, Pizer B, Murray M
EJC Paediatric Oncology. 2024;3:.

Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes
Dottermusch M, Biabani A, Lempertz T, Schumann Y, Navolic J, Godbole S, Obrecht D, Frank S, Dorostkar M, Voß H, Schlüter H, Rutkowski S, Schüller U, Neumann J
NEURO-ONCOLOGY. 2024;26(5):935-949.

Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features
Dottermusch M, Ryba A, Ricklefs F, Flitsch J, Schmid S, Glatzel M, Saeger W, Neumann J, Schüller U
ACTA NEUROPATHOL. 2024;147(1):16.

Unclassifiable CNS tumors in DNA methylation-based classification: clinical challenges and prognostic impact
Drexler R, Brembach F, Sauvigny J, Ricklefs F, Eckhardt A, Bode H, Gempt J, Lamszus K, Westphal M, Schüller U, Mohme M
ACTA NEUROPATHOL COM. 2024;12(1):9.

A prognostic neural epigenetic signature in high-grade glioma
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller P, Sahm F, Menstel J, Zimmer D, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
NAT MED. 2024;30(6):1622-1635.

Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma
Drexler R, Khatri R, Schüller U, Eckhardt A, Ryba A, Sauvigny T, Dührsen L, Mohme M, Ricklefs T, Bode H, Hausmann F, Huber T, Bonn S, Voß H, Neumann J, Silverbush D, Hovestadt V, Suvà M, Lamszus K, Gempt J, Westphal M, Heiland D, Hänzelmann S, Ricklefs F
ACTA NEUROPATHOL. 2024;147(1):21.

Applications of Nanopore sequencing in precision cancer medicine
Dyshlovoy S, Paigin S, Afflerbach A, Lobermeyer A, Werner S, Schüller U, Bokemeyer C, Schuh A, Bergmann L, von Amsberg G, Joosse S
INT J CANCER. 2024;155(12):2129-2140.

Mean global DNA methylation serves as independent prognostic marker in IDH wild type glioblastoma
Eckhardt A, Drexler R, Schoof M, Struve N, Capper D, Jelgersma C, Onken J, Harter P, Weber K, Divé I, Rothkamm K, Hoffer K, Klumpp L, Ganser K, Petersen C, Ricklefs F, Kriegs M, Schüller U
NEURO-ONCOLOGY. 2024;26(3):503-513.

Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Ehm P, Horn S, Hoffer K, Kriegs M, Horn M, Giehler S, Nalaskowski M, Rehbach C, Horstmann M, Jücker M
CELL COMMUN SIGNAL. 2024;22(1):360.

ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies
Elitzur S, Shiloh R, Loeffen J, Pastorczak A, Takagi M, Bomken S, Baruchel A, Lehrnbecher T, Tasian S, Abla O, Arad-Cohen N, Astigarraga I, Ben-Harosh M, Bodmer N, Brozou T, Ceppi F, Chugaeva L, Dalla Pozza L, Ducassou S, Escherich G, Farah R, Gibson A, Hasle H, Hoveyan J, Jacoby E, Jazbec J, Junk S, Kolenova A, Lazic J, Lo Nigro L, Mahlaoui N, Miller L, Papadakis V, Pecheux L, Pillon M, Sarouk I, Stary J, Stiakaki E, Strullu M, Tran T, Ussowicz M, Verdu-Amoros J, Wakulinska A, Zawitkowska J, Stoppa-Lyonnet D, Taylor A, Shiloh Y, Izraeli S, Minard-Colin V, Schmiegelow K, Nirel R, Attarbaschi A, Borkhardt A
BLOOD. 2024;144(11):1193-1205.

Radiation Therapy Plays an Important Role in the Treatment of Atypical Teratoid/Rhabdoid Tumors: Analysis of the EU-RHAB Cohorts and Their Precursors
Frisch S, Libuschewski H, Peters S, Gerß J, von Hoff K, Kortmann R, Nemes K, Rutkowski S, Hasselblatt M, Pietsch T, Frühwald M, Timmermann B
INT J RADIAT ONCOL. 2024;119(4):1147-1157.

Unnecessary diagnostic imaging requested by medical students during a first day of residency simulation: an explorative study.
Gärtner J, Bußenius L, Prediger S, Harendza S
BMC MED EDUC. 2024.

Multiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
Godbole S, Voß H, Gocke A, Schlumbohm S, Schumann Y, Peng B, Mynarek M, Rutkowski S, Dottermusch M, Dorostkar M, Korshunov A, Mair T, Pfister S, Kwiatkowski M, Hotze M, Neumann P, Hartmann C, Weis J, Liesche-Starnecker F, Guan Y, Moritz M, Siebels B, Struve N, Schlüter H, Schüller U, Krisp C, Neumann J
NAT COMMUN. 2024;15(1):6237.

Clinically relevant molecular hallmarks of PFA ependymomas display intratumoral heterogeneity and correlate with tumor morphology
Gödicke S, Kresbach C, Ehlert M, Obrecht D, Altendorf L, Hack K, von Hoff K, Carén H, Melcher V, Kerl K, Englinger B, Filbin M, Pajtler K, Gojo J, Pietsch T, Rutkowski S, Schüller U
ACTA NEUROPATHOL. 2024;147(1):23.

Abdominal Aspergillosis – an Underdiagnosed Disease? Three Cases of Abdominal Aspergillosis in Severely Immunocompromised Infants
Hauch R, Jankofsky M, Klohs S, Herden U, Blohm M, Winkler B
KLIN PADIATR. 2024;236(3):189-192.

PaedVacCOVID - safety of the BNT162b2 vaccine against the SARS-CoV-2 in children with and without comorbidities aged 5 to 11 years
Holzwarth S, Saadat K, Jorczyk M, Dreßen S, Kotsias-Konopelska S, Schlegtendal A, Maier C, Schmitt J, Paul K, Pagel J, Muntau A, Berner R, Brinkmann F, Toepfner N
INFECTION. 2024.

Child-centredness in paediatric magnetic resonance imaging: Information needs and experiences of children requiring magnetic resonance imaging and their parents
Inhestern L, Herrmann J, Schürmann J, Meister R, Nawka M, Mynarek M, Linhart D, Bergelt C
CHILD CARE HLTH DEV. 2024;50(1):e13157.

Reintegration into school, kindergarten and work in families of childhood cancer survivors after a family-oriented rehabilitation program
Inhestern L, Nasse M, Krauth K, Kandels D, Rutkowski S, Escherich G, Bergelt C
FRONT PEDIATR. 2024;12:1288567.

Erklärbare Künstliche Intelligenz in der Pathologie
Klauschen F, Dippel J, Keyl P, Jurmeister P, Bockmayr M, Mock A, Buchstab O, Alber M, Ruff L, Montavon G, Müller K
PATHOLOGIE. 2024;45(2):133-139.

Toward Explainable Artificial Intelligence for Precision Pathology
Klauschen F, Dippel J, Keyl P, Jurmeister P, Bockmayr M, Mock A, Buchstab O, Alber M, Ruff L, Montavon G, Müller K
ANNU REV PATHOL-MECH. 2024;19:541-570.

Transcriptomics-based characterization of the immuno-stromal microenvironment in pediatric low-grade glioma
Körner M, Spohn M, Schüller U, Bockmayr M
ONCOIMMUNOLOGY. 2024;13(1):2386789.

Intraventricular SHH inhibition proves efficient in SHH medulloblastoma mouse model and prevents systemic side effects
Kresbach C, Holst L, Schoof M, Leven T, Göbel C, Neyazi S, Tischendorf J, Loose C, Wrzeszcz A, Yorgan T, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2024;26(4):609-622.

Finding a balance in reduced toxicity hematopoietic stem cell transplantation for thalassemia: role of infused CD3+ cell count and immunosuppression
Meissner B, Lang P, Bader P, Hoenig M, Müller I, Meisel R, Greil J, Sauer M, Metzler M, Corbacioglu S, Burkhardt B, Wölfl M, Strahm B, Kafa K, Basu O, Lode H, Gruhn B, Cario H, Ozga A, Zimmermann M, Jarisch A, Beier R
BONE MARROW TRANSPL. 2024;59(5):587-596.

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Mochmann L, Treue D, Bockmayr M, Silva P, Zasada C, Mastrobuoni G, Bayram S, Forbes M, Jurmeister P, Liebig S, Blau O, Schleich K, Splettstoesser B, Nordmann T, von der Heide E, Isaakidis K, Schulze V, Busch C, Siddiq H, Schlee C, Hester S, Fransecky L, Neumann M, Kempa S, Klauschen F, Baldus C
CANCER GENE THER. 2024;31(9):1344-1356.

Risk factors for domain-specific neurocognitive outcome in pediatric survivors of a brain tumor in the posterior fossa - Results of the HIT 2000 trial
Mynarek M, Rossius A, Guiard A, Ottensmeier H, von Hoff K, Obrecht-Sturm D, Bußenius L, Friedrich C, von Bueren A, Gerber N, Traunwieser T, Kortmann R, Warmuth-Metz M, Bison B, Thomale U, Krauss J, Pietsch T, Clifford S, Pfister S, Sturm D, Sahm F, Tischler T, Rutkowski S
NEURO-ONCOLOGY. 2024;26(11):2113-2124.

Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
Neyazi S, Yamazawa E, Hack K, Tanaka S, Nagae G, Kresbach C, Umeda T, Eckhardt A, Tatsuno K, Pohl L, Hana T, Bockmayr M, Kim P, Dorostkar M, Takami T, Obrecht D, Takai K, Suwala A, Komori T, Godbole S, Wefers A, Otani R, Neumann J, Higuchi F, Schweizer L, Nakanishi Y, Monoranu C, Takami H, Engertsberger L, Yamada K, Ruf V, Nomura M, Mohme T, Mukasa A, Herms J, Takayanagi S, Mynarek M, Matsuura R, Lamszus K, Ishii K, Kluwe L, Imai H, von Deimling A, Koike T, Benesch M, Kushihara Y, Snuderl M, Nambu S, Frank S, Omura T, Hagel C, Kugasawa K, Mautner V, Ichimura K, Rutkowski S, Aburatani H, Saito N, Schüller U
ACTA NEUROPATHOL. 2024;147(1):22.

Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, Alonso M, Antonelli M, Bailey S, Baugh J, Biassoni V, Blattner Johnson M, Broniscer A, Carai A, Colafati G, Colditz N, Corbacioglu S, Crampsie S, Entz-Werle N, Eyrich M, Friker L, Frühwald M, Garrè M, Gerber N, Giangaspero F, Gil-da-Costa M, Graf N, Hargrave D, Hauser P, Herrlinger U, Hoffmann M, Hulleman E, Izquierdo E, Jacobs S, Karremann M, Kattamis A, Kebudi R, Kortmann R, Kwiecien R, Massimino M, Mastronuzzi A, Miele E, Morana G, Noack C, Pentikainen V, Perwein T, Pfister S, Pietsch T, Roka K, Rossi S, Rutkowski S, Schiavello E, Seidel C, Štěrba J, Sturm D, Sumerauer D, Tacke A, Temelso S, Valentini C, van Vuurden D, Varlet P, Veldhuijzen van Zanten S, Vinci M, von Bueren A, Warmuth-Metz M, Wesseling P, Wiese M, Wolff J, Zamecnik J, Morales La Madrid A, Bison B, Gielen G, Jones D, Jones C, Kramm C
NEURO-ONCOLOGY. 2024;26(9):1723-1737.

Pineal anlage tumor: clinical and diagnostic features, and rationales for treatment
Obrecht-Sturm D, Pfaff E, Mynarek M, Bison B, Rodehüser M, Becker M, Kietz S, Pfister S, Jones D, Sturm D, von Deimling A, Sahm F, Kortmann R, Schwarz R, Pietsch T, Fleischhack G, Rutkowski S
J NEURO-ONCOL. 2024;166(2):359-368.

Treatment response as surrogate to predict risk for disease progression in pediatric medulloblastoma with persistent magnetic resonance imaging lesions after first-line treatment
Obrecht-Sturm D, Schömig L, Mynarek M, Bison B, Schwarz R, Pietsch T, Pfister S, Sill M, Sturm D, Sahm F, Kortmann R, Gerber N, von Bueren A, Fleischhack G, Schüller U, Nussbaumer G, Benesch M, Rutkowski S
NEURO-ONCOLOGY. 2024;26(9):1712-1722.

Distinct relapse pattern across molecular ependymoma types
Obrecht-Sturm D, Schoof M, Eckhardt A, Mynarek M, Gilbert M, Aldape K, Armstrong T, Ramaswamy V, Bockmayr M, von Hoff K, Fleischhack G, Adolph J, Tippelt S, Pfister S, Pajtler K, Sturm D, Drexler R, Ricklefs F, Stepien N, Gojo J, Pietsch T, Warmuth-Metz M, Kortmann R, Timmermann B, Haberler C, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2024 [Epub ahead of print].

ETV6::RUNX1 Acute Lymphoblastic Leukemia: how much therapy is needed for cure?
Østergaard A, Fiocco M, de Groot-Kruseman H, Moorman A, Vora A, Zimmermann M, Schrappe M, Biondi A, Escherich G, Stary J, Imai C, Imamura T, Heyman M, Schmiegelow K, Pieters R
LEUKEMIA. 2024;38(7):1477-1487.

Addressing gaps and enhancing experiences in support services for families of pediatric cancer survivors
Paul V, Inhestern L, Sigmund D, Winzig J, Rutkowski S, Escherich G, Bergelt C
PEDIATR RES. 2024 [Epub ahead of print].

The needs of families of pediatric cancer survivors: challenges and developments in psychosocial support services
Paul V, Inhestern L, Sigmund D, Winzig J, Rutkowski S, Escherich G, Bergelt C
PEDIATR RES. 2024 [Epub ahead of print].

Haematopoietic stem cell transplantation after reduced intensity conditioning in children and adolescents with chronic myeloid leukaemia: A prospective multicentre trial of the I-BFM Study Group
Pichler H, Sedlacek P, Meisel R, Beier R, Faraci M, Kalwak K, Ifversen M, Müller I, Stein J, Vettenranta K, Kropshofer G, Kolenova A, Karlhuber S, Glogova E, Poetschger U, Peters C, Suttorp M, Matthes-Leodolter S, Balduzzi A
BRIT J HAEMATOL. 2024;205(1):268-279.

Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
Pohl L, Leitheiser M, Obrecht D, Schweizer L, Wefers A, Eckhardt A, Raffeld M, Sturm D, Pajtler K, Rutkowski S, Fukuoka K, Ichimura K, Bockmayr M, Schüller U
ACTA NEUROPATHOL. 2024;147(1):24.

Glycan Structures in Osteosarcoma as Targets for Lectin-Based Chimeric Antigen Receptor Immunotherapy
Prasse N, Wessolowski C, Müller I, Cornils K, Franke A
INT J MOL SCI. 2024;25(10):.

Twinning to reduce research and innovation inequalities in paediatric solid tumours across Europe
Rascon J, Blackute R, Cerkauskiene A, Taschner-Mandl S, Andrade N, Planinic A, Rutkowski S, Schüller U, Nysom K, Tuckuviene R, Brok J, Schmiegelow K, van den Heuvel-Eibrink M, van der Perk M, Haupt R, Muraca M, Saraceno D, Geoerger B, Manuzi G, Ladenstein R
EJC Paediatric Oncology. 2024;3:.

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells
Rieckmann L, Spohn M, Ruff L, Agorku D, Becker L, Borchers A, Krause J, O'Reilly R, Hille J, Velthaus-Rusik J, Beumer N, Günther A, Willnow L, Imbusch C, Iglauer P, Simon R, Franzenburg S, Winter H, Thomas M, Bokemeyer C, Gagliani N, Krebs C, Sprick M, Hardt O, Riethdorf S, Trumpp A, Stoecklein N, Peine S, Rosenstiel P, Pantel K, Loges S, Janning M
MOL CANCER. 2024;23(1):93.

Diagnosing intravascular B-cell lymphoma using nanopore sequencing of cell-free DNA from cerebrospinal fluid
Schmidt B, Afflerbach A, Ludewig P, Dirksen P, Paulsen F, Magnus T, Alawi M, Schüller U, Weisel K, Bokemeyer C, Christopeit M
ESMO OPEN. 2024;9(11):103974.

Anaplastic histology and distinct molecular features in a small series of spinal cord ependymomas
Schüller U, Gocke A, Godbole S, Delbridge C, Thomas C, Neumann J
ACTA NEUROPATHOL. 2024;147(1):83.

Morphology-based molecular classification of spinal cord ependymomas using deep neural networks
Schumann Y, Dottermusch M, Schweizer L, Krech M, Lempertz T, Schüller U, Neumann P, Neumann J
BRAIN PATHOL. 2024;34(5):e13239.

Medulloblastoma in children with Fanconi anemia: Association with FA-D1/FA-N, SHH type and poor survival independent of treatment strategies
Sönksen M, Obrecht-Sturm D, Hernáiz Driever P, Sauerbrey A, Graf N, Kontny U, Reimann C, Langhein M, Kordes U, Schwarz R, Obser T, Boschann F, Schüller U, Altendorf L, Goschzik T, Pietsch T, Mynarek M, Rutkowski S
NEURO-ONCOLOGY. 2024;26(11):2125-2139.

Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Stegat L, Eckhardt A, Gocke A, Neyazi S, Pohl L, Schmid S, Dottermusch M, Frank S, Pinnschmidt H, Herms J, Glatzel M, Snuderl M, Schweizer L, Thomas C, Neumann J, Dorostkar M, Schüller U, Wefers A
ACTA NEUROPATHOL. 2024;148(1):.

An artificial intelligence-assisted clinical framework to facilitate diagnostics and translational discovery in hematologic neoplasia
Tang M, Antić Ž, Fardzadeh P, Pietzsch S, Schröder C, Eberhardt A, van Bömmel A, Escherich G, Hofmann W, Horstmann M, Illig T, McCrary J, Lentes J, Metzler M, Nejdl W, Schlegelberger B, Schrappe M, Zimmermann M, Miarka-Walczyk K, Pastorczak A, Cario G, Renard B, Stanulla M, Bergmann A
EBIOMEDICINE. 2024;104:105171.

Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies
Traunwieser T, Loos E, Ottensmeier H, Gastberger K, Nemes K, Mynarek M, Bison B, Kandels D, Neumayer P, Neumann-Holbeck A, Lüttich P, Baust K, Faulstich-Ritter K, John R, Kreisch A, Landmann J, Manteufel E, Nest A, Prüfe J, Schubert L, Stamm W, Timmermann B, Gerss J, Rutkowski S, Schlegel P, Eyrich M, Gnekow A, Frühwald M
PEDIATR BLOOD CANCER. 2024;71(5):e30910.

Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer
van Kalsbeek R, Hudson M, Mulder R, Ehrhardt M, Green D, Mulrooney D, Hakkert J, den Hartogh J, Nijenhuis A, van Santen H, Schouten-van Meeteren A, van Tinteren H, Verbruggen L, Conklin H, Jacola L, Webster R, Partanen M, Kollen W, Grootenhuis M, Pieters R, Kremer L
NAT MED. 2024;30(2):603.

Tyrosine kinase inhibitor resistance in de novo BCR::ABL1-positive BCP-ALL beyond kinase domain mutations
van Outersterp I, Boer J, van de Ven C, Reichert C, Boeree A, Kruisinga B, de Groot-Kruseman H, Escherich G, Sijs-Szabo A, Rijneveld A, den Boer M
BLOOD ADV. 2024;8(8):1835-1845.

Tyrosine kinase inhibitor response of ABL-class acute lymphoblastic leukemia: the role of kinase type and SH3 domain
van Outersterp I, Tasian S, Reichert C, Boeree A, de Groot-Kruseman H, Escherich G, Boer J, den Boer M
BLOOD. 2024;143(21):2178-2189.

A Multimodal Lifestyle Psychosocial Survivorship Program in Young Cancer Survivors: The CARE for CAYA Program-A Randomized Clinical Trial Embedded in a Longitudinal Cohort Study
von Grundherr J, Elmers S, Koch B, Hail L, Mann J, Escherich G, Bergelt C, Samland L, Jensen W, Vettorazzi E, Stark M, Valentini L, Baumann F, Singer S, Reer R, Beller R, Calaminus G, Faber J, Classen C, Gebauer J, Hilgendorf I, Koehler M, Puzik A, Salzmann N, Sander A, Schiffmann L, Sokalska-Duhme M, Schuster S, Kock-Schoppenhauer A, Bokemeyer C, Sinn M, Stein A, Dwinger S, Salchow J
JAMA NETW OPEN. 2024;7(3):e242375.

CD301 and LSECtin glycan-binding receptors of innate immune cells serve as prognostic markers and potential predictors of immune response in breast cancer subtypes
Wegscheider A, Wojahn I, Gottheil P, Spohn M, Käs J, Rosin O, Ulm B, Nollau P, Wagener C, Niendorf A, Wolters-Eisfeld G
GLYCOBIOLOGY. 2024;34(3):.

Suizidhilfe durch Ärzt*innen - zwischen Dürfen, Können und Sollen
Winkler B
2024. Ethik des assistierten Suizids. Bozzaro C, Richter G, Rehmann-Sutter C (Hrsg.). 1. Aufl. Bielefeld: transcript Verlag, 59-71.

And what about today? Burden and support needs of adolescent childhood cancer survivors in long-term follow-up care-A qualitative content analysis
Winzig J, Inhestern L, Sigmund D, Paul V, Hail L, Rutkowski S, Escherich G, Bergelt C
CHILD CARE HLTH DEV. 2024;50(1):e13207.

Exploring the perspective of adolescent childhood cancer survivors on follow-up care and their concerns regarding the transition process-A qualitative content analysis
Winzig J, Inhestern L, Sigmund D, Paul V, Hail L, Rutkowski S, Escherich G, Bergelt C
CANCER MED-US. 2024;13(10):.

2023

Germ Cell Maintenance and Sustained Testosterone and Precursor Hormone Production in Human Prepubertal Testis Organ Culture with Tissues from Boys 7 Years+ under Conditions from Adult Testicular Tissue
Aden N, Bleeke M, Kordes U, Brunne B, Holstermann B, Biemann R, Ceglarek U, Soave A, Salzbrunn A, Schneider S, Kopylow K
CELLS-BASEL. 2023;12(3):.

Multimodal cartography of human lymphopoiesis reveals B and T/NK/ILC lineages are subjected to differential regulation
Alhaj Hussen K, Chabaane E, Nelson E, Lekiashvili S, Diop S, Keita S, Evrard B, Lardenois A, Delord M, Verhoeyen E, Cornils K, Kasraian Z, Macintyre E, Cumano A, Garrick D, Goodhardt M, Andrieu G, Asnafi V, Chalmel F, Canque B
ISCIENCE. 2023;26(10):.

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study
Attarbaschi A, Möricke A, Harrison C, Mann G, Baruchel A, De Moerloose B, Conter V, Devidas M, Elitzur S, Escherich G, Hunger S, Horibe K, Manabe A, Loh M, Pieters R, Schmiegelow K, Silverman L, Stary J, Vora A, Pui C, Schrappe M, Zimmermann M
J CLIN ONCOL. 2023;41(7):1404-1422.

Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma
Au-Yeung R, Padilla L, Zimmermann M, Reinke S, Oschlies I, Escherich G, Woessmann W, Burkhardt B, Klapper W
LEUKEMIA. 2023;37(2):488-491.

Health-Related Quality of Life and Mental Health of Children with Embryonal Abdominal Tumors
Behrendt P, Boettcher M, Zierke K, Najem S, Zapf H, Reinshagen K, Wößmann W, Boettcher J
CHILDREN-BASEL. 2023;10(10):.

Improving outcomes of childhood and young adult non-Hodgkin lymphoma: 25 years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma
Beishuizen A, Mellgren K, Andrés M, Auperin A, Bacon C, Bomken S, Burke G, Burkhardt B, Brugieres L, Chiang A, Damm-Welk C, d'Amore E, Horibe K, Kabickova E, Khanam T, Kontny U, Klapper W, Lamant L, Le Deley M, Loeffen J, Macintyre E, Mann G, Meyer-Wentrup F, Michgehl U, Minard-Colin V, Mussolin L, Oschlies I, Patte C, Pillon M, Reiter A, Rigaud C, Roncery L, Salaverria I, Simonitsch-Klupp I, Uyttebroeck A, Verdu-Amoros J, Williams D, Woessmann W, Wotherspoon A, Wrobel G, Zimmermann M, Attarbaschi A, Turner S
LANCET HAEMATOL. 2023;10(3):e213-e224.

Immunodeficiency with susceptibility to lymphoma with complex genotype affecting energy metabolism (FBP1, ACAD9) and vesicle trafficking (RAB27A)
Brauer N, Maruta Y, Lisci M, Strege K, Oschlies I, Nakamura H, Böhm S, Lehmberg K, Brandhoff L, Ehl S, Parvaneh N, Klapper W, Fukuda M, Griffiths G, Hennies H, Niehues T, Ammann S
FRONT IMMUNOL. 2023;14:1151166.

G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
Cetin M, Rieckmann T, Hoffer K, Riepen B, Christiansen S, Gatzemeier F, Feyerabend S, Schoof M, Schüller U, Petersen C, Mynarek M, Rothkamm K, Kriegs M, Struve N
RADIAT ONCOL. 2023;18(1):.

Left ventricular diastolic filling patterns in competitive triathletes with and without myocardial fibrosis by cardiac magnetic resonance time-volume analysis
Chen H, Jungesblut J, Saering D, Muellerleile K, Beitzen-Heineke A, Harms P, Erley J, Schoennagel B, Schneider J, Cavus E, Fischer R, Lund G, Adam G, Tahir E
EUR J RADIOL. 2023;158:.

Isolated extradural sacrococcygeal ependymoma mimicking teratoma in a 5-year-old boy
Claviez A, Moritz J, Yuan M, Vieth S, Bergholz R, Ahmeti H, Schüller U
KLIN PADIATR. 2023;235(3):185-187.

Elevated RIPK3 correlates with disease burden in myelofibrosis
Dill V, Wagner C, Keller E, Fernandez-Hernandez F, Shoumariyeh K, Odinius T, Buschhorn L, Hauch R, Suren C, Hecker J, Herhaus P, Sandherr M, Schmidt B, Slotta-Huspenina J, Bassermann F, Höckendorf U, Jilg S, Branca C, Vosberg S, Jost P
BLOOD ADV. 2023;7(7):1219-1224.

Unveiling the identities of null cell tumours: Epigenomics corroborate subtle histological cues in pituitary neuroendocrine tumour/adenoma classification
Dottermusch M, Schüller U, Hagel C, Saeger W
NEUROPATH APPL NEURO. 2023;49(1):e12870.

Rapid Determination of Nutmeg Shell Content in Ground Nutmeg Using FT-NIR Spectroscopy and Machine Learning
Drees A, Bockmayr B, Bockmayr M, Fischer M
FOODS. 2023;12(15):.

Targeted anticonvulsive treatment of IDH-wildtype glioblastoma based on DNA methylation subclasses
Drexler R, Göttsche J, Sauvigny T, Schüller U, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Heiland D, Delev D, Venkataramani V, Winkler F, Weller J, Zeyen T, Herrlinger U, Gempt J, Ricklefs F, Dührsen L
NEURO-ONCOLOGY. 2023;25(5):1006-1008.

Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers A, Neumann J, Bode H, Hausmann F, Huber T, Bonn S, Jütten K, Delev D, Weber K, Harter P, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough M, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà M, Krishna S, Hervey-Jumper S, Schüller U, Heiland D, Hänzelmann S, Ricklefs F
bioRxiv. 2023.

Epigenetic profiling reveals a strong association between lack of 5-ALA fluorescence and EGFR amplification in IDH-wildtype glioblastoma
Drexler R, Sauvigny T, Schüller U, Eckhardt A, Maire C, Khatri R, Hausmann F, Hänzelmann S, Huber T, Bonn S, Bode H, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOL PRACT. 2023;10(5):462-471.

DNA methylation subclasses predict the benefit from gross total tumor resection in IDH-wildtype glioblastoma patients
Drexler R, Schüller U, Eckhardt A, Filipski K, Hartung T, Harter P, Divé I, Forster M, Czabanka M, Jelgersma C, Onken J, Vajkoczy P, Capper D, Siewert C, Sauvigny T, Lamszus K, Westphal M, Dührsen L, Ricklefs F
NEURO-ONCOLOGY. 2023;25(2):315-325.

Long-Term Antibody Response to SARS-CoV-2 in Children
Dunay G, Barroso M, Woidy M, Danecka M, Engels G, Hermann K, Neumann F, Paul K, Beime J, Escherich G, Fehse K, Grinstein L, Haniel F, Haupt L, Hecher L, Kehl T, Kemen C, Kemper M, Kobbe R, Kohl A, Klokow T, Nörz D, Olfe J, Schlenker F, Schmiesing J, Schrum J, Sibbertsen F, Stock P, Tiede S, Vettorazzi E, Zazara D, Zapf A, Lütgehetmann M, Oh J, Mir T, Muntau A, Gersting S
J CLIN IMMUNOL. 2023;43(1):46-56.

SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model
Ehm P, Rietow R, Wegner W, Bußmann L, Kriegs M, Dierck K, Horn S, Streichert T, Horstmann M, Jücker M
CELLS-BASEL. 2023;12(13):1798.

EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy
Elitzur S, Vora A, Burkhardt B, Inaba H, Attarbaschi A, Baruchel A, Escherich G, Gibson B, Liu H, Loh M, Moorman A, Möricke A, Pieters R, Uyttebroeck A, Baird S, Bartram J, Barzilai-Birenboim S, Batra S, Ben-Harosh M, Bertrand Y, Buitenkamp T, Caldwell K, Drut R, Geerlinks A, Gilad G, Grainger J, Haouy S, Heaney N, Huang M, Ingham D, Krenova Z, Kuhlen M, Lehrnbecher T, Manabe A, Niggli F, Paris C, Revel-Vilk S, Rohrlich P, Sinno M, Szczepanski T, Tamesberger M, Warrier R, Wolfl M, Nirel R, Izraeli S, Borkhardt A, Schmiegelow K
BLOOD. 2023;141(7):743-755.

Preclinical patient-derived modeling of castration-resistant prostate cancer facilitates individualized assessment of homologous recombination repair deficient disease
Elsesy M, Oh-Hohenhorst S, Oing C, Eckhardt A, Burdak-Rothkamm S, Alawi M, Müller C, Schüller U, Maurer T, von Amsberg G, Petersen C, Rothkamm K, Mansour W
MOL ONCOL. 2023;17(6):1129-1147.

Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study
Erker C, Mynarek M, Bailey S, Mazewski C, Baroni L, Massimino M, Hukin J, Aguilera D, Cappellano A, Ramaswamy V, Lassaletta A, Perreault S, Kline C, Rajagopal R, Michaiel G, Zapotocky M, Santa-Maria Lopez V, La Madrid A, Cacciotti C, Sandler E, Hoffman L, Klawinski D, Khan S, Salloum R, Hoppmann A, Larouche V, Dorris K, Toledano H, Gilheeney S, Abdelbaki M, Wilson B, Tsang D, Knipstein J, Oren M, Shah S, Murray J, Ginn K, Wang Z, Fleischhack G, Obrecht D, Tonn S, Harrod V, Matheson K, Crooks B, Strother D, Cohen K, Hansford J, Mueller S, Margol A, Gajjar A, Dhall G, Finlay J, Northcott P, Rutkowski S, Clifford S, Robinson G, Bouffet E, Lafay-Cousin L
J CLIN ONCOL. 2023;41(10):1921-1932.

Long-term sequelae after immunotherapeutic approaches in haematological malignancies-what do we know?
Escherich G, Hough R
LANCET HAEMATOL. 2023;10(6):e395-e396.

Multiple sclerosis, disease-modifying drugs and risk for adverse perinatal and pregnancy outcomes: Results from a population-based cohort study
Fink K, Gorczyca A, Alping P, Englund S, Farmand S, Langer-Gould A, Piehl F, McKay K, Frisell T, Razaz N
MULT SCLER J. 2023;29(6):731-740.

Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
Franke A, Wessolowski C, Thaden V, Müller I, Cornils K
GENE THER. 2023;30(7-8):603-611.

Surgical Experience Affects the Outcome of Central Venous Access Catheter Implantation in Children: A Retrospective Cohort Study
Fritsch L, Le M, Elrod J, Wössmann W, Vincent D, Reinshagen K, Boettcher M
J PEDIAT HEMATOL ONC. 2023;45(2):57-62.

Mitochondrial DNA mutations in Medulloblastoma
Funke V, Sandmann S, Melcher V, Seggewiss J, Horvath J, Jäger N, Kool M, Jones D, Pfister S, Milde T, Rutkowski S, Mynarek M, Varghese J, Sträter R, Rust S, Seelhöfer A, Reunert J, Fiedler B, Schüller U, Marquardt T, Kerl K
ACTA NEUROPATHOL COM. 2023;11(1):124.

Group-specific cellular metabolism in Medulloblastoma
Funke V, Walter C, Melcher V, Wei L, Sandmann S, Hotfilder M, Varghese J, Jäger N, Kool M, Jones D, Pfister S, Milde T, Mynarek M, Rutkowski S, Seggewiss J, Jeising D, de Faria F, Marquardt T, Albert T, Schüller U, Kerl K
J TRANSL MED. 2023;21(1):363.

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.

MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice
Göbel C, Godbole S, Schoof M, Holdhof D, Kresbach C, Loose C, Neumann J, Schüller U
ACTA NEUROPATHOL COM. 2023;11(1):174.

Molecular characterisation defines clinically-actionable heterogeneity within Group 4 medulloblastoma and improves disease risk-stratification
Goddard J, Castle J, Southworth E, Fletcher A, Crosier S, Martin-Guerrero I, García-Ariza M, Navajas A, Masliah-Planchon J, Bourdeaut F, Dufour C, Ayrault O, Goschzik T, Pietsch T, Sill M, Pfister S, Rutkowski S, Richardson S, Hill R, Williamson D, Bailey S, Schwalbe E, Clifford S, Hicks D
ACTA NEUROPATHOL. 2023;145(5):651-666.

Evaluating the safety of perioperative dexamethasone treatment: A retrospective analysis of a single center pediatric low-grade glioma cohort
Gorodezki D, Zipfel J, Queudeville M, Holzer U, Bevot A, Schittenhelm J, Nägele T, Schuhmann M, Ebinger M
INT J CANCER. 2023;152(9):1875-1883.

Phase II Trial of Dabrafenib Plus Trametinib in Relapsed/Refractory BRAF V600–Mutant Pediatric High-Grade Glioma
Hargrave D, Terashima K, Hara J, Kordes U, Upadhyaya S, Sahm F, Bouffet E, Packer R, Witt O, Sandalic L, Kieloch A, Russo M, Cohen K
J CLIN ONCOL. 2023;41(33):5174-5183.

Correction: Impact of COVID-19 Related Restrictions on Infections in Children with Cancer or after Hematopoietic SCT
Hauch R, Hinrichs M, Ruhwald R, Schrum J, Rutkowski S, Woessmann W, Winkler B
KLIN PADIATR. 2023;235(3):e1-e2.

Impact of COVID-19 Related Restrictions on Infections in Children with Cancer or after Hematopoietic SCT: A Monocentric, Retrospective Study
Hauch R, Hinrichs M, Ruhwald R, Schrum J, Rutkowski S, Woessmann W, Winkler B
KLIN PADIATR. 2023;235(3):159-166.

Integrating copy number data of 64 iAMP21 BCP-ALL patients narrows the common region of amplification to 1.57 Mb
Hormann F, Hoogkamer A, Boeree A, Sonneveld E, Escherich G, den Boer M, Boer J
FRONT ONCOL. 2023;13:1128560.

Solid pseudopapillary neoplasms of the pancreas in childhood and adolescence-an analysis of the German Registry for Rare Pediatric Tumors (STEP)
Jentzsch C, Fuchs J, Agaimy A, Vokuhl C, Escherich G, Blattmann C, Warmann S, Schmidt A, Schäfer J, Brecht I, Schneider D, Abele M
EUR J PEDIATR. 2023;182(12):5341-5352.

Recurrent atypical teratoid/rhabdoid tumors (AT/RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics
Johann P, Altendorf L, Efremova E, Holsten T, Steinbügl M, Nemes K, Eckhardt A, Kresbach C, Bockmayr M, Koch A, Haberler C, Antonelli M, DeSisto J, Schuhmann M, Hauser P, Siebert R, Bens S, Kool M, Green A, Hasselblatt M, Frühwald M, Schüller U
ACTA NEUROPATHOL. 2023;146(3):527-541.

Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification
Keck M, Sill M, Wittmann A, Joshi P, Stichel D, Beck P, Okonechnikow K, Sievers P, Wefers A, Roncaroli F, Avula S, McCabe M, Hayden J, Wesseling P, Øra I, Nistér M, Kranendonk M, Tops B, Zapotocky M, Zamecnik J, Vasiljevic A, Fenouil T, Meyronet D, von Hoff K, Schüller U, Loiseau H, Figarella-Branger D, Kramm C, Sturm D, Scheie D, Rauramaa T, Pesola J, Gojo J, Haberler C, Brandner S, Jacques T, Sexton Oates A, Saffery R, Koscielniak E, Baker S, Yip S, Snuderl M, Ud Din N, Samuel D, Schramm K, Blattner-Johnson M, Selt F, Ecker J, Milde T, von Deimling A, Korshunov A, Perry A, Pfister S, Sahm F, Solomon D, Jones D
ACTA NEUROPATHOL. 2023;145(1):49-69.

Single-cell gene regulatory network prediction by explainable AI
Keyl P, Bischoff P, Dernbach G, Bockmayr M, Fritz R, Horst D, Blüthgen N, Montavon G, Müller K, Klauschen F
NUCLEIC ACIDS RES. 2023;51(4):e20.

Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma
Knörr F, Schellekens K, Schoot R, Landman-Parker J, Teltschik H, Förster J, Riquelme A, Huitema A, Van Eijkelenburg N, Beishuizen A, Zwaan C, Woessmann W, Van der Lugt J
HAEMATOLOGICA. 2023;108(5):1442-1446.

Allogeneic haematopoietic cell transplant in patients with relapsed/refractory anaplastic large cell lymphoma - Response
Knörr F, Woessmann W
BRIT J HAEMATOL. 2023;200(1):107-108.

Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome
Kolodziejczak A, Guerrini-Rousseau L, Planchon J, Ecker J, Selt F, Mynarek M, Obrecht D, Sill M, Autry R, Zhao E, Hirsch S, Amouyal E, Dufour C, Ayrault O, Torrejon J, Waszak S, Ramaswamy V, Pentikainen V, Demir H, Clifford S, Schwalbe E, Massimi L, Snuderl M, Galbraith K, Karajannis M, Hill K, Li B, Walsh M, White C, Redmond S, Loizos L, Jakob M, Kordes U, Schmid I, Hauer J, Blattmann C, Filippidou M, Piccolo G, Scheurlen W, Farrag A, Grund K, Sutter C, Pietsch T, Frank S, Schewe D, Malkin D, Ben-Arush M, Sehested A, Wong T, Wu K, Liu Y, Carceller F, Mueller S, Stoller S, Taylor M, Tabori U, Bouffet E, Kool M, Sahm F, von Deimling A, Korshunov A, von Hoff K, Kratz C, Sturm D, Jones D, Rutkowski S, van Tilburg C, Witt O, Bougeard G, Pajtler K, Pfister S, Bourdeaut F, Milde T
NEURO-ONCOLOGY. 2023;25(12):2273-2286.

Transcriptome analysis stratifies second-generation non-WNT/non-SHH medulloblastoma subgroups into clinically tractable subtypes
Korshunov A, Okonechnikov K, Schrimpf D, Tonn S, Mynarek M, Koster J, Sievers P, Milde T, Sahm F, Jones D, von Deimling A, Pfister S, Kool M
ACTA NEUROPATHOL. 2023;145(6):829-842.

Atypical Neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities
Kresbach C, Dottermusch M, Eckhardt A, Ristow I, Paplomatas P, Altendorf L, Wefers A, Bockmayr M, Belakhoua S, Tran I, Pohl L, Neyazi S, Bode H, Farschtschi S, Well L, Friedrich R, Reuss D, Snuderl M, Hagel C, Mautner V, Schüller U
NEURO-ONCOLOGY. 2023;25(9):1644-1655.

Epigenetic Modification of Mesenchymal Stromal Cells Derived from Bone Marrow and Embryonal Tumors to Facilitate Immunotherapeutic Approaches in Pediatric Malignancies
Kruchen A, Johann P, Rekowski L, Müller I
CURR ISSUES MOL BIOL. 2023;45(3):2121-2135.

Reduced Humoral and Cellular Immune Response to Primary COVID-19 mRNA Vaccination in Kidney Transplanted Children Aged 5–11 Years
Lalia J, Schild R, Lütgehetmann M, Dunay G, Kallinich T, Kobbe R, Massoud M, Oh J, Pietzsch L, Schulze-Sturm U, Schuetz C, Sibbertsen F, Speth F, Thieme S, Witkowski M, Berner R, Muntau A, Gersting S, Toepfner N, Pagel J, Paul K
VIRUSES-BASEL. 2023;15(7):1553.

Activated phosphoinositide 3-kinase δ syndrome: Update from the ESID Registry and comparison with other autoimmune-lymphoproliferative inborn errors of immunity
Maccari M, Wolkewitz M, Schwab C, Lorenzini T, Leiding J, Aladjdi N, Abolhassani H, Abou-Chahla W, Aiuti A, Azarnoush S, Baris S, Barlogis V, Barzaghi F, Baumann U, Bloomfield M, Bohynikova N, Bodet D, Boutboul D, Bucciol G, Buckland M, Burns S, Cancrini C, Cathébras P, Cavazzana M, Cheminant M, Chinello M, Ciznar P, Coulter T, D'Aveni M, Ekwall O, Eric Z, Eren E, Fasth A, Frange P, Fournier B, Garcia-Prat M, Gardembas M, Geier C, Ghosh S, Goda V, Hammarström L, Hauck F, Heeg M, Heropolitanska-Pliszka E, Hilfanova A, Jolles S, Karakoc-Aydiner E, Kindle G, Kiykim A, Klemann C, Koletsi P, Koltan S, Kondratenko I, Körholz J, Krüger R, Jeziorski E, Levy R, Le Guenno G, Lefevre G, Lougaris V, Marzollo A, Mahlaoui N, Malphettes M, Meinhardt A, Merlin E, Meyts I, Milota T, Moreira F, Moshous D, Mukhina A, Neth O, Neubert J, Neven B, Nieters A, Nove-Josserand R, Oksenhendler E, Ozen A, Olbrich P, Perlat A, Pac M, Schmid J, Pacillo L, Parra-Martinez A, Paschenko O, Pellier I, Sefer A, Plebani A, Plantaz D, Prader S, Raffray L, Ritterbusch H, Riviere J, Rivalta B, Rusch S, Sakovich I, Savic S, Scheible R, Schleinitz N, Schuetz C, Schulz A, Sediva A, Semeraro M, Sharapova S, Shcherbina A, Slatter M, Sogkas G, Soler-Palacin P, Speckmann C, Stephan J, Suarez F, Tommasini A, Trück J, Uhlmann A, van Aerde K, van Montfrans J, von Bernuth H, Warnatz K, Williams T, Worth A, Ip W, Picard C, Catherinot E, Nademi Z, Grimbacher B, Forbes Satter L, Kracker S, Chandra A, Condliffe A, Ehl S
J ALLERGY CLIN IMMUN. 2023;152(4):984-996.e10.

Identification of low and very high-risk patients with non-WNT/non-SHH medulloblastoma by improved clinico-molecular stratification of the HIT2000 and I-HIT-MED cohorts
Mynarek M, Obrecht D, Sill M, Sturm D, Kloth-Stachnau K, Selt F, Ecker J, von Hoff K, Juhnke B, Goschzik T, Pietsch T, Bockmayr M, Kool M, von Deimling A, Witt O, Schüller U, Benesch M, Gerber N, Sahm F, Jones D, Korshunov A, Pfister S, Rutkowski S, Milde T
ACTA NEUROPATHOL. 2023;145(1):97-112.

Rhabdoid tumors in patients conceived following ART: is there an association?
Nemes K, Benesch M, Kolarova J, Johann P, Hasselblatt M, Thomas C, Bens S, Glaser S, Ammerpohl O, Liaugaudiene O, Sadeghipour A, von der Weid N, Schmid I, Gidding C, Erdreich-Epstein A, Khurana C, Ebetsberger-Dachs G, Lemmer A, Khatib Z, Hernández Marqués C, Pears J, Quehenberger F, Kordes U, Vokuhl C, Gerss J, Schwarz H, Bison B, Biegel J, Siebert R, Frühwald M
HUM REPROD. 2023;38(10):2028-2038.

Generation of new transgenic SMARCA4-deficient mouse models results in neuromuscular weakness and paralysis of limbs
Neyazi S, Altendorf L, Schwetje D, Göbel C, Schoof M, Holdhof D, Schüller U
BRAIN PATHOL. 2023;33(3):e13146.

A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma
Ng C, Obrecht D, Wells O, Zapotocky M, Sumerauer D, Coltin H, Khuong-Quang D, Eisenstat D, Kinross K, White C, Algar E, Luck A, Witt H, Schüller U, Mynarek M, Pietsch T, Gerber N, Benesch M, Warmuth-Metz M, Kortmann R, Bison B, Taylor M, Rutkowski S, Pfister S, Jones D, Gottardo N, von Hoff K, Pajtler K, Ramaswamy V, Hansford J
NEURO-ONCOL ADV. 2023;5(1):vdad057.

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation
Niesen J, Hermans-Borgmeyer I, Krüger C, Schoof M, Modemann F, Schüller U
ISCIENCE. 2023;26(9):107501.

Kinder und Jugendliche mit intrakraniellem Ependymom – Empfehlungen der HIT-MED-Studiengruppe der GPOH zur Erstlinientherapie
Obrecht D, Mynarek M, Stickan-Verfürth M, Bison B, Schüller U, Pajtler K, Hagel C, Thomale U, Fleischhack G, Timmermann B, Rutkowski S
KLIN PADIATR. 2023;235(3):167-177.

The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia
Østergaard A, Enshaei A, Pieters R, Vora A, Horstmann M, Escherich G, Johansson B, Heyman M, Schmiegelow K, Hoogerbrugge P, den Boer M, Kuiper R, Moorman A, Boer J, van Leeuwen F
HEMASPHERE. 2023;7(5):e875.

Antimicrobial use in pediatric oncology and hematology in Germany and Austria, 2020/2021: a cross-sectional, multi-center point-prevalence study with a multi-step qualitative adjudication process
Papan C, Reifenrath K, Last K, Attarbaschi A, Graf N, Groll A, Hübner J, Laws H, Lehrnbecher T, Liese J, Martin L, Tenenbaum T, Vieth S, von Both U, Wagenpfeil G, Weichert S, Hufnagel M, Simon A
LANCET REG HEALTH-EU. 2023;28:100599.

Emotional and behavioral problems of pediatric cancer survivors and their siblings: Concordance of child self-report and parent proxy-report
Paul V, Inhestern L, Winzig J, Nasse M, Krauth K, Rutkowski S, Escherich G, Bergelt C
PSYCHO-ONCOLOGY. 2023;32(8):1248-1256.

Outcome for Children and Young Adults With T-Cell ALL and Induction Failure in Contemporary Trials
Raetz E, Rebora P, Conter V, Schrappe M, Devidas M, Escherich G, Imai C, De Moerloose B, Schmiegelow K, Burns M, Elitzur S, Pieters R, Attarbaschi A, Yeoh A, Pui C, Stary J, Cario G, Bodmer N, Moorman A, Buldini B, Vora A, Valsecchi M
J CLIN ONCOL. 2023;41(32):5025-5034.

Diagnosis and management of ALK-positive anaplastic large cell lymphoma in children and adolescents
Rigaud C, Knörr F, Brugières L, Woessmann W
BEST PRACT RES CL HA. 2023;36(1):101444.

Development of a centralised triage centre for children with cancer and blood disorders in response to the humanitarian crisis in Ukraine
Salek M, Mueller A, Alanbousi I, Cepowska Z, Dutkiewicz M, Earl J, Evseev D, Kizyma R, Kliuchkivska K, Kolodrubiec J, Matczak K, Nogovitsyna Y, Oszer A, Pogorelyy M, Raciborska A, Rasul S, Sokolowski I, Sopilnyak A, Vinitsky A, Wlodarski M, Wobst N, Yakimkova T, Rodriguez-Galindo C, Wise P, Mlynarski W, Agulnik A
LANCET ONCOL. 2023;24(12):1315-1318.

Th1 cytokines in pediatric acute lymphoblastic leukemia
Schober S, Rottenberger J, Hilz J, Schmid E, Ebinger M, Feuchtinger T, Handgretinger R, Lang P, Queudeville M
CANCER IMMUNOL IMMUN. 2023;72(11):3621-3634.

The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice
Schoof M, Epplen G, Walter C, Ballast A, Holdhof D, Göbel C, Neyazi S, Varghese J, Albert T, Kerl K, Schüller U
ONCOGENESIS. 2023;12(1):36.

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures
Schoof M, Godbole S, Albert T, Dottermusch M, Walter C, Ballast A, Qin N, Olivera M, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter L, Epplen G, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach A, Eckhardt A, Münter D, Verma A, Struve N, Jones D, Remke M, Neumann J, Kerl K, Schüller U
NAT COMMUN. 2023;14(1):7717.

Generalized Infantile Myofibromatosis with Extensive Small Bowel Involvement in a Neonate
Schubert J, Wößmann W, Königs I, Clauditz T, Kordes U, Reinshagen K
Z GEBURTSH NEONATOL. 2023;227(3):231-235.

MAP kinase activating death domain deficiency is a novel cause of impaired lymphocyte cytotoxicity
Schütze K, Groß M, Cornils K, Wustrau K, Schneppenheim S, Lenhartz H, Korenke G, Janka G, Ledig S, Müller I, Ehl S, Lehmberg K
BLOOD ADV. 2023;7(8):1531-1535.

Prospective Newborn Screening for SCID in Germany: A First Analysis by the Pediatric Immunology Working Group (API)
Speckmann C, Nennstiel U, Hönig M, Albert M, Ghosh S, Schuetz C, Brockow I, Hörster F, Niehues T, Ehl S, Wahn V, Borte S, Lehmberg K, Baumann U, Beier R, Krüger R, Bakhtiar S, Kuehl J, Klemann C, Kontny U, Holzer U, Meinhardt A, Morbach H, Naumann-Bartsch N, Rothoeft T, Kreins A, Davies E, Schneider D, Bernuth H, Klingebiel T, Hoffmann G, Schulz A, Hauck F
J CLIN IMMUNOL. 2023;43(5):965-978.

Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
Sturm D, Capper D, Andreiuolo F, Gessi M, Kölsche C, Reinhardt A, Sievers P, Wefers A, Ebrahimi A, Suwala A, Gielen G, Sill M, Schrimpf D, Stichel D, Hovestadt V, Daenekas B, Rode A, Hamelmann S, Previti C, Jäger N, Buchhalter I, Blattner-Johnson M, Jones B, Warmuth-Metz M, Bison B, Grund K, Sutter C, Hirsch S, Dikow N, Hasselblatt M, Schüller U, Gerber N, White C, Buntine M, Kinross K, Algar E, Hansford J, Gottardo N, Hernáiz Driever P, Gnekow A, Witt O, Müller H, Calaminus G, Fleischhack G, Kordes U, Mynarek M, Rutkowski S, Frühwald M, Kramm C, von Deimling A, Pietsch T, Sahm F, Pfister S, Jones D
NAT MED. 2023;29(4):917-926.

Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy
Tonn S, Korshunov A, Obrecht D, Sill M, Spohn M, von Hoff K, Milde T, Pietsch T, Goschzik T, Bison B, Juhnke B, Struve N, Sturm D, Sahm F, Bockmayr M, Friedrich C, von Bueren A, Gerber N, Benesch M, Jones D, Kool M, Wefers A, Schüller U, Pfister S, Rutkowski S, Mynarek M
NEURO-ONCOLOGY. 2023;25(8):1518-1529.

Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment
Träger M, Schweizer L, Pérez E, Schmid S, Hain E, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann D, Dorostkar M, Feyer P, May S, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
NEURO-ONCOLOGY. 2023;25(7):1286-1298.

Blinatumomab Added to Chemotherapy in Infant Lymphoblastic Leukemia
van der Sluis I, de Lorenzo P, Kotecha R, Attarbaschi A, Escherich G, Nysom K, Stary J, Ferster A, Brethon B, Locatelli F, Schrappe M, Scholte-van Houtem P, Valsecchi M, Pieters R
NEW ENGL J MED. 2023;388(17):1572-1581.

ABL-class Genomic Breakpoint Q-PCR: A Patient-specific Approach for MRD Monitoring in Acute Lymphoblastic Leukemia
van Outersterp I, van der Velden V, Hoogeveen P, Vaitkevičienė G, Sonneveld E, van Haaften G, Kuiper R, Zur Stadt U, Escherich G, Boer J, den Boer M
HEMASPHERE. 2023;7(10):e967.

Parent-reported health-related quality of life in pediatric childhood cancer survivors and factors associated with poor health-related quality of life in aftercare
Winzig J, Inhestern L, Paul V, Nasse M, Krauth K, Kandels D, Rutkowski S, Escherich G, Bergelt C
QUAL LIFE RES. 2023;32(10):2965-2974.

Effects of a Pretend Play Intervention on Health-Related Quality of Life in Children With Cancer: A Swedish-German Study
Witt S, Quitmann J, Höglund A, Russ S, Kaman A, Escherich G, Frygner-Holm S
J PEDIAT HEMAT ONC N. 2023;40(3):158-169.

2022

Global effort to evacuate Ukrainian children with cancer and blood disorders who have been affected by war
Agulnik A, Kizyma R, Salek M, Wlodarski M, Pogorelyy M, Oszer A, Yakimkova T, Nogovitsyna Y, Dutkiewicz M, Dalle J, Dirksen U, Eggert A, Fernández-Teijeiro A, Greiner J, Kraal K, Mueller A, Sramkova L, Zecca M, Wise P, Mlynarski W
LANCET HAEMATOL. 2022;9(9):e645-e647.

Reduced-Intensity/Reduced-Toxicity Conditioning Approaches Are Tolerated in XIAP Deficiency but Patients Fare Poorly with Acute GVHD
Arnold D, Nofal R, Wakefield C, Lehmberg K, Wustrau K, Albert M, Morris E, Heimall J, Bunin N, Kumar A, Jordan M, Cole T, Choo S, Brettig T, Speckmann C, Ehl S, Salamonowicz M, Wahlstrom J, Rao K, Booth C, Worth A, Marsh R
J CLIN IMMUNOL. 2022;42(1):36-45.

Clinical Trials in High-Risk Medulloblastoma: Evolution of the SIOP-Europe HR-MB Trial
Bailey S, André N, Gandola L, Massimino M, Rutkowski S, Clifford S
CANCERS. 2022;14(2):.

MR Imaging and Clinical Characteristics of Diffuse Glioneuronal Tumor with Oligodendroglioma-like Features and Nuclear Clusters
Benesch M, Perwein T, Apfaltrer G, Langer T, Neumann A, Brecht I, Schuhmann M, Cario H, Frühwald M, Vollert K, van Buiren M, Deng M, Seitz A, Haberler C, Mynarek M, Kramm C, Sahm F, Robe P, Dankbaar J, Hoff K, Warmuth-Metz M, Bison B
AM J NEURORADIOL. 2022;43(10):1523-1529.

Mucha-Habermann disease: a pediatric case report and proposal of a risk score
Blohm M, Ebenebe C, Rau C, Escherich C, Johannsen J, Escherich G, Driemeyer J, Nagel P, Kobbe R, Lütgehetmann M, Lennartz M, Booken N, Schneider S, Singer D
INT J DERMATOL. 2022;61(4):401-409.

Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease
Bockmayr M, Harnisch K, Pohl L, Schweizer L, Mohme T, Körner M, Alawi M, Suwala A, Dorostkar M, Monoranu C, Hasselblatt M, Wefers A, Capper D, Hench J, Frank S, Richardson T, Tran I, Liu E, Snuderl M, Engertsberger L, Benesch M, von Deimling A, Obrecht D, Mynarek M, Rutkowski S, Glatzel M, Neumann J, Schüller U
NEURO-ONCOLOGY. 2022;24(10):1689-1699.

Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma
Borgenvik A, Holmberg K, Bolin S, Zhao M, Savov V, Rosén G, Hutter S, Garancher A, Suryo Rahmanto A, Bergström T, Olsen T, Mainwaring O, Sattanino D, Verbaan A, Rusert J, Sundstrom A, Ballester Bravo M, Dang Y, Wenz A, Richardson S, Fotaki G, Hill R, Dubuc A, Kalushkova A, Remke M, Cancer M, Jernberg-Wiklund H, Giraud G, Chen X, Taylor M, Sangfelt O, Clifford S, Schüller U, Wechsler-Reya R, Weishaupt H, Swartling F
CANCER RES. 2022;82(24):4586-4603.

Hypersensitivity to Pegylated E.colia sparaginase as first-line treatment in contemporary paediatric acute lymphoblastic leukaemia protocols: a meta-analysis of the Ponte di Legno Toxicity working group
Brigitha L, Fiocco M, Pieters R, Albertsen B, Escherich G, Lopez-Lopez E, Mondelaers V, Vora A, Vrooman L, Schmiegelow K, van der Sluis I
EUR J CANCER. 2022;162:65-75.

Looking back: Identifying supportive care and unmet needs of parents of children receiving specialist paediatric palliative care from the bereavement perspective
Bronsema A, Theißen T, Oechsle K, Wikert J, Escherich G, Rutkowski S, Bokemeyer C, Ullrich A
BMC PALLIAT CARE. 2022;21(1):.

Remission, treatment failure, and relapse in pediatric ALL: An international consensus of the Ponte-di-Legno Consortium
Buchmann S, Schrappe M, Baruchel A, Biondi A, Borowitz M, Campbell M, Cario G, Cazzaniga G, Escherich G, Harrison C, Heyman M, Hunger S, Kiss C, Liu H, Locatelli F, Loh M, Manabe A, Mann G, Pieters R, Pui C, Rives S, Schmiegelow K, Silverman L, Stary J, Vora A, Brown P
BLOOD. 2022;139(12):1785-1793.

Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age
Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G
NAT COMMUN. 2022;13(1):.

Hematopoietic Stem Cell Transplantation with Mesenchymal Stromal Cells in Children with Metachromatic Leukodystrophy
Cabanillas Stanchi K, Böhringer J, Strölin M, Groeschel S, Lenglinger K, Treuner C, Kehrer C, Laugwitz L, Bevot A, Kaiser N, Schumm M, Lang P, Handgretinger R, Krägeloh-Mann I, Müller I, Döring M
STEM CELLS DEV. 2022;31(7-8):163-175.

Structure and dynamics of the von Willebrand Factor C6 domain
Chen P, Kutzki F, Mojzisch A, Simon B, Xu E, Aponte-Santamaría C, Horny K, Jeffries C, Schneppenheim R, Wilmanns M, Brehm M, Gräter F, Hennig J
J STRUCT BIOL. 2022;214(4):.

Does the Y chromosome play a role for outcome in childhood acute lymphoblastic leukemia?
Conter V, Schrappe M, Escherich G
CANCER-AM CANCER SOC. 2022;128(9):1727-1729.

Quantification of Minimal Disease by Digital PCR in ALK-Positive Anaplastic Large Cell Lymphoma: A Step towards Risk Stratification in International Trials?
Damm-Welk C, Lovisa F, Contarini G, Lüdersen J, Carraro E, Knörr F, Förster J, Zimmermann M, Sala A, Vinti L, Tondo A, Pillon M, Woessmann W, Mussolin L
CANCERS. 2022;14(7):.

Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency
Das A, Sudhaman S, Morgenstern D, Coblentz A, Chung J, Stone S, Alsafwani N, Liu Z, Karsaneh O, Soleimani S, Ladany H, Chen D, Zatzman M, Cabric V, Nobre L, Bianchi V, Edwards M, Sambira Nahum L, Ercan A, Nabbi A, Constantini S, Dvir R, Yalon-Oren M, Campino G, Caspi S, Larouche V, Reddy A, Osborn M, Mason G, Lindhorst S, Bronsema A, Magimairajan V, Opocher E, De Mola R, Sabel M, Frojd C, Sumerauer D, Samuel D, Cole K, Chiaravalli S, Massimino M, Tomboc P, Ziegler D, George B, Van Damme A, Hijiya N, Gass D, McGee R, Mordechai O, Bowers D, Laetsch T, Lossos A, Blumenthal D, Sarosiek T, Yen L, Knipstein J, Bendel A, Hoffman L, Luna-Fineman S, Zimmermann S, Scheers I, Nichols K, Zapotocky M, Hansford J, Maris J, Dirks P, Taylor M, Kulkarni A, Shroff M, Tsang D, Villani A, Xu W, Aronson M, Durno C, Shlien A, Malkin D, Getz G, Maruvka Y, Ohashi P, Hawkins C, Pugh T, Bouffet E, Tabori U
NAT MED. 2022;28(1):125-135.

Primary central nervous system sarcoma with DICER1 mutation-treatment results of a novel molecular entity in pediatric Peruvian patients
Diaz Coronado R, Mynarek M, Koelsche C, Mora Alferez P, Casavilca Zambrano S, Wachtel Aptowitzer A, Sahm F, von Deimling A, Schüller U, Spohn M, Sturm D, Pfister S, Morales La Madrid A, Sernaque Quintana R, Sarria Bardales G, Negreiros Chinchihuara T, Ojeda Medina L, Garcia-Corrochano Medina P, Campos Sanchez D, Ponce Farfan J, Rutkowski S, Garcia Leon J
CANCER-AM CANCER SOC. 2022;128(4):697-707.

Types of deviation and review criteria in pretreatment central quality control of tumor bed boost in medulloblastoma-an analysis of the German Radiotherapy Quality Control Panel in the SIOP PNET5 MB trial
Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Weber D, Frick S, Gurtner K, Matuschek C, Harrabi S, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber N, Obrecht D, Rutkowski S, Timmermann B, Kortmann R
STRAHLENTHER ONKOL. 2022;198(3):282-290.

Spatial molecular profiling of a central nervous system low-grade diffusely infiltrative tumour with INI1 deficiency featuring a high-grade atypical teratoid/rhabdoid tumour component
Dottermusch M, Schumann Y, Kordes U, Hasselblatt M, Neumann J
NEUROPATH APPL NEURO. 2022;48(3):e12777.

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial
Eichinger A, Poetschger U, Glogova E, Bader P, Basu O, Beier R, Burkhardt B, Classen C, Claviez A, Corbacioglu S, Deubzer H, Greil J, Gruhn B, Güngör T, Kafa K, Kühl J, Lang P, Lange B, Meisel R, Müller I, Sauer M, Schlegel P, Schulz A, Stachel D, Strahm B, Wawer A, Peters C, Albert M
LEUKEMIA. 2022;36(11):2567-2576.

Maternal versus paternal living kidney transplant donation is associated with lower rejection in young pediatric recipients: A Collaborative Transplant Study report
Engels G, Döhler B, Tönshoff B, Oh J, Kruchen A, Müller I, Süsal C
PEDIATR TRANSPLANT. 2022;26(1):.

Akute lymphoblastische Leukämie
Escherich G, Möricke A, Horstmann M, Schrappe M
2022. Kompendium Internistische Onkologie. Schmoll H (Hrsg.). 5. Aufl. Berlin, Heidelberg: Springer, .

Aktualisierte AWMF Leitlinie über die Diagnostik und Therapie der akuten lymphoblastische Leukämie im Kindesalter
Escherich G, Schrappe M
KLIN PADIATR. 2022;234(6):363-367.

Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. Results from the randomized clinical trial 08-09 of the Cooperative Acute Lymphoblastic Leukemia Study Group
Escherich G, Zur Stadt U, Borkhardt A, Dilloo D, Faber J, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Spohn M, Zimmermann M, Horstmann M
HAEMATOLOGICA. 2022;107(5):1026-1033.

ATRT-SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance
Federico A, Thomas C, Miskiewicz K, Woltering N, Zin F, Nemes K, Bison B, Johann P, Hawes D, Bens S, Kordes U, Albrecht S, Dohmen H, Hauser P, Keyvani K, van Landeghem F, Lund E, Scheie D, Mawrin C, Monoranu C, Parm Ulhøi B, Pietsch T, Reinhard H, Riemenschneider M, Sehested A, Sumerauer D, Siebert R, Paulus W, Frühwald M, Kool M, Hasselblatt M
ACTA NEUROPATHOL. 2022;143(6):697-711.

Local and Systemic Therapy of Recurrent Medulloblastomas in Children and Adolescents: Results of the P-HIT-REZ 2005 Study
Gaab C, Adolph J, Tippelt S, Mikasch R, Obrecht D, Mynarek M, Rutkowski S, Pfister S, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann R, Dietzsch S, Pietsch T, Timmermann B, Sträter R, Bode U, Faldum A, Kwiecien R, Fleischhack G
CANCERS. 2022;14(3):.

PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
Garces de Los Fayos Alonso I, Zujo L, Wiest I, Kodajova P, Timelthaler G, Edtmayer S, Zrimšek M, Kollmann S, Giordano C, Kothmayer M, Neubauer H, Dey S, Schlederer M, Schmalzbauer B, Limberger T, Probst C, Pusch O, Högler S, Tangermann S, Merkel O, Schiefer A, Kornauth C, Prutsch N, Zimmerman M, Abraham B, Anagnostopoulos J, Quintanilla-Martinez L, Mathas S, Wolf P, Stoiber D, Staber P, Egger G, Klapper W, Woessmann W, Look T, Gunning P, Turner S, Moriggl R, Lagger S, Kenner L
MOL CANCER. 2022;21(1):172.

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas
Goschzik T, Mynarek M, Doerner E, Schenk A, Spier I, Warmuth-Metz M, Bison B, Obrecht D, Struve N, Kortmann R, Schmid M, Aretz S, Rutkowski S, Pietsch T
ACTA NEUROPATHOL. 2022;144(6):1143-1156.

The Reconstitution Dynamics of Cultivated Hematopoietic Stem Cells and Progenitors Is Independent of Age
Gotzhein F, Aranyossy T, Thielecke L, Sonntag T, Thaden V, Fehse B, Müller I, Glauche I, Cornils K
INT J MOL SCI. 2022;23(6):.

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors
Graf M, Interlandi M, Moreno N, Holdhof D, Göbel C, Melcher V, Mertins J, Albert T, Kastrati D, Alfert A, Holsten T, de Faria F, Meisterernst M, Rossig C, Warmuth-Metz M, Nowak J, Meyer Zu Hörste G, Mayère C, Nef S, Johann P, Frühwald M, Dugas M, Schüller U, Kerl K
NAT COMMUN. 2022;13(1):.

Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity
Groß M, Speckmann C, May A, Gajardo-Carrasco T, Wustrau K, Maier S, Panning M, Huzly D, Agaimy A, Bryceson Y, Choo S, Chow C, Dückers G, Fasth A, Fraitag S, Gräwe K, Haxelmans S, Holzinger D, Hudowenz O, Hübschen J, Khurana C, Kienle K, Klifa R, Korn K, Kutzner H, Lämmermann T, Ledig S, Lipsker D, Meeths M, Naumann-Bartsch N, Rascon J, Schänzer A, Seidl M, Tesi B, Vauloup-Fellous C, Vollmer-Kary B, Warnatz K, Wehr C, Neven B, Vargas P, Sepulveda F, Lehmberg K, Schmitt-Graeff A, Ehl S
J ALLERGY CLIN IMMUN. 2022;149(1):388-399.e4.

A conformational transition of the D'D3 domain primes von Willebrand factor for multimerization
Gruber S, Löf A, Hausch A, Kutzki F, Jöhr R, Obser T, König G, Schneppenheim R, Aponte-Santamaría C, Gräter F, Brehm M, Benoit M, Lipfert J
BLOOD ADV. 2022;6(17):5198-5209.

Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
Hageb A, Thalheim T, Nattamai K, Möhrle B, Saçma M, Sakk V, Thielecke L, Kerstin C, Grandy C, Port F, Gottschalk K, Mallm J, Glauche I, Galle J, Mulaw M, Geiger H
LIFE SCI ALLIANCE. 2022;5(8):.

Refining M1 stage in medulloblastoma: criteria for cerebrospinal fluid cytology and implications for improved risk stratification from the HIT-2000 trial
Hagel C, Sloman V, Mynarek M, Petrasch K, Obrecht D, Kühl J, Deinlein F, Schmid R, von Bueren A, Friedrich C, Juhnke B, Gerber N, Kwiecien R, Girschick H, Höller A, Zapf A, von Hoff K, Rutkowski S
EUR J CANCER. 2022;164:30-38.

Low-grade diffusely infiltrative tumour (LGDIT), SMARCB1-mutant: A clinical and histopathological distinct entity showing epigenetic similarity with ATRT-MYC
Hasselblatt M, Thomas C, Federico A, Bens S, Hellström M, Casar-Borota O, Kordes U, Neumann J, Dottermusch M, Rodriguez F, Lo A, Cheng S, Hendson G, Hukin J, Hartmann C, Koch A, Capper D, Siebert R, Paulus W, Nemes K, Johann P, Frühwald M, Kool M
NEUROPATH APPL NEURO. 2022;48(4):e12797.

SMARCB1-deficient and SMARCA4-deficient Malignant Brain Tumors With Complex Copy Number Alterations and TP53 Mutations May Represent the First Clinical Manifestation of Li-Fraumeni Syndrome
Hasselblatt M, Thomas C, Federico A, Nemes K, Johann P, Bison B, Bens S, Dahlum S, Kordes U, Redlich A, Lessel L, Pajtler K, Mawrin C, Schüller U, Nolte K, Kramm C, Hinz F, Sahm F, Giannini C, Penkert J, Kratz C, Pfister S, Siebert R, Paulus W, Kool M, Frühwald M
AM J SURG PATHOL. 2022;46(9):1277-1283.

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults
Hines M, von Bahr Greenwood T, Beutel G, Beutel K, Hays J, Horne A, Janka G, Jordan M, van Laar J, Lachmann G, Lehmberg K, Machowicz R, Miettunen P, La Rosée P, Shakoory B, Zinter M, Henter J
CRIT CARE MED. 2022;50(5):860-872.

Magnetic Resonance Imaging Characteristics of Molecular Subgroups in Pediatric H3 K27M Mutant Diffuse Midline Glioma
Hohm A, Karremann M, Gielen G, Pietsch T, Warmuth-Metz M, Vandergrift L, Bison B, Stock A, Hoffmann M, Pham M, Kramm C, Nowak J
CLIN NEURORADIOL. 2022;32(1):249-258.

ALK inhibition as a salvage therapy for a relapsed unclassifiable sarcomatous CNS tumor with EML4/ALK fusion in an infant
Holsten T, Bronsema A, Sturm D, Sahm F, Rutkowski S, Ulrich S, Wößmann W, Kordes U
PEDIATR BLOOD CANCER. 2022;69(8):.

Gain-of-function variant p.Pro2555Arg of von Willebrand factor increases aggregate size through altering stem dynamics
Huck V, Chen P, Xu E, Tischer A, Klemm U, Aponte-Santamaría C, Mess C, Obser T, Kutzki F, König G, Denis C, Gräter F, Wilmanns M, Auton M, Schneider S, Schneppenheim R, Hennig J, Brehm M
THROMB HAEMOSTASIS. 2022;122(2):226-239.

Children with cancer and their families after active treatment: analyses of biopsychosocial needs and implications for healthcare - a study protocol
Inhestern L, Paul V, Winzig J, Rutkowski S, Escherich G, Bergelt C
BMJ OPEN. 2022;12(4):e055633.

Treatment of embryonal tumors with multilayered rosettes with carboplatin/etoposide induction and high-dose chemotherapy within the prospective P-HIT trial
Juhnke B, Gessi M, Gerber N, Friedrich C, Mynarek M, von Bueren A, Haberler C, Schüller U, Kortmann R, Timmermann B, Bison B, Warmuth-Metz M, Kwiecien R, Pfister S, Spix C, Pietsch T, Kool M, Rutkowski S, von Hoff K
NEURO-ONCOLOGY. 2022;24(1):127-137.

DNA methylation-based classification of sinonasal tumors
Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann L, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund V, Forster M, Lechner M, Lorenzo-Guerra S, Hermsen M, Johann P, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister S, Jones D, Sill M, von Deimling A, Snuderl M, Müller K, Forgó E, Howitt B, Mertins P, Klauschen F, Capper D
NAT COMMUN. 2022;13(1):.

Patient-level proteomic network prediction by explainable artificial intelligence
Keyl P, Michael B, Heim D, Dernbach G, Montavon G, Müller K, Klauschen F
NPJ PRECIS ONCOL. 2022;6(1):.

Immune Ablation and Stem Cell Rescue in Two Pediatric Patients with Progressive Severe Chronic Graft-Versus-Host Disease
Kloehn J, Kruchen A, Schütze K, Wustrau K, Schrum J, Müller I
INT J MOL SCI. 2022;23(23):.

NET Release of Long-Term Surviving Neutrophils
Kolman J, Pagerols Raluy L, Müller I, Nikolaev V, Trochimiuk M, Appl B, Wadehn H, Dücker C, Stoll F, Boettcher M, Reinshagen K, Trah J
FRONT IMMUNOL. 2022;13:815412.

Gene expression profiling of Group 3 medulloblastomas defines a clinically tractable stratification based on KIRREL2 expression
Korshunov A, Okonechnikov K, Stichel D, Schrimpf D, Delaidelli A, Tonn S, Mynarek M, Sievers P, Sahm F, Jones D, von Deimling A, Pfister S, Kool M
ACTA NEUROPATHOL. 2022;144(2):339-352.

Long-term survival of an adolescent glioblastoma patient under treatment with vinblastine and valproic acid illustrates importance of methylation profiling
Kresbach C, Bronsema A, Guerreiro H, Rutkowski S, Schüller U, Winkler B
CHILD NERV SYST. 2022;38(2):479-483.

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond
Kresbach C, Neyazi S, Schüller U
BRAIN PATHOL. 2022;32(4):.

MODL-03. Establishment of intraventricular Shh inhibition as a therapeutic option for young patients with medulloblastoma
Kresbach C, Schoof M, Holst L, Leven T, Yorgan T, Wrzeszcz A, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2022;24(S1):i168.

Osteonekrosen – gravierende Therapiefolge bei akuter lymphoblastischer Leukämie
Kuhlen M, Kunstreich M, Gökbuget N, Escherich G
ORTHOPADIE. 2022;51(10):792-799.

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma
Lechner M, Takahashi Y, Turri-Zanoni M, Liu J, Counsell N, Hermsen M, Kaur R, Zhao T, Ramanathan M, Schartinger V, Emanuel O, Helman S, Varghese J, Dudas J, Riechelmann H, Sprung S, Haybaeck J, Howard D, Engel N, Stewart S, Brooks L, Pickles J, Jacques T, Fenton T, Williams L, Vaz F, O'Flynn P, Stimpson P, Wang S, Hannan S, Unadkat S, Hughes J, Dwivedi R, Forde C, Randhawa P, Gane S, Joseph J, Andrews P, Royle G, Franchi A, Maragliano R, Battocchio S, Bewicke-Copley H, Pipinikas C, Webster A, Thirlwell C, Ho D, Teschendorff A, Zhu T, Steele C, Pillay N, Vanhaesebroeck B, Mohyeldin A, Fernandez-Miranda J, Park K, Le Q, West R, Saade R, Manes R, Omay S, Vining E, Judson B, Yarbrough W, Sansovini M, Silvia N, Grassi I, Bongiovanni A, Capper D, Schüller U, Thavaraj S, Sandison A, Surda P, Hopkins C, Ferrari M, Mattavelli D, Rampinelli V, Facchetti F, Nicolai P, Bossi P, Henriquez O, Magliocca K, Solares C, Wise S, Llorente J, Patel Z, Nayak J, Hwang P, Lacy P, Woods R, O'Neill J, Jay A, Carnell D, Forster M, Ishii M, London N, Bell D, Gallia G, Castelnuovo P, Severi S, Lund V, Hanna E
EUR J CANCER. 2022;162:221-236.

Machine Learning Models Predict the Primary Sites of Head and Neck Squamous Cell Carcinoma Metastases Based on DNA Methylation
Leitheiser M, Capper D, Seegerer P, Lehmann A, Schüller U, Müller K, Klauschen F, Jurmeister P, Michael B
J PATHOL. 2022;256(4):378-387.

Laparoscopic Subtotal Splenectomy in Children and Adolescents With Spherocytosis
Le M, Grosse R, Elrod J, Klinke M, Reinshagen K, Boettcher M
DTSCH ARZTEBL INT. 2022;119(49):848-849.

Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development
Li Q, Han Z, Singh N, Terré B, Fame R, Arif U, Page T, Zahran T, Abdeltawab A, Huang Y, Cao P, Wang J, Lu H, Lidov H, Surendran K, Wu L, Virga J, Zhao Y, Ulrich S, Wechsler-Reya R, Lehtinen M, Roy S, Liu Z, Stracker T, Zhao H
CELL DEATH DIFFER. 2022;29(8):1596-1610.

Allogeneic hematopoietic stem cell transplantation for adult HLH: a retrospective study by the chronic malignancies and inborn errors working parties of EBMT
Machowicz R, Suarez F, Wiktor-Jedrzejczak W, Eikema D, de Wreede L, Blok H, Isaksson C, Einsele H, Poiré X, van Dorp S, Nikolousis E, Johansson J, Kobbe G, Zecca M, Arnold R, Gerbitz A, Finke J, Díez-Martín J, Bonifazi F, McQuaker G, Lenhoff S, Rohrlich P, Theobald M, Ljungman P, Collin M, Albert M, Ehninger G, Carlson K, Halaburda K, Lehmberg K, Schönland S, Yakoub-Agha I, Gennery A, Lankester A, Kröger N
BONE MARROW TRANSPL. 2022;57(5):817-823.

Influence of Fetomaternal Microchimerism on Maternal NK Cell Reactivity against the Child's Leukemic Blasts
Martin L, Kruchen A, Fehse B, Müller I
BIOMEDICINES. 2022;10(3):.

A new amplicon-based gene panel for next generation sequencing characterization of meningiomas
Mawrin C, Koch R, Waldt N, Sandalcioglu I, Braunsdorf W, Warnke J, Goehre F, Meisel H, Ewald C, Neyazi S, Schüller U, Kirches E
BRAIN PATHOL. 2022;32(2):.

Amsacrine combined with etoposide and methylprednisolone is a feasible and safe component in first-line intensified treatment of pediatric patients with high-risk acute lymphoblastic leukemia in CoALL08-09 trial
Mezger K, Ebert S, Muhle H, Stadt U, Borkhardt A, Dilloo D, Faber J, Feuchtinger T, Imschweiler T, Jorch N, Pekrun A, Schmid I, Schramm F, Zimmermann M, Horstmann M, Escherich G
PEDIATR BLOOD CANCER. 2022;69(12):.

Characterization of IG-MYC-breakpoints and their application for quantitative minimal disease monitoring in high-risk pediatric Burkitt-lymphoma and -leukemia
Möker P, Zur Stadt U, Zimmermann M, Alawi M, Mueller S, Finger J, Knörr F, Riquelme A, Oschlies I, Klapper W, Bradtke J, Burkhardt B, Woessmann W, Damm-Welk C
LEUKEMIA. 2022;36(9):2343-2346.

Thirteen-month-old girl with hyporegenerative macrocytic anemia due to Brown-Vialetto-Van Laere syndrome 2
Naami N, Borkhardt A, Yoshimi A, Grinstein L, Escherich G
AM J HEMATOL. 2022;97(11):1495-1496.

Infants and Newborns with Atypical Teratoid Rhabdoid Tumors (ATRT) and Extracranial Malignant Rhabdoid Tumors (eMRT) in the EU-RHAB Registry: A Unique and Challenging Population
Nemes K, Johann P, Steinbügl M, Gruhle M, Bens S, Kachanov D, Teleshova M, Hauser P, Simon T, Tippelt S, Eberl W, Chada M, Lopez V, Grigull L, Hernáiz-Driever P, Eyrich M, Pears J, Milde T, Reinhard H, Leipold A, van de Wetering M, Gil-da-Costa M, Ebetsberger-Dachs G, Kerl K, Lemmer A, Boztug H, Furtwängler R, Kordes U, Vokuhl C, Hasselblatt M, Bison B, Kröncke T, Melchior P, Timmermann B, Gerss J, Siebert R, Frühwald M
CANCERS. 2022;14(9):.

Long noncoding RNAs as regulators of pediatric acute myeloid leukemia
Neyazi S, Ng M, Heckl D, Klusmann J
Molecular and cellular pediatrics. 2022;9(1):.

Can Machine Learning Models Predict Asparaginase-associated Pancreatitis in Childhood Acute Lymphoblastic Leukemia
Nielsen R, Wolthers B, Helenius M, Albertsen B, Clemmensen L, Nielsen K, Kanerva J, Niinimäki R, Frandsen T, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Aytan-Aktug D, Liu H, Möricke A, Samarasinghe S, van der Sluis I, Stanulla M, Tulstrup M, Yadav R, Zapotocka E, Schmiegelow K, Gupta R
J PEDIAT HEMATOL ONC. 2022;44(3):e628-e636.

Clinical and molecular characterization of isolated M1 disease in pediatric medulloblastoma: experience from the German HIT-MED studies
Obrecht D, Mynarek M, Hagel C, Kwiecien R, Spohn M, Bockmayr M, Bison B, Pfister S, Jones D, Sturm D, von Deimling A, Sahm F, von Hoff K, Juhnke B, Benesch M, Gerber N, Friedrich C, von Bueren A, Kortmann R, Schwarz R, Pietsch T, Fleischhack G, Schüller U, Rutkowski S
J NEURO-ONCOL. 2022;157(1):37-48.

Essential medicines for childhood cancer in Europe: a pan-European, systematic analysis by SIOPE
Otth M, Brack E, Kearns P, Kozhaeva O, Ocokoljic M, Schoot R, Vassal G
LANCET ONCOL. 2022;23(12):1537-1546.

Fear of progression in parents of childhood cancer survivors: prevalence and associated factors
Peikert M, Inhestern L, Krauth K, Escherich G, Rutkowski S, Kandels D, Schiekiera L, Bergelt C
J CANCER SURVIV. 2022;16(4):823-833.

Genotype-phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry
Penkert J, Strüwe F, Dutzmann C, Doergeloh B, Montellier E, Freycon C, Keymling M, Schlemmer H, Sänger B, Hoffmann B, Gerasimov T, Blattmann C, Fetscher S, Frühwald M, Hettmer S, Kordes U, Ridola V, Kroiss Benninger S, Mastronuzzi A, Schott S, Nees J, Prokop A, Redlich A, Seidel M, Zimmermann S, Pajtler K, Pfister S, Hainaut P, Kratz C
J HEMATOL ONCOL. 2022;15(1):.

Proton Beam Therapy for Pediatric Tumors of the Central Nervous System-Experiences of Clinical Outcome and Feasibility from the KiProReg Study
Peters S, Frisch S, Stock A, Merta J, Bäumer C, Blase C, Schuermann E, Tippelt S, Bison B, Frühwald M, Rutkowski S, Fleischhack G, Timmermann B
CANCERS. 2022;14(23):.

Evaluation of dose, volume and outcome in children with localized, intracranial ependymoma treated with proton therapy within the prospective KiProReg Study
Peters S, Merta J, Schmidt L, Jazmati D, Kramer P, Blase C, Tippelt S, Fleischhack G, Stock A, Bison B, Rutkowski S, Pietsch T, Kortmann R, Timmermann B
NEURO-ONCOLOGY. 2022;24(7):1193-1202.

Coping with Diffuse Intrinsic Pontine Glioma in Children - Findings from an Interview Study on Bereaved Parents
Radlanski K, Hartwig M, Kordes U
KLIN PADIATR. 2022;234(6):374-381.

Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia
Ramos-Muntada M, Trincado J, Blanco J, Bueno C, Rodríguez-Cortez V, Bataller A, López-Millán B, Schwab C, Ortega M, Velasco P, Blanco M, Nomdedeu J, Ramírez-Orellana M, Minguela A, Fuster J, Cuatrecasas E, Camós M, Ballerini P, Escherich G, Boer J, DenBoer M, Hernández-Rivas J, Calasanz M, Cazzaniga G, Harrison C, Menéndez P, Molina O
MOL ONCOL. 2022;16(16):2899-2919.

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Ravi V, Will P, Kueckelhaus J, Sun N, Joseph K, Salié H, Vollmer L, Kuliesiute U, von Ehr J, Benotmane J, Neidert N, Follo M, Scherer F, Goeldner J, Behringer S, Franco P, Khiat M, Zhang J, Hofmann U, Fung C, Ricklefs F, Lamszus K, Boerries M, Ku M, Beck J, Sankowski R, Schwabenland M, Prinz M, Schüller U, Killmer S, Bengsch B, Walch A, Delev D, Schnell O, Heiland D
CANCER CELL. 2022;40(6):639-655.e13.

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution
Richter-Pechańska P, Kunz J, Rausch T, Erarslan-Uysal B, Bornhauser B, Frismantas V, Assenov Y, Zimmermann M, Happich M, von Knebel-Doeberitz C, von Neuhoff N, Köhler R, Stanulla M, Schrappe M, Cario G, Escherich G, Kirschner-Schwabe R, Eckert C, Avigad S, Pfister S, Muckenthaler M, Bourquin J, Korbel J, Kulozik A
LEUKEMIA. 2022;36(7):1759-1768.

DNA Methylation subclass Receptor Tyrosine Kinase II (RTK II) is predictive for seizure development in glioblastoma patients
Ricklefs F, Drexler R, Wollmann K, Eckhardt A, Heiland D, Sauvigny T, Maire C, Lamszus K, Westphal M, Schüller U, Dührsen L
NEURO-ONCOLOGY. 2022;24(11):1886-1897.

Genetic and epigenetic profiling identifies two distinct classes of spinal meningiomas
Ricklefs F, Fita K, Mohme M, Mawrin C, Rahmanzade R, Sahm F, Dührsen L, Göbel C, Lamszus K, Westphal M, Schüller U, Eicker S
ACTA NEUROPATHOL. 2022;144(5):1057-1059.

Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort
Römer T, Franzen S, Kravets H, Farrag A, Makowska A, Christiansen H, Eble M, Timmermann B, Staatz G, Mottaghy F, Bührlen M, Hagenah U, Puzik A, Driever P, Greiner J, Jorch N, Tippelt S, Schneider D, Kropshofer G, Overbeck T, Christiansen H, Brozou T, Escherich G, Becker M, Friesenbichler W, Feuchtinger T, Puppe W, Heussen N, Hilgers R, Kontny U
CANCERS. 2022;14(5):.

Comparison of single copy gene‑based duplex quantitative PCR and digital droplet PCR for monitoring of expansion of CD19‑directed CAR T cells in treated patients
Schubert M, Berger C, Kunz A, Schmitt A, Badbaran A, Neuber B, Zeschke S, Wang L, Riecken K, Hückelhoven-Krauss A, Müller I, Müller-Tidow C, Dreger P, Kröger N, Ayuk F, Schmitt M, Fehse B
INT J ONCOL. 2022;60(5):.

Differential Diagnosis of Hyperferritinemia in Critically Ill Patients
Schuster F, Nyvlt P, Heeren P, Spies C, Adam M, Schenk T, Brunkhorst F, Janka G, La Rosée P, Lachmann C, Lachmann G
J CLIN MED. 2022;12(1):.

Artificial intelligence and pathology: From principles to practice and future applications in histomorphology and molecular profiling
Stenzinger A, Alber M, Allgäuer M, Jurmeister P, Bockmayr M, Budczies J, Lennerz J, Eschrich J, Kazdal D, Schirmacher P, Wagner A, Tacke F, Capper D, Müller K, Klauschen F
SEMIN CANCER BIOL. 2022;84:129-143.

Increased replication stress and R-loop accumulation in EGFRvIII expressing glioblastoma present new therapeutic opportunities
Struve N, Hoffer K, Weik A, Riepen B, Krug L, Cetin M, Burmester J, Ott L, Liebing J, Gatzemeier F, Müller-Goebel J, Bußmann L, Parplys A, Unger K, Mansour W, Schüller U, Rieckmann T, Petersen C, Rothkamm K, Short S, Kriegs M
NEURO-ONCOL ADV. 2022;4(1):vdab180.

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0-45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol
Toksvang L, Als-Nielsen B, Bacon C, Bertasiute R, Duarte X, Escherich G, Helgadottir E, Johannsdottir I, Jónsson Ó, Kozlowski P, Langenskjöld C, Lepik K, Niinimäki R, Overgaard U, Punab M, Räty R, Segers H, van der Sluis I, Smith O, Strullu M, Vaitkevičienė G, Wik H, Heyman M, Schmiegelow K
BMC CANCER. 2022;22(1):.

Persistence of MERS-CoV-spike-specific B cells and antibodies after late third immunization with the MVA-MERS-S vaccine
Weskamm L, Fathi A, Raadsen M, Mykytyn A, Koch T, Spohn M, Friedrich M, , Haagmans B, Becker S, Sutter G, Dahlke C, Addo M
CELL REP MED. 2022;3(7):.

Final results of the Choroid Plexus Tumor study CPT-SIOP-2000
Wolff J, Van Gool S, Kutluk T, Diez B, Kebudi R, Timmermann B, Garami M, Sterba J, Fuller G, Bison B, Kordes U
J NEURO-ONCOL. 2022;156(3):599-613.

2021

Ex vivo testis explant culture of human testicular tissue
Aden N, Soave A, Kordes U, Bleeke M, Salzbrunn A, von Kopylow K
J Reprodmed Endokrinol. 2021;2020(17 (Supplementum 1), 39-40):.

Systemic chemotherapy of pediatric recurrent ependymomas: results from the German HIT-REZ studies
Adolph J, Fleischhack G, Gaab C, Mikasch R, Mynarek M, Rutkowski S, Schüller U, Pfister S, Pajtler K, Milde T, Witt O, Bison B, Warmuth-Metz M, Kortmann R, Dietzsch S, Pietsch T, Timmermann B, Tippelt S
J NEURO-ONCOL. 2021;155(2):193-202.

Local and Systemic Therapy of Recurrent Ependymoma in Children and Adolescents: Short- and Long-term Results of the E-HIT-REZ 2005 Study
Adolph J, Fleischhack G, Mikasch R, Zeller J, Warmuth-Metz M, Bison B, Mynarek M, Rutkowski S, Schüller U, von Hoff K, Obrecht D, Pietsch T, Pfister S, Pajtler K, Witt O, Witt H, Kortmann R, Timmermann B, Krauß J, Frühwald M, Faldum A, Kwiecien R, Bode U, Tippelt S
NEURO-ONCOLOGY. 2021;23(6):1012-1023.

An extracellular vesicle-related gene expression signature identifies high-risk patients in medulloblastoma
Albert T, Interlandi M, Sill M, Graf M, Moreno N, Menck K, Rohlmann A, Melcher V, Korbanka S, Meyer Zu Hörste G, Lautwein T, Frühwald M, Krebs C, Holdhof D, Schoof M, Bleckmann A, Missler M, Dugas M, Schüller U, Jäger N, Pfister S, Kerl K
NEURO-ONCOLOGY. 2021;23(4):586-598.

Recommendations for Diagnosis and Treatment of Children with Transient Abnormal Myelopoiesis (TAM) and Myeloid Leukemia in Down Syndrome (ML-DS)
Al-Kershi S, Golnik R, Flasinski M, Waack K, Rasche M, Creutzig U, Dworzak M, Reinhardt D, Klusmann J
KLIN PADIATR. 2021;233(6):267-277.

Is hematopoietic stem cell transplantation a therapeutic option for mucolipidosis type II?
Ammer L, Pohl S, Breyer S, Aries C, Denecke J, Perez A, Petzoldt M, Schrum J, Müller I, Muschol N
MOL GENET METAB REP. 2021;26:.

Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia
Andrés-Jensen L, Attarbaschi A, Bardi E, Barzilai-Birenboim S, Bhojwani D, Hagleitner M, Halsey C, Harila-Saari A, van Litsenburg R, Hudson M, Jeha S, Kato M, Kremer L, Mlynarski W, Möricke A, Pieters R, Piette C, Raetz E, Ronceray L, Toro C, Grazia Valsecchi M, Vrooman L, Weinreb S, Winick N, Schmiegelow K
LANCET HAEMATOL. 2021;8(7):e513-e523.

SMARCA4-deficient rhabdoid tumours show intermediate molecular features between SMARCB1-deficient rhabdoid tumours and small cell carcinomas of the ovary, hypercalcaemic type
Andrianteranagna M, Cyrta J, Masliah-Planchon J, Nemes K, Corsia A, Leruste A, Holdhof D, Kordes U, Orbach D, Corradini N, Entz-Werle N, Pierron G, Castex M, Brouchet A, Weingertner N, Ranchère D, Fréneaux P, Delattre O, Bush J, Leary A, Frühwald M, Schüller U, Servant N, Bourdeaut F
J PATHOL. 2021;255(1):1-15.

Second malignant neoplasms after treatment of non-Hodgkin's lymphoma-a retrospective multinational study of 189 children and adolescents
Attarbaschi A, Carraro E, Ronceray L, Andrés M, Barzilai-Birenboim S, Bomken S, Brugières L, Burkhardt B, Ceppi F, Chiang A, Csoka M, Fedorova A, Jazbec J, Kabickova E, Loeffen J, Mellgren K, Miakova N, Moser O, Osumi T, Pourtsidis A, Rigaud C, Uyttebroeck A, Woessmann W, Pillon M
LEUKEMIA. 2021;35(2):534-549.

Molecular features of non-anaplastic peripheral T-cell lymphoma in children and adolescents
Au-Yeung R, Richter J, Iaccarino I, Abramov D, Bacon C, Balagué O, d'Amore E, Simonitsch-Klupp I, Hebeda K, Nakazawa A, Oschlies I, Kontny U, Woessmann W, Burkhardt B, Klapper W
PEDIATR BLOOD CANCER. 2021;68(11):.

Irradiation-free re-conditioning in children following graft failure of a T cell-depleted graft from a haploidentical parent
Aydin S, Kruchen A, Wustrau K, Doering M, Schrum J, Müller I
BONE MARROW TRANSPL. 2021;56(6):1452-1454.

Genotypes of European and Iranian patients with type 3 von Willebrand disease enrolled in 3WINTERS-IPS
Baronciani L, Peake I, Schneppenheim R, Goodeve A, Ahmadinejad M, Badiee Z, Baghaipour M, Benitez O, Bodó I, Budde U, Cairo A, Castaman G, Eshghi P, Goudemand J, Hassenpflug W, Hoorfar H, Karimi M, Keikhaei B, Lassila R, Leebeek F, Lopez Fernandez M, Mannucci P, Marino R, Nikšić N, Oyen F, Santoro C, Tiede A, Toogeh G, Tosetto A, Trossaert M, Zetterberg E, Eikenboom J, Federici A, Peyvandi F
BLOOD ADV. 2021;5(15):2987-3001.

Medulloblastoma tumor classification using deep transfer learning with multi-scale EfficientNets
Bengs M, Bockmayr M, Schüller U, Schlaefer A
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2021.

Multi-Scale Input Strategies for Medulloblastoma Tumor Classification using Deep Transfer Learning
Bengs M, Pant S, Bockmayr M, Schüller U, Schlaefer A
Current Directions in Biomedical Engineering. 2021;7(1):.

Morphological and molecular breast cancer profiling through explainable machine learning
Binder A, Bockmayr M, Hägele M, Wienert S, Heim D, Hellweg K, Ishii M, Stenzinger A, Hocke A, Denkert C, Müller K, Klauschen F
NAT MACH INTELL. 2021;3(4):355-366.

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma
Bočkaj I, Martini T, de Camargo Magalhães E, Bakker P, Meeuwsen-de Boer T, Armandari I, Meuleman S, Mondria M, Stok C, Kok Y, Bakker B, Wardenaar R, Seiler J, Broekhuis M, van den Bos H, Spierings D, Ringnalda F, Clevers H, Schüller U, van Vugt M, Foijer F, Bruggeman S
PLOS GENET. 2021;17(11):.

Cauda equina paragangliomas express HOXB13
Bockmayr M, Körner M, Schweizer L, Schüller U
NEUROPATH APPL NEURO. 2021;47(6):889-890.

Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study
Boer J, Valsecchi M, Hormann F, Antić Ž, Zaliova M, Schwab C, Cazzaniga G, Arfeuille C, Cavé H, Attarbaschi A, Strehl S, Escherich G, Imamura T, Ohki K, Grüber T, Sutton R, Pastorczak A, Lammens T, Lambert F, Li C, Carrillo de Santa Pau E, Hoffmann S, Möricke A, Harrison C, Den Boer M, De Lorenzo P, Stam R, Bergmann A, Pieters R
LEUKEMIA. 2021;35(10):2978-2982.

Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndrome
Bortnick R, Wlodarski M, de Haas V, De Moerloose B, Dworzak M, Hasle H, Masetti R, Starý J, Turkiewicz D, Ussowicz M, Kozyra E, Albert M, Bader P, Bordon V, Cario G, Beier R, Schulte J, Bresters D, Müller I, Pichler H, Sedlacek P, Sauer M, Zecca M, Göhring G, Yoshimi A, Noellke P, Erlacher M, Locatelli F, Niemeyer C, Strahm B
BONE MARROW TRANSPL. 2021;56(11):2732-2741.

Treatment and Outcome Analysis of 639 Relapsed Non-Hodgkin Lymphomas in Children and Adolescents and Resulting Treatment Recommendations
Burkhardt B, Taj M, Garnier N, Minard-Colin V, Hazar V, Mellgren K, Osumi T, Fedorova A, Myakova N, Verdu-Amoros J, Andres M, Kabickova E, Attarbaschi A, Chiang A, Bubanska E, Donska S, Hjalgrim L, Wachowiak J, Pieczonka A, Uyttebroeck A, Lazic J, Loeffen J, Buechner J, Niggli F, Csoka M, Krivan G, Palma J, Burke G, Beishuizen A, Koeppen K, Mueller S, Herbrueggen H, Woessmann W, Zimmermann M, Balduzzi A, Pillon M
CANCERS. 2021;13(9):.

Analyzing tyrosine kinase activity in head and neck cancer by functional kinomics: Identification of hyperactivated Src-family kinases as prognostic markers and potential targets
Bußmann L, Hoffer K, von Bargen C, Droste C, Lange T, Kemmling J, Schröder-Schwarz J, Vu A, Akingunsade L, Nollau P, Rangarajan S, de Wijn R, Oetting A, Müller C, Böckelmann L, Zech H, Berger J, Möckelmann N, Busch C, Böttcher A, Gatzemeier F, Klinghammer K, Simnica D, Binder M, Struve N, Rieckmann T, Schumacher U, Clauditz T, Betz C, Petersen C, Rothkamm K, Münscher A, Kriegs M
INT J CANCER. 2021;149(5):1166 - 1180.

DNA Polymerase and Mismatch Repair Exert Distinct Microsatellite Instability Signatures in Normal and Malignant Human Cells
Chung J, Maruvka Y, Sudhaman S, Kelly J, Haradhvala N, Bianchi V, Edwards M, Forster V, Nunes N, Galati M, Komosa M, Deshmukh S, Cabric V, Davidson S, Zatzman M, Light N, Hayes R, Brunga L, Anderson N, Ho B, Hodel K, Siddaway R, Morrissy A, Bowers D, Larouche V, Bronsema A, Osborn M, Cole K, Opocher E, Mason G, Thomas G, George B, Ziegler D, Lindhorst S, Vanan M, Yalon-Oren M, Reddy A, Massimino M, Tomboc P, Van Damme A, Lossos A, Durno C, Aronson M, Morgenstern D, Bouffet E, Huang A, Taylor M, Villani A, Malkin D, Hawkins C, Pursell Z, Shlien A, Kunkel T, Getz G, Tabori U
CANCER DISCOV. 2021;11(5):1176-1191.

The Polycomb Protein Bmi1 is a Key Effector of the H3.3 K27m Oncohistone
Cui W, Xydous M, Haschke A, Korf K, Spohn M, Pohlmann D, Sweet S, Ip W, Wrzeszcz A, Indenbirken D, Ma H, Müller J, Kruchen A, Sternsdorf T
Social Science Research Network. 2021 [Epub ahead of print].

Neuro-meningeal relapse in anaplastic large-cell lymphoma: incidence, risk factors and prognosis - a report from the European intergroup for childhood non-Hodgkin lymphoma
Del Baldo G, Abbas R, Woessmann W, Horibe K, Pillon M, Burke A, Beishuizen A, Rigaud C, Le Deley M, Lamant L, Brugières L
BRIT J HAEMATOL. 2021;192(6):1039-1048.

Outcomes of paediatric patients with B-cell acute lymphocytic leukaemia with ABL-class fusion in the pre-tyrosine-kinase inhibitor era. a multicentre, retrospective, cohort study
den Boer M, Cario G, Moorman A, Boer J, de Groot-Kruseman H, Fiocco M, Escherich G, Imamura T, Yeoh A, Sutton R, Dalla-Pozza L, Kiyokawa N, Schrappe M, Roberts K, Mullighan C, Hunger S, Vora A, Attarbaschi A, Zaliova M, Elitzur S, Cazzaniga G, Biondi A, Loh M, Pieters R
LANCET HAEMATOL. 2021;8(1):e55-e66.

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma
DeSisto J, Lucas Jr J, Xu K, Donson A, Lin T, Sanford B, Wu G, Tran Q, Hedges D, Hsu C, Armstrong G, Arnold M, Bhatia S, Flannery P, Lemma R, Hardie L, Schüller U, Venkataraman S, Hoffman L, Dorris K, Mulcahy Levy J, Hankinson T, Handler M, Liu A, Foreman N, Vibhakar R, Jones K, Allen S, Zhang J, Baker S, Merchant T, Orr B, Green A
NAT COMMUN. 2021;12(1):.

Pretreatment central quality control for craniospinal irradiation in non-metastatic medulloblastoma: First experiences of the German radiotherapy quality control panel in the SIOP PNET5 MB trial
Dietzsch S, Braesigk A, Seidel C, Remmele J, Kitzing R, Schlender T, Mynarek M, Geismar D, Jablonska K, Schwarz R, Pazos M, Walser M, Frick S, Gurtner K, Matuschek C, Harrabi S, Glück A, Lewitzki V, Dieckmann K, Benesch M, Gerber N, Rutkowski S, Timmermann B, Kortmann R
STRAHLENTHER ONKOL. 2021;197(8):674-682.

Long-term follow-up after the application of mesenchymal stromal cells in children and adolescents with steroid-refractory graft-versus-host disease
Döring M, Cabanillas Stanchi K, Lenglinger K, Treuner C, Gieseke F, Erbacher A, Mezger M, Vaegler M, Schlegel P, Greil J, Bettoni da Cunha Riehm C, Faul C, Schumm M, Lang P, Handgretinger R, Müller I
STEM CELLS DEV. 2021;30(5):234-246.

Co-activation of Sonic hedgehog and Wnt signaling in murine retinal precursor cells drives ocular lesions with features of intraocular medulloepithelioma
Dottermusch M, Sumisławski P, Krevet J, Middelkamp M, Voß H, Siebels B, Bartsch H, Sotlar K, Meyer P, Frank S, Korshunov A, Glatzel M, Schüller U, Neumann J
ONCOGENESIS. 2021;10(11):78.

Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance
Durno C, Ercan A, Bianchi V, Edwards M, Aronson M, Galati M, Atenafu E, Abebe-Campino G, Al-Battashi A, Alharbi M, Azad V, Baris H, Basel D, Bedgood R, Bendel A, Ben-Shachar S, Blumenthal D, Blundell M, Bornhorst M, Bronsema A, Cairney E, Rhode S, Caspi S, Chamdin A, Chiaravalli S, Constantini S, Crooks B, Das A, Dvir R, Farah R, Foulkes W, Frenkel Z, Gallinger B, Gardner S, Gass D, Ghalibafian M, Gilpin C, Goldberg Y, Goudie C, Hamid S, Hampel H, Hansford J, Harlos C, Hijiya N, Hsu S, Kamihara J, Kebudi R, Knipstein J, Koschmann C, Kratz C, Larouche V, Lassaletta A, Lindhorst S, Ling S, Link M, Loret De Mola R, Luiten R, Lurye M, Maciaszek J, MagimairajanIssai V, Maher O, Massimino M, McGee R, Mushtaq N, Mason G, Newmark M, Nicholas G, Nichols K, Nicolaides T, Opocher E, Osborn M, Oshrine B, Pearlman R, Pettee D, Rapp J, Rashid M, Reddy A, Reichman L, Remke M, Robbins G, Roy S, Sabel M, Samuel D, Scheers I, Schneider K, Sen S, Stearns D, Sumerauer D, Swallow C, Taylor L, Thomas G, Toledano H, Tomboc P, Van Damme A, Winer I, Yalon M, Yen L, Zapotocky M, Zelcer S, Ziegler D, Zimmermann S, Hawkins C, Malkin D, Bouffet E, Villani A, Tabori U
J CLIN ONCOL. 2021;39(25):2779-2790.

Is neutralization of IFN-γ sufficient to control inflammation in HLH?
Ehl S, von Bahr Greenwood T, Bergsten E, Fischer A, Henter J, Hines M, Lehmberg K, Janka G, Moshous D, Nichols K
PEDIATR BLOOD CANCER. 2021;68(3):e28886.

Current recommendations for clinical surveillance and genetic testing in rhabdoid tumor predisposition: a report from the SIOPE Host Genome Working Group
Frühwald M, Nemes K, Boztug H, Cornips M, Evans D, Farah R, Glentis S, Jorgensen M, Katsibardi K, Hirsch S, Jahnukainen K, Kventsel I, Kerl K, Kratz C, Pajtler K, Kordes U, Ridola V, Stutz E, Bourdeaut F
FAM CANCER. 2021;20(4):305-316.

IDH2 R172 Mutations Across Poorly Differentiated Sinonasal Tract Malignancies: Forty Molecularly Homogenous and Histologically Variable Cases With Favorable Outcome
Glöss S, Jurmeister P, Thieme A, Schmid S, Cai W, Serrette R, Perner S, Ribbat-Idel J, Pagenstecher A, Bläker H, Keber U, Stadelmann C, Zechel S, Johann P, Hasselblatt M, Paulus W, Thomas C, Dohmen H, Baumhoer D, Frank S, Agaimy A, Schüller U, Vasudevaraja V, Snuderl M, Liu C, Pfister D, Jungbluth A, Ghossein R, Xu B, Capper D, Dogan S
AM J SURG PATHOL. 2021;45(9):1190-1204.

Double adenomas of the pituitary reveal distinct lineage markers, copy number alterations, and epigenetic profiles
Hagel C, Schüller U, Flitsch J, Knappe U, Kellner U, Bergmann M, Buslei R, Buchfelder M, Rüdiger T, Herms J, Saeger W
PITUITARY. 2021;24(6):904-913.

A "Goldilocks" approach to CNS leukemia is needed
Halsey C, Escherich G
BLOOD. 2021;138(4):288-289.

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
Hashem H, Bucciol G, Ozen S, Unal S, Bozkaya I, Akarsu N, Taskinen M, Koskenvuo M, Saarela J, Dimitrova D, Hickstein D, Hsu A, Holland S, Krance R, Sasa G, Kumar A, Müller I, Abreu de Sousa M, Delafontaine S, Moens L, Babor F, Barzaghi F, Cicalese M, Bredius R, van Montfrans J, Baretta V, Cesaro S, Stepensky P, Benedicte N, Moshous D, Le Guenno G, Boutboul D, Dalal J, Brooks J, Dokmeci E, Dara J, Lucas C, Hambleton S, Wilson K, Jolles S, Koc Y, Güngör T, Schnider C, Candotti F, Steinmann S, Schulz A, Chambers C, Hershfield M, Ombrello A, Kanakry J, Meyts I
J CLIN IMMUNOL. 2021;41(7):1633-1647.

Genetic testing and surveillance in infantile myofibromatosis: a report from the SIOPE Host Genome Working Group
Hettmer S, Dachy G, Seitz G, Agaimy A, Duncan C, Jongmans M, Hirsch S, Kventsel I, Kordes U, de Krijger R, Metzler M, Michaeli O, Nemes K, Poluha A, Ripperger T, Russo A, Smetsers S, Sparber-Sauer M, Stutz E, Bourdeaut F, Kratz C, Demoulin J
FAM CANCER. 2021;20(4):327-336.

Relapsed Medulloblastoma in Pre-Irradiated Patients: Current Practice for Diagnostics and Treatment
Hill R, Plasschaert S, Timmermann B, Dufour C, Aquilina K, Avula S, Donovan L, Lequin M, Pietsch T, Thomale U, Tippelt S, Wesseling P, Rutkowski S, Clifford S, Pfister S, Bailey S, Fleischhack G
CANCERS. 2021;14(1):.

Atypical teratoid/rhabdoid tumors (ATRTs) with SMARCA4 mutation are molecularly distinct from SMARCB1-deficient cases
Holdhof D, Johann P, Spohn M, Bockmayr M, Safaei S, Joshi P, Masliah-Planchon J, Ho B, Andrianteranagna M, Bourdeaut F, Huang A, Kool M, Upadhyaya S, Bendel A, Indenbirken D, Foulkes W, Bush J, Creytens D, Kordes U, Frühwald M, Hasselblatt M, Schüller U
ACTA NEUROPATHOL. 2021;141(2):291-301.

Simultaneous Brg1 Knockout and MYCN Overexpression in Cerebellar Granule Neuron Precursors Is Insufficient to Drive Tumor Formation but Temporarily Enhances their Proliferation and Delays their Migration
Holdhof D, On J, Schoof M, Göbel C, Schüller U
CEREBELLUM. 2021;20(3):410-419.

Brahma-related gene 1 has time-specific roles during brain and eye development
Holdhof D, Schoof M, Neyazi S, Spohn M, Kresbach C, Göbel C, Hellwig M, Indenbirken D, Moreno N, Kerl K, Schüller U
DEVELOPMENT. 2021;148(10):.

Detailed Clinical and Histopathological Description of 8 Cases of Molecularly Defined CNS Neuroblastomas
Holsten T, Lubieniecki F, Spohn M, Mynarek M, Bison B, Löbel U, Rutkowski S, Schüller U
J NEUROPATH EXP NEUR. 2021;80(1):52-59.

Genome-wide interference of ZNF423 with B-lineage transcriptional circuitries in acute lymphoblastic leukemia
Iglesias P, Puller A, Seoane M, Spohn M, Raasch S, Klokow M, Müller J, Burkhardt L, Indenbirken D, Horstmann M
BLOOD ADV. 2021;5(5):1209-1223.

Feasibility of Proton Beam Therapy for Infants with Brain Tumours: Experiences from the Prospective KiProReg Registry Study
Jazmati D, Steinmeier T, Ahamd Khalil D, Frisch S, Peters S, Schulze Schleithoff S, Bäumer C, Rutkowski S, Frühwald M, Blase C, Tippelt S, Timmermann B
CLIN ONCOL-UK. 2021;33(7):e295-e304.

Integrative genomic analysis of pediatric T- cell lymphoblastic lymphoma reveals candidates of clinical significance
Khanam T, Sandmann S, Seggewiss J, Ruether C, Zimmermann M, Norvil A, Bartenhagen C, Randau G, Mueller S, Herbrüggen H, Hoffmann P, Herms S, Wei L, Wöste M, Wünsch C, Gowher H, Oschlies I, Klapper W, Woessmann W, Dugas M, Burkhardt B
BLOOD. 2021;137(17):2347-2359.

Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas
Kirches E, Sahm F, Korshunov A, Bluecher C, Waldt N, Kropf S, Schrimpf D, Sievers P, Stichel D, Schüller U, Schittenhelm J, Riemenschneider M, Karajannis M, Perry A, Pietsch T, Boekhoff S, Capper D, Beck K, Paramasivam N, Schlesner M, Brastianos P, Müller H, Pfister S, Mawrin C
ACTA NEUROPATHOL. 2021;142(5):873-886.

Defining the Spectrum, Treatment and Outcome of Patients With Genetically Confirmed Gorlin Syndrome From the HIT-MED Cohort
Kloth K, Obrecht D, Sturm D, Pietsch T, Warmuth-Metz M, Bison B, Mynarek M, Rutkowski S
FRONT ONCOL. 2021;11:.

Influence of transfusions, hemodialysis and extracorporeal life support on hyperferritinemia in critically ill patients
Knaak C, Schuster F, Nyvlt P, Heeren P, Spies C, Schenk T, La Rosée P, Janka G, Brunkhorst F, Lachmann G
PLOS ONE. 2021;16(7):.

Dose-adjusted EPOCH-rituximab or intensified B-NHL therapy for pediatric primary mediastinal large B-cell lymphoma
Knörr F, Zimmermann M, Attarbaschi A, Kabickova E, Maecker-Kolhoff B, Ruf S, Kühnle I, Ebinger M, Garthe A, Simonitsch-Klupp I, Oschlies I, Klapper W, Burkhardt B, Wößmann W
HAEMATOLOGICA. 2021;106(12):3232-3235.

Sarcoma classification by DNA methylation profiling
Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss D, Blattner M, Worst B, Heilig C, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler K, Reinhardt A, Wefers A, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss F, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik A, Kool M, Romero-Pérez L, Grünewald T, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers Y, Weidema M, Mentzel T, Griewank K, de Álava E, Martín J, Gastearena M, Chang K, Low S, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner V, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens W, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado O, Sáinz-Jaspeado M, Mora J, Alonso J, Del Muro X, Moran S, Esteller M, Benhamida J, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones D, Fröhling S, Pfister S, von Deimling A
NAT COMMUN. 2021;12(1):498.

Evidence for a low-penetrant extended phenotype of rhabdoid tumor predisposition syndrome type 1 from a kindred with gain of SMARCB1 exon 6
Kordes U, Mautner V, Oyen F, Hagel C, Hartmann C, Heuser M, Frühwald M, Hasselblatt M, Oehl-Huber K, Siebert R, Schneppenheim R, Schüller U
PEDIATR BLOOD CANCER. 2021;68(10):e29185.

Evidence for a low-penetrant extended phenotype of RTPS1 from a kindred with gain of SMARCB1 exon 6
Kordes U, Mautner V, Oyen F, Hagel C, Hartmann C, Heuser M, Frühwald M, Hasselblatt M, Oehl-Huber K, Siebert R, Schneppenheim R, Schüller U
2021.

Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype
Kresbach C, Dorostkar M, Suwala A, Wefers A, Schweizer L, Engertsberger L, Bison B, Mynarek M, Kloth-Stachnau K, Spohn M, von Deimling A, Benesch M, Hagel C, Mautner V, Rutkowski S, Schüller U
ACTA NEUROPATHOL. 2021;141(6):971-974.

EXTH-70. ESTABLISHMENT OF INTRAVENTRICULAR SHH INHIBITION AS A THERAPEUTIC OPTION IN YOUNG PATIENTS WITH MEDULLOBLASTOMA
Kresbach C, Schoof M, Leven T, Holst L, Yorgan T, Wrzeszcz A, Rutkowski S, Schüller U
NEURO-ONCOLOGY. 2021;23(Supplement_6):vi179.

Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma
Kumar R, Smith K, Deng M, Terhune C, Robinson G, Orr B, Liu A, Lin T, Billups C, Chintagumpala M, Bowers D, Hassall T, Hansford J, Khuong-Quang D, Crawford J, Bendel A, Gururangan S, Schroeder K, Bouffet E, Bartels U, Fisher M, Cohn R, Partap S, Kellie S, McCowage G, Paulino A, Rutkowski S, Fleischhack G, Dhall G, Klesse L, Leary S, Nazarian J, Kool M, Wesseling P, Ryzhova M, Zheludkova O, Golanov A, McLendon R, Packer R, Dunham C, Hukin J, Fouladi M, Faria C, Pimentel J, Walter A, Jabado N, Cho Y, Perreault S, Croul S, Zapotocky M, Hawkins C, Tabori U, Taylor M, Pfister S, Klimo P, Boop F, Ellison D, Merchant T, Onar-Thomas A, Korshunov A, Jones D, Gajjar A, Ramaswamy V, Northcott P
J CLIN ONCOL. 2021;39(7):807-821.

HSCT is effective in patients with PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome
Laberko A, Burlakov V, Maier S, Abinun M, Skinner R, Kozlova A, Suri D, Lehmberg K, Müller I, Balashov D, Novichkova G, Holzinger D, Gennery A, Shcherbina A
J ALLERGY CLIN IMMUN. 2021;148(1):250-255.e1.

Primary haemophagocytic lymphohistiocytosis (Chédiak-Higashi Syndrome) triggered by acute SARS-CoV-2 infection in a six-week-old infant
Lange M, Linden T, Müller H, Flasskuehler M, Koester H, Lehmberg K, Ledig S, Ehl S, Heep A, Beske F
BRIT J HAEMATOL. 2021;195(2):198-200.

Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target
Larose H, Prokoph N, Matthews J, Schlederer M, Högler S, Alsulami A, Ducray S, Nuglozeh E, Fazaludeen F, Elmouna A, Ceccon M, Mologni L, Gambacorti-Passerini C, Hoefler G, Lobello C, Pospisilova S, Janikova A, Woessmann W, Damm-Welk C, Zimmermann M, Federova A, Malone A, Smith O, Wasik M, Inghirami G, Lamant L, Blundell T, Klapper W, Merkel O, Burke G, Mian S, Ashankyty I, Kenner L, Turner S
HAEMATOLOGICA. 2021;106(6):1693-1704.

Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma
Liang H, Costanza M, Prutsch N, Zimmerman M, Gurnhofer E, Montes-Mojarro I, Abraham B, Prokoph N, Stoiber S, Tangermann S, Lobello C, Oppelt J, Anagnostopoulos I, Hielscher T, Pervez S, Klapper W, Zammarchi F, Silva D, Garcia K, Baker D, Janz M, Schleussner N, Fend F, Pospíšilová Š, Janiková A, Wallwitz J, Stoiber D, Simonitsch-Klupp I, Cerroni L, Pileri S, de Leval L, Sibon D, Fataccioli V, Gaulard P, Assaf C, Knörr F, Damm-Welk C, Woessmann W, Turner S, Look A, Mathas S, Kenner L, Merkel O
NAT COMMUN. 2021;12(1):.

Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study
Liu A, Li B, Pfaff E, Gudenas B, Vasiljevic A, Orr B, Dufour C, Snuderl M, Karajannis M, Rosenblum M, Hwang E, Ng H, Hansford J, Szathmari A, Faure-Conter C, Merchant T, Levine M, Bouvier N, von Hoff K, Mynarek M, Rutkowski S, Sahm F, Kool M, Hawkins C, Onar-Thomas A, Robinson G, Gajjar A, Pfister S, Bouffet E, Northcott P, Jones D, Huang A
ACTA NEUROPATHOL. 2021;141(5):771-785.

Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire C, Fuh M, Kaulich K, Fita K, Stevic I, Heiland D, Welsh J, Jones J, Görgens A, Ricklefs T, Dührsen L, Sauvigny T, Joosse S, Reifenberger G, Pantel K, Glatzel M, Miklosi A, Felce J, Caselli M, Pereno V, Reimer R, Schlüter H, Westphal M, Schüller U, Lamszus K, Ricklefs F
NEURO-ONCOLOGY. 2021;23(7):1087-1099.

Recommendations for Age-Appropriate Testing, Timing, and Frequency of Audiologic Monitoring During Childhood Cancer Treatment: An International Society of Paediatric Oncology Supportive Care Consensus Report
Meijer A, van den Heuvel-Eibrink M, Brooks B, Am Zehnhoff-Dinnesen A, Knight K, Freyer D, Chang K, Hero B, Papadakis V, Frazier A, Blattmann C, Windsor R, Morland B, Bouffet E, Rutkowski S, Tytgat G, Geller J, Hunter L, Sung L, Calaminus G, Carleton B, Helleman H, Foster J, Kruger M, Cohn R, Landier W, van Grotel M, Brock P, Hoetink A, Rajput K
JAMA ONCOL. 2021;7(10):1550-1558.

Minimal residual disease, long-term outcome, and IKZF1 deletions in children and adolescents with Down syndrome and acute lymphocytic leukaemia: a matched cohort study
Michels N, Boer J, Enshaei A, Sutton R, Heyman M, Ebert S, Fiocco M, de Groot-Kruseman H, van der Velden V, Barbany G, Escherich G, Vora A, Trahair T, Dalla-Pozza L, Pieters R, Zur Stadt U, Schmiegelow K, Moorman A, Zwaan C, den Boer M
LANCET HAEMATOL. 2021;8(10):e700-e710.

Case Report: Hemophagocytic Lymphohistiocytosis and Non-Tuberculous Mycobacteriosis Caused by a Novel GATA2 Variant
Mika T, Vangala D, Eckhardt M, La Rosée P, Lange C, Lehmberg K, Wohlschläger C, Biskup S, Fuchs I, Mann J, Ehl S, Warnatz K, Schroers R
FRONT IMMUNOL. 2021;12:.

Second malignancies after treatment of childhood non-Hodgkin lymphoma: a report of the Berlin-Frankfurt-Muenster study group
Moser O, Zimmermann M, Meyer U, Klapper W, Oschlies I, Schrappe M, Attarbaschi A, Mann G, Niggli F, Spix C, Kontny U, Klingebiel T, Reiter A, Burkhardt B, Woessmann W
HAEMATOLOGICA. 2021;106(5):1390-1400.

Minimal Disease Monitoring in Pediatric Non-Hodgkin's Lymphoma: Current Clinical Application and Future Challenges
Mussolin L, Damm-Welk C, Pillon M, Woessmann W
CANCERS. 2021;13(8):.

SIOP PNET5 MB Trial: History and Concept of a Molecularly Stratified Clinical Trial of Risk-Adapted Therapies for Standard-Risk Medulloblastoma
Mynarek M, Milde T, Padovani L, Janssens G, Kwiecien R, Mosseri V, Clifford S, Doz F, Rutkowski S
CANCERS. 2021;13(23):.

Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK)
Nemes K, Bens S, Kachanov D, Teleshova M, Hauser P, Simon T, Tippelt S, Woessmann W, Beck O, Flotho C, Grigull L, Driever P, Schlegel P, Khurana C, Hering K, Kolb R, Leipold A, Abbink F, Gil-Da-Costa M, Benesch M, Kerl K, Lowis S, Marques C, Graf N, Nysom K, Vokuhl C, Melchior P, Kröncke T, Schneppenheim R, Kordes U, Gerss J, Siebert R, Furtwängler R, Frühwald M
EUR J CANCER. 2021;142:112-122.

Auswirkungen der COVID-19 Pandemie auf die medizinische Versorgung von Patienten mit angeborenen Blutungsneigungen
Olivieri M, Halimeh S, Wermes C, Hassenpflug W, Holstein K, von Mackensen S
GESUNDHEITSWESEN. 2021;83(4):282-290.

Inhibition of nuclear export restores nuclear localization and residual tumor suppressor function of truncated SMARCB1/INI1 protein in a molecular subset of atypical teratoid/rhabdoid tumors
Pathak R, Zin F, Thomas C, Bens S, Gayden T, Karamchandani J, Dudley R, Nemes K, Johann P, Oyen F, Kordes U, Jabado N, Siebert R, Paulus W, Kool M, Frühwald M, Albrecht S, Kalpana G, Hasselblatt M
ACTA NEUROPATHOL. 2021;142(2):361-374.

Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration
Pearson A, Barry E, Mossé Y, Ligas F, Bird N, de Rojas T, Zimmerman Z, Wilner K, Woessmann W, Weiner S, Weigel B, Venkatramani R, Valteau D, Trahair T, Smith M, Singh S, Selvaggi G, Scobie N, Schleiermacher G, Richardson N, Park J, Nysom K, Norga K, Merino M, McDonough J, Matloub Y, Marshall L, Lowe E, Lesa G, Irwin M, Karres D, Gajjar A, Doz F, Fox E, DuBois S, Donoghue M, Casanova M, Caron H, Buenger V, Bradford D, Blanc P, Barone A, Reaman G, Vassal G
EUR J CANCER. 2021;157:198-213.

Reconstructing clonal evolution in relapsed and non-relapsed Burkitt lymphoma
Reutter K, Sandmann S, Rohde J, Müller S, Wöste M, Khanam T, Michgehl U, Klapper W, Wößmann W, Seggewiß J, Lenz G, Dugas M, Burkhardt B
LEUKEMIA. 2021;35(2):639-643.

68Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas – Imaging analysis and histological validation
Röhrich M, Syed M, Liew D, Giesel F, Liermann J, Choyke P, Wefers A, Ritz T, Szymbara M, Schillings L, Heger U, Rathke H, Kratochwil C, Huber P, Deimling A, Debus J, Kauczor H, Haberkorn U, Adeberg S
RADIOTHER ONCOL. 2021;160:192-201.

Follow-up evaluation of a web-based pediatric brain tumor board in Latin America
Rosabal-Obando M, Osorio D, Lassaletta A, La Madrid A, Bartels U, Finlay J, Qaddoumi I, Rutkowski S, Mynarek M
PEDIATR BLOOD CANCER. 2021;68(9):e29073.

DIMEimmune: Robust estimation of infiltrating lymphocytes in CNS tumors from DNA methylation profiles
Safaei S, Mohme M, Niesen J, Schüller U, Bockmayr M
ONCOIMMUNOLOGY. 2021;10(1):.

Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
Sahoo S, Pastor V, Goodings C, Voss R, Kozyra E, Szvetnik A, Noellke P, Dworzak M, Starý J, Locatelli F, Masetti R, Schmugge M, De Moerloose B, Catala A, Kállay K, Turkiewicz D, Hasle H, Buechner J, Jahnukainen K, Ussowicz M, Polychronopoulou S, Smith O, Fabri O, Barzilai S, de Haas V, Baumann I, Schwarz-Furlan S, Niewisch M, Sauer M, Burkhardt B, Lang P, Bader P, Beier R, Müller I, Albert M, Meisel R, Schulz A, Cario G, Panda P, Wehrle J, Hirabayashi S, Derecka M, Durruthy-Durruthy R, Göhring G, Yoshimi-Noellke A, Ku M, Lebrecht D, Erlacher M, Flotho C, Strahm B, Niemeyer C, Wlodarski M
NAT MED. 2021;27(10):1806-1817.

Effects of a structured counselling-based intervention to improve physical activity behaviour of adolescents and young adult cancer survivors - the randomized phase II Motivate AYA - MAYA trial
Salchow J, Koch B, Mann J, von Grundherr J, Elmers S, Dwinger S, Escherich G, Vettorazzi E, Reer R, Sinn M, Baumann F, Bokemeyer C, Stein A, Jensen W
CLIN REHABIL. 2021;35(8):1164-1174.

Insights into diastolic function analyses using cardiac magnetic resonance imaging: impact of trabeculae and papillary muscles
Schoennagel B, Müllerleile K, Tahir E, Starekova J, Grosse R, Yamamura J, Bannas P, Adam G, Fischer R
INSIGHTS IMAGING. 2021;12(1):.

Malignant gliomas with H3F3A G34R mutation or MYCN amplification in pediatric patients with Li Fraumeni syndrome
Schoof M, Kordes U, Volk A, Al-Kershi S, Kresbach C, Schüller U
ACTA NEUROPATHOL. 2021;142(3):591-593.

Correction to: Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(4):627.

Mutations within FGFR1 are associated with superior outcome in a series of 83 diffuse midline gliomas with H3F3A K27M mutations
Schüller U, Iglauer P, Dorostkar M, Mawrin C, Herms J, Giese A, Glatzel M, Neumann J
ACTA NEUROPATHOL. 2021;141(2):323-325.

SSBP2-CSF1R is a recurrent fusion in B-lineage acute lymphoblastic leukemia with diverse genetic presentation and variable outcome
Schwab C, Roberts K, Boer J, Gohring G, Steinemann D, Vora A, Macartney C, Hough R, Thorn Z, Dillon R, Escherich G, Cazzaniga G, Schlegelberger B, Loh M, Den Boer M, Moorman A, Harrison C
BLOOD. 2021;137(13):1835-1838.

Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors
Sievers P, Henneken S, Blume C, Sill M, Schrimpf D, Stichel D, Okonechnikov K, Reuss D, Benzel J, Maaß K, Kool M, Sturm D, Zheng T, Ghasemi D, Kohlhof-Meinecke P, Cruz O, Suñol M, Lavarino C, Ruf V, Boldt H, Pagès M, Pouget C, Schweizer L, Kranendonk M, Akhtar N, Bunkowski S, Stadelmann C, Schüller U, Mueller W, Dohmen H, Acker T, Harter P, Mawrin C, Beschorner R, Brandner S, Snuderl M, Abdullaev Z, Aldape K, Gilbert M, Armstrong T, Ellison D, Capper D, Ichimura K, Reifenberger G, Grundy R, Jabado N, Krskova L, Zapotocky M, Vicha A, Varlet P, Wesseling P, Rutkowski S, Korshunov A, Wick W, Pfister S, Jones D, von Deimling A, Pajtler K, Sahm F
ACTA NEUROPATHOL. 2021;142(5):827-839.

The transcriptional landscape of Shh medulloblastoma
Skowron P, Farooq H, Cavalli F, Morrissy A, Ly M, Hendrikse L, Wang E, Djambazian H, Zhu H, Mungall K, Trinh Q, Zheng T, Dai S, Stucklin A, Vladoiu M, Fong V, Holgado B, Nor C, Wu X, Abd-Rabbo D, Bérubé P, Wang Y, Luu B, Suarez R, Rastan A, Gillmor A, Lee J, Zhang X, Daniels C, Dirks P, Malkin D, Bouffet E, Tabori U, Loukides J, Doz F, Bourdeaut F, Delattre O, Masliah-Planchon J, Ayrault O, Kim S, Meyronet D, Grajkowska W, Carlotti C, de Torres C, Mora J, Eberhart C, Van Meir E, Kumabe T, French P, Kros J, Jabado N, Lach B, Pollack I, Hamilton R, Rao A, Giannini C, Olson J, Bognár L, Klekner A, Zitterbart K, Phillips J, Thompson R, Cooper M, Rubin J, Liau L, Garami M, Hauser P, Li K, Ng H, Poon W, Yancey Gillespie G, Chan J, Jung S, McLendon R, Thompson E, Zagzag D, Vibhakar R, Ra Y, Garre M, Schüller U, Shofuda T, Faria C, López-Aguilar E, Zadeh G, Hui C, Ramaswamy V, Bailey S, Jones S, Mungall A, Moore R, Calarco J, Stein L, Bader G, Reimand J, Ragoussis J, Weiss W, Marra M, Suzuki H, Taylor M
NAT COMMUN. 2021;12(1):1749.

Genetic and Clinical Predictors of Left Atrial Thrombus: A Single Center Case-Control Study
Springer A, Schleberger R, Oyen F, Hoffmann B, Willems S, Meyer C, Langer F, Schnabel R, Kirchhof P, Schneppenheim R, Lemoine M
CLIN APPL THROMB-HEM. 2021;27:10760296211021171.

Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors
Steinbügl M, Nemes K, Johann P, Kröncke T, Tüchert S, da Costa M, Ebinger M, Schüller U, Sehested A, Hauser P, Reinhard H, Sumerauer D, Hettmer S, Jakob M, Hasselblatt M, Siebert R, Witt O, Gerss J, Kerl K, Frühwald M
PEDIATR BLOOD CANCER. 2021;68(12):.

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data
Stichel D, Schrimpf D, Sievers P, Reinhardt A, Suwala A, Sill M, Reuss D, Korshunov A, Casalini B, Sommerkamp A, Ecker J, Selt F, Sturm D, Gnekow A, Koch A, Simon M, Hernáiz Driever P, Schüller U, Capper D, van Tilburg C, Witt O, Milde T, Pfister S, Jones D, von Deimling A, Sahm F, Wefers A
NEUROPATH APPL NEURO. 2021;47(3):406-414.

Diagnostics and Diagnosis of Late Effects in Childhood Brain Tumour Survivors
Tallen G, Mynarek M, Tischler T, Weller M, Rutkowski S
2021. Late Treatment Effects and Cancer Survivor Care in the Young. Beck J, Bokemeyer C, Langer T (Hrsg.). 1. Aufl. Cham: Springer Nature Switzerland, 239-251.

Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations
Thalhammer J, Kindle G, Nieters A, Rusch S, Seppänen M, Fischer A, Grimbacher B, Edgar D, Buckland M, Mahlaoui N, Ehl S
J ALLERGY CLIN IMMUN. 2021;148(5):1332-1341.e5.

Atypical Teratoid/Rhabdoid Tumor (AT/RT) With Molecular Features of Pleomorphic Xanthoastrocytoma
Thomas C, Federico A, Sill M, Bens S, Oyen F, Nemes K, Johann P, Hartmann C, Hartmann W, Sumerauer D, Paterno V, Samii A, Kordes U, Siebert R, Frühwald M, Paulus W, Kool M, Hasselblatt M
AM J SURG PATHOL. 2021;45(9):1228-1234.

Transposable element insertion as a mechanism of SMARCB1 inactivation in atypical teratoid/rhabdoid tumor
Thomas C, Oehl-Huber K, Bens S, Soschinski P, Koch A, Nemes K, Oyen F, Kordes U, Kool M, Frühwald M, Hasselblatt M, Siebert R
GENE CHROMOSOME CANC. 2021;60(8):586-590.

The genetic landscape of choroid plexus tumors in children and adults
Thomas C, Soschinski P, Zwaig M, Oikonomopoulos S, Okonechnikov K, Pajtler K, Sill M, Schweizer L, Koch A, Neumann J, Schüller U, Sahm F, Rauschenbach L, Keyvani K, Proescholdt M, Riemenschneider M, Segewiß J, Ruckert C, Grauer O, Monoranu C, Lamszus K, Patrizi A, Kordes U, Siebert R, Kool M, Ragoussis J, Foulkes W, Paulus W, Rivera B, Hasselblatt M
NEURO-ONCOLOGY. 2021;23(4):650-660.

TERT promoter mutation and chromosome 6 loss define a high-risk subtype of ependymoma evolving from posterior fossa subependymoma
Thomas C, Thierfelder F, Träger M, Soschinski P, Müther M, Edelmann D, Förster A, Geiler C, Kim H, Filipski K, Harter P, Schittenhelm J, Eckert F, Ntoulias G, May S, Stummer W, Onken J, Vajkoczy P, Schüller U, Heppner F, Capper D, Koch A, Kaul D, Paulus W, Hasselblatt M, Schweizer L
ACTA NEUROPATHOL. 2021;141(6):959-970.

The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets
van Tilburg C, Pfaff E, Pajtler K, Langenberg K, Fiesel P, Jones B, Balasubramanian G, Stark S, Johann P, Blattner-Johnson M, Schramm K, Dikow N, Hirsch S, Sutter C, Grund K, von Stackelberg A, Kulozik A, Lissat A, Borkhardt A, Meisel R, Reinhardt D, Klusmann J, Fleischhack G, Tippelt S, von Schweinitz D, Schmid I, Kramm C, von Bueren A, Calaminus G, Vorwerk P, Graf N, Westermann F, Fischer M, Eggert A, Burkhardt B, Wößmann W, Nathrath M, Hecker-Nolting S, Frühwald M, Schneider D, Brecht I, Ketteler P, Fulda S, Koscielniak E, Meister M, Scheer M, Hettmer S, Schwab M, Tremmel R, Øra I, Hutter C, Gerber N, Lohi O, Kazanowska B, Kattamis A, Filippidou M, Goemans B, Zwaan C, Milde T, Jäger N, Wolf S, Reuss D, Sahm F, von Deimling A, Dirksen U, Freitag A, Witt R, Lichter P, Kopp-Schneider A, Jones D, Molenaar J, Capper D, Pfister S, Witt O
CANCER DISCOV. 2021;11(11):2764-2779.

Therapeutic implications of improved molecular diagnostics for rare CNS-embryonal tumor entities: results of an international, retrospective study
von Hoff K, Haberler C, Schmitt-Hoffner F, Schepke E, de Rojas T, Jacobs S, Zapotocky M, Sumerauer D, Perek-Polnik M, Dufour C, van Vuurden D, Slavc I, Gojo J, Pickles J, Gerber N, Massimino M, Gil-da-Costa M, Garami M, Kumirova E, Sehested A, Scheie D, Cruz O, Moreno L, Cho J, Zeller B, Bovenschen N, Grotzer M, Alderete D, Snuderl M, Zheludkova O, Golanov A, Okonechnikov K, Mynarek M, Juhnke B, Rutkowski S, Schüller U, Pizer B, Zezschwitz B, Kwiecien R, Wechsung M, Konietschke F, Hwang E, Sturm D, Pfister S, von Deimling A, Rushing E, Ryzhova M, Hauser P, Łastowska M, Wesseling P, Giangaspero F, Hawkins C, Figarella-Branger D, Eberhart C, Burger P, Gessi M, Korshunov A, Jacques T, Capper D, Pietsch T, Kool M
NEURO-ONCOLOGY. 2021;23(9):1597-1611.

SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2
von Wenserski L, Schultheiß C, Bolz S, Schliffke S, Simnica D, Willscher E, Gerull H, Wolters-Eisfeld G, Riecken K, Fehse B, Altfeld M, Nollau P, Binder M
LEUKEMIA. 2021;35(4):1073-1086.

Multicentric dermatofibrosarcoma protuberans in a child with severe combined immunodeficiency due to adenosine deaminase deficiency
Wahjudi T, Kutzner H, Bleeke M, Hoeger P
PEDIATR DERMATOL. 2021;38(4):875-878.

Clinical and genetic characteristics of children with acute lymphoblastic leukemia and Li-Fraumeni syndrome
Winter G, Kirschner-Schwabe R, Groeneveld-Krentz S, Escherich G, Möricke A, von Stackelberg A, Stanulla M, Bailey S, Richter L, Steinemann D, Ripperger T, Escudero A, Farah R, Lohi O, Wadt K, Jongmans M, van Engelen N, Eckert C, Kratz C
LEUKEMIA. 2021;35(5):1475-1479.

Ependymoma relapse goes along with a relatively stable epigenome, but a severely altered tumor morphology
Yang D, Holsten T, Börnigen D, Frank S, Mawrin C, Glatzel M, Schüller U
BRAIN PATHOL. 2021;31(1):33-44.

Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion-Positive Supratentorial Ependymomas
Zheng T, Ghasemi D, Okonechnikov K, Korshunov A, Sill M, Maass K, Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber N, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson A, Ramaswamy V, Capper D, Ellison D, Herold-Mende C, Schüller U, Brandner S, Driever P, Kros J, Snuderl M, Milde T, Grundy R, Hoshino M, Mack S, Gilbertson R, Jones D, Kool M, von Deimling A, Pfister S, Sahm F, Kawauchi D, Pajtler K
CANCER DISCOV. 2021;11(9):2230-2247.

Simple Measurement of IgA Predicts Immunity and Mortality in Ataxia-Telangiectasia
Zielen S, Duecker R, Woelke S, Donath H, Bakhtiar S, Buecker A, Kreyenberg H, Huenecke S, Bader P, Mahlaoui N, Ehl S, El-Helou S, Pietrucha B, Plebani A, van der Flier M, van Aerde K, Kilic S, Reda S, Kostyuchenko L, McDermott E, Galal N, Pignata C, Pérez J, Laws H, Niehues T, Kutukculer N, Seidel M, Marques L, Ciznar P, Edgar J, Soler-Palacín P, von Bernuth H, Krueger R, Meyts I, Baumann U, Kanariou M, Grimbacher B, Hauck F, Graf D, Granado L, Prader S, Reisli I, Slatter M, Rodríguez-Gallego C, Arkwright P, Bethune C, Deripapa E, Sharapova S, Lehmberg K, Davies E, Schuetz C, Kindle G, Schubert R
J CLIN IMMUNOL. 2021;41(8):1878-1892.

Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup.
Zin F, Cotter J, Haberler C, Dottermusch M, Neumann J, Schüller U, Schweizer L, Thomas C, Nemes K, Johann P, Kool M, Frühwald M, Paulus W, Judkins A, Hasselblatt M
BRAIN PATHOL. 2021;31(5):e12967.

Supratentorial ependymoma in childhood: more than just RELA or YAP
Zschernack V, Jünger S, Mynarek M, Rutkowski S, Garre M, Ebinger M, Neu M, Faber J, Erdlenbruch B, Claviez A, Bielack S, Brozou T, Frühwald M, Dörner E, Dreschmann V, Stock A, Solymosi L, Hench J, Frank S, Vokuhl C, Waha A, Andreiuolo F, Pietsch T
ACTA NEUROPATHOL. 2021;141(3):455-466.

2020

Functional flow cytometry of monocytes for routine diagnosis of innate primary immunodeficiencies
Ammann S, Fuchs S, Martin-Martin L, Castro C, Spielberger B, Klemann C, Elling R, Heeg M, Speckmann C, Hainmann I, Kaiser-Labusch P, Horneff G, Thalhammer J, Bredius R, Stadt U, Lehmberg K, Fuchs I, von Spee-Mayer C, Henneke P, Ehl S
J ALLERGY CLIN IMMUN. 2020;145(1):434-437.e4.

Rare non-Hodgkin lymphoma of childhood and adolescence: A consensus diagnostic and therapeutic approach to pediatric-type follicular lymphoma, marginal zone lymphoma, and nonanaplastic peripheral T-cell lymphoma
Attarbaschi A, Abla O, Arias Padilla L, Beishuizen A, Burke G, Brugières L, Bruneau J, Burkhardt B, d'Amore E, Klapper W, Kontny U, Pillon M, Taj M, Turner S, Uyttebroeck A, Woessmann W, Mellgren K
PEDIATR BLOOD CANCER. 2020;67(8):e28416.

Experience with provisional WHO-entities large B-cell lymphoma with IRF4-rearrangement and Burkitt-like lymphoma with 11q aberration in paediatric patients of the NHL-BFM group
Au-Yeung R, Arias Padilla L, Zimmermann M, Oschlies I, Siebert R, Woessmann W, Burkhardt B, Klapper W
BRIT J HAEMATOL. 2020;190(5):753-763.

Accurate In-Vivo Quantification of CD19 CAR-T Cells after Treatment with Axicabtagene Ciloleucel (Axi-Cel) and Tisagenlecleucel (Tisa-Cel) Using Digital PCR
Badbaran A, Berger C, Riecken K, Kruchen A, Geffken M, Müller I, Kröger N, Ayuk F, Fehse B
CANCERS. 2020;12(7):.

A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure-activity relationships in alveolar macrophages
Bannuscher A, Karkossa I, Buhs S, Nollau P, Kettler K, Balas M, Dinischiotu A, Hellack B, Wiemann M, Luch A, von Bergen M, Haase A, Schubert K
NANOTOXICOLOGY. 2020;14(2):181-195.

Treatment response of CNS high-grade neuroepithelial tumors with MN1 alteration
Baroni L, Rugilo C, Lubieniecki F, Sampor C, Freytes C, Nobre L, Hansford J, Malalasekera V, Zapotocky M, Dodgshun A, Martinez O, La Madrid A, Lavarino C, Suñol M, Rutkowski S, Schuller U, Bouffet E, Ramaswamy V, Alderete D
PEDIATR BLOOD CANCER. 2020;67(12):e28627.

Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma
Begemann M, Waszak S, Robinson G, Jäger N, Sharma T, Knopp C, Kraft F, Moser O, Mynarek M, Guerrini-Rousseau L, Brugieres L, Varlet P, Pietsch T, Bowers D, Chintagumpala M, Sahm F, Korbel J, Rutkowski S, Eggermann T, Gajjar A, Northcott P, Elbracht M, Pfister S, Kontny U, Kurth I
J CLIN ONCOL. 2020;38(1):43-50.

Spinal cord atypical teratoid/rhabdoid tumors in children: Clinical, genetic, and outcome characteristics in a representative European cohort
Benesch M, Nemes K, Neumayer P, Hasselblatt M, Timmermann B, Bison B, Ebetsberger-Dachs G, Bourdeaut F, Dufour C, Biassoni V, Morales La Madrid A, Entz-Werle N, Laithier V, Quehenberger F, Weis S, Sumerauer D, Siebert R, Bens S, Schneppenheim R, Kool M, Modena P, Fouyssac F, C Frühwald M
PEDIATR BLOOD CANCER. 2020;67(1):e28022.

Stem cell transplantation for children with hemophagocytic lymphohistiocytosis: results from the HLH-2004 study
Bergsten E, Horne A, Hed Myrberg I, Aricó M, Astigarraga I, Ishii E, Janka G, Ladisch S, Lehmberg K, McClain K, Minkov M, Nanduri V, Rosso D, Sieni E, Winiarski J, Henter J
BLOOD ADV. 2020;4(15):3754-3766.

Early clinical course after hematopoietic stem cell transplantation in children with juvenile metachromatic leukodystrophy
Beschle J, Döring M, Kehrer C, Raabe C, Bayha U, Strölin M, Böhringer J, Bevot A, Kaiser N, Bender B, Grimm A, Lang P, Müller I, Krägeloh-Mann I, Groeschel S
Molecular and cellular pediatrics. 2020;7(1):12.

Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry
Birndt S, Schenk T, Heinevetter B, Brunkhorst F, Maschmeyer G, Rothmann F, Weber T, Müller M, Panse J, Penack O, Schroers R, Braess J, Frickhofen N, Ehl S, Janka G, Lehmberg K, Pletz M, Hochhaus A, Ernst T, La Rosée P
J CANCER RES CLIN. 2020;146(4):1065-1077.

Leukemia-induced dysfunctional TIM-3+CD4+ bone marrow T cells increase risk of relapse in pediatric B-precursor ALL patients
Blaeschke F, Willier S, Stenger D, Lepenies M, Horstmann M, Escherich G, Zimmermann M, Rojas Ringeling F, Canzar S, Kaeuferle T, Rohlfs M, Binder V, Klein C, Feuchtinger T
LEUKEMIA. 2020;34(10):2607-2620.

Genome-wide analysis of acute leukemia and clonally related histiocytic sarcoma in a series of three pediatric patients
Bleeke M, Johann P, Gröbner S, Alten J, Cario G, Schäfer H, Klapper W, Khoury J, Pfister S, Müller I
PEDIATR BLOOD CANCER. 2020;67(2):e28074.

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis
Blincoe A, Heeg M, Campbell P, Hines M, Khojah A, Klein-Gitelman M, Talano J, Speckmann C, Touzot F, Lankester A, Legger G, Rivière J, Garcia-Prat M, Alonso L, Putti M, Lehmberg K, Maier S, El Chazli Y, Elmaksoud M, Astigarraga I, Kurjane N, Bulina I, Kenina V, Bryceson Y, Rascon J, Lortie A, Goldstein G, Booth C, Worth A, Wassmer E, Schmitt E, Warren J, Bednarski J, Ali S, Chiang K, Krueger J, Henry M, Holland S, Marsh R, Ehl S, Haddad E
J CLIN IMMUNOL. 2020;40(6):901-916.

Multiclass cancer classification in fresh frozen and formalin-fixed paraffin-embedded tissue by DigiWest multiplex protein analysis
Bockmayr T, Erdmann G, Treue D, Jurmeister P, Schneider J, Arndt A, Heim D, Bockmayr M, Sachse C, Klauschen F
LAB INVEST. 2020;100(10):1288-1299.

Successful Stem Cell Apheresis Using Spectra Optia in a 6 kg Child With Atypical Teratoid/Rhabdoid Tumor
Brust P, Schubert C, Blohm M, Winkler B
J PEDIAT HEMATOL ONC. 2020;42(7):e692-e695.

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes
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Quantification of minimal disseminated disease by quantitative PCR and digital PCR for NPM-ALK as prognostic factor in children with anaplastic large cell lymphoma
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HAEMATOLOGICA. 2020;105(8):2141-2149.

Evaluation of Prognostic Factors and Role of Participation in a Randomized Trial or a Prospective Registry in Pediatric and Adolescent Nonmetastatic Medulloblastoma - A Report From the HIT 2000 Trial
Dietzsch S, Placzek F, Pietschmann K, von Bueren A, Matuschek C, Glück A, Guckenberger M, Budach V, Welzel J, Pöttgen C, Schmidberger H, Heinzelmann F, Paulsen F, Escudero M, Schwarz R, Hornung D, Martini C, Grosu A, Stueben G, Jablonska K, Dunst J, Stranzl-Lawatsch H, Dieckmann K, Timmermann B, Pietsch T, Warmuth-Metz M, Bison B, Kwiecien R, Benesch M, Gerber N, Grotzer M, Pfister S, Clifford S, von Hoff K, Klagges S, Rutkowski S, Kortmann R, Mynarek M
ADV RADIAT ONCOL. 2020;5(6):1158-1169.

A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome
Drivas T, Li D, Nair D, Alaimo J, Alders M, Altmüller J, Barakat T, Bebin E, Bertsch N, Blackburn P, Blesson A, Bouman A, Brockmann K, Brunelle P, Burmeister M, Cooper G, Denecke J, Dieux-Coëslier A, Dubbs H, Ferrer A, Gal D, Bartik L, Gunderson L, Hasadsri L, Jain M, Karimov C, Keena B, Klee E, Kloth K, Lace B, Macchiaiolo M, Marcadier J, Milunsky J, Napier M, Ortiz-Gonzalez X, Pichurin P, Pinner J, Powis Z, Prasad C, Radio F, Rasmussen K, Renaud D, Rush E, Saunders C, Selcen D, Seman A, Shinde D, Smith E, Smol T, Snijders Blok L, Stoler J, Tang S, Tartaglia M, Thompson M, van de Kamp J, Wang J, Weise D, Weiss K, Woitschach R, Wollnik B, Yan H, Zackai E, Zampino G, Campeau P, Bhoj E
EUR J HUM GENET. 2020;28(10):1422-1431.

Heterogeneous phenotypes in families with duplications of the paternal allele within the imprinting center 1 (H19/IGF2:TSS-DMR) in 11p15.5
Eggermann T, Kraft F, Kloth K, Klopocki E, Hüning I, Hempel M, Kunstmann E
CLIN GENET. 2020;98(4):418-419.

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia
Enshaei A, O'Connor D, Bartram J, Hancock J, Harrison C, Hough R, Samarasinghe S, den Boer M, Boer J, de Groot-Kruseman H, Marquart H, Noren-Nystrom U, Schmiegelow K, Schwab C, Horstmann M, Escherich G, Heyman M, Pieters R, Vora A, Moppett J, Moorman A
BLOOD. 2020;135(17):1438-1446.

Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors
Erarslan-Uysal B, Kunz J, Rausch T, Richter-Pechańska P, van Belzen I, Frismantas V, Bornhauser B, Ordoñez-Rueada D, Paulsen M, Benes V, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Loukanov T, Gorenflo M, Waszak S, Bourquin J, Muckenthaler M, Korbel J, Kulozik A
EMBO MOL MED. 2020;12(9):e12104.

Targeted busulfan-based reduced-intensity conditioning and HLA-matched HSCT cure hemophagocytic lymphohistiocytosis
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BLOOD ADV. 2020;4(9):1998-2010.

Age and DNA-methylation subgroup as potential independent risk factors for treatment stratification in children with Atypical Teratoid/Rhabdoid Tumors (ATRT)
Frühwald M, Hasselblatt M, Nemes K, Bens S, Steinbügl M, Johann P, Kerl K, Hauser P, Quiroga E, Solano-Paez P, Biassoni V, Gil-da-Costa M, Perek-Polnik M, van de Wetering M, Sumerauer D, Pears J, Stabell N, Holm S, Hengartner H, Gerber N, Grotzer M, Boos J, Ebinger M, Tippelt S, Paulus W, Furtwängler R, Hernáiz-Driever P, Reinhard H, Rutkowski S, Schlegel P, Schmid I, Kortmann R, Timmermann B, Warmuth-Metz M, Kordes U, Gerss J, Nysom K, Schneppenheim R, Siebert R, Kool M, Graf N
NEURO-ONCOLOGY. 2020;22(7):1006–1017.

Resolving challenges in deep learning-based analyses of histopathological images using explanation methods
Hägele M, Seegerer P, Lapuschkin S, Bockmayr M, Samek W, Klauschen F, Müller K, Binder A
SCI REP-UK. 2020;10(1):6423.

Tuberculosis-Associated HLH in an 8-Month-Old Infant: A Case Report and Review
Hauch H, Skrzypek S, Woessmann W, Lehmberg K, Ehl S, Speckmann C, Schneck E, Koerholz D, Jux C, Neuhäuser C
FRONT PEDIATR. 2020;8:.

Juvenile Blastic Plasmacytoid Dendritic Cell Neoplasm
Hayani K, Escherich G, Koch K, French L, Wolff H
ACTA DERM-VENEREOL. 2020;100(15):adv00245.

Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation
Hellwig M, Merk D, Lutz B, Schüller U
CANCER GENE THER. 2020;27(5):294-300.

Treatment and outcome of IG-MYC+ neoplasms with precursor B-cell phenotype in childhood and adolescence
Herbrueggen H, Mueller S, Rohde J, Arias Padilla L, Moericke A, Attarbaschi A, Zimmermann M, Ratei R, Brueggemann M, Siebert R, Goehring G, Schlegelberger B, Bradtke J, Klapper W, Woessmann W, Burkhardt B
LEUKEMIA. 2020;34(3):942-946.

hGFAP-Positive Stem Cells Depend on Brg1 for Proper Formation of Cerebral and Cerebellar Structures
Holdhof D, Schoof M, Hellwig M, Holdhof N, Niesen J, Schüller U
CEREB CORTEX. 2020;30(3):1382-1392.

Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment
Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso M, Domínguez-Pinilla N, Bourquin J, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch J, Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh A, Elitzur S, Vora A, Li C, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice M, Buldini B, Conter V, Stary J, Schrappe M
EUR J CANCER. 2020;132:11-16.

Parents' perception of their children's process of reintegration after childhood cancer treatment
Inhestern L, Peikert M, Krauth K, Escherich G, Rutkowski S, Kandels D, Bergelt C
PLOS ONE. 2020;15(10):e0239967.

Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity
Jägle S, Heeg M, Grün S, Rensing-Ehl A, Maccari M, Klemann C, Jones N, Lehmberg K, Bettoni C, Warnatz K, Grimbacher B, Biebl A, Schauer U, Hague R, Neth O, Mauracher A, Pachlopnik Schmid J, Fabre A, Kostyuchenko L, Führer M, Lorenz M, Schwarz K, Rohr J, Ehl S
CLIN IMMUNOL. 2020;210:108316.

Ependymomas in infancy: underlying genetic alterations, histological features, and clinical outcome
Jünger S, Andreiuolo F, Mynarek M, Dörner E, Zur Mühlen A, Rutkowski S, von Bueren A, Pietsch T
CHILD NERV SYST. 2020;36(11):2693-2700.

CDKN2A deletion in supratentorial ependymoma with RELA alteration indicates a dismal prognosis: a retrospective analysis of the HIT ependymoma trial cohort
Jünger S, Andreiuolo F, Mynarek M, Wohlers I, Rahmann S, Klein-Hitpass L, Dörner E, Zur Mühlen A, Velez-Char N, von Hoff K, Warmuth-Metz M, Kortmann R, Timmermann B, von Bueren A, Rutkowski S, Pietsch T
ACTA NEUROPATHOL. 2020;140(3):405-407.

Treosulfan-fludarabine-thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies
Kalwak K, Mielcarek M, Patrick K, Styczynski J, Bader P, Corbacioglu S, Burkhardt B, Sykora K, Drabko K, Gozdzik J, Fagioli F, Greil J, Gruhn B, Beier R, Locatelli F, Müller I, Schlegel P, Sedlacek P, Stachel K, Hemmelmann C, Möller A, Baumgart J, Vora A
BONE MARROW TRANSPL. 2020;55(10):1996-2007.

Register und Studien in der Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) – Welchen Beitrag leisten sie zum Fortschritt?
Klingebiel T, Jürgens H, Glauche I, Gnekow A, Kandels D, Woessmann W, Schneider D, Suttorp M
KLIN PADIATR. 2020;232(3):124-135.

Mucopolysaccharidosis type I due to maternal uniparental disomy of chromosome 4 with partial isodisomy of 4p16.3p15.2
Kloth K, Vater I, Lindschau R, Rau I, Caliebe A, Muschol N
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Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore
Knaak C, Nyvlt P, Schuster F, Spies C, Heeren P, Schenk T, Balzer F, La Rosée P, Janka G, Brunkhorst F, Keh D, Lachmann G
CRIT CARE. 2020;24(1):244.

Hemophagocytic Lymphohistiocytosis in Critically Ill Patients
Knaak C, Schuster F, Spies C, Vorderwülbecke G, Nyvlt P, Schenk T, Balzer F, La Rosée P, Janka G, Brunkhorst F, Keh D, Lachmann G
SHOCK. 2020;53(6):701-709.

Stem Cell Transplantation and Vinblastine Monotherapy for Relapsed Pediatric Anaplastic Large Cell Lymphoma: Results of the International, Prospective ALCL-Relapse Trial
Knörr F, Brugières L, Pillon M, Zimmermann M, Ruf S, Attarbaschi A, Mellgren K, Burke G, Uyttebroeck A, Wróbel G, Beishuizen A, Aladjidi N, Reiter A, Woessmann W
J CLIN ONCOL. 2020;38(34):3999-4009.

Hyperferritinemia in Critically Ill Patients
Lachmann G, Knaak C, Vorderwülbecke G, La Rosée P, Balzer F, Schenk T, Schuster F, Nyvlt P, Janka G, Brunkhorst F, Keh D, Spies C
CRIT CARE MED. 2020;48(4):459-465.

Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation
Letzer A, Lehmann K, Mess C, König G, Obser T, Peine S, Schneppenheim S, Budde U, Schneider S, Schneppenheim R, Brehm M
PLOS ONE. 2020;15(5):e0232637.

Glioma escape signature and clonal development under immune pressure
Maire C, Mohme M, Bockmayr M, Fita K, Riecken K, Börnigen D, Alawi M, Failla A, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K
J CLIN INVEST. 2020;130(10):5257-5271.

Macrophage-tumor cell interaction promotes ATRT progression and chemoresistance
Melcher V, Graf M, Interlandi M, Moreno N, de Faria F, Kim S, Kastrati D, Korbanka S, Alfert A, Gerß J, Meyer Zu Hörste G, Hartmann W, Frühwald M, Dugas M, Schüller U, Hasselblatt M, Albert T, Kerl K
ACTA NEUROPATHOL. 2020;139(5):913-936.

Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape
Mohme M, Maire C, Schliffke S, Joosse S, Alawi M, Matschke J, Schüller U, Dierlamm J, Martens T, Pantel K, Riethdorf S, Lamszus K, Westphal M
ACTA NEUROPATHOL COM. 2020;8(1):.

Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Long Term Results of the International ALCL99 Trial
Mussolin L, Le Deley M, Carraro E, Damm-Welk C, Attarbaschi A, Williams D, Burke A, Horibe K, Nakazawa A, Wrobel G, Mann G, Csóka M, Uyttebroeck A, Fernández-Delgado Cerdá R, Beishuizen A, Mellgren K, Burkhardt B, Klapper W, Turner S, D'Amore E, Lamant L, Reiter A, Woessmann W, Brugières L, Pillon M
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Young children with medulloblastoma: Important open questions and the high-risk dilemma
Mynarek M, Rutkowski S
NEURO-ONCOLOGY. 2020;22(12):1723-1724.

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort
Mynarek M, von Hoff K, Pietsch T, Ottensmeier H, Warmuth-Metz M, Bison B, Pfister S, Korshunov A, Sharma T, Jaeger N, Ryzhova M, Zheludkova O, Golanov A, Rushing E, Hasselblatt M, Koch A, Schüller U, von Deimling A, Sahm F, Sill M, Riemenschneider M, Dohmen H, Monoranu C, Sommer C, Staszewski O, Mawrin C, Schittenhelm J, Brück W, Filipski K, Hartmann C, Meinhardt M, Pietschmann K, Haberler C, Slavc I, Gerber N, Grotzer M, Benesch M, Schlegel P, Deinlein F, von Bueren A, Friedrich C, Juhnke B, Obrecht D, Fleischhack G, Kwiecien R, Faldum A, Kortmann R, Kool M, Rutkowski S
J CLIN ONCOL. 2020;38(18):2028-2040.

Molecular characterization of histopathological ependymoma variants
Neumann J, Spohn M, Obrecht D, Mynarek M, Thomas C, Hasselblatt M, Dorostkar M, Wefers A, Frank S, Monoranu C, Koch A, Witt H, Kool M, Pajtler K, Rutkowski S, Glatzel M, Schüller U
ACTA NEUROPATHOL. 2020;139(2):305-318.

Pik3ca mutations significantly enhance the growth of Shh medulloblastoma and lead to metastatic tumour growth in a novel mouse model
Niesen J, Ohli J, Sedlacik J, Dührsen L, Hellwig M, Spohn M, Holsten T, Schüller U
CANCER LETT. 2020;477:10-18.

Treatment of children under 4 years of age with medulloblastoma and ependymoma in the HIT2000/HIT-REZ 2005 trials: Neuropsychological outcome 5 years after treatment
Ottensmeier H, Schlegel P, Eyrich M, Wolff J, Juhnke B, von Hoff K, Frahsek S, Schmidt R, Faldum A, Fleischhack G, von Bueren A, Friedrich C, Resch A, Warmuth-Metz M, Krauss J, Kortmann R, Bode U, Kühl J, Rutkowski S
PLOS ONE. 2020;15(1):e0227693.

Fear of progression in parents of childhood cancer survivors: A Dyadic data analysis
Peikert M, Inhestern L, Krauth K, Escherich G, Rutkowski S, Kandels D, Bergelt C
PSYCHO-ONCOLOGY. 2020;29(10):1678-1685.

Returning to daily life: a qualitative interview study on parents of childhood cancer survivors in Germany
Peikert M, Inhestern L, Krauth K, Escherich G, Rutkowski S, Kandels D, Bergelt C
BMJ OPEN. 2020;10(3):e033730.

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations
Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis M, Schuhmann M, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr B, Ellison D, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister S, Jones D
ACTA NEUROPATHOL. 2020;139(2):243-257.

IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma
Prokoph N, Probst N, Lee L, Monahan J, Matthews J, Liang H, Bahnsen K, Montes-Mojarro I, Karaca Atabay E, Sharma G, Malik V, Larose H, Forde S, Ducray S, Lobello C, Wang Q, Luan S, Pospisilova S, Gambacorti-Passerini C, Burke A, Pervez S, Attarbaschi A, Janikova A, Pacquement H, Landman-Parker J, Lambilliotte A, Schleiermacher G, Klapper W, Jauch R, Woessmann W, Vassal G, Kenner L, Merkel O, Mologni L, Chiarle R, Brugieres L, Geoerger B, Barbieri I, Turner S
BLOOD. 2020;136(14):1657-1669.

Genome-wide DNA methylation profiles distinguish silent from non-silent ACTH adenomas
Ricklefs F, Fita K, Rotermund R, Piffko A, Schmid S, Capper D, Buslei R, Buchfelder M, Burkhardt T, Matschke J, Lamszus K, Westphal M, Schüller U, Flitsch J
ACTA NEUROPATHOL. 2020;140(1):95-97.

Social inequalities in the participation and activity of children and adolescents with leukemia, brain tumors, and sarcomas (SUPATEEN): a protocol for a multicenter longitudinal prospective observational study
Roick J, Berner R, Bernig T, Erdlenbruch B, Escherich G, Faber J, Klein C, Bochennek K, Kratz C, Kühr J, Längler A, Lode H, Metzler M, Müller H, Reinhardt D, Sauerbrey A, Schepper F, Scheurlen W, Schneider D, Schwabe G, Richter M
BMC PEDIATR. 2020;20(1):48.

An 8-Year-Old Girl with Posterior Fossa Mass
Ruf V, Schöler A, Capper D, Arzberger T, Herms J, Schüller U
BRAIN PATHOL. 2020;30(3):713-714.

Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors - presentation of the CARE for CAYA-Program study protocol and associated literature review
Salchow J, Mann J, Koch B, von Grundherr J, Jensen W, Elmers S, Straub L, Vettorazzi E, Escherich G, Rutkowski S, Dwinger S, Bergelt C, Sokalska-Duhme M, Bielack S, Calaminus G, Baust K, Classen C, Rössig C, Faber J, Faller H, Hilgendorf I, Gebauer J, Langer T, Metzler M, Schuster S, Niemeyer C, Puzik A, Reinhardt D, Dirksen U, Sander A, Köhler M, Habermann J, Bokemeyer C, Stein A
BMC CANCER. 2020;20(1):16.

DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions
Sandoval-Pérez A, Berger R, Garaizar A, Farr S, Brehm M, König G, Schneider S, Collepardo-Guevara R, Huck V, Rädler J, Aponte-Santamaría C
NUCLEIC ACIDS RES. 2020;48(13):7333-7344.

Hematopoietic stem cell transplantation for children with acute myeloid leukemia-results of the AML SCT-BFM 2007 trial
Sauer M, Lang P, Albert M, Bader P, Creutzig U, Eyrich M, Greil J, Gruhn B, Holter W, Klingebiel T, Kremens B, von der Leyen H, Mauz-Körholz C, Meisel R, Mischke K, Müller I, Niemeyer C, Peters C, Pohler C, Reinhardt D, Burkhardt B, Schlegel P, Schulz A, Schrum J, Sedlacek P, Strahm B, Woessmann W, Handgretinger R, Zimmermann M, Borkhardt A
LEUKEMIA. 2020;34(2):613-624.

Synovial sarcoma disease characteristics and primary tumor sites differ between patient age groups: a report of the Cooperative Weichteilsarkom Studiengruppe (CWS)
Scheer M, Blank B, Bauer S, Vokuhl C, Stegmaier S, Feuchtgruber S, Henssen A, Sparber-Sauer M, Eggert A, Handgretinger R, Pekrun A, Rossig C, Rutkowski S, Schlegel P, Schrappe M, Simon T, Kazanowska B, Niggli F, Ladenstein R, Ljungman G, Jahnukainen K, Fuchs J, Bielack S, Koscielniak E, Klingebiel T
J CANCER RES CLIN. 2020;146(4):953-960.

Effects of the growth pattern of medulloblastoma on short-term neurological impairments after surgery: results from the prospective multicenter HIT-SIOP PNET 4 study
Schepke E, Tisell M, Kennedy C, Puget S, Ferroli P, Chevignard M, Doz F, Pizer B, Rutkowski S, Massimino M, Navajas A, Schwalbe E, Hicks D, Clifford S, Pietsch T, Lannering B
J NEUROSURG-PEDIATR. 2020;1-9.

Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF
Schneider M, Fallah M, Mess C, Obser T, Schneppenheim R, Alexander-Katz A, Schneider S, Huck V
BMC MOL CELL BIOL. 2020;21(1):64.

The basic helix-loop-helix transcription factor TCF4 impacts brain architecture as well as neuronal morphology and differentiation
Schoof M, Hellwig M, Harrison L, Holdhof D, Lauffer M, Niesen J, Virdi S, Indenbirken D, Schüller U
EUR J NEUROSCI. 2020;51(11):2219-2235.

Molecular characterization of CNS paragangliomas identifies cauda equina paragangliomas as a distinct tumor entity
Schweizer L, Thierfelder F, Thomas C, Soschinski P, Suwala A, Stichel D, Wefers A, Wessels L, Misch M, Kim H, Jödicke R, Teichmann D, Kaul D, Kahn J, Bockmayr M, Hasselblatt M, Younsi A, Unterberg A, Knie B, Walter J, Al Safatli D, May S, Jödicke A, Ntoulias G, Moskopp D, Vajkoczy P, Heppner F, Capper D, Hartmann W, Hartmann C, von Deimling A, Reuss D, Schöler A, Koch A
ACTA NEUROPATHOL. 2020;140(6):893-906.

Interpretable Deep Neural Network to Predict Estrogen Receptor Status from Haematoxylin-Eosin Images
Seegerer P, Binder A, Saitenmacher R, Bockmayr M, Alber M, Jurmeister P, Klauschen F, Müller K
2020. Artificial Intelligence and Machine Learning for Digital Pathology. Holzinger A, Goebel R, Mengel M, Müller H (Hrsg.). 1. Aufl. Cham: Springer Heidelberg, 16-37.

Incidence of SCID in Germany from 2014 to 2015 an ESPED* Survey on Behalf of the API*** Erhebungseinheit für Seltene Pädiatrische Erkrankungen in Deutschland (German Paediatric Surveillance Unit) ** Arbeitsgemeinschaft Pädiatrische Immunologie
Shai S, Perez-Becker R, Andres O, Bakhtiar S, Bauman U, von Bernuth H, Classen C, Dückers G, El-Helou S, Gangfuß A, Ghosh S, Grimbacher B, Hauck F, Hoenig M, Husain R, Kindle G, Kipfmueller F, Klemann C, Krüger R, Lainka E, Lehmberg K, Lohrmann F, Morbach H, Naumann-Bartsch N, Oommen P, Schulz A, Seidemann K, Speckmann C, Sykora K, von Kries R, Niehues T
J CLIN IMMUNOL. 2020;40(5):708-717.

Can we optimise doxorubicin treatment regimens for children with cancer?: Pharmacokinetic simulations and a Delphi consensus procedure
Siebel C, Würthwein G, Lanvers-Kaminsky C, André N, Berthold F, Castelli I, Chastagner P, Doz F, English M, Escherich G, Frühwald M, Graf N, Groll A, Ruggiero A, Hempel G, Boos J
BMC PHARMACOL TOXICO. 2020;21(1):37.

Systematic analysis of the human tumor cell binding to human vs. murine E- and P-selectin under static vs. dynamic conditions
Starzonek S, Maar H, Labitzky V, Wicklein D, Rossdam C, Buettner F, Wolters-Eisfeld G, Guengoer C, Wagener C, Schumacher U, Lange T
GLYCOBIOLOGY. 2020;30(9):695-709.

Favorable outcomes of hematopoietic stem cell transplantation in children and adolescents with Diamond-Blackfan anemia
Strahm B, Loewecke F, Niemeyer C, Albert M, Ansari M, Bader P, Bertrand Y, Burkhardt B, Da Costa L, Ferster A, Fischer A, Güngör T, Gruhn B, Hainmann I, Kapp F, Lang P, Müller I, Schulz A, Szvetnik A, Wlodarski M, Noellke P, Leblanc T, Dalle J
BLOOD ADV. 2020;4(8):1760-1769.

EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma
Struve N, Binder Z, Stead L, Brend T, Bagley S, Faulkner C, Ott L, Müller-Goebel J, Weik A, Hoffer K, Krug L, Rieckmann T, Bußmann L, Henze M, Morrissette J, Kurian K, Schüller U, Petersen C, Rothkamm K, O Rourke D, Short S, Kriegs M
ONCOGENE. 2020;39(15):3041-3055.

Ulceration in Prolidase Deficiency: Successful Treatment with Anticoagulants
Süßmuth K, Metze D, Muresan A, Lehmberg K, Zur Stadt U, Speckmann C, Park J, Marquardt T, Oji V, Goerge T
ACTA DERM-VENEREOL. 2020;100(1):adv00002.

Comparison of von Willebrand factor platelet-binding activity assays: ELISA overreads type 2B with loss of HMW multimers
Szederjesi A, Baronciani L, Budde U, Castaman G, Colpani P, Lawrie A, Liu Y, Montgomery R, Peyvandi F, Schneppenheim R, Patzke J, Bodó I
J THROMB HAEMOST. 2020;18(10):2513-2523.

Acute impact of an endurance race on cardiac function and biomarkers of myocardial injury in triathletes with and without myocardial fibrosis
Tahir E, Scherz B, Starekova J, Muellerleile K, Fischer R, Schoennagel B, Warncke M, Stehning C, Cavus E, Bohnen S, Radunski U, Blankenberg S, Simon P, Pressler A, Adam G, Patten M, Lund G
EUR J PREV CARDIOL. 2020;27(1):94-104.

genBaRcode - a comprehensive R package for genetic barcode analysis
Thielecke L, Cornils K, Glauche I
BIOINFORMATICS. 2020;36(7):2189-2194.

Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors
Thomas C, Metrock K, Kordes U, Hasselblatt M, Dhall G
J NEURO-ONCOL. 2020;148(1):39-45.

Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults
Thomas C, Wefers A, Bens S, Nemes K, Agaimy A, Oyen F, Vogelgesang S, Rodriguez F, Brett F, McLendon R, Bodi I, Burel-Vandenbos F, Keyvani K, Tippelt S, Poulsen F, Lipp E, Giannini C, Reifenberger G, Kuchelmeister K, Pietsch T, Kordes U, Siebert R, Frühwald M, Johann P, Sill M, Kool M, von Deimling A, Paulus W, Hasselblatt M
ACTA NEUROPATHOL. 2020;139(2):277-286.

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease
Tischer A, Brehm M, Machha V, Moon-Tasson L, Benson L, Nelton K, Leger R, Obser T, Martinez-Vargas M, Whitten S, Chen D, Pruthi R, Bergen H, Cruz M, Schneppenheim R, Auton M
J MOL BIOL. 2020;432(2):305-323.

Bleeding symptoms in patients diagnosed as type 3 von Willebrand disease: Results from 3WINTERS-IPS, an international and collaborative cross-sectional study
Tosetto A, Badiee Z, Baghaipour M, Baronciani L, Battle J, Berntorp E, Bodó I, Budde U, Castaman G, Eikenboom J, Eshghi P, Ettorre C, Goodeve A, Goudemand J, Hay C, Hoorfar H, Karimi M, Keikhaei B, Lassila R, Leebeek F, Lopez Fernandez M, Mannucci P, Mazzucconi M, Morfini M, Oldenburg J, Peake I, Parra Lòpez R, Peyvandi F, Schneppenheim R, Tiede A, Toogeh G, Trossaert M, Zekavat O, Zetterberg E, Federici A
J THROMB HAEMOST. 2020;18(9):2145-2154.

Long-term cognitive deficits in pediatric low-grade glioma (LGG) survivors reflect pretreatment conditions-report from the German LGG studies
Traunwieser T, Kandels D, Pauls F, Pietsch T, Warmuth-Metz M, Bison B, Krauss J, Kortmann R, Timmermann B, Thomale U, Luettich P, Neumann-Holbeck A, Tischler T, Hernáiz Driever P, Witt O, Gnekow A
NEURO-ONCOL ADV. 2020;2(1):.

Influence of anti-thymocyte globulin plasma levels on outcome parameters in stem cell transplanted children
Vogelsang V, Kruchen A, Wustrau K, Spohn M, Müller I
INT IMMUNOPHARMACOL. 2020;83:106371.

Cerebrospinal fluid evaluation in adult patients with medulloblastoma
von Bueren A, Hagel C, Rutkowski S
LANCET ONCOL. 2020;21(3):e120.

Impact of COVID-19 pandemic on mental health of patients with inherited bleeding disorders in Germany
von Mackensen S, Halimeh S, Siebert M, Wermes C, Hassenpflug W, Holstein K, Olivieri M
HAEMOPHILIA. 2020;26(6):e272-e281.

Germline Elongator mutations in Sonic Hedgehog medulloblastoma
Waszak S, Robinson G, Gudenas B, Smith K, Forget A, Kojic M, Garcia-Lopez J, Hadley J, Hamilton K, Indersie E, Buchhalter I, Kerssemakers J, Jäger N, Sharma T, Rausch T, Kool M, Sturm D, Jones D, Vasilyeva A, Tatevossian R, Neale G, Lombard B, Loew D, Nakitandwe J, Rusch M, Bowers D, Bendel A, Partap S, Chintagumpala M, Crawford J, Gottardo N, Smith A, Dufour C, Rutkowski S, Eggen T, Wesenberg F, Kjaerheim K, Feychting M, Lannering B, Schüz J, Johansen C, Andersen T, Röösli M, Kuehni C, Grotzer M, Remke M, Puget S, Pajtler K, Milde T, Witt O, Ryzhova M, Korshunov A, Orr B, Ellison D, Brugieres L, Lichter P, Nichols K, Gajjar A, Wainwright B, Ayrault O, Korbel J, Northcott P, Pfister S
NATURE. 2020;580(7803):396-401.

Cell Versus Cytokine - Directed Therapies for Hemophagocytic Lymphohistiocytosis (HLH) in Inborn Errors of Immunity
Wegehaupt O, Wustrau K, Lehmberg K, Ehl S
FRONT IMMUNOL. 2020;11:.

Progressive or relapsed Burkitt lymphoma or leukemia in children and adolescents after BFM-type first-line therapy
Woessmann W, Zimmermann M, Meinhardt A, Müller S, Hauch H, Knörr F, Oschlies I, Klapper W, Niggli F, Kabickova E, Attarbaschi A, Reiter A, Burkhardt B
BLOOD. 2020;135(14):1124-1132.

Using the SNAP-Tag technology to easily measure and demonstrate apoptotic changes in cancer and blood cells with different dyes
Woitok M, Grieger E, Akinrinmade O, Bethke S, Pham A, Stein C, Fendel R, Fischer R, Barth S, Niesen J
PLOS ONE. 2020;15(12):e0243286.

Risk factors for mixed chimerism in children with hemophagocytic lymphohistiocytosis after reduced toxicity conditioning
Wustrau K, Greil J, Sykora K, Albert M, Burkhardt B, Lang P, Meisel R, Wössmann W, Beier R, Schulz A, Bader P, Chada M, Kühl J, Schlegel P, Speckmann C, Gruhn B, Seidel M, Wawer A, Ozga A, Janka G, Ehl S, Müller I, Lehmberg K
PEDIATR BLOOD CANCER. 2020;67(9):e28523.

2019

Characterization of VWF gene conversions causing von Willebrand disease
Ahmad F, Kannan M, Obser T, Budde U, Schneppenheim S, Saxena R, Schneppenheim R
BRIT J HAEMATOL. 2019;184(5):817-825.

Zinkmangel als Ursache eines „Dekubitus“ beim Frühgeborenen?
Asselborn J, Thayssen M, Lehmberg K, Apostolidou S, Singer D
Z GEBURTSH NEONATOL. 2019;223(6):369-372.

Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents
Attarbaschi A, Abla O, Ronceray L, Bansil S, Bomken S, Burkhardt B, Ceppi F, Chiang A, Dave H, Fedorova A, Henry M, Jazbec J, Kabickova E, Kotecha R, Lazic J, Loeffen J, Miakova N, Osumi T, Pillon M, Pourtsidis A, Rigaud C, Tamamyan G, Tandon S, Uyttebroeck A, Verdu-Amoros J, Woessmann W, Wrobel G, Giulino-Roth L
BLOOD ADV. 2019;3(24):4291-4297.

CD38 is not expressed in pediatric ALK-positive anaplastic large cell lymphoma
Au-Yeung R, Burkhardt B, Woessmann W, Klapper W
PEDIATR BLOOD CANCER. 2019;66(3):e27541.

Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency
Aydin S, Freeman A, Al-Herz W, Al-Mousa H, Arnaout R, Aydin R, Barlogis V, Belohradsky B, Bonfim C, Bredius R, Chu J, Ciocarlie O, Doğu F, Gaspar H, Geha R, Gennery A, Hauck F, Hawwari A, Hickstein D, Hoenig M, Ikinciogullari A, Klein C, Kumar A, Ifversen M, Matthes S, Metin A, Neven B, Pai S, Parikh S, Picard C, Renner E, Sanal Ö, Schulz A, Schuster F, Shah N, Shereck E, Slatter M, Su H, van Montfrans J, Woessmann W, Ziegler J, Albert M
J ALLER CL IMM-PRACT. 2019;7(3):848-855.

Presence of centromeric but absence of telomeric group B KIR haplotypes in stem cell donors improve leukaemia control after HSCT for childhood ALL
Babor F, Peters C, Manser A, Glogova E, Sauer M, Pötschger U, Ahlmann M, Cario G, Feuchtinger T, Gruhn B, Güngör T, Kremens B, Lang P, Mezger M, Müller I, Mytilineos J, Oevermann L, Pichler H, Scherenschlich N, Schuster F, Siepermann M, Stachel D, Strahm B, Wössmann W, Escherich G, Zimmermann M, Schrappe M, Borkhardt A, Eckert C, Bader P, Uhrberg M, Meisel R
BONE MARROW TRANSPL. 2019;54(11):1847-1858.

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia
Bastian L, Schroeder M, Eckert C, Schlee C, Tanchez J, Kämpf S, Wagner D, Schulze V, Isaakidis K, Lázaro-Navarro J, Hänzelmann S, James A, Ekici A, Burmeister T, Schwartz S, Schrappe M, Horstmann M, Vosberg S, Krebs S, Blum H, Hecht J, Greif P, Rieger M, Brüggemann M, Gökbuget N, Neumann M, Baldus C
LEUKEMIA. 2019;33(8):1895-1909.

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series
Benesch M, Mynarek M, Witt H, Warmuth-Metz M, Pietsch T, Bison B, Pfister S, Pajtler K, Kool M, Schüller U, Pietschmann K, Juhnke B, Tippelt S, Fleischhack G, Schmid I, Kramm C, Vorwerk P, Beilken A, Classen C, Hernáiz Driever P, Kropshofer G, Imschweiler T, Lemmer A, Kortmann R, Rutkowski S, von Hoff K
ONCOLOGIST. 2019;24(9):e921-e929.

Long-term follow-up of Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia treated with the EsPhALL2004 study: high white blood cell count at diagnosis is the strongest prognostic factor
Biondi A, Cario G, De Lorenzo P, Castor A, Conter V, Leoni V, Gandemer V, Pieters R, Stary J, Escherich G, Campbell M, Attarbaschi A, Li C, Vora A, Bradtke J, Saha V, Valsecchi M, Schrappe M
HAEMATOLOGICA. 2019;104(1):e13-e16.

Immunologic Profiling of Mutational and Transcriptional Subgroups in Pediatric and Adult High-Grade Gliomas
Bockmayr M, Klauschen F, Maire C, Rutkowski S, Westphal M, Lamszus K, Schüller U, Mohme M
CANCER IMMUNOL RES. 2019;7(9):1401-1411.

Inositol hexakisphosphate increases the size of platelet aggregates
Brehm M, Klemm U, Rehbach C, Erdmann N, Kolšek K, Lin H, Aponte-Santamaría C, Gräter F, Rauch B, Riley A, Mayr G, Potter B, Windhorst S
BIOCHEM PHARMACOL. 2019;161:14-25.

New options of cancer treatment employing InsP6
Brehm M, Windhorst S
BIOCHEM PHARMACOL. 2019;163:206-214.

Clostridium difficile infection after pediatric solid organ transplantation: a practical single-center experience
Breuer C, Döring S, Rohde H, Rutkowski S, Müller I, Oh J
PEDIATR NEPHROL. 2019;34(7):1269-1275.

Comparison of procalcitonin and C-reactive protein as early diagnostic marker for the identification of transplant-related adverse events after allogeneic hematopoietic stem cell transplantation in pediatric patients
Cabanillas Stanchi K, Queudeville M, Malaval C, Feucht J, Schlegel P, Dobratz M, Seitz C, Müller I, Lang P, Handgretinger R, Döring M
J CANCER RES CLIN. 2019;145(11):2779-2791.

A multicenter study of patients with multisystem Langerhans cell histiocytosis who develop secondary hemophagocytic lymphohistiocytosis
Chellapandian D, Hines M, Zhang R, Jeng M, van den Bos C, Santa-María López V, Lehmberg K, Sieni E, Wang Y, Nakano T, Williams J, Fustino N, Astigarraga I, Dunkel I, Abla O, van Halteren A, Pei D, Cheng C, Weitzman S, Sung L, Nichols K
CANCER-AM CANCER SOC. 2019;125(6):963-971.

Diffuse Glioneuronal tumour with Oligodendroglioma-like features and Nuclear Clusters (DGONC) - a molecularly-defined glioneuronal CNS tumour class displaying recurrent monosomy 14
Deng M, Sill M, Sturm D, Stichel D, Witt H, Ecker J, Wittmann A, Schittenhelm J, Ebinger M, Schuhmann M, Figarella-Branger D, Aronica E, Staszewski O, Preusser M, Haberler C, Lauten M, Schüller U, Hartmann C, Snuderl M, Dunham C, Jabado N, Wesseling P, Deckert M, Keyvani K, Gottardo N, Giangaspero F, von Hoff K, Ellison D, Pietsch T, Herold Mende C, Milde T, Witt O, Kool M, Korshunov A, Wick W, von Deimling A, Pfister S, Jones D, Sahm F
NEUROPATH APPL NEURO. 2019 [Epub ahead of print].

Improving Stratification for Children With Late Bone Marrow B-Cell Acute Lymphoblastic Leukemia Relapses With Refined Response Classification and Integration of Genetics
Eckert C, Groeneveld-Krentz S, Kirschner-Schwabe R, Hagedorn N, Chen-Santel C, Bader P, Borkhardt A, Cario G, Escherich G, Panzer-Grümayer R, Astrahantseff K, Eggert A, Sramkova L, Attarbaschi A, Bourquin J, Peters C, Henze G, von Stackelberg A
J CLIN ONCOL. 2019;37(36):3493-3506.

The German National Registry of Primary Immunodeficiencies (2012-2017)
El-Helou S, Biegner A, Bode S, Ehl S, Heeg M, Maccari M, Ritterbusch H, Speckmann C, Rusch S, Scheible R, Warnatz K, Atschekzei F, Beider R, Ernst D, Gerschmann S, Jablonka A, Mielke G, Schmidt R, Schürmann G, Sogkas G, Baumann U, Klemann C, Viemann D, von Bernuth H, Krüger R, Hanitsch L, Scheibenbogen C, Wittke K, Albert M, Eichinger A, Hauck F, Klein C, Rack-Hoch A, Sollinger F, Avila A, Borte M, Borte S, Fasshauer M, Hauenherm A, Kellner N, Müller A, Ülzen A, Bader P, Bakhtiar S, Lee J, Heß U, Schubert R, Wölke S, Zielen S, Ghosh S, Laws H, Neubert J, Oommen P, Hönig M, Schulz A, Steinmann S, Schwarz K, Dückers G, Lamers B, Langemeyer V, Niehues T, Shai S, Graf D, Müglich C, Schmalzing M, Schwaneck E, Tony H, Dirks J, Haase G, Liese J, Morbach H, Foell D, Hellige A, Wittkowski H, Masjosthusmann K, Geberzahn L, Hedrich C, Müller C, Rösen-Wolff A, Roesler J, Zimmermann A, Behrends U, Rieber N, Schauer U, Handgretinger R, Holzer U, Henes J, Kanz L, Boesecke C, Rockstroh J, Schwarze-Zander C, Wasmuth J, Dilloo D, Hülsmann B, Schönberger S, Schreiber S, Zeuner R, Ankermann T, von Bismarck P, Huppertz H, Kaiser-Labusch P, Greil J, Jakoby D, Kulozik A, Metzler M, Naumann-Bartsch N, Sobik B, Graf N, Heine S, Kobbe R, Lehmberg K, Müller I, Herrmann F, Horneff G, Klein A, Peitz J, Schmidt N, Bielack S, Groß-Wieltsch U, Classen C, Klasen J, Deutz P, Kamitz D, Lassay L, Tenbrock K, Wagner N, Bernbeck B, Brummel B, Lara-Villacanas E, Münstermann E, Schneider D, Tietsch N, Westkemper M, Weiß M, Kramm C, Kühnle I, Kullmann S, Girschick H, Specker C, Vinnemeier-Laubenthal E, Haenicke H, Schweigerer L, Müller T, Stiefel M, Belohradsky B, Soetedjo V, Kindle G, Grimbacher B
FRONT IMMUNOL. 2019;10:1272.

Fatal Myelotoxicity Following Palliative Chemotherapy With Cisplatin and Gemcitabine in a Patient With Stage IV Cholangiocarcinoma Linked to Post Mortem Diagnosis of Fanconi Anemia
Engel N, Schliffke S, Schüller U, Frenzel C, Bokemeyer C, Kubisch C, Lessel D
FRONT ONCOL. 2019;9:420.

Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study
Fleischhack G, Massimino M, Warmuth-Metz M, Khuhlaeva E, Janssen G, Graf N, Rutkowski S, Beilken A, Schmid I, Biassoni V, Gorelishev S, Kramm C, Reinhard H, Schlegel P, Kortmann R, Reuter D, Bach F, Iznaga-Escobar N, Bode U
J NEURO-ONCOL. 2019;143(1):107-113.

Pegvaliase: Immunological profile and recommendations for the clinical management of hypersensitivity reactions in patients with phenylketonuria treated with this enzyme substitution therapy
Hausmann O, Daha M, Longo N, Knol E, Müller I, Northrup H, Brockow K
MOL GENET METAB. 2019;128(1-2):84-91.

TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma
Hellwig M, Lauffer M, Bockmayr M, Spohn M, Merk D, Harrison L, Ahlfeld J, Kitowski A, Neumann J, Ohli J, Holdhof D, Niesen J, Schoof M, Kool M, Kraus C, Zweier C, Holmberg D, Schüller U
ACTA NEUROPATHOL. 2019;137(4):657-673.

Predictive factors associated with ventriculoperitoneal shunting after posterior fossa tumor surgery in children
Helmbold L, Kammler G, Regelsberger J, Fritzsche F, Emami P, Schüller U, Krajewski K
CHILD NERV SYST. 2019;35(5):779-788.

Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets
Hoell J, Ginzel S, Kuhlen M, Kloetgen A, Gombert M, Fischer U, Hein D, Demir S, Stanulla M, Schrappe M, Zur Stadt U, Bader P, Babor F, Schuster F, Strahm B, Alten J, Moericke A, Escherich G, von Stackelberg A, Thiele R, McHardy A, Peters C, Bornhauser B, Bourquin J, Krause S, Enczmann J, Meyer L, Eckert C, Borkhardt A, Meisel R
BLOOD ADV. 2019;3(20):3143-3156.

High sensitivity and clonal stability of the genomic fusion as single marker for response monitoring in ETV6-RUNX1-positive acute lymphoblastic leukemia
Hoffmann J, Krumbholz M, Gutiérrez H, Fillies M, Szymansky A, Bleckmann K, Zur Stadt U, Köhler R, Kuiper R, Horstmann M, von Stackelberg A, Eckert C, Metzler M
PEDIATR BLOOD CANCER. 2019;66(8):e27780.

NUTM1 is a recurrent fusion gene partner in B cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2
Hormann F, Hoogkamer A, Beverloo H, Boeree A, Dingjan I, Wattel M, Stam R, Escherich G, Pieters R, den Boer M, Boer J
HAEMATOLOGICA. 2019;104(10):e455-e459.

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA
Hou Y, Pinheiro J, Sahm F, Reuss D, Schrimpf D, Stichel D, Casalini B, Koelsche C, Sievers P, Wefers A, Reinhardt A, Ebrahimi A, Fernández-Klett F, Pusch S, Meier J, Schweizer L, Paulus W, Prinz M, Hartmann C, Plate K, Reifenberger G, Pietsch T, Varlet P, Pagès M, Schüller U, Scheie D, de Stricker K, Frank S, Hench J, Pollo B, Brandner S, Unterberg A, Pfister S, Jones D, Korshunov A, Wick W, Capper D, Blümcke I, von Deimling A, Bertero L
ACTA NEUROPATHOL. 2019;137(5):837-846.

Von Willebrand Factor Mediates Pneumococcal Aggregation and Adhesion in Blood Flow
Jagau H, Behrens I, Lahme K, Lorz G, Köster R, Schneppenheim R, Obser T, Brehm M, König G, Kohler T, Rohde M, Frank R, Tegge W, Fulde M, Hammerschmidt S, Steinert M, Bergmann S
FRONT MICROBIOL. 2019;10:511.

Improved risk-stratification for posterior fossa ependymoma of childhood considering clinical, histological and genetic features - a retrospective analysis of the HIT ependymoma trial cohort
Jünger S, Mynarek M, Wohlers I, Dörner E, Mühlen A, Velez-Char N, von Hoff K, Rutkowski S, Warmuth-Metz M, Kortmann R, Timmermann B, Rahmann S, Klein-Hitpass L, von Bueren A, Pietsch T
ACTA NEUROPATHOL COM. 2019;7(1):181.

Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases
Jurmeister P, Bockmayr M, Seegerer P, Bockmayr T, Treue D, Montavon G, Vollbrecht C, Arnold A, Teichmann D, Bressem K, Schüller U, von Laffert M, Müller K, Capper D, Klauschen F
SCI TRANSL MED. 2019;11(509):.

Immunhistochemische Analyse von Bcl-2, nukleärem S100A4, MITF und Ki67 zur Risikostratifizierung von Melanomen im Frühstadium - ein kombinierter immunhistochemischer Score
Jurmeister P, Bockmayr M, Treese C, Stein U, Lenze D, Jöhrens K, Friedling F, Dietel M, Klauschen F, Marsch W, Fiedler E, von Laffert M
J DTSCH DERMATOL GES. 2019;17(8):800-809.

Immunohistochemical analysis of Bcl-2, nuclear S100A4, MITF and Ki67 for risk stratification of early-stage melanoma - A combined IHC score for melanoma risk stratification
Jurmeister P, Bockmayr M, Treese C, Stein U, Lenze D, Jöhrens K, Friedling F, Dietel M, Klauschen F, Marsch W, Fiedler E, von Laffert M
J DTSCH DERMATOL GES. 2019;17(8):800-808.

EZH2 Inhibition in Ewing Sarcoma Upregulates G Expression for Targeting with Gene-Modified T Cells
Kailayangiri S, Altvater B, Lesch S, Balbach S, Göttlich C, Kühnemundt J, Mikesch J, Schelhaas S, Jamitzky S, Meltzer J, Farwick N, Greune L, Fluegge M, Kerl K, Lode H, Siebert N, Müller I, Walles H, Hartmann W, Rossig C
MOL THER. 2019;27(5):933-946.

An in-depth multi-omics analysis in RLE-6TN rat alveolar epithelial cells allows for nanomaterial categorization
Karkossa I, Bannuscher A, Hellack B, Bahl A, Buhs S, Nollau P, Luch A, Schubert K, von Bergen M, Haase A
PART FIBRE TOXICOL. 2019;16(1):38.

Alteration in GPIIb/IIIa Binding of VWD-Associated von Willebrand Factor Variants with C-Terminal Missense Mutations
König G, Obser T, Marggraf O, Schneppenheim S, Budde U, Schneppenheim R, Brehm M
THROMB HAEMOSTASIS. 2019;119(7):1102-1111.

Analyzing expression and phosphorylation of the EGF receptor in HNSCC
Kriegs M, Clauditz T, Hoffer K, Bartels J, Buhs S, Gerull H, Zech H, Bußmann L, Struve N, Rieckmann T, Petersen C, Betz C, Rothkamm K, Nollau P, Münscher A
SCI REP-UK. 2019;9(1):13564.

Osteonecrosis in children with acute lymphoblastic leukemia at initial diagnosis and prior to any chemotherapy
Krull K, Kunstreich M, Bronsema A, Bleckmann K, Classen C, Erdlenbruch B, Jorch N, Kolb R, Leipold A, Moser O, Prokop A, Scheurlen W, Steinbach D, Klasen-Sansone J, Klee D, Escherich G, Moericke A, Schrappe M, Borkhardt A, Kuhlen M
LEUKEMIA LYMPHOMA. 2019;60(1):78-84.

Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas
Kunz M, Albert N, Unterrainer M, la Fougere C, Egensperger R, Schüller U, Lutz J, Kreth S, Tonn J, Kreth F, Thon N
NEURO-ONCOLOGY. 2019;21(2):274-284.

Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells
Kurze A, Buhs S, Eggert D, Oliveira-Ferrer L, Müller V, Niendorf A, Wagener C, Nollau P
CELL COMMUN SIGNAL. 2019;17(1):107.

The molecular landscape of ETMR at diagnosis and relapse
Lambo S, Gröbner S, Rausch T, Waszak S, Schmidt C, Gorthi A, Romero J, Mauermann M, Brabetz S, Krausert S, Buchhalter I, Koster J, Zwijnenburg D, Sill M, Hübner J, Mack N, Schwalm B, Ryzhova M, Hovestadt V, Papillon-Cavanagh S, Chan J, Landgraf P, Ho B, Milde T, Witt O, Ecker J, Sahm F, Sumerauer D, Ellison D, Orr B, Darabi A, Haberler C, Figarella-Branger D, Wesseling P, Schittenhelm J, Remke M, Taylor M, Gil-da-Costa M, Łastowska M, Grajkowska W, Hasselblatt M, Hauser P, Pietsch T, Uro-Coste E, Bourdeaut F, Masliah-Planchon J, Rigau V, Alexandrescu S, Wolf S, Li X, Schüller U, Snuderl M, Karajannis M, Giangaspero F, Jabado N, von Deimling A, Jones D, Korbel J, von Hoff K, Lichter P, Huang A, Bishop A, Pfister S, Korshunov A, Kool M
NATURE. 2019;576(7786):274-280.

Recommendations for the management of hemophagocytic lymphohistiocytosis in adults
La Rosée P, Horne A, Hines M, von Bahr Greenwood T, Machowicz R, Berliner N, Birndt S, Gil-Herrera J, Girschikofsky M, Jordan M, Kumar A, van Laar J, Lachmann G, Nichols K, Ramanan A, Wang Y, Wang Z, Janka G, Henter J
BLOOD. 2019;133(23):2465-2477.

Haematopoietic Stem Cell Transplantation for Primary Haemophagocytic Lymphohistiocytosis
Lehmberg K, Moshous D, Booth C
FRONT PEDIATR. 2019;7:435.

Advancing multimer analysis of von Willebrand factor by single-molecule AFM imaging
Löf A, König G, Schneppenheim S, Schneppenheim R, Benoit M, Budde U, Müller J, Brehm M
PLOS ONE. 2019;14(1):e0210963.

Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
Löf A, Walker P, Sedlak S, Gruber S, Obser T, Brehm M, Benoit M, Lipfert J
P NATL ACAD SCI USA. 2019;116(38):18798-18807.

IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia
Lopes B, Meyer C, Barbosa T, Poubel C, Mansur M, Duployez N, Bashton M, Harrison C, Zur Stadt U, Horstmann M, Pombo-de-Oliveira M, Palmi C, Cazzaniga G, Venn N, Sutton R, Alonso C, Tsaur G, Gupta S, Bakhshi S, Marschalek R, Emerenciano M
TRANSL ONCOL. 2019;12(5):726-732.

Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma
Mastrella G, Hou M, Li M, Stoecklein V, Zdouc N, Volmar M, Miletic H, Reinhard S, Herold-Mende C, Kleber S, Eisenhut K, Gargiulo G, Synowitz M, Vescovi A, Harter P, Penninger J, Wagner E, Mittelbronn M, Bjerkvig R, Hambardzumyan D, Schüller U, Tonn J, Radke J, Glass R, Kälin R
CANCER RES. 2019;79(9):2298-2313.

Manifestations and Treatment of Adult-onset Symptomatic Optic Pathway Glioma in Neurofibromatosis Type 1
Mehlan J, Schüttauf F, Salamon J, Kordes U, Friedrich R, Mautner V
ANTICANCER RES. 2019;39(2):827-831.

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions
Meyer C, Lopes B, Caye-Eude A, Cavé H, Arfeuille C, Cuccuini W, Sutton R, Venn N, Oh S, Tsaur G, Escherich G, Feuchtinger T, Kosasih H, Khaw S, Ekert P, Pombo-de-Oliveira M, Bidet A, Djahanschiri B, Ebersberger I, Zaliova M, Zuna J, Zermanova Z, Juvonen V, Grümayer R, Fazio G, Cazzaniga G, Larghero P, Emerenciano M, Marschalek R
LEUKEMIA. 2019;33(9):2306-2340.

The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection
Miarka L, Hauser C, Helm O, Holdhof D, Beckinger S, Egberts J, Gundlach J, Lenk L, Rahn S, Mikulits W, Trauzold A, Sebens S
CANCERS. 2019;11(6):.

Minimal Disseminated and Minimal Residual Disease in Pediatric Non-Hodgkin Lymphoma
Mussolin L, Damm-Welk C, Wößmann W
2019. Non-Hodgkin´s Lymphoma in Children and Adolescence. Abla O, Attarbaschi A (Hrsg.). 1. Aufl. Cham: Springer, 119 - 129.

Gemtuzumab Ozogamicin in children with relapsed or refractory acute myeloid leukemia: a report by Berlin-Frankfurt-Münster study group
Niktoreh N, Lerius B, Zimmermann M, Gruhn B, Escherich G, Bourquin J, Dworzak M, Sramkova L, Rossig C, Creutzig U, Reinhardt D, Rasche M
HAEMATOLOGICA. 2019;104(1):120-127.

Medulloblastoma
Northcott P, Robinson G, Kratz C, Mabbott D, Pomeroy S, Clifford S, Rutkowski S, Ellison D, Malkin D, Taylor M, Gajjar A, Pfister S
NAT REV DIS PRIMERS. 2019;5(1):11.

MRI Phenotype of RELA-fused Pediatric Supratentorial Ependymoma
Nowak J, Jünger S, Huflage H, Seidel C, Hohm A, Vandergrift L, von Hoff K, Rutkowski S, Pietsch T, Warmuth-Metz M
CLIN NEURORADIOL. 2019;29(4):595-604.

Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia-A prospective international multicenter trial on behalf of the BFM-SG and the EBMT-PDWP
Pichler H, Lawitschka A, Glogova E, Willasch A, von Luettichau I, Lehrnbecher T, Matthes-Martin S, Lang P, Bader P, Sykora K, Schrum J, Kremens B, Ehlert K, Albert M, Kuhlen M, Meisel R, Guengoer T, Strahm B, Gruhn B, Schulz A, Woessmann W, Poetschger U, Peters C
AM J HEMATOL. 2019;94(8):880-890.

Outcome of Infants Younger Than 1 Year With Acute Lymphoblastic Leukemia Treated With the Interfant-06 Protocol: Results From an International Phase III Randomized Study
Pieters R, De Lorenzo P, Ancliffe P, Aversa L, Brethon B, Biondi A, Campbell M, Escherich G, Ferster A, Gardner R, Kotecha R, Lausen B, Li C, Locatelli F, Attarbaschi A, Peters C, Rubnitz J, Silverman L, Stary J, Szczepanski T, Vora A, Schrappe M, Valsecchi M
J CLIN ONCOL. 2019;37(25):2246-2256.

Food authentication: Multi-elemental analysis of white asparagus for provenance discrimination
Richter B, Gurk S, Wagner D, Bockmayr M, Fischer M
FOOD CHEM. 2019;286:475-482.

Relapse of a group 4 medulloblastoma after 18 years as proven by histology and DNA methylation profiling
Ricklefs F, Fritzsche F, Winkler B, Meissner B, Dührsen L, Westphal M, Rutkowski S, Martens T, Schüller U
CHILD NERV SYST. 2019;35(6):1029-1033.

Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy
Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, Horst A, Sturm A, de la Motte C, Fiocchi C
INFLAMM BOWEL DIS. 2019;25(2):294-305.

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
Schneppenheim R, Hellermann N, Brehm M, Klemm U, Obser T, Huck V, Schneider S, Denis C, Tischer A, Auton M, März W, Xu E, Wilmanns M, Zotz R
BLOOD. 2019;133(4):356-365.

Allogeneic hematopoietic stem cell transplantation in two brothers with DNA ligase IV deficiency -a case report and review of the literature
Schober S, Schilbach K, Doering M, Cabanillas Stanchi K, Holzer U, Kasteleiner P, Schittenhelm J, Schaefer J, Müller I, Lang P, Handgretinger R
BMC PEDIATR. 2019;19(1):346.

Health status, Health-Related Quality of Life and Socio-economic Outcome in Childhood Brain Tumor Survivors: a German Cohort Study
Scholtes C, Baust K, Weinhold L, Creutzig U, Gnekow A, Hinz A, Kaatsch P, Kreitz K, Langer T, Rutkowski S, Singer S, Spix C, Teske C, Schmid M, Dilloo D, Calaminus G
NEURO-ONCOLOGY. 2019 [Epub ahead of print];2019(21):1069-1081.

The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration
Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, Peters F, Immenschuh J, Hellwig M, Niesen J, Mall V, Ertl-Wagner B, Hagel C, Spohn M, Lutz B, Sedlacik J, Indenbirken D, Merk D, Schüller U
ACTA NEUROPATHOL COM. 2019;7(1):199.

Daunorubicin during delayed intensification decreases the incidence of infectious complications - a randomized comparison in trial CoALL 08-09
Schramm F, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Imschweiler T, Christiansen H, Faber J, Feuchtinger T, Schmid I, Beron G, Horstmann M, Escherich G
LEUKEMIA LYMPHOMA. 2019;60(1):60-68.

Results of CoALL 07-03 study childhood ALL based on combined risk assessment by in vivo and in vitro pharmacosensitivity
Schramm F, Zur Stadt U, Zimmermann M, Jorch N, Pekrun A, Borkhardt A, Imschweiler T, Christiansen H, Faber J, Schmid I, Feuchtinger T, Beron G, den Boer M, Pieters R, Horstmann M, Janka-Schaub G, Escherich G
BLOOD ADV. 2019;3(22):3688-3699.

Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair
Seoane M, Buhs S, Iglesias P, Strauss J, Puller A, Müller J, Gerull H, Feldhaus S, Alawi M, Brandner J, Eggert D, Du J, Thomale J, Wild P, Zimmermann M, Sternsdorf T, Schumacher U, Nollau P, Fisher D, Horstmann M
ONCOGENE. 2019;38(19):3616-3635.

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes
Sharma T, Schwalbe E, Williamson D, Sill M, Hovestadt V, Mynarek M, Rutkowski S, Robinson G, Gajjar A, Cavalli F, Ramaswamy V, Taylor M, Lindsey J, Hill R, Jäger N, Korshunov A, Hicks D, Bailey S, Kool M, Chavez L, Northcott P, Pfister S, Clifford S
ACTA NEUROPATHOL. 2019;138(2):309-326.

Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia
Steeghs E, Boer J, Hoogkamer A, Boeree A, de Haas V, de Groot-Kruseman H, Horstmann M, Escherich G, Pieters R, den Boer M
SCI REP-UK. 2019;9(1):4634.

Imaging Characteristics of Wingless Pathway Subgroup Medulloblastomas: Results from the German HIT/SIOP-Trial Cohort
Stock A, Mynarek M, Pietsch T, Pfister S, Clifford S, Goschzik T, Sturm D, Schwalbe E, Hicks D, Rutkowski S, Bison B, Pham M, Warmuth-Metz M
AM J NEURORADIOL. 2019;40(11):1811-1817.

Contrast enhancement is a prognostic factor in IDH1/2 mutant, but not in wild-type WHO grade II/III glioma as confirmed by machine learning
Suchorska B, Schüller U, Biczok A, Lenski M, Albert N, Giese A, Kreth F, Ertl-Wagner B, Tonn J, Ingrisch M
EUR J CANCER. 2019;107:15-27.

Effect of renal denervation procedure on left ventricular mass, myocardial strain and diastolic function by CMR on a 12-month follow-up
Tahir E, Koops A, Warncke M, Starekova J, Neumann J, Waldeyer C, Avanesov M, Lund G, Fischer R, Adam G, Blankenberg S, Wenzel U, Brunner F
JPN J RADIOL. 2019;37(9):642-650.

Two molecularly distinct atypical teratoid/rhabdoid tumors (or tumor components) occurring in an infant with rhabdoid tumor predisposition syndrome 1
Thomas C, Knerlich-Lukoschus F, Reinhard H, Johann P, Sturm D, Sahm F, Bens S, Vogt J, Nemes K, Oyen F, Kordes U, Siebert R, Schneppenheim R, Messing-Jünger M, Pietsch T, von Deimling A, Paulus W, Pfister S, Kool M, Frühwald M, Hasselblatt M
ACTA NEUROPATHOL. 2019;137(5):847-850.

Nanobody-targeting of epidermal growth factor receptor (EGFR) ectodomain variants overcomes resistance to therapeutic EGFR antibodies
Tintelnot J, Baum N, Schultheiss C, Braig F, Trentmann M, Finter J, Fumey W, Bannas P, Fehse B, Riecken K, Schütze K, Bokemeyer C, Rösner T, Valerius T, Peipp M, Koch-Nolte F, Binder M
MOL CANCER THER. 2019;18(4):823-833.

Proteogenomic systems analysis identifies targeted therapy resistance mechanisms in EGFR-mutated lung cancer
Treue D, Bockmayr M, Stenzinger A, Heim D, Hester S, Klauschen F
INT J CANCER. 2019;144(3):545-557.

Identification of Distant Metastases From Recurrent Gliosarcoma Using Whole-Body 18F-FDG PET/CT
Unterrainer M, Ruf V, Cyran C, Brendel M, Thon N, Herms J, Schüller U, Tonn J, Bartenstein P, Albert N
CLIN NUCL MED. 2019;44(11):923-924.

The International Hereditary Thrombotic Thrombocytopenic Purpura Registry: key findings at enrollment until 2017
van Dorland H, Taleghani M, Sakai K, Friedman K, George J, Hrachovinova I, Knöbl P, von Krogh A, Schneppenheim R, Aebi-Huber I, Bütikofer L, Largiadèr C, Cermakova Z, Kokame K, Miyata T, Yagi H, Terrell D, Vesely S, Matsumoto M, Lämmle B, Fujimura Y, Kremer Hovinga J
HAEMATOLOGICA. 2019;104(10):2107-2115.

Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
van Tilburg C, Milde T, Witt R, Ecker J, Hielscher T, Seitz A, Schenk J, Buhl J, Riehl D, Frühwald M, Pekrun A, Rossig C, Wieland R, Flotho C, Kordes U, Gruhn B, Simon T, Linderkamp C, Sahm F, Taylor L, Freitag A, Burhenne J, Foerster K, Meid A, Pfister S, Karapanagiotou-Schenkel I, Witt O
CLIN EPIGENETICS. 2019;11(1):188.

The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
Velthaus A, Cornils K, Hennigs J, Grüb S, Stamm H, Wicklein D, Bokemeyer C, Heuser M, Windhorst S, Fiedler W, Wellbrock J
CANCERS. 2019;11(11):.

Rare mature B-cell lymphomas in children and adolescents
Woessmann W, Quintanilla-Martinez L
HEMATOL ONCOL. 2019;37 Suppl 1:53-61.

Gliosarcoma Is Driven by Alterations in PI3K/Akt, RAS/MAPK Pathways and Characterized by Collagen Gene Expression Signature
Wojtas B, Gielniewski B, Wojnicki K, Maleszewska M, Mondal S, Nauman P, Grajkowska W, Glass R, Schüller U, Herold-Mende C, Kaminska B
CANCERS. 2019;11(3):.

Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report
Wolthers B, Frandsen T, Patel C, Abaji R, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grosjean M, Krajinovic M, Larsen E, Liang D, Möricke A, Rasmussen K, Samarasinghe S, Silverman L, van der Sluis I, Stanulla M, Tulstrup M, Yadav R, Yang W, Zapotocka E, Gupta R, Schmiegelow K
HAEMATOLOGICA. 2019;104(3):556-563.

Risikofaktoren für einen gemischten Chimerismus nach Stammzelltransplantation mit Treosulfan- oder Melphalanbasierter Konditionierung bei Kindern und Jugendlichen mit primärer Hämophagozytischer Lymphohistiozytose
Wustrau K, Albert M, Bader P, Beier R, Burkhardt B, Chada M, Greil J, Gruhn B, Kühl J, Lang P, Meisel R, Schulz A, Seidel M, Speckmann C, Sykora K, Wawer A, Wößmann W, Ozga A, Janka-Schaub G, Ehl S, Müller I, Lehmberg K
2019. Monatsschrift Kinderheilkunde > Ausgabe 7/2018 . 646-647.

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor
Xu E, von Bülow S, Chen P, Lenting P, Kolšek K, Aponte-Santamaría C, Simon B, Foot J, Obser T, Schneppenheim R, Gräter F, Denis C, Wilmanns M, Hennig J
BLOOD. 2019;133(4):366-376.

Characterization of novel, recurrent genomic rearrangements as sensitive MRD targets in childhood B-cell precursor ALL
Zur Stadt U, Alawi M, Adao M, Indenbirken D, Escherich G, Horstmann M
BLOOD CANCER J. 2019;9(12):96.

2018

Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07)
Beier D, Proescholdt M, Reinert C, Pietsch T, Jones D, Pfister S, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs S, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H, Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann R, Bogdahn U, Hau P
NEURO-ONCOLOGY. 2018;20(3):400-410.

Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial
Biondi A, Gandemer V, De Lorenzo P, Cario G, Campbell M, Castor A, Pieters R, Baruchel A, Vora A, Leoni V, Stary J, Escherich G, Li C, Cazzaniga G, Cavé H, Bradtke J, Conter V, Saha V, Schrappe M, Grazia Valsecchi M
LANCET HAEMATOL. 2018;5(12):e641-e652.

Subgroup-specific immune and stromal microenvironment in medulloblastoma
Bockmayr M, Mohme M, Klauschen F, Winkler B, Budczies J, Rutkowski S, Schüller U
ONCOIMMUNOLOGY. 2018;7(9):e1462430.

Allogeneic haematopoietic stem cell transplantation eliminates alloreactive inhibitory antibodies after liver transplantation for bile salt export pump deficiency
Brinkert F, Pukite I, Krebs-Schmitt D, Briem-Richter A, Stindt J, Häussinger D, Keitel V, Müller I, Grabhorn E
J HEPATOL. 2018;69(4):961-965.

DNA methylation-based reclassification of olfactory neuroblastoma
Capper D, Engel N, Stichel D, Lechner M, Glöss S, Schmid S, Koelsche C, Schrimpf D, Niesen J, Wefers A, Jones D, Sill M, Weigert O, Ligon K, Olar A, Koch A, Forster M, Moran S, Tirado O, Sáinz-Japeado M, Mora J, Esteller M, Alonso J, Del Muro X, Paulus W, Felsberg J, Reifenberger G, Glatzel M, Frank S, Monoranu C, Lund V, von Deimling A, Pfister S, Buslei R, Ribbat-Idel J, Perner S, Gudziol V, Meinhardt M, Schüller U
ACTA NEUROPATHOL. 2018;136(2):255-271.

Correction to: DNA methylation-based reclassification of olfactory neuroblastoma
Capper D, Engel N, Stichel D, Lechner M, Glöss S, Schmid S, Kölsche C, Schrimpf D, Niesen J, Wefers A, Jones D, Sill M, Weigert O, Ligon K, Olar A, Koch A, Forster M, Moran S, Tirado O, Sáinz-Jaspeado M, Mora J, Esteller M, Alonso J, Del Muro X, Paulus W, Felsberg J, Reifenberger G, Glatzel M, Frank S, Monoranu C, Lund V, von Deimling A, Pfister S, Buslei R, Ribbat-Idel J, Perner S, Gudziol V, Meinhardt M, Schüller U
ACTA NEUROPATHOL. 2018;136(3):505.

DNA methylation-based classification of central nervous system tumours
Capper D, Jones D, Sill M, Hovestadt V, Schrimpf D, Sturm D, Koelsche C, Sahm F, Chavez L, Reuss D, Kratz A, Wefers A, Huang K, Pajtler K, Schweizer L, Stichel D, Olar A, Engel N, Lindenberg K, Harter P, Braczynski A, Plate K, Dohmen H, Garvalov B, Coras R, Hölsken A, Hewer E, Bewerunge-Hudler M, Schick M, Fischer R, Beschorner R, Schittenhelm J, Staszewski O, Wani K, Varlet P, Pages M, Temming P, Lohmann D, Selt F, Witt H, Milde T, Witt O, Aronica E, Giangaspero F, Rushing E, Scheurlen W, Geisenberger C, Rodriguez F, Becker A, Preusser M, Haberler C, Bjerkvig R, Cryan J, Farrell M, Deckert M, Hench J, Frank S, Serrano J, Kannan K, Tsirigos A, Brück W, Hofer S, Brehmer S, Seiz-Rosenhagen M, Hänggi D, Hans V, Rozsnoki S, Hansford J, Kohlhof P, Kristensen B, Lechner M, Lopes B, Mawrin C, Ketter R, Kulozik A, Khatib Z, Heppner F, Koch A, Jouvet A, Keohane C, Mühleisen H, Mueller W, Pohl U, Prinz M, Benner A, Zapatka M, Gottardo N, Driever P, Kramm C, Müller H, Rutkowski S, von Hoff K, Frühwald M, Gnekow A, Fleischhack G, Tippelt S, Calaminus G, Monoranu C, Perry A, Jones C, Jacques T, Radlwimmer B, Gessi M, Pietsch T, Schramm J, Schackert G, Westphal M, Reifenberger G, Wesseling P, Weller M, Collins V, Blümcke I, Bendszus M, Debus J, Huang A, Jabado N, Northcott P, Paulus W, Gajjar A, Robinson G, Taylor M, Jaunmuktane Z, Ryzhova M, Platten M, Unterberg A, Wick W, Karajannis M, Mittelbronn M, Acker T, Hartmann C, Aldape K, Schüller U, Buslei R, Lichter P, Kool M, Herold-Mende C, Ellison D, Hasselblatt M, Snuderl M, Brandner S, Korshunov A, von Deimling A, Pfister S
NATURE. 2018;555(7697):469-474.

Heterogeneity within the PF-EPN-B ependymoma subgroup
Cavalli F, Hübner J, Sharma T, Luu B, Sill M, Zapotocky M, Mack S, Witt H, Lin T, Shih D, Ho B, Santi M, Emery L, Hukin J, Dunham C, McLendon R, Lipp E, Gururangan S, Grossbach A, French P, Kros J, van Veelen M, Rao A, Giannini C, Leary S, Jung S, Faria C, Mora J, Schüller U, Alonso M, Chan J, Klekner A, Chambless L, Hwang E, Massimino M, Eberhart C, Karajannis M, Lu B, Liau L, Zollo M, Ferrucci V, Carlotti C, Tirapelli D, Tabori U, Bouffet E, Ryzhova M, Ellison D, Merchant T, Gilbert M, Armstrong T, Korshunov A, Pfister S, Taylor M, Aldape K, Pajtler K, Kool M, Ramaswamy V
ACTA NEUROPATHOL. 2018;136(2):227-237.

Recommendations for the Use of Etoposide-Based Therapy and Bone Marrow Transplantation for the Treatment of HLH: Consensus Statements by the HLH Steering Committee of the Histiocyte Society
Ehl S, Astigarraga I, von Bahr Greenwood T, Hines M, Horne A, Ishii E, Janka G, Jordan M, La Rosée P, Lehmberg K, Machowicz R, Nichols K, Sieni E, Wang Z, Henter J
J ALLER CL IMM-PRACT. 2018;6(5):1508-1517.

Comment on: "Successful use of nitrous oxide during lumbar punctures: A call for nitrous oxide in pediatric oncology clinics"
Forster V, Escherich G, Halsey C
PEDIATR BLOOD CANCER. 2018;65(5):e26930.

T-cell gene therapy for perforin deficiency corrects cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations
Ghosh S, Carmo M, Calero-Garcia M, Ricciardelli I, Bustamante Ogando J, Blundell M, Schambach A, Ashton-Rickardt P, Booth C, Ehl S, Lehmberg K, Thrasher A, Gaspar H
J ALLERGY CLIN IMMUN. 2018;142(3):904-913.

Prognostic effect of whole chromosomal aberration signatures in standard-risk, non-WNT/non-SHH medulloblastoma: a retrospective, molecular analysis of the HIT-SIOP PNET 4 trial
Goschzik T, Schwalbe E, Hicks D, Smith A, Zur Muehlen A, Figarella-Branger D, Doz F, Rutkowski S, Lannering B, Pietsch T, Clifford S
LANCET ONCOL. 2018;19(12):1602-1616.

Author Correction: The landscape of genomic alterations across childhood cancers
Gröbner S, Worst B, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva V, Johann P, Balasubramanian G, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik A, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter G, Schulte J, Siebert R, Westermann F, Molenaar J, Vassal G, Witt H, Burkhardt B, Kratz C, Witt O, van Tilburg C, Kramm C, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick A, Zhang J, Liu Y, Zhou X, Waanders A, Zwijnenburg D, Raman P, Brors B, Weber U, Northcott P, Pajtler K, Kool M, Piro R, Korbel J, Schlesner M, Eils R, Jones D, Lichter P, Chavez L, Zapatka M, Pfister S
NATURE. 2018;559(7714):E10.

The landscape of genomic alterations across childhood cancers
Gröbner S, Worst B, Weischenfeldt J, Buchhalter I, Kleinheinz K, Rudneva V, Johann P, Balasubramanian G, Segura-Wang M, Brabetz S, Bender S, Hutter B, Sturm D, Pfaff E, Hübschmann D, Zipprich G, Heinold M, Eils J, Lawerenz C, Erkek S, Lambo S, Waszak S, Blattmann C, Borkhardt A, Kuhlen M, Eggert A, Fulda S, Gessler M, Wegert J, Kappler R, Baumhoer D, Burdach S, Kirschner-Schwabe R, Kontny U, Kulozik A, Lohmann D, Hettmer S, Eckert C, Bielack S, Nathrath M, Niemeyer C, Richter G, Schulte J, Siebert R, Westermann F, Molenaar J, Vassal G, Witt H, Burkhardt B, Kratz C, Witt O, van Tilburg C, Kramm C, Fleischhack G, Dirksen U, Rutkowski S, Frühwald M, von Hoff K, Wolf S, Klingebiel T, Koscielniak E, Landgraf P, Koster J, Resnick A, Zhang J, Liu Y, Zhou X, Waanders A, Zwijnenburg D, Raman P, Brors B, Weber U, Northcott P, Pajtler K, Kool M, Piro R, Korbel J, Schlesner M, Eils R, Jones D, Lichter P, Chavez L, Zapatka M, Pfister S
NATURE. 2018;555(7696):321-327.

Medulloblastoma in adults: A retrospective single institution analysis
Hadi I, Roengvoraphoj O, Niyazi M, Roeder F, Schüller U, Belka C, Nachbichler S
STRAHLENTHER ONKOL. 2018;194(3):225-234.

Glial papillary tumour of the spinal cord with SMARCB1/INI1-loss and favourable long-term outcome
Hasselblatt M, Kurniawan A, Rozsnoki S, Johann P, Bens S, Oyen F, Schneppenheim R, Siebert R, Capper D, Kool M, Schul C, Paulus W
NEUROPATH APPL NEURO. 2018;44(2):229-232.

Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany
Hassenpflug W, Obser T, Bode J, Oyen F, Budde U, Schneppenheim S, Schneppenheim R, Brehm M
THROMB HAEMOSTASIS. 2018;118(4):709-722.

Supplementary Therapeutic Recommendations
Hassenpflug W, Schneppenheim R
DTSCH ARZTEBL INT. 2018;155(37):608.

Is an infectious trigger always required for primary hemophagocytic lymphohistiocytosis? Lessons from in utero and neonatal disease
Heeg M, Ammann S, Klemann C, Panning M, Falcone V, Hengel H, Lehmberg K, Zur Stadt U, Wustrau K, Janka G, Ehl S
PEDIATR BLOOD CANCER. 2018;65(11):e27344.

Recurrence of Ewing sarcoma: Is detection by imaging follow-up protocol associated with survival advantage?
Heinemann M, Ranft A, Langer T, Jürgens H, Kreyer J, Vieth V, Schäfers M, Weckesser M, Simon T, Hassenpflug W, Corbacioglu S, Bielack S, Mayer-Steinacker R, Kühne T, van den Berg H, Gelderblom H, Bauer S, Stegger L, Dirksen U
PEDIATR BLOOD CANCER. 2018;65(7):e27011.

Germline variants in SMARCB1 and other members of the BAF chromatin-remodeling complex across human disease entities: a meta-analysis
Holsten T, Bens S, Oyen F, Nemes K, Hasselblatt M, Kordes U, Siebert R, Frühwald M, Schneppenheim R, Schüller U
EUR J HUM GENET. 2018;26(8):1083-1093.

Group 3 medulloblastoma in a patient with a GYS2 germline mutation and glycogen storage disease 0a
Holsten T, Tsiakas K, Kordes U, Bison B, Pietsch T, Rutkowski S, Santer R, Schüller U
CHILD NERV SYST. 2018;34(3):581-584.

Biology and Treatment of Hemophagocytic Lymphohistiocytosis
Janka-Schaub G
Iran J Blood Cancer. 2018;10(4):108-113.

RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia
Jerchel I, Hoogkamer A, Ariës I, Steeghs E, Boer J, Besselink N, Boeree A, van de Ven C, de Groot-Kruseman H, de Haas V, Horstmann M, Escherich G, Zwaan C, Cuppen E, Koudijs M, Pieters R, den Boer M
LEUKEMIA. 2018;32(4):931-940.

Sellar Region Atypical Teratoid/Rhabdoid Tumors (ATRT) in Adults Display DNA Methylation Profiles of the ATRT-MYC Subgroup
Johann P, Bens S, Oyen F, Wagener R, Giannini C, Perry A, Raisanen J, Reis G, Nobusawa S, Arita K, Felsberg J, Reifenberger G, Agaimy A, Buslei R, Capper D, Pfister S, Schneppenheim R, Siebert R, Frühwald M, Paulus W, Kool M, Hasselblatt M
AM J SURG PATHOL. 2018;42(4):506-511.

Postmortem MR diffusion-weighted imaging of the liver: time-behavior of the hepatic apparent diffusion coefficient in the early death interval
Keller S, Schmidt T, Kim A, Fischer R, Heinemann A, Adam G, Yamamura J
INT J LEGAL MED. 2018;132(1):263-268.

Scoring of tumor-infiltrating lymphocytes: from visual estimation to machine learning
Klauschen F, Müller K, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen T, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson A, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt S, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C
SEMIN CANCER BIOL. 2018;52(Pt 2):151-157.

Differences in maxillomandibular morphology among patients with mucopolysaccharidoses I, II, III, IV and VI: a retrospective MRI study
Koehne T, Köhn A, Friedrich R, Kordes U, Schinke T, Muschol N, Kahl-Nieke B
CLIN ORAL INVEST. 2018;22(3):1541-1549.

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations
Koelsche C, Mynarek M, Schrimpf D, Bertero L, Serrano J, Sahm F, Reuss D, Hou Y, Baumhoer D, Vokuhl C, Flucke U, Petersen I, Brück W, Rutkowski S, Zambrano S, Garcia Leon J, Diaz Coronado R, Gessler M, Tirado O, Mora J, Alonso J, Garcia Del Muro X, Esteller M, Sturm D, Ecker J, Milde T, Pfister S, Korshunov A, Snuderl M, Mechtersheimer G, Schüller U, Jones D, von Deimling A
ACTA NEUROPATHOL. 2018;136(2):327-337.

Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis
Krautz C, Maier S, Brunner M, Langheinrich M, Giamarellos-Bourboulis E, Gogos C, Armaganidis A, Kunath F, Grützmann R, Weber G
J CRIT CARE. 2018;45:71-75.

Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe
Kube S, Vokuhl C, Dantonello T, Scheer M, Hallmen E, Feuchtgruber S, Escherich G, Niggli F, Kuehnle I, von Kalle T, Bielack S, Klingebiel T, Koscielniak E
PEDIATR BLOOD CANCER. 2018;65(6):e27012.

Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high-risk or relapsed ALL - results of the ALL-SCT 2003 trial
Kuhlen M, Bader P, Sauer M, Albert M, Gruhn B, Güngör T, Kropshofer G, Lang P, Lawitschka A, Metzler M, Pentek F, Rossig C, Schlegel P, Schrappe M, Schrum J, Schulz A, Schwinger W, von Stackelberg A, Strahm B, Suttorp M, Luettichau I, Wößmann W, Borkhardt A, Meisel R, Poetschger U, Glogova E, Peters C
BRIT J HAEMATOL. 2018;183(1):104-109.

Diffusionsgewichtete MRT und 18F-FDG-PET-CT bei Kindern mit mediastinalam Lymphom vor und nach zwei Zyklen Chemotherapie
Kupka M, Stoffels M, Regier M, Berliner C, Klutmann S, Winkler B, Groth M, Adam G, Herrmann J
ROFO-FORTSCHR RONTG. 2018;190(S 01):40-41.

Langzeitbeobachtung ehemaliger krebskranker Kinder und Jugendlicher
Langer T, Grabow D, Kaatsch P, Creutzig U, Eggert A, Escherich G, Calaminus G
KLIN PADIATR. 2018;230(6):291-298.

Hämophagozytische Lymphohistiozytose
Lehmberg K
2018. Referenz Hämatologie. Kreuzer K (Hrsg.). Georg Thieme Verlag KG, .

Histiozytäre Erkrankungen
Lehmberg K
2018. Pädiatrische Hämatologie und Onkologie. Niemeyer C, Eggert A (Hrsg.). 2. Aufl. Springer, .

Assessment of Oncological Outcomes After Radical Prostatectomy According to Preoperative and Postoperative Cancer of the Prostate Risk Assessment Scores: Results from a Large, Two-center Experience
Leyh-Bannurah S, Dell'Oglio P, Zaffuto E, Briganti A, Schiffmann J, Pompe R, Tilki D, Heinzer H, Graefen M, Karakiewicz P, Budäus L
EUR UROL FOCUS. 2018.

Neuroimaging findings in children with hereditary hemophagocytic lymphohistiocytosis – report from the German reference center
Löbel U, Wustrau K, Müller I, Janka-Schaub G, Fiehler J, Lehmberg K
2018. NeuroRAD 2018 - 53. Jahrestagung der Deutschen Gesellschaft für Neuroradiologe e.V.. .

A biophysical view on von Willebrand factor activation
Löf A, Müller J, Brehm M
J CELL PHYSIOL. 2018;233(2):799-810.

Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis
Lucchini G, Marsh R, Gilmour K, Worth A, Nademi Z, Rao A, Booth C, Amrolia P, Silva J, Chiesa R, Wynn R, Lehmberg K, Astigarraga I, Güngör T, Stary J, Moshous D, Ifversen M, Zinn D, Jordan M, Kumar A, Yasumi T, Veys P, Rao K
BLOOD. 2018;132(19):2088-2096.

A track of the clones: new developments in cellular barcoding
Lyne A, Kent D, Laurenti E, Cornils K, Glauche I, Perié L
EXP HEMATOL. 2018;68:15-20.

Hypereosinophilia as Presenting Symptom of a Pre-B-ALL
Maier S, Zoghbi A, Escherich G, Winkler B
KLIN PADIATR. 2018;230(3):160-161.

CD34+ selected stem cell boosts can improve poor graft function after paediatric allogeneic stem cell transplantation
Mainardi C, Ebinger M, Enkel S, Feuchtinger T, Teltschik H, Eyrich M, Schumm M, Rabsteyn A, Schlegel P, Seitz C, Schwarze C, Müller I, Greil J, Bader P, Schlegel P, Martin D, Holzer U, Döring M, Handgretinger R, Lang P
BRIT J HAEMATOL. 2018;180(1):90-99.

Pediatric acute lymphoblastic leukemia-Conquering the CNS across the choroid plexus
März M, Meyer S, Erb U, Georgikou C, Horstmann M, Hetjens S, Weiß C, Fallier-Becker P, Vandenhaute E, Ishikawa H, Schroten H, Dürken M, Karremann M
LEUKEMIA RES. 2018;71:47-54.

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma
Merk D, Ohli J, Merk N, Thatikonda V, Morrissy S, Schoof M, Schmid S, Harrison L, Filser S, Ahlfeld J, Erkek S, Raithatha K, Andreska T, Weißhaar M, Launspach M, Neumann J, Shakarami M, Plenker D, Marra M, Li Y, Mungall A, Moore R, Ma Y, Jones S, Lutz B, Ertl-Wagner B, Rossi A, Wagener R, Siebert R, Jung A, Eberhart C, Lach B, Sendtner M, Pfister S, Taylor M, Chavez L, Kool M, Schüller U
DEV CELL. 2018;44(6):709-724.e6.

Autoinflammatory mutation in NLRC4 reveals a leucine-rich repeat (LRR)-LRR oligomerization interface
Moghaddas F, Zeng P, Zhang Y, Schützle H, Brenner S, Hofmann S, Berner R, Zhao Y, Lu B, Chen X, Zhang L, Cheng S, Winkler S, Lehmberg K, Canna S, Czabotar P, Wicks I, De Nardo D, Hedrich C, Zeng H, Masters S
J ALLERGY CLIN IMMUN. 2018;142(6):1956-1967.e6.

The extraordinary challenge of treating patients with congenital rhabdoid tumors-a collaborative European effort
Nemes K, Clément N, Kachanov D, Bens S, Hasselblatt M, Timmermann B, Schneppenheim R, Gerss J, Siebert R, Furtwängler R, Bourdeaut F, Frühwald M
PEDIATR BLOOD CANCER. 2018;65:e26999.

Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy
Nicolay J, Thorn V, Daniel C, Amann K, Siraskar B, Lang F, Hillgruber C, Goerge T, Hoffmann S, Gorzelanny C, Huck V, Mess C, Obser T, Schneppenheim R, Fleming I, Schneider M, Schneider S
SCI REP-UK. 2018;8(1):10945.

Multilayered omics-based analysis of a head and neck cancer model of cisplatin resistance reveals intratumoral heterogeneity and treatment-induced clonal selection
Niehr F, Eder T, Pilz T, Konschak R, Treue D, Klauschen F, Bockmayr M, Türkmen S, Jöhrens K, Budach V, Tinhofer I
CLIN CANCER RES. 2018;24(1):158-168.

Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy
Posch S, Obser T, König G, Schneppenheim R, Tampé R, Hinterdorfer P
J CHEM PHYS. 2018;148(12):123310.

Autologous Mesenchymal Stroma Cells Are Superior to Allogeneic Ones in Bone Defect Regeneration
Rapp A, Bindl R, Erbacher A, Kruchen A, Rojewski M, Schrezenmeier H, Müller I, Ignatius A
INT J MOL SCI. 2018;19(9):.

PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia
Richter-Pechańska P, Kunz J, Bornhauser B, von Knebel Doeberitz C, Rausch T, Erarslan-Uysal B, Assenov Y, Frismantas V, Marovca B, Waszak S, Zimmermann M, Seemann J, Happich M, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Muckenthaler M, Korbel J, Bourquin J, Kulozik A
EMBO MOL MED. 2018;10(12):e9443.

Integrated analysis of dynamic FET PET/CT parameters, histology, and methylation profiling of 44 gliomas
Röhrich M, Huang K, Schrimpf D, Albert N, Hielscher T, von Deimling A, Schüller U, Dimitrakopoulou-Strauss A, Haberkorn U
EUR J NUCL MED MOL I. 2018;45(9):1573-1584.

Hirntumoren des Kindes- und Jugendalters
Rutkowski S
TUMORDIAGN THER. 2018;39(08):513-517.

Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group
Rutkowski S, Modena P, Williamson D, Kerl K, Nysom K, Pizer B, Bartels U, Puget S, Doz F, Michalski A, von Hoff K, Chevignard M, Avula S, Murray M, Schönberger S, Czech T, Schouten-van Meeteren A, Kordes U, Kramm C, van Vuurden D, Hulleman E, Janssens G, Solanki G, van Veelen M, Thomale U, Schuhmann M, Jones C, Giangaspero F, Figarella-Branger D, Pietsch T, Clifford S, Pfister S, Van Gool S
LANCET ONCOL. 2018;19(8):e419-e428.

The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia
Schliffke S, Buhs S, Bolz S, Gerull H, von Wenserski L, Riecken K, Fehse B, Nollau P, Binder M
BLOOD. 2018;131(15):1755-1758.

Impact of Whole Lung Irradiation on Survival Outcome in Patients With Lung Relapsed Ewing Sarcoma
Scobioala S, Ranft A, Wolters H, Jabar S, Paulussen M, Timmermann B, Juergens H, Hassenpflug W, Klingebiel T, Elsayad K, Eich H, Dirksen U
INT J RADIAT ONCOL. 2018;102(3):584-592.

Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
Shemer A, Grozovski J, Tay T, Tao J, Volaski A, Süß P, Ardura-Fabregat A, Gross-Vered M, Kim J, David E, Chappell-Maor L, Thielecke L, Glass C, Cornils K, Prinz M, Jung S
NAT COMMUN. 2018;9(1):5206.

Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL
Siekmann I, Dierck K, Prall S, Klokow M, Strauss J, Buhs S, Wrzeszcz A, Bockmayr M, Beck F, Trochimiuk M, Gottschling K, Martens V, Khosh-Naucke M, Gerull H, Müller J, Behrmann L, Blohm M, Zahedi R, Jeremias I, Sickmann A, Nollau P, Horstmann M
BLOOD ADV. 2018;2(19):2554-2567.

High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia
Steeghs E, Bakker M, Hoogkamer A, Boer J, Hartman Q, Stalpers F, Escherich G, de Haas V, de Groot-Kruseman H, Pieters R, den Boer M
SCI REP-UK. 2018;8(1):693.

An international collaborative study to compare different von Willebrand factor glycoprotein Ib binding activity assays: the COMPASS-VWF study
Szederjesi A, Baronciani L, Budde U, Castaman G, Lawrie A, Liu Y, Montgomery R, Peyvandi F, Schneppenheim R, Várkonyi A, Patzke J, Bodó I
J THROMB HAEMOST. 2018 [Epub ahead of print].

Retrospective analysis on thermal injuries in children-Demographic, etiological and clinical data of German and Austrian pediatric hospitals 2006-2015-Approaching the new German burn registry
Tegtmeyer L, Herrnstadt G, Maier S, Thamm O, Klinke M, Reinshagen K, Koenigs I
BURNS. 2018;44(1):150-157.

Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET
Vettermann F, Felsberg J, Reifenberger G, Hasselblatt M, Forbrig R, Berding G, la Fougère C, Galldiks N, Schittenhelm J, Weis J, Albert N, Schüller U
CLIN NUCL MED. 2018;43(12):895-898.

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort
Waszak S, Northcott P, Buchhalter I, Robinson G, Sutter C, Groebner S, Grund K, Brugières L, Jones D, Pajtler K, Morrissy A, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin B, Zhou X, Baciu C, Lawerenz C, Chan J, Varlet P, Guerrini-Rousseau L, Fults D, Grajkowska W, Hauser P, Jabado N, Ra Y, Zitterbart K, Shringarpure S, De La Vega F, Bustamante C, Ng H, Perry A, MacDonald T, Hernáiz Driever P, Bendel A, Bowers D, McCowage G, Chintagumpala M, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen T, Röösli M, Kuehni C, Grotzer M, Kjaerheim K, Monoranu C, Archer T, Duke E, Pomeroy S, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova M, Milde T, Kratz C, Samuel D, Zhang J, Solomon D, Marra M, Eils R, Bartram C, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson R, Korshunov A, Taylor M, Lichter P, Malkin D, Gajjar A, Korbel J, Pfister S
LANCET ONCOL. 2018;19(6):785-798.

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008
Whelan J, Le Deley M, Dirksen U, Le Teuff G, Brennan B, Gaspar N, Hawkins D, Amler S, Bauer S, Bielack S, Blay J, Burdach S, Castex M, Dilloo D, Eggert A, Gelderblom H, Gentet J, Hartmann W, Hassenpflug W, Hjorth L, Jimenez M, Klingebiel T, Kontny U, Kruseova J, Ladenstein R, Laurence V, Lervat C, Marec-Berard P, Marreaud S, Michon J, Morland B, Paulussen M, Ranft A, Reichardt P, van den Berg H, Wheatley K, Judson I, Lewis I, Craft A, Juergens H, Oberlin O
J CLIN ONCOL. 2018 [Epub ahead of print];JCO2018782516.

Comparison of immune reconstitution after allogeneic versus autologous stem cell transplantation in 182 patients
Wiegering V, Eyrich M, Winkler B, Schlegel P
J PEDIAT HEMATOL ONC. 2018;41(5):e302-e307.

Exploring the potential of a pretend play intervention in young patients with leukemia
Witt S, Escherich G, Rutkowski S, Kappelhoff G, Frygner-Holm S, Russ S, Bullinger M, Quitmann J
J PEDIATR NURS. 2018;44:E98-E106.

Risk factors for mixed chimerism after stem cell transplantation with treosulfan or melphalan based conditioning regimens in children and adolescents with primary hemophagocytic lymphohistocytosis
Wustrau K, Albert M, Bader P, Beier R, Burkhardt B, Chada M, Greil J, Gruhn B, Kühl J, Lang P, Meisel R, Schulz A, Seidel M, Speckmann C, Sykora K, Wawer A, Wößmann W, Ozga A, Ehl S, Müller I, Lehmberg K
2018. Bone Marrow Transplantation (2018) Abstracts Collection. .

2017

Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
Ahlfeld J, Filser S, Schmidt F, Wefers A, Merk D, Glaß R, Herms J, Schüller U
SCI REP-UK. 2017;7(1):6137.

Primary and secondary hemophagocytic lymphohistiocytosis have different patterns of T-cell activation, differentiation and repertoire
Ammann S, Lehmberg K, Zur Stadt U, Janka-Schaub G, Rensing-Ehl A, Klemann C, Heeg M, Bode S, Fuchs I, Ehl S
EUR J IMMUNOL. 2017;47(2):364-373.

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification
Andreiuolo F, Le Teuff G, Bayar M, Kilday J, Pietsch T, von Bueren A, Witt H, Korshunov A, Modena P, Pfister S, Pagès M, Castel D, Giangaspero F, Chimelli L, Varlet P, Rutkowski S, Frappaz D, Massimino M, Grundy R, Grill J
PLOS ONE. 2017;12(6):e0178351.

Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism
Aponte-Santamaría C, Lippok S, Mittag J, Obser T, Schneppenheim R, Baldauf C, Gräter F, Budde U, Rädler J
BIOPHYS J. 2017;112(1):57-65.

Genetic barcodes facilitate competitive clonal analyses in vivo
Aranyossy T, Thielecke L, Glauche I, Fehse B, Cornils K
HUM GENE THER. 2017;28(10):926-937.

Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis
Becher P, Gotzhein F, Klingel K, Escher F, Blankenberg S, Westermann D, Lindner D
J IMMUNOL RES. 2017.

Confirmed efficacy of etoposide and dexamethasone in HLH Treatment: long-term results of the cooperative HLH-2004 study
Bergsten E, Horne A, Aricó M, Astigarraga I, Egeler R, Filipovich A, Ishii E, Janka G, Ladisch S, Lehmberg K, McClain K, Minkov M, Montgomery S, Nanduri V, Rosso D, Henter J
BLOOD. 2017;130(25):2728-2738.

Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions
Biasetti J, Sampath K, Cortez A, Azhir A, Gilad A, Kickler T, Obser T, Ruggeri Z, Katz J
INT J BIOMED IMAGING. 2017;2017:8318906.

Tyrosine kinase fusion genes in pediatric BCR-ABL1-like acute lymphoblastic leukemia
Boer J, Steeghs E, Marchante J, Boeree A, Beaudoin J, Beverloo H, Kuiper R, Escherich G, van der Velden V, van der Schoot C, de Groot-Kruseman H, Pieters R, den Boer M
ONCOTARGET. 2017;8(3):4618-4628.

Enzymatic characterization of novel arylsulfatase A variants using human arylsulfatase A-deficient immortalized mesenchymal stromal cells
Böhringer J, Santer R, Schumacher N, Gieseke F, Cornils K, Pechan M, Kustermann-Kuhn B, Handgretinger R, Schöls L, Harzer K, Krägeloh-Mann I, Müller I
HUM MUTAT. 2017;38(11):1511-1520.

Atypical teratoid/rhabdoid tumor arising in a malignant glioma
Bozzai B, Hasselblatt M, Turányi E, Frühwald M, Siebert R, Bens S, Schneppenheim R, Kool M, Stelczer G, Hortobágyi T, Hauser P
PEDIATR BLOOD CANCER. 2017;64(1):96-99.

Resistance to anti-CD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking
Braig F, Brandt A, Goebeler M, Tony H, Kurze A, Nollau P, Bumm T, Böttcher S, Bargou R, Binder M
BLOOD. 2017;129(1):100-104.

Von Willebrand factor processing
Brehm M
HAMOSTASEOLOGIE. 2017;37(1):59-72.

Mutation patterns in genes encoding interferon signaling and antigen presentation: A pan-cancer survey with implications for the use of immune checkpoint inhibitors
Budczies J, Bockmayr M, Klauschen F, Endris V, Fröhling S, Schirmacher P, Denkert C, Stenzinger A
GENE CHROMOSOME CANC. 2017;56(8):651-659.

Identification of Tyrosine Phosphorylated Proteins by SH2 Domain Affinity Purification and Mass Spectrometry
Buhs S, Gerull H, Nollau P
Methods Mol Biol. 2017;1555:407-418.

SH2 Domain Histochemistry
Buhs S, Nollau P
Methods Mol Biol. 2017;1555:535-545.

Comprehensive Analysis of Hypermutation in Human Cancer
Campbell B, Light N, Fabrizio D, Zatzman M, Fuligni F, de Borja R, Davidson S, Edwards M, Elvin J, Hodel K, Zahurancik W, Suo Z, Lipman T, Wimmer K, Kratz C, Bowers D, Laetsch T, Dunn G, Johanns T, Grimmer M, Smirnov I, Larouche V, Samuel D, Bronsema A, Osborn M, Stearns D, Raman P, Cole K, Storm P, Yalon M, Opocher E, Mason G, Thomas G, Sabel M, George B, Ziegler D, Lindhorst S, Issai V, Constantini S, Toledano H, Elhasid R, Farah R, Dvir R, Dirks P, Huang A, Galati M, Chung J, Ramaswamy V, Irwin M, Aronson M, Durno C, Taylor M, Rechavi G, Maris J, Bouffet E, Hawkins C, Costello J, Meyn M, Pursell Z, Malkin D, Tabori U, Shlien A
CELL. 2017;171(5):1042-1056.e10.

Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients
Chiang S, Wood S, Tesi B, Akar H, Al-Herz W, Ammann S, Belen F, Caliskan U, Kaya Z, Lehmberg K, Patiroglu T, Tokgoz H, Ünüvar A, Introne W, Henter J, Nordenskjöld M, Ljunggren H, Meeths M, Ehl S, Krzewski K, Bryceson Y
FRONT IMMUNOL. 2017;8:426.

Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion
Cornils K, Thielecke L, Winkelmann D, Aranyossy T, Lesche M, Dahl A, Roeder I, Fehse B, Glauche I
MOL CANCER. 2017;16(1):120.

Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation
Döring M, Cabanillas Stanchi K, Queudeville M, Feucht J, Blaeschke F, Schlegel P, Feuchtinger T, Lang P, Müller I, Handgretinger R, Heinz W
J CANCER RES CLIN. 2017;143(7):1281-1292.

Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol
Driessen E, de Lorenzo P, Campbell M, Felice M, Ferster A, Hann I, Vora A, Hovi L, Escherich G, Li C, Mann G, Leblanc T, Locatelli F, Biondi A, Rubnitz J, Schrappe M, Silverman L, Stary J, Suppiah R, Szczepanski T, Valsecchi M, Pieters R
LEUKEMIA. 2017;31(12):2854.

Frondoside A induces AIF-associated caspase-independent apoptosis in Burkitt lymphoma cells
Dyshlovoy S, Rast S, Hauschild J, Otte K, Alsdorf W, Madanchi R, Kalinin V, Silchenko A, Avilov S, Dierlamm J, Honecker F, Stonik V, Bokemeyer C, von Amsberg G
LEUKEMIA LYMPHOMA. 2017;58(12):2905-2915.

Building a National Framework for Adolescent and Young Adult Hematology and Oncology and Transition from Pediatric to Adult Care: Report of the Inaugural Meeting of the "AjET" Working Group of the German Society for Pediatric Oncology and Hematology
Escherich G, Bielack S, Maier S, Braungart R, Brümmendorf T, Freund M, Grosse R, Hoferer A, Kampschulte R, Koch B, Lauten M, Milani V, Ross H, Schilling F, Wöhrle D, Cario H, Dirksen U
J ADOLESC YOUNG ADUL. 2017;6(2):194-199.

The role of constitutive activation of FMS-related tyrosine kinase-3 andmutational status in infants with-rearranged acute lymphoblastic leukemia
Fedders H, Alsadeq A, Schmäh J, Vogiatzi F, Zimmermann M, Möricke A, Lenk L, Stadt U, Horstmann M, Pieters R, Schrappe M, Stanulla M, Cario G, Schewe D
HAEMATOLOGICA. 2017;102(11):e438-e442.

Tropomyosin receptor kinase C (TrkC) expression in medulloblastoma: relation to the molecular subgroups and impact on treatment response
Friedrich C, Shalaby T, Oehler C, Pruschy M, Seifert B, Picard D, Remke M, Warmuth-Metz M, Kortmann R, Rutkowski S, Grotzer M, von Bueren A
CHILD NERV SYST. 2017;33(9):1463-1471.

Pilomatrixoma of the Neck/Shoulder Region Mimicking a Rapidly Growing Neoplasm of Peripheral Nerve Sheath Origin in Neurofibromatosis Type 1
Friedrich R, Schüller U, Hagel C
ANTICANCER RES. 2017;37(12):6907-6910.

Geographical variability in survival of European children with central nervous system tumours
Gatta G, Peris-Bonet R, Visser O, Stiller C, Marcos-Gragera R, Sánchez M, Lacour B, Kaatsch P, Berrino F, Rutkowski S, Botta L
EUR J CANCER. 2017;82:137-148.

ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas
Grausam K, Dooyema S, Bihannic L, Premathilake H, Morrissy A, Forget A, Schaefer A, Gundelach J, Macura S, Maher D, Wang X, Heglin A, Ge X, Zeng E, Puget S, Chandrasekar I, Surendran K, Bram R, Schüller U, Talyor M, Ayrault O, Zhao H
CANCER RES. 2017;77(14):3766-3777.

Ex Vivo Assessment of Coronary Atherosclerotic Plaque by Grating-Based Phase-Contrast Computed Tomography: Correlation With Optical Coherence Tomography
Habbel C, Hetterich H, Willner M, Herzen J, Steigerwald K, Auweter S, Schüller U, Hausleiter J, Massberg S, Reiser M, Pfeiffer F, Saam T, Bamberg F
INVEST RADIOL. 2017;52(4):223-231.

Hematopoietic stem cell transplantation rescues the hematological, immunological and vascular phenotype in DADA2
Hashem H, Kumar A, Müller I, Babor F, Bredius R, Dalal J, Hsu A, Holland S, Hickstein D, Jolles S, Krance R, Sasa G, Taskinen M, Koskenvuo M, Saarela J, van Montfrans J, Wilson K, Bosch B, Moens L, Hershfield M, Meyts I
BLOOD. 2017;130(24):2682-2688.

Dark-field imaging in coronary atherosclerosis
Hetterich H, Webber N, Willner M, Herzen J, Birnbacher L, Auweter S, Schüller U, Bamberg F, Notohamiprodjo S, Bartsch H, Wolf J, Marschner M, Pfeiffer F, Reiser M, Saam T
EUR J RADIOL. 2017;94:38-45.

Liver transplantation as a potentially lifesaving measure in neuroblastoma stage 4S
Holsten T, Schuster T, Grabhorn E, Hero B, Frühwald M
PEDIATR HEMAT ONCOL. 2017;34(1):17-23.

How to Treat Involvement of the Central Nervous System in Hemophagocytic Lymphohistiocytosis?
Horne A, Wickström R, Jordan M, Yeh E, Naqvi A, Henter J, Janka G
CURR TREAT OPTION NE. 2017;19(1):3.

Radiomic Analysis Reveals Prognostic Information in T1-Weighted Baseline Magnetic Resonance Imaging in Patients With Glioblastoma
Ingrisch M, Schneider M, Nörenberg D, Negrao de Figueiredo G, Maier-Hein K, Suchorska B, Schüller U, Albert N, Brückmann H, Reiser M, Tonn J, Ertl-Wagner B
INVEST RADIOL. 2017;52(6):360-366.

Cribriform neuroepithelial tumor: Molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome
Johann P, Hovestadt V, Thomas C, Jeibmann A, Heß K, Bens S, Oyen F, Hawkins C, Pierson C, Aldape K, Kim S, Widing E, Sumerauer D, Hauser P, van Landeghem F, Ryzhova M, Korshunov A, Capper D, Jones D, Pfister S, Schneppenheim R, Siebert R, Paulus W, Frühwald M, Kool M, Hasselblatt M
BRAIN PATHOL. 2017;27(4):411-418.

Refining medulloblastoma subgroups
Juhnke B, Mynarek M, Rutkowski S
LANCET ONCOL. 2017;18(7):847-848.

Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN
Kilday J, Caldarelli M, Massimi L, Chen R, Lee Y, Liang M, Parkes J, Naiker T, van Veelen M, Michiels E, Mallucci C, Pettorini B, Meijer L, Dorfer C, Czech T, Diezi M, Schouten-van Meeteren A, Holm S, Gustavsson B, Benesch M, Müller H, Hoffmann A, Rutkowski S, Flitsch J, Escherich G, Grotzer M, Spoudeas H, Azquikina K, Capra M, Jiménez-Guerra R, MacDonald P, Johnston D, Dvir R, Constantini S, Kuo M, Yang S, Bartels U
NEURO-ONCOLOGY. 2017;19(10):1398-1407.

Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation
Klemann C, Ammann S, Heizmann M, Fuchs S, Bode S, Heeg M, Fuchs H, Lehmberg K, Zur Stadt U, Roll C, Vraetz T, Speckmann C, Lorenz M, Schwarz K, Rohr J, Feske S, Ehl S
J ALLERGY CLIN IMMUN. 2017;140(6):1721-1724.

Evolution of disease activity and biomarkers on and off rapamycin in 28 patients with autoimmune lymphoproliferative syndrome
Klemann C, Esquivel M, Magerus-Chatinet A, Lorenz M, Fuchs I, Neveux N, Castelle M, Rohr J, Bettoni da Cunha C, Ebinger M, Kobbe R, Kremens B, Kollert F, Gambineri E, Lehmberg K, Seidel M, Siepermann K, Voelker T, Schuster V, Goldacker S, Schwarz K, Speckmann C, Picard C, Fischer A, Rieux-Laucat F, Ehl S, Rensing-Ehl A, Neven B
HAEMATOLOGICA. 2017;102(2):e52-e56.

Osteonecrosis develops independently from radiological leukemic infiltration of bone in adolescents with acute lymphoblastic leukemia - first findings of the OPAL trial
Krull K, Kunstreich M, Klasen-Sansone J, Kloetgen A, Gruener F, Escherich G, Bleckmann K, Moericke A, Schrappe M, Jorch N, Steinbach D, Classen C, Guggemos A, Kolb R, Klee D, Borkhardt A, Kuhlen M
LEUKEMIA LYMPHOMA. 2017;58(10):2363-2369.

Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy
Kuhlen M, Bleckmann K, Möricke A, Schrappe M, Vieth S, Escherich G, Bronsema A, Vonalt A, Queudeville M, Zwaan C, Ebinger M, Debatin K, Klingebiel T, Koscielniak E, Rossig C, Burkhardt B, Kolb R, Eckert C, Borkhardt A, von Stackelberg A, Chen-Santel C
BRIT J HAEMATOL. 2017;179(2):272-283.

The epidemiology of sickle cell disease in Germany following recent large-scale immigration
Kunz J, Cario H, Grosse R, Jarisch A, Lobitz S, Kulozik A
PEDIATR BLOOD CANCER. 2017;64(7):.

Results and conclusions of the European Intergroup EURO-LB02 trial in children and adolescents with lymphoblastic lymphoma
Landmann E, Burkhardt B, Zimmermann M, Meyer U, Woessmann W, Klapper W, Wrobel G, Rosolen A, Pillon M, Escherich G, Attarbaschi A, Beishuizen A, Mellgren K, Wynn R, Ratei R, Plesa A, Schrappe M, Reiter A, Bergeron C, Patte C, Bertrand Y
HAEMATOLOGICA. 2017;102(12):2086-2096.

Inherited Thrombotic Thrombocytopenic Purpura (Upshaw Schulman Syndrome) as Differential Diagnosis to Neonatal Septicaemia with Disseminated Intravascular Coagulation - a Case Series
Lehmberg K, Hassenpflug W, Klaassen I, Hillebrand G, Oyen F, Budde U, Singer D, Schneppenheim R
Z GEBURTSH NEONATOL. 2017;221(1):39-42.

Measles virus envelope pseudotyped lentiviral vectors transduce quiescent human HSCs at an efficiency without precedent
Lévy C, Amirache F, Girard-Gagnepain A, Frecha C, Roman-Rodríguez F, Bernadin O, Costa C, Nègre D, Gutierrez-Guerrero A, Vranckx L, Clerc I, Taylor N, Thielecke L, Cornils K, Bueren J, Rio P, Gijsbers R, Cosset F, Verhoeyen E
BLOOD ADV. 2017;1(23):2088-2104.

Comparison of 11 Active Surveillance Protocols in Contemporary European Men Treated With Radical Prostatectomy
Leyh-Bannurah S, Karakiewicz P, Dell'Oglio P, Briganti A, Schiffmann J, Pompe R, Sauter G, Schlomm T, Heinzer H, Huland H, Graefen M, Budäus L
CLIN GENITOURIN CANC. 2017 [Epub ahead of print].

Biophysical approaches promote advances in the understanding of von Willebrand factor processing and function
Löf A, Müller J, Benoit M, Brehm M
Adv Biol Regul. 2017;63:81-91.

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy
Louis D, Aldape K, Brat D, Capper D, Ellison D, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor T, Cairncross J, Pfister S, Rutkowski S, Weller M, Wick W, von Deimling A
ACTA NEUROPATHOL. 2017;133(1):1-3.

cIMPACT-NOW (the consortium to inform molecular and practical approaches to CNS tumor taxonomy): a new initiative in advancing nervous system tumor classification
Louis D, Aldape K, Brat D, Capper D, Ellison D, Hawkins C, Paulus W, Perry A, Reifenberger G, Figarella-Branger D, Wesseling P, Batchelor T, Gregory Cairncross J, Pfister S, Rutkowski S, Weller M, Wick W, von Deimling A
BRAIN PATHOL. 2017;27(6):851-852.

Similar but not the same: Differential diagnosis of HLH and sepsis
Machowicz R, Janka G, Wiktor-Jedrzejczak W
CRIT REV ONCOL HEMAT. 2017;114:1-12.

Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome
Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, Weitzman S, Espada G, Gao Y, Anton J, Kitoh T, Kasapcopur O, Sanner H, Merino R, Astigarraga I, Alessio M, Jeng M, Chasnyk V, Nichols K, Huasong Z, Li C, Micalizzi C, Ruperto N, Martini A, Cron R, Ravelli A, Horne A
J PEDIATR-US. 2017;189:72-78.e3.

Spatial heterogeneity in medulloblastoma
Morrissy A, Cavalli F, Remke M, Ramaswamy V, Shih D, Holgado B, Farooq H, Donovan L, Garzia L, Agnihotri S, Kiehna E, Mercier E, Mayoh C, Papillon-Cavanagh S, Nikbakht H, Gayden T, Torchia J, Picard D, Merino D, Vladoiu M, Luu B, Wu X, Daniels C, Horswell S, Thompson Y, Hovestadt V, Northcott P, Jones D, Peacock J, Wang X, Mack S, Reimand J, Albrecht S, Fontebasso A, Thiessen N, Li Y, Schein J, Lee D, Carlsen R, Mayo M, Tse K, Tam A, Dhalla N, Ally A, Chuah E, Cheng Y, Plettner P, Li H, Corbett R, Wong T, Long W, Loukides J, Buczkowicz P, Hawkins C, Tabori U, Rood B, Myseros J, Packer R, Korshunov A, Lichter P, Kool M, Pfister S, Schüller U, Dirks P, Huang A, Bouffet E, Rutka J, Bader G, Swanton C, Ma Y, Moore R, Mungall A, Majewski J, Jones S, Das S, Malkin D, Jabado N, Marra M, Taylor M
NAT GENET. 2017;49(5):780-788.

Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data
Mynarek M, Pizer B, Dufour C, van Vuurden D, Garami M, Massimino M, Fangusaro J, Davidson T, Gil-da-Costa M, Sterba J, Benesch M, Gerber N, Juhnke B, Kwiecien R, Pietsch T, Kool M, Clifford S, Ellison D, Giangaspero F, Wesseling P, Gilles F, Gottardo N, Finlay J, Rutkowski S, von Hoff K
NEURO-ONCOLOGY. 2017;19(4):576-585.

Medulloblastoma: experimental models and reality
Neumann J, Swartling F, Schüller U
ACTA NEUROPATHOL. 2017;134(5):679-689.

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Neumann J, Wefers A, Lambo S, Bianchi E, Bockstaller M, Dorostkar M, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider M, Renner-Müller I, Merk D, Shakarami M, Sharma T, Chavez L, Glass R, Chan J, Taketo M, Neumann P, Kool M, Schüller U
NAT MED. 2017;23(10):1191-1202.

Mutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome
Oud M, Tuijnenburg P, Hempel M, van Vlies N, Ren Z, Ferdinandusse S, Jansen M, Santer R, Johannsen J, Bacchelli C, Alders M, Li R, Davies R, Dupuis L, Cale C, Wanders R, Pals S, Ocaka L, James C, Müller I, Lehmberg K, Strom T, Engels H, Williams H, Beales P, Roepman R, Dias P, Brunner H, Cobben J, Hall C, Hartley T, Le Quesne Stabej P, Mendoza-Londono R, Davies E, de Sousa S, Lessel D, Arts H, Kuijpers T
AM J HUM GENET. 2017;100(2):281-296.

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants
Pajtler K, Mack S, Ramaswamy V, Smith C, Witt H, Smith A, Hansford J, von Hoff K, Wright K, Hwang E, Frappaz D, Kanemura Y, Massimino M, Faure-Conter C, Modena P, Tabori U, Warren K, Holland E, Ichimura K, Giangaspero F, Castel D, von Deimling A, Kool M, Dirks P, Grundy R, Foreman N, Gajjar A, Korshunov A, Finlay J, Gilbertson R, Ellison D, Aldape K, Merchant T, Bouffet E, Pfister S, Taylor M
ACTA NEUROPATHOL. 2017;133(1):5-12.

Mutual A domain interactions in the force sensing protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
J STRUCT BIOL. 2017;197(1):57-64.

Das CARE-for-CAYA-Programm. Präventionskonzept für junge Menschen nach Krebserkrankung
Quidde J, Koch B, Salchow J, Jensen W, von Grundherr J, Escherich G, Rutkowski S, Schulz-Kindermann F, Bergelt C, Bokemeyer C, Sokalska-Duhme M, Bielak S, Calaminus G, Classen C, Rössig C, Faber J, Faller H, Hilgendorf I, Langer T, Metzler M, Schuster S, Niemeyer C, Pierce A, Reinhardt D, Dirksen U, Sander A, Köhler M, Stein A
Forum. Das offizielle Magazin der Deutschen Krebsgesellschaft e.V.. 2017;32(06):479-484.

Versorgung von Patienten nach Krebserkrankung im Kindes-, Jugend- oder jungen Erwachsenenalter
Quidde J, Koch B, Salchow J, Jensen W, von Grundherr J, Escherich G, Rutkowski S, Schulz-Kindermann F, Bergelt C, Bokemeyer C, Sokalska-Duhme M, Bielak S, Calaminus G, Classen C, Rössig C, Faber J, Faller H, Hilgendorf I, Langer T, Metzler M, Schuster S, Niemeyer C, Pierce A, Reinhardt D, Dirksen U, Sander A, Köhler M, Stein A
J Onkol - Z Onkol Fortb. 2017;2017(10):862-866.

Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004
Rasche M, von Neuhoff C, Dworzak M, Bourquin J, Bradtke J, Göhring G, Escherich G, Fleischhack G, Graf N, Gruhn B, Haas O, Klingebiel T, Kremens B, Lehrnbecher T, von Stackelberg A, Tchinda J, Zemanova Z, Thiede C, von Neuhoff N, Zimmermann M, Creutzig U, Reinhardt D
LEUKEMIA. 2017;31(12):2807-2814.

Kaposiformes Hämangioendotheliom mit Kasabach-Merritt-Syndrom: erfolgreiche Therapie mit Sirolimus
Reichel A, Hamm H, Wiegering V, Wiewrodt B, Neubauer H, Ernestus K, Winkler B
J DTSCH DERMATOL GES. 2017;15(3):329-331.

Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: successful treatment with sirolimus
Reichel A, Hamm H, Wiegering V, Wiewrodt B, Neubauer H, Ernestus K, Winkler B
J DTSCH DERMATOL GES. 2017;15(3):329-331.

Adverse Effects of Antidepressants for Chronic Pain: A Systematic Review and Meta-analysis
Riediger C, Schuster T, Barlinn K, Maier S, Weitz J, Siepmann T
FRONT NEUROL. 2017;8:307.

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology
Ripperger T, Bielack S, Borkhardt A, Brecht I, Burkhardt B, Calaminus G, Debatin K, Deubzer H, Dirksen U, Eckert C, Eggert A, Erlacher M, Fleischhack G, Frühwald M, Gnekow A, Goehring G, Graf N, Hanenberg H, Hauer J, Hero B, Hettmer S, von Hoff K, Horstmann M, Hoyer J, Illig T, Kaatsch P, Kappler R, Kerl K, Klingebiel T, Kontny U, Kordes U, Körholz D, Koscielniak E, Kramm C, Kuhlen M, Kulozik A, Lamottke B, Leuschner I, Lohmann D, Meinhardt A, Metzler M, Meyer L, Moser O, Nathrath M, Niemeyer C, Nustede R, Pajtler K, Paret C, Rasche M, Reinhardt D, Rieß O, Russo A, Rutkowski S, Schlegelberger B, Schneider D, Schneppenheim R, Schrappe M, Schroeder C, von Schweinitz D, Simon T, Sparber-Sauer M, Spix C, Stanulla M, Steinemann D, Strahm B, Temming P, Thomay K, von Bueren A, Vorwerk P, Witt O, Wlodarski M, Wössmann W, Zenker M, Zimmermann S, Pfister S, Kratz C
AM J MED GENET A. 2017;173(4):1017-1037.

Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients
Scheijen B, Boer J, Marke R, Tijchon E, van Ingen Schenau D, Waanders E, van Emst L, van der Meer L, Pieters R, Escherich G, Horstmann M, Sonneveld E, Venn N, Sutton R, Dalla-Pozza L, Kuiper R, Hoogerbrugge P, den Boer M, van Leeuwen F
HAEMATOLOGICA. 2017;102(3):541-551.

Minimal methylation classifier (MIMIC): A novel method for derivation and rapid diagnostic detection of disease-associated DNA methylation signatures
Schwalbe E, Hicks D, Rafiee G, Bashton M, Gohlke H, Enshaei A, Potluri S, Matthiesen J, Mather M, Taleongpong P, Chaston R, Silmon A, Curtis A, Lindsey J, Crosier S, Smith A, Goschzik T, Doz F, Rutkowski S, Lannering B, Pietsch T, Bailey S, Williamson D, Clifford S
SCI REP-UK. 2017;7(1):13421.

Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura
Scully M, Knöbl P, Kentouche K, Rice L, Windyga J, Schneppenheim R, Kremer Hovinga J, Kajiwara M, Fujimura Y, Maggiore C, Doralt J, Hibbard C, Martell L, Ewenstein B
BLOOD. 2017;130(19):2055-2063.

MRI-based quantitative susceptibility mapping (QSM) and R2* mapping of liver iron overload Comparison with SQUID-based biomagnetic liver susceptometry
Sharma S, Fischer R, Schoennagel B, Nielsen P, Kooijman H, Yamamura J, Adam G, Bannas P, Hernando D, Reeder S
MAGN RESON MED. 2017;78(1):264-270.

Clinical and Molecular Heterogeneity of RTEL1 Deficiency
Speckmann C, Sahoo S, Rizzi M, Hirabayashi S, Karow A, Serwas N, Hoemberg M, Damatova N, Schindler D, Vannier J, Boulton S, Pannicke U, Göhring G, Thomay K, Verdu-Amoros J, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl S, Niemeyer C, Boztug K, Wlodarski M
FRONT IMMUNOL. 2017;8:449.

Corrigendum: Clinical and Molecular Heterogeneity of RTEL1 Deficiency
Speckmann C, Sahoo S, Rizzi M, Hirabayashi S, Karow A, Serwas N, Hoemberg M, Damatova N, Schindler D, Vannier J, Boulton S, Pannicke U, Göhring G, Thomay K, Verdu-Amoros J, Hauch H, Woessmann W, Escherich G, Laack E, Rindle L, Seidl M, Rensing-Ehl A, Lausch E, Jandrasits C, Strahm B, Schwarz K, Ehl S, Niemeyer C, Boztug K, Wlodarski M
FRONT IMMUNOL. 2017;8:1250.

JAK2 aberrations in childhood B-cell precursor acute lymphoblastic leukemia
Steeghs E, Jerchel I, de Goffau-Nobel W, Hoogkamer A, Boer J, Boeree A, van de Ven C, Koudijs M, Besselink N, de Groot-Kruseman H, Zwaan C, Horstmann M, Pieters R, den Boer M
ONCOTARGET. 2017;8(52):89923-89938.

Outcome in unresectable glioblastoma: MGMT promoter methylation makes the difference
Thon N, Thorsteinsdottir J, Eigenbrod S, Schüller U, Lutz J, Kreth S, Belka C, Tonn J, Niyazi M, Kreth F
J NEUROL. 2017;264(2):350-358.

Short- and Long-term Functional Outcomes and Quality of Life after Radical Prostatectomy: Patient-reported Outcomes from a Tertiary High-volume Center
Tian Z, Preisser F, Tennstedt P, Beyer B, Michl U, Graefen M, Huland H, Karakiewicz P, Tilki D
EUR UROL FOCUS. 2017;3(6):615-620.

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping
Tischer A, Machha V, Frontroth J, Brehm M, Obser T, Schneppenheim R, Mayne L, Walter Englander S, Auton M
J MOL BIOL. 2017;429(14):2161-2177.

Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia
Vesely C, Frech C, Eckert C, Cario G, Mecklenbräuker A, Zur Stadt U, Nebral K, Kraler F, Fischer S, Attarbaschi A, Schuster M, Bock C, Cavé H, von Stackelberg A, Schrappe M, Horstmann M, Mann G, Haas O, Panzer-Grümayer R
LEUKEMIA. 2017;31(7):1491-1501.

K27M midline gliomas display malignant progression by imaging and histology
Vettermann F, Neumann J, Suchorska B, Bartenstein P, Giese A, Dorostkar M, Albert N, Schüller U
NEUROPATH APPL NEURO. 2017;43(5):458-462.

Left atrial active contractile function parameters assessed by cardiac MR are sensitive to myocardial iron
Wehbe M, Yamamura J, Fischer R, Grosse R, Berliner C, Graessner J, Lund G, Adam G, Schoennagel B
J MAGN RESON IMAGING. 2017;45(2):535-541.

Conserved IKAROS-regulated genes associated with B-progenitor acute lymphoblastic leukemia outcome
Witkowski M, Hu Y, Roberts K, Boer J, McKenzie M, Liu G, Le Grice O, Tremblay C, Ghisi M, Willson T, Horstmann M, Aifantis I, Cimmino L, Frietze S, den Boer M, Mullighan C, Smyth G, Dickins R
J EXP MED. 2017;214(3):773-791.

Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study
Wolthers B, Frandsen T, Baruchel A, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grell K, Inaba H, Kovacs G, Liang D, Mateos M, Mondelaers V, Möricke A, Ociepa T, Samarasinghe S, Silverman L, van der Sluis I, Stanulla M, Vrooman L, Yano M, Zapotocka E, Schmiegelow K
LANCET ONCOL. 2017;18(9):1238-1248.

Lineage switch under blinatumomab treatment of relapsed common acute lymphoblastic leukemia without MLL rearrangement
Zoghbi A, Zur Stadt U, Winkler B, Müller I, Escherich G
PEDIATR BLOOD CANCER. 2017;64(11):11.

2016

Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome
Ammann S, Schulz A, Krägeloh-Mann I, Dieckmann N, Niethammer K, Fuchs S, Eckl K, Plank R, Werner R, Altmüller J, Thiele H, Nürnberg P, Bank J, Strauss A, von Bernuth H, Zur Stadt U, Grieve S, Griffiths G, Lehmberg K, Hennies H, Ehl S
BLOOD. 2016;127(8):997-1006.

Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report
Arnhold V, Oyen F, Schneppenheim R, Haberl H, Koch A, Frühwald M, Hernáiz Driever P
CHILD NERV SYST. 2016;32(6):1157-61.

Improved 6-year overall survival in AT/RT - results of the registry study Rhabdoid 2007
Bartelheim K, Nemes K, Seeringer A, Kerl K, Buechner J, Boos J, Graf N, Dürken M, Gerss J, Hasselblatt M, Kortmann R, Teichert von Luettichau I, Nagel I, Nygaard R, Oyen F, Quiroga E, Schlegel P, Schmid I, Schneppenheim R, Siebert R, Solano-Paez P, Timmermann B, Warmuth-Metz M, Frühwald M
CANCER MED-US. 2016;5(8):1765-75.

Analysis of a cohort of 101 CDAII patients: description of 24 new molecular variants and genotype-phenotype correlations
Bianchi P, Schwarz K, Högel J, Fermo E, Vercellati C, Grosse R, van Wijk R, van Zwieten R, Barcellini W, Zanella A, Heimpel H
BRIT J HAEMATOL. 2016;175(4):696-704.

Unterarmgangrän bei "normaler" Gerinnung.
Blohm M, Lehmberg K, Schrum J, Helmke K, Ridderbusch I, Schneppenheim R, Singer D
Z GEBURTSH NEONATOL. 2016;220:133-134.

Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study
Boer J, van der Veer A, Rizopoulos D, Fiocco M, Sonneveld E, de Groot-Kruseman H, Kuiper R, Hoogerbrugge P, Horstmann M, Zaliova M, Palmi C, Trka J, Fronkova E, Emerenciano M, do Socorro Pombo-de-Oliveira M, Mlynarski W, Szczepanski T, Nebral K, Attarbaschi A, Venn N, Sutton R, Schwab C, Enshaei A, Vora A, Stanulla M, Schrappe M, Cazzaniga G, Conter V, Zimmermann M, Moorman A, Pieters R, den Boer M
LEUKEMIA. 2016;30(1):32-8.

Feasibility of CD3/CD19 depletion of a bone marrow graft
Bonig H, Müller I
CYTOTHERAPY. 2016;18(10):1345-7.

Treatment and outcome of Ganglioneuroma and Ganglioneuroblastoma intermixed
Decarolis B, Simon T, Krug B, Leuschner I, Vokuhl C, Kaatsch P, von Schweinitz D, Klingebiel T, Müller I, Schweigerer L, Berthold F, Hero B
BMC CANCER. 2016;16:542.

MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties
Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S, von Bueren A, Krauss J, Schweitzer T, Vince G, Picard D, Eyrich M, Rosenwald A, Ramaswamy V, Taylor M, Remke M, Monoranu C, Beilhack A, Schlegel P, Wölfl M
BMC CANCER. 2016;16(1):115.

Ferritin as an early marker of graft rejection after allogeneic hematopoietic stem cell transplantation in pediatric patients
Döring M, Cabanillas Stanchi K, Feucht J, Queudeville M, Teltschik H, Lang P, Feuchtinger T, Handgretinger R, Müller I
ANN HEMATOL. 2016;95(2):311-23.

Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol
Driessen E, de Lorenzo P, Campbell M, Felice M, Ferster A, Hann I, Vora A, Hovi L, Escherich G, Li C, Mann G, Leblanc T, Locatelli F, Biondi A, Rubnitz J, Schrappe M, Silverman L, Stary J, Suppiah R, Szczepanski T, Valsecchi M, Pieters R
LEUKEMIA. 2016;30(5):1184-1187.

Incidence and Risk Factors for Developing Dengue-Associated Hemophagocytic Lymphohistiocytosis in Puerto Rico, 2008 - 2013
Ellis E, Sharp T, Pérez-Padilla J, González L, Poole-Smith B, Lebo E, Baker C, Delorey M, Torres-Velasquez B, Ochoa E, Rivera-Garcia B, Díaz-Pinto H, Clavell L, Puig-Ramos A, Janka G, Janka-Schaub G, Tomashek K
PLOS NEGLECT TROP D. 2016;10(8):e0004939.

Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium
Engel N, Neumann J, Ahlfeld J, Wefers A, Merk D, Ohli J, Schüller U
PLOS ONE. 2016;11(11):e0166690.

Complementarity determining region-independent recognition of a superantigen by B-cell antigen receptors of mantle cell lymphoma
Fichtner M, Spies E, Seismann H, Riecken K, Engels N, Gösch B, Dierlamm J, Gerull H, Nollau P, Klapper W, Dreyling M, Binder M, Trepel M
HAEMATOLOGICA. 2016;101(9):e378-81.

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
Fielitz K, Althoff K, De Preter K, Nonnekens J, Ohli J, Elges S, Hartmann W, Klöppel G, Knösel T, Schulte M, Klein-Hitpass L, Beisser D, Reis H, Eyking A, Cario E, Schulte J, Schramm A, Schüller U
ONCOTARGET. 2016;7(46):74415-74426.

Pubertal Development in Pediatric Kidney Transplant Patients Receiving Mammalian Target of Rapamycin Inhibitors or Conventional Immunosuppression
Förster J, Ahlenstiel-Grunow T, Zapf A, Mynarek M, Pape L
TRANSPLANTATION. 2016;100(11):2461-2470.

Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma
Friedrich C, von Bueren A, Kolevatova L, Bernreuther C, Grob T, Sepulveda-Falla D, van den Boom L, Westphal M, Simon R, Glatzel M
CHILD NERV SYST. 2016;32(2):281-90.

Evidence of H3 K27M mutations in posterior fossa ependymomas
Gessi M, Capper D, Sahm F, Huang K, von Deimling A, Tippelt S, Fleischhack G, Scherbaum D, Alfer J, Juhnke B, von Hoff K, Rutkowski S, Warmuth-Metz M, Chavez L, Pfister S, Pietsch T, Jones D, Sturm D
ACTA NEUROPATHOL. 2016;132(4):635-7.

Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation
Greil J, Verga-Falzacappa M, Echner N, Behnisch W, Bandapalli O, Pechanska P, Immenschuh S, Vijayan V, Balla J, Tsukahara H, Schneider M, Janka-Schaub G, Claus M, Longerich T, Muckenthaler M, Kulozik A
HAEMATOLOGICA. 2016;101(11):e436-e439.

Long-term Outcome of Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Juvenile Metachromatic Leukodystrophy Compared With Nontransplanted Control Patients
Groeschel S, Kühl J, Bley A, Kehrer C, Weschke B, Döring M, Böhringer J, Schrum J, Santer R, Kohlschütter A, Krägeloh-Mann I, Müller I
JAMA NEUROL. 2016;73(9):1133-40.

The Prevalence of Sickle Cell Disease and Its Implication for Newborn Screening in Germany (Hamburg Metropolitan Area)
Grosse R, Lukacs Z, Cobos P, Oyen F, Ehmen C, Muntau B, Timmann C, Noack B
PEDIATR BLOOD CANCER. 2016;63(1):168-70.

The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis
Hartz B, Marsh R, Rao K, Henter J, Jordan M, Filipovich L, Bader P, Beier R, Burkhardt B, Meisel R, Schulz A, Winkler B, Albert M, Greil J, Karasu G, Woessmann W, Corbaciologlu S, Gruhn B, Holter W, Kühl J, Lang P, Seidel M, Veys P, Löfstedt A, Ammann S, Ehl S, Janka G, Müller I, Lehmberg K
BLOOD. 2016;127(25):3281-90.

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis
Hasselblatt M, Thomas C, Hovestadt V, Schrimpf D, Johann P, Bens S, Oyen F, Peetz-Dienhart S, Crede Y, Wefers A, Vogel H, Riemenschneider M, Antonelli M, Giangaspero F, Bernardo M, Giannini C, Ud Din N, Perry A, Keyvani K, van Landeghem F, Sumerauer D, Hauser P, Capper D, Korshunov A, Jones D, Pfister S, Schneppenheim R, Siebert R, Frühwald M, Kool M
ACTA NEUROPATHOL. 2016;132(1):149-51.

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes
Johann P, Erkek S, Zapatka M, Kerl K, Buchhalter I, Hovestadt V, Jones D, Sturm D, Hermann C, Segura Wang M, Korshunov A, Rhyzova M, Gröbner S, Brabetz S, Chavez L, Bens S, Gröschel S, Kratochwil F, Wittmann A, Sieber L, Geörg C, Wolf S, Beck K, Oyen F, Capper D, van Sluis P, Volckmann R, Koster J, Versteeg R, von Deimling A, Milde T, Witt O, Kulozik A, Ebinger M, Shalaby T, Grotzer M, Sumerauer D, Zamecnik J, Mora J, Jabado N, Taylor M, Huang A, Aronica E, Bertoni A, Radlwimmer B, Pietsch T, Schüller U, Schneppenheim R, Northcott P, Korbel J, Siebert R, Frühwald M, Lichter P, Eils R, Gajjar A, Hasselblatt M, Pfister S, Kool M
CANCER CELL. 2016;29(3):379-93.

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
Kaufman C, Mosimann C, Fan Z, Yang S, Thomas A, Ablain J, Tan J, Fogley R, van Rooijen E, Hagedorn E, Ciarlo C, White R, Matos D, Puller A, Santoriello C, Liao E, Young R, Zon L
SCIENCE. 2016;351(6272):aad2197.

Rapid Diagnosis of an AT/RT by the Detection of a Heterozygous SMARCB1 Germ Line Deletion in an Infant
Kerl K, Oyen F, Giannikopoulou D, Rössig C, Rellensmann G, Sandkötter J, Brentrup A, Selzer G, Schneppenheim R, Frühwald M
PEDIATR BLOOD CANCER. 2016;63(8):1451-3.

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis
Kirschbaum K, Sonner J, Zeller M, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler M, Wick W, Tews B, Chen J, Heiland S, Bendszus M, Platten M, Breckwoldt M
P NATL ACAD SCI USA. 2016;113(46):13227-13232.

Allergic-like reactions to asparaginase: Atypical allergies without asparaginase inactivation
Kloos R, Pieters R, Escherich G, van der Sluis I
PEDIATR BLOOD CANCER. 2016;63(11):1928-34.

Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream
Langenfurth A, Gu S, Bautze V, Zhang C, Neumann J, Schüller U, Stock K, Wolf S, Maier A, Mastrella G, Pak A, Cheng H, Kälin R, Holmbeck K, Strotmann J, Kettenmann H, Glass R
SCI REP-UK. 2016;6:32203.

von Willebrand factor is dimerized by protein disulfide isomerase
Lippok S, Kolšek K, Löf A, Eggert D, Vanderlinden W, Müller J, König G, Obser T, Röhrs K, Schneppenheim S, Budde U, Baldauf C, Aponte-Santamaría C, Gräter F, Schneppenheim R, Rädler J, Brehm M
BLOOD. 2016;127(9):1183-91.

Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers
Lippok S, Radtke M, Obser T, Kleemeier L, Schneppenheim R, Budde U, Netz R, Rädler J
BIOPHYS J. 2016;110(3):545-54.

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
Li Y, Buijs-Gladdines J, Canté-Barrett K, Stubbs A, Vroegindeweij E, Smits W, van Marion R, Dinjens W, Horstmann M, Kuiper R, Buijsman R, Zaman G, van der Spek P, Pieters R, Meijerink J
PLOS MED. 2016;13(12):e1002200.

COBL is a novel hotspot for IKZF1 deletions in childhood acute lymphoblastic leukemia
Lopes B, Meyer C, Barbosa T, Stadt U, Horstmann M, Venn N, Heatley S, White D, Sutton R, Pombo-de-Oliveira M, Marschalek R, Emerenciano M
ONCOTARGET. 2016;7(33):53064-53073.

Your critical care patient may have HLH (hemophagocytic lymphohistiocytosis)
Machowicz R, Janka-Schaub G, Wiktor-Jedrzejczak W
CRIT CARE. 2016;20(1):215.

Childhood medulloblastoma
Massimino M, Biassoni V, Gandola L, Garrè M, Gatta G, Giangaspero F, Poggi G, Rutkowski S
CRIT REV ONCOL HEMAT. 2016;105:35-51.

Treosulfan based conditioning for allogeneic HSCT in children with chronic granulomatous disease: a multicentre experience
Morillo-Gutierrez B, Beier R, Rao K, Burroughs L, Schulz A, Ewins A, Gibson B, Sedlacek P, Krol L, Strahm B, Zaidman I, Kalwak K, Talano J, Woolfrey A, Fraser C, Meyts I, Müller I, Wachowiak J, Bernardo M, Veys P, Sykora K, Gennery A, Slatter M
BLOOD. 2016;128(3):440-8.

pH-Dependent Interactions in Dimers Govern the Mechanics and Structure of von Willebrand Factor
Müller J, Löf A, Mielke S, Obser T, Bruetzel L, Vanderlinden W, Lipfert J, Schneppenheim R, Benoit M
BIOPHYS J. 2016;111(2):312-22.

Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction
Müller J, Mielke S, Löf A, Obser T, Beer C, Bruetzel L, Pippig D, Vanderlinden W, Lipfert J, Schneppenheim R, Benoit M
P NATL ACAD SCI USA. 2016;113(5):1208-13.

Von Willebrand factor regulates complement on endothelial cells
Noone D, Riedl M, Pluthero F, Bowman M, Liszewski M, Lu L, Quan Y, Balgobin S, Schneppenheim R, Schneppenheim S, Budde U, James P, Atkinson J, Palaniyar N, Kahr W, Licht C
KIDNEY INT. 2016;90(1):123-34.

Identification and characterization of the elusive mutation causing the historical von Willebrand Disease type IIC Miami
Obser T, Ledford-Kraemer M, Oyen F, Brehm M, Denis C, Marschalek R, Montgomery R, Sadler J, Schneppenheim S, Budde U, Schneppenheim R
J THROMB HAEMOST. 2016;14(9):1725-35.

Intraventricular etoposide safety and toxicity profile in children and young adults with refractory or recurrent malignant brain tumors
Pajtler K, Tippelt S, Siegler N, Reichling S, Zimmermann M, Mikasch R, Bode U, Gnekow A, Pietsch T, Benesch M, Rutkowski S, Fleischhack G
J NEURO-ONCOL. 2016;128(3):463-71.

Reply to letter that comments on 'Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy'
Pompe R, von Bueren A, Mynarek M, von Hoff K, Rutkowski S
EUR J CANCER. 2016;56:181-2.

Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor
Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm M, Gruber H, Netz R, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P
DATA BRIEF. 2016;8:1080-7.

Risk assessment of relapse by lineage-specific monitoring of chimerism in children undergoing allogeneic stem cell transplantation for acute lymphoblastic leukemia
Preuner S, Peters C, Pötschger U, Daxberger H, Fritsch G, Geyeregger R, Schrauder A, von Stackelberg A, Schrappe M, Bader P, Ebell W, Eckert C, Lang P, Sykora K, Schrum J, Kremens B, Ehlert K, Albert M, Meisel R, Lawitschka A, Mann G, Panzer-Grümayer R, Güngör T, Holter W, Strahm B, Gruhn B, Schulz A, Woessmann W, Lion T
HAEMATOLOGICA. 2016;101(6):741-6.

Improved nutrition in adolescents and young adults after childhood cancer - INAYA study
Quidde J, von Grundherr J, Koch B, Bokemeyer C, Escherich G, Valentini L, Buchholz D, Schilling G, Stein A
BMC CANCER. 2016;16(1):872.

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis
Ramaswamy V, Hielscher T, Mack S, Lassaletta A, Lin T, Pajtler K, Jones D, Luu B, Cavalli F, Aldape K, Remke M, Mynarek M, Rutkowski S, Gururangan S, McLendon R, Lipp E, Dunham C, Hukin J, Eisenstat D, Fulton D, van Landeghem F, Santi M, van Veelen M, Van Meir E, Osuka S, Fan X, Muraszko K, Tirapelli D, Oba-Shinjo S, Marie S, Carlotti C, Lee J, Rao A, Giannini C, Faria C, Nunes S, Mora J, Hamilton R, Hauser P, Jabado N, Petrecca K, Jung S, Massimi L, Zollo M, Cinalli G, Bognár L, Klekner A, Hortobágyi T, Leary S, Ermoian R, Olson J, Leonard J, Gardner C, Grajkowska W, Chambless L, Cain J, Eberhart C, Ahsan S, Massimino M, Giangaspero F, Buttarelli F, Packer R, Emery L, Yong W, Soto H, Liau L, Everson R, Grossbach A, Shalaby T, Grotzer M, Karajannis M, Zagzag D, Wheeler H, von Hoff K, Alonso M, Tuñon T, Schüller U, Zitterbart K, Sterba J, Chan J, Guzman M, Elbabaa S, Colman H, Dhall G, Fisher P, Fouladi M, Gajjar A, Goldman S, Hwang E, Kool M, Ladha H, Vera-Bolanos E, Wani K, Lieberman F, Mikkelsen T, Omuro A, Pollack I, Prados M, Robins H, Soffietti R, Wu J, Metellus P, Tabori U, Bartels U, Bouffet E, Hawkins C, Rutka J, Dirks P, Pfister S, Merchant T, Gilbert M, Armstrong T, Korshunov A, Ellison D, Taylor M
J CLIN ONCOL. 2016;34(21):2468-77.

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford S, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott P, Gajjar A, Robinson G, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister S, Taylor M, Pomeroy S
ACTA NEUROPATHOL. 2016;131(6):821-31.

Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice
Rapp A, Bindl R, Recknagel S, Erbacher A, Müller I, Schrezenmeier H, Ehrnthaller C, Gebhard F, Ignatius A
PLOS ONE. 2016;11(2):e0147465.

Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens E, De Benedetti F, Filipovic A, Grom A, Henter J, Ilowite N, Jordan M, Khubchandani R, Kitoh T, Lehmberg K, Lovell D, Miettunen P, Nichols K, Ozen S, Pachlopnik Schmid J, Ramanan A, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron R
BMJ OPEN. 2016;2(1):e000161.

2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative
Ravelli A, Minoia F, Davì S, Horne A, Bovis F, Pistorio A, Aricò M, Avcin T, Behrens E, De Benedetti F, Filipovic L, Grom A, Henter J, Ilowite N, Jordan M, Khubchandani R, Kitoh T, Lehmberg K, Lovell D, Miettunen P, Nichols K, Ozen S, Pachlopnik Schmid J, Ramanan A, Russo R, Schneider R, Sterba G, Uziel Y, Wallace C, Wouters C, Wulffraat N, Demirkaya E, Brunner H, Martini A, Ruperto N, Cron R
ANN RHEUM DIS. 2016;75(3):481-9.

Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study
Sabel M, Fleischhack G, Tippelt S, Gustafsson G, Doz F, Kortmann R, Massimino M, Navajas A, von Hoff K, Rutkowski S, Warmuth-Metz M, Clifford S, Pietsch T, Pizer B, Lannering B
J NEURO-ONCOL. 2016;129(3):515-24.

Musculoskeletal manifestations in mucopolysaccharidosis type I (Hurler syndrome) following hematopoietic stem cell transplantation
Schmidt M, Breyer S, Löbel U, Yarar S, Stücker R, Ullrich K, Müller I, Muschol N
ORPHANET J RARE DIS. 2016;11(1):93.

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia Treatment: a Delphi consensus
Schmiegelow K, Attarbaschi A, Barzilai S, Escherich G, Frandsen T, Halsey C, Hough R, Jeha S, Kato M, Liang D, Mikkelsen T, Möricke A, Niinimäki R, Piette C, Putti M, Raetz E, Silverman L, Skinner R, Tuckuviene R, van der Sluis I, Zapotocka E
LANCET ONCOL. 2016;17(6):e231-9.

Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature
Schrey D, Lechón F, Malietzis G, Moreno L, Dufour C, Chi S, Lafay-Cousin L, von Hoff K, Athanasiou T, Marshall L, Zacharoulis S
J NEURO-ONCOL. 2016;126(1):81-90.

Rapid Capture Next-Generation Sequencing in Clinical Diagnostics of Kinase Pathway Aberrations in B-Cell Precursor ALL
Stadt U, Escherich G, Indenbirken D, Alawi M, Adao M, Horstmann M
PEDIATR BLOOD CANCER. 2016;63(7):1283-6.

Molecular Analysis of Hybrid Neurofibroma/Schwannoma Identifies Common Monosomy 22 and α-T-Catenin/CTNNA3 as a Novel Candidate Tumor Suppressor
Stahn V, Nagel I, Fischer-Huchzermeyer S, Oyen F, Schneppenheim R, Gesk S, Bohring A, Chikobava L, Young P, Gess B, Werner M, Senner V, Harder A
AM J PATHOL. 2016;186(12):3285-3296.

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Sturm D, Orr B, Toprak U, Hovestadt V, Jones D, Capper D, Sill M, Buchhalter I, Northcott P, Leis I, Ryzhova M, Koelsche C, Pfaff E, Allen S, Balasubramanian G, Worst B, Pajtler K, Brabetz S, Johann P, Sahm F, Reimand J, Mackay A, Carvalho D, Remke M, Phillips J, Perry A, Cowdrey C, Drissi R, Fouladi M, Giangaspero F, Łastowska M, Grajkowska W, Scheurlen W, Pietsch T, Hagel C, Gojo J, Lötsch D, Berger W, Slavc I, Haberler C, Jouvet A, Holm S, Hofer S, Prinz M, Keohane C, Fried I, Mawrin C, Scheie D, Mobley B, Schniederjan M, Santi M, Buccoliero A, Dahiya S, Kramm C, von Bueren A, von Hoff K, Rutkowski S, Herold-Mende C, Frühwald M, Milde T, Hasselblatt M, Wesseling P, Rößler J, Schüller U, Ebinger M, Schittenhelm J, Frank S, Grobholz R, Vajtai I, Hans V, Schneppenheim R, Zitterbart K, Collins V, Aronica E, Varlet P, Puget S, Dufour C, Grill J, Figarella-Branger D, Wolter M, Schuhmann M, Shalaby T, Grotzer M, van Meter T, Monoranu C, Felsberg J, Reifenberger G, Snuderl M, Forrester L, Koster J, Versteeg R, Volckmann R, van Sluis P, Wolf S, Mikkelsen T, Gajjar A, Aldape K, Moore A, Taylor M, Jones C, Jabado N, Karajannis M, Eils R, Schlesner M, Lichter P, von Deimling A, Pfister S, Ellison D, Korshunov A, Kool M
CELL. 2016;164(5):1060-72.

Treatment of graft failure with TNI-based reconditioning and haploidentical stem cells in paediatric patients
Teltschik H, Heinzelmann F, Gruhn B, Feuchtinger T, Schlegel P, Schumm M, Kremens B, Müller I, Ebinger M, Schwarze C, Ottinger H, Zips D, Handgretinger R, Lang P
BRIT J HAEMATOL. 2016;175(1):115-22.

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups
Thomas C, Sill M, Ruland V, Witten A, Hartung S, Kordes U, Jeibmann A, Beschorner R, Keyvani K, Bergmann M, Mittelbronn M, Pietsch T, Felsberg J, Monoranu C, Varlet P, Hauser P, Olar A, Grundy R, Wolff J, Korshunov A, Jones D, Bewerunge-Hudler M, Hovestadt V, von Deimling A, Pfister S, Paulus W, Capper D, Hasselblatt M
NEURO-ONCOLOGY. 2016;18(6):790-6.

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Torchia J, Golbourn B, Feng S, Ho K, Sin-Chan P, Vasiljevic A, Norman J, Guilhamon P, Garzia L, Agamez N, Lu M, Chan T, Picard D, de Antonellis P, Khuong-Quang D, Planello A, Zeller C, Barsyte-Lovejoy D, Lafay-Cousin L, Letourneau L, Bourgey M, Yu M, Gendoo D, Dzamba M, Barszczyk M, Medina T, Riemenschneider A, Morrissy A, Ra Y, Ramaswamy V, Remke M, Dunham C, Yip S, Ng H, Lu J, Mehta V, Albrecht S, Pimentel J, Chan J, Somers G, Faria C, Roque L, Fouladi M, Hoffman L, Moore A, Wang Y, Choi S, Hansford J, Catchpoole D, Birks D, Foreman N, Strother D, Klekner A, Bognár L, Garami M, Hauser P, Hortobágyi T, Wilson B, Hukin J, Carret A, Van Meter T, Hwang E, Gajjar A, Chiou S, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat D, Scheinemann K, Fleming A, Johnston D, Michaud J, Zelcer S, Hammond R, Afzal S, Ramsay D, Sirachainan N, Hongeng S, Larbcharoensub N, Grundy R, Lulla R, Fangusaro J, Druker H, Bartels U, Grant R, Malkin D, McGlade C, Nicolaides T, Tihan T, Phillips J, Majewski J, Montpetit A, Bourque G, Bader G, Reddy A, Gillespie G, Warmuth-Metz M, Rutkowski S, Tabori U, Lupien M, Brudno M, Schüller U, Pietsch T, Judkins A, Hawkins C, Bouffet E, Kim S, Dirks P, Taylor M, Erdreich-Epstein A, Arrowsmith C, De Carvalho D, Rutka J, Jabado N, Huang A
CANCER CELL. 2016;30(6):891-908.

EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis
Usemann J, Ernst T, Schäfer V, Lehmberg K, Seeger K
AM J MED GENET A. 2016;170(5):1274-7.

Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation
van der Sluis I, Vrooman L, Pieters R, Baruchel A, Escherich G, Goulden N, Mondelaers V, de Toledo J, Rizzari C, Silverman L, Whitlock J
HAEMATOLOGICA. 2016;101(3):279-85.

Small cell undifferentiated (SCUD) hepatoblastomas: All malignant rhabdoid tumors?
Vokuhl C, Oyen F, Häberle B, von Schweinitz D, Schneppenheim R, Leuschner I
GENE CHROMOSOME CANC. 2016;55(12):925-931.

Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters
von Bueren A, Kortmann R, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S
J CLIN ONCOL. 2016;34(34):4151-4160.

Influence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy
Vora A, Andreano A, Pui C, Hunger S, Schrappe M, Moericke A, Biondi A, Escherich G, Silverman L, Goulden N, Taskinen M, Pieters R, Horibe K, Devidas M, Locatelli F, Valsecchi M
J CLIN ONCOL. 2016;34(9):919-26.

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia
Wojtuszkiewicz A, Assaraf Y, Hoekstra M, Sciarrillo R, Jansen G, Peters G, Pieters R, Sonneveld E, Escherich G, Kaspers G, Cloos J
HAEMATOLOGICA. 2016;101(7):e291-4.

2015

Force-sensitive autoinhibition of the von Willebrand factor is mediated by interdomain interactions
Aponte-Santamaria C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Grater F
BIOPHYS J. 2015;108(9):2312-21.

Force-sensitive autoinhibition of the von Willebrand factor mediated by inter-domain interactions
Aponte-Santamaría C, Huck V, Posch S, Bronowska A, Grässle S, Brehm M, Obser T, Schneppenheim R, Hinterdorfer P, Schneider S, Baldauf C, Gräter F
BIOPHYS J. 2015;108(9):2312-21.

Monitoring of Minimal Residual Disease After Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia Allows for the Identification of Impending Relapse: Results of the ALL-BFM-SCT 2003 Trial
Bader P, Kreyenberg H, von Stackelberg A, Eckert C, Salzmann-Manrique E, Meisel R, Poetschger U, Stachel D, Schrappe M, Alten J, Schrauder A, Schulz A, Lang P, Müller I, Albert M, Willasch A, Klingebiel T, Peters C
J CLIN ONCOL. 2015;33(11):1275 - 84.

Radiation therapy for choroid plexus carcinoma patients with Li-Fraumeni Syndrome: advantageous or detrimental?
Bahar M, Kordes U, Tekautz T, Wolff J
ANTICANCER RES. 2015;35(5):3013-3017.

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice
Baldauf C, Jeschke A, Kanbach V, Catala-Lehnen P, Baumhoer D, Gerull H, Buhs S, Amling M, Nollau P, Harroch S, Schinke T
PLOS ONE. 2015;10(9):e0137745.

Bestimmung des hypophysären Eisengehaltes mittels Multi-Echo-MRT-R2 Messungen
Berliner C, Brehmer M, Fischer R, Grosse R, Karul M, Keller S, Schönnagel B, Wang J, Adam G, Yamamura J
ROFO-FORTSCHR RONTG. 2015;187(S 01):WISS105_1.

The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis
Bode S, Ammann S, Al-Herz W, Bataneant M, Dvorak C, Gehring S, Gennery A, Gilmour K, Gonzalez-Granado L, Groß-Wieltsch U, Ifversen M, Lingman-Framme J, Matthes-Martin S, Mesters R, Meyts I, van Montfrans J, Pachlopnik Schmid J, Pai S, Soler-Palacin P, Schuermann U, Schuster V, Seidel M, Speckmann C, Stepensky P, Sykora K, Tesi B, Vraetz T, Waruiru C, Bryceson Y, Moshous D, Lehmberg K, Jordan M, Ehl S
HAEMATOLOGICA. 2015;100(7):978-88.

Platelet dependent von Willebrand factor activity. Nomenclature and methodology: communication from the SSC of the ISTH
Bodó I, Eikenboom J, Montgomery R, Patzke J, Schneppenheim R, Di Paola J
J THROMB HAEMOST. 2015;13(7):1345-1350.

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures
Boer J, Marchante J, Evans W, Horstmann M, Escherich G, Pieters R, Den Boer M
HAEMATOLOGICA. 2015;100(9):e354-7.

Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy
Câmara-Costa H, Resch A, Kieffer V, Lalande C, Poggi G, Kennedy C, Bull K, Calaminus G, Grill J, Doz F, Rutkowski S, Massimino M, Kortmann R, Lannering B, Dellatolas G, Chevignard M
INT J RADIAT ONCOL. 2015;92(5):978-85.

Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia
Chao M, Ebell W, Bader P, Beier R, Burkhardt B, Feuchtinger T, Handgretinger R, Hanenberg H, Koehl U, Kratz C, Kremens B, Lang P, Meisel R, Müller I, Roessig C, Sauer M, Schlegel P, Schulz A, Strahm B, Thol F, Sykora K
KLIN PADIATR. 2015;227(3):157-65.

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial
Clifford S, Lannering B, Schwalbe E, Hicks D, O'Toole K, Nicholson S, Goschzik T, Zur Mühlen A, Figarella-Branger D, Doz F, Rutkowski S, Gustafsson G, Pietsch T
ONCOTARGET. 2015;6(36):38827-39.

A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression
Dadras S, Lin R, Razavi G, Kawakami A, Du J, Feige E, Milner D, Loda M, Granter S, Detmar M, Widlund H, Horstmann M, Fisher D
AM J PATHOL. 2015;185(1):252-65.

Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation
Döring M, Cabanillas Stanchi K, Mezger M, Erbacher A, Feucht J, Pfeiffer M, Lang P, Handgretinger R, Müller I
BMC CANCER. 2015;15:Art. 607.

Antifungal prophylaxis with posaconazole vs. fluconazole or itraconazole in pediatric patients with neutropenia
Döring M, Eikemeier M, Cabanillas Stanchi K, Hartmann U, Ebinger M, Schwarze C, Schulz A, Handgretinger R, Müller I
EUR J CLIN MICROBIOL. 2015;34(6):1189-1200.

A Case of a Bilateral Cicatricial Upper Eyelid Entropion After Hematopoietic Stem Cell Transplantation in Mucopolysaccharidosis Type I
Dulz S, Wagenfeld L, Richard G, Schrum J, Muschol N, Keserü M
OPHTHAL PLAST RECONS. 2015.

Monitoring minimal residual disease in children with high-risk relapses of acute lymphoblastic leukemia: Prognostic relevance of early and late assessment
Eckert C, Hagedorn N, Sramkova L, Mann G, Panzer-Grümayer R, Peters C, Bourquin J, Klingebiel T, Borkhardt A, Cario G, Alten J, Escherich G, Astrahantseff K, Seeger K, Henze G, von Stackelberg A
LEUKEMIA. 2015;29(8):1648-1655.

Novel Patient with Late-Onset Familial Hemophagocytic Lymphohistiocytosis with STXBP2 Mutations Presenting with Autoimmune Hepatitis, Neurological Manifestations and Infections Associated with Hypogammaglobulinemia
Esmaeilzadeh H, Bemanian M, Nabavi M, Arshi S, Fallahpour M, Fuchs I, Zur Stadt U, Warnatz K, Ammann S, Ehl S, Lehmberg K, Rezaei N
J CLIN IMMUNOL. 2015;35(1):22-25.

Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT Trials: clinical findings of a rare disease
Friedrich C, Warmuth-Metz M, von Bueren A, Nowak J, Bison B, von Hoff K, Pietsch T, Kortmann R, Rutkowski S
J NEUROSURG-PEDIATR. 2015;15(3):227-35.

Molecular stratification of medulloblastoma: Comparison of histological and genetic methods to detect Wnt activated tumors
Goschzik T, Zur Mühlen A, Kristiansen G, Haberler C, Stefanits H, Friedrich C, von Hoff K, Rutkowski S, Pfister S, Pietsch T
NEUROPATH APPL NEURO. 2015;41(2):135-144.

Late-onset hemophagocytic lymphohistiocytosis (HLH) in an adult female with Griscelli syndrome type 2 (GS2)
Henkes M, Finke J, Warnatz K, Ammann S, Stadt U, Janka-Schaub G, Brugger W
ANN HEMATOL. 2015;94(6):1057-60.

High-resolution genomic analysis does not qualify atypical plexus papilloma as a separate entity among choroid plexus tumors
Japp A, Gessi M, Messing-Jünger M, Denkhaus D, Zur Mühlen A, Wolff J, Hartung S, Kordes U, Klein-Hitpass L, Pietsch T
J NEUROPATH EXP NEUR. 2015;74(2):110-20.

Multipotent Mesenchymal Stromal Cells: Possible Culprits in Solid Tumors?
Johann P, Müller I
Stem Cells Int. 2015;2015:914632.

Generation of high-titre virus stocks using BrK.219, a B-cell line infected stably with recombinant Kaposi's sarcoma-associated herpesvirus
Kati S, Hage E, Mynarek M, Ganzenmueller T, Indenbirken D, Grundhoff A, Schulz T
J VIROL METHODS. 2015;217:79-86.

Detection of SMARCB1 loss in ascites cells in the diagnosis of an abdominal rhabdoid tumor
Kerl K, Oyen F, Leuschner I, Schneppenheim R, Nagel I, Siebert R, Groll A, Hartmann W, Barth P, Bartelheim K, Seringer A, Wardelmann E, Frühwald M
PEDIATR BLOOD CANCER. 2015;62(5):897-900.

Risk of Rotavirus Vaccination for Children with SCID
Klinkenberg D, Blohm M, Hoehne M, Mas Marques A, Malecki M, Schildgen V, Schneppenheim R, Müller I, Schildgen O, Kobbe R
PEDIATR INFECT DIS J. 2015;34(1):114-5.

Donor choice in haploidentical stem cell transplantation: fetal microchimerism is associated with better outcome in pediatric leukemia patients
Kruchen A, Stahl T, Gieseke F, Binder T, Özcan Z, Meisel R, Kreyenberg H, Bader P, Gruhn B, Greil J, Pfeiffer M, Döring M, Handgretinger R, Fehse B, Müller I
BONE MARROW TRANSPL. 2015;50(10):1367-1370.

GRP78 knockdown does not affect cytotoxicity of cisplatin in ovarian cancer cells
Kullmann M, Kotz S, Hellwig M, Kalayda G, Metzger S, Jaehde U
INT J CLIN PHARM TH. 2015;53(12):1038-40.

Out of the haemophagocytic lymphohistiocytosis niche
Lehmberg K
LANCET HAEMATOL. 2015;2(12):e508-9.

Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies
Lehmberg K, Nichols K, Henter J, Girschikofsky M, Greenwood T, Jordan M, Kumar A, Minkov M, La Rosée P, Weitzman S
HAEMATOLOGICA. 2015;100(8):997-1004.

Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents
Lehmberg K, Sprekels B, Nichols K, Woessmann W, Müller I, Suttorp M, Bernig T, Beutel K, Bode S, Kentouche K, Kolb R, Längler A, Minkov M, Schilling F, Schmid I, Vieth S, Ehl S, Zur Stadt U, Janka G
BRIT J HAEMATOL. 2015;170(4):539-49.

Clinical and Molecular Characterization of Patients with Heterozygous Mutations in Wilms Tumor Suppressor Gene 1
Lehnhardt A, Karnatz N, Ahlenstiel-Grunow T, Benz K, Benz M, Budde K, Büscher A, Fehr T, Feldkötter M, Graf N, Höcker B, Jungraithmayr T, Klaus G, Koehler B, Konrad M, Kranz B, Montoya C, Müller D, Neuhaus T, Oh J, Pape L, Pohl M, Royer-Pokora B, Querfeld U, Schneppenheim R, Staude H, Spartà G, Timmermann K, Wilkening F, Wygoda S, Bergmann C, Kemper M
CLIN J AM SOC NEPHRO. 2015;10(5):825-831.

Severe neurotoxicity following intrathecal methotrexate with nitrous oxide sedation in a child with acute lymphoblastic leukemia
Löbel U, Trah J, Escherich G
PEDIATR BLOOD CANCER. 2015;62(3):539-41.

KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia
Malinowska-Ozdowy K, Frech C, Schönegger A, Eckert C, Cazzaniga G, Stanulla M, Zur Stadt U, Mecklenbräuker A, Schuster M, Kneidinger D, von Stackelberg A, Locatelli F, Schrappe M, Horstmann M, Attarbaschi A, Bock C, Mann G, Haas O, Panzer-Grümayer R
LEUKEMIA. 2015;29(8):1656-1667.

Platelet-type von Willebrand Disease: Diagnostic Challenges. Flaws and Pitfalls Experienced in the THROMKID Quality Project
Maurer M, Mesters R, Schneppenheim R, Knoefler R, Streif W
KLIN PADIATR. 2015;227(3):131-6.

Delayed Diagnosis of Platelet-type von Willebrand Disease in a 72-year-old Lady
Maurer M, Mesters R, Schneppenheim R, Streif W
KLIN PADIATR. 2015;227(3):171-172.

Klinische Praxis - Spenderfindung und Stammzelltransplantation
Müller I
2015. Rettende Geschwister. Schües C, Rehmann-Sutter C (Hrsg.). 2015. Aufl. Münster: Mentis, 25 - 32.

Systematic comparison of MRI findings in pediatric ependymoblastoma with ependymoma and CNS primitive neuroectodermal tumor not otherwise specified
Nowak J, Seidel C, Pietsch T, Alkonyi B, Fuss T, Friedrich C, von Hoff K, Rutkowski S, Warmuth-Metz M
NEURO-ONCOLOGY. 2015;17(8):1157-65.

Localization of SHH medulloblastoma in mice depends on the age at its initiation
Ohli J, Neumann J, Grammel D, Schüller U
ACTA NEUROPATHOL. 2015;130(2):307-9.

Neuropsychological short assessment of disease- and treatment-related intelligence deficits in children with brain tumours
Ottensmeier H, Zimolong B, Wolff J, Ehrich J, Galley N, von Hoff K, Kuehl J, Rutkowski S
EUR J PAEDIATR NEURO. 2015;19(3):298-307.

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
Pajtler K, Witt H, Sill M, Jones D, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz H, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman L, Donson A, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong T, Gupta N, Allen J, Karajannis M, Zagzag D, Hasselblatt M, Kulozik A, Witt O, Collins V, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo M, von Deimling A, Lichter P, Taylor M, Gilbertson R, Ellison D, Aldape K, Korshunov A, Kool M, Pfister S
CANCER CELL. 2015;27(5):728-43.

Stem-cell transplantation in children with acute lymphoblastic leukemia: A prospective international multicenter trial comparing sibling donors with matched unrelated donors-The ALL-SCT-BFM-2003 trial
Peters C, Schrappe M, von Stackelberg A, Schrauder A, Bader P, Ebell W, Lang P, Sykora K, Schrum J, Kremens B, Ehlert K, Albert M, Meisel R, Matthes-Martin S, Gungor T, Holter W, Strahm B, Gruhn B, Schulz A, Woessmann W, Poetschger U, Zimmermann M, Klingebiel T
J CLIN ONCOL. 2015;33(11):1265-74.

Pancreatic iron and fat assessment by MRI-R2* in patients with iron overload diseases
Pfeifer C, Schoennagel B, Grosse R, Wang Z, Graessner J, Nielsen P, Adam G, Fischer R, Yamamura J
J MAGN RESON IMAGING. 2015.

Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy
Pompe R, von Bueren A, Mynarek M, von Hoff K, Friedrich C, Kwiecien R, Treulieb W, Lindow C, Deinlein F, Fleischhack G, Kuehl J, Rutkowski S
EUR J CANCER. 2015;51(17):2634-2642.

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration
Pui C, Yang J, Hunger S, Pieters R, Schrappe M, Biondi A, Vora A, Baruchel A, Silverman L, Schmiegelow K, Escherich G, Horibe K, Benoit Y, Izraeli S, Yeoh A, Liang D, Downing J, Evans W, Relling M, Mullighan C
J CLIN ONCOL. 2015;33(27):2938-48.

Systemic mesenchymal stem cell administration enhances bone formation in fracture repair but not load-induced bone formation
Rapp A, Bindl R, Heilmann A, Erbacher A, Müller I, Brenner R, Ignatius A
EUR CELLS MATER. 2015;29:22-34.

A 2013/2014 northern hemisphere season surface antigen inactivated trivalent influenza vaccine - Assessing the immunogenicity and safety in an open label, uncontrolled study
Roggelin L, Vinnemeier C, Meyer S, Witte K, Marx L, Theeß W, Burchard G, Rolling T, Cramer J
HUM VACC IMMUNOTHER. 2015;11(10):2370-5.

Psychische Belastungen von Kindern und Jugendlichen nach einer Leukämie oder Lymphomerkrankung
Sautier L, Sarkar S, Petersen M, Mehnert A, Escherich G
PRAX KINDERPSYCHOL K. 2015;64(4):273-289.

Identification and Characterization of Novel Variations in Platelet G-Protein Coupled Receptor (GPCR) Genes in Patients Historically Diagnosed with Type 1 von Willebrand Disease
Stockley J, Nisar S, Leo V, Sabi E, Cunningham M, Eikenboom J, Lethagen S, Schneppenheim R, Goodeve A, Watson S, Mundell S, Daly M
PLOS ONE. 2015;10(12):e0143913.

Strategies to improve the quality of survival for childhood brain tumour survivors
Tallen G, Resch A, Calaminus G, Wiener A, Leiss U, Pletschko T, Friedrich C, Langer T, Grabow D, Driever P, Kortmann R, Timmermann B, Pietsch T, Warmuth-Metz M, Bison B, Thomale U, Krauss J, Mynarek M, von Hoff K, Ottensmeier H, Frühwald M, Kramm C, Temming P, Müller H, Witt O, Kordes U, Fleischhack G, Gnekow A, Rutkowski S
EUR J PAEDIATR NEURO. 2015;19(6):619-39.

Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children
Thomas C, Ruland V, Kordes U, Hartung S, Capper D, Pietsch T, Gerß J, Wolff J, Paulus W, Hasselblatt M
ACTA NEUROPATHOL. 2015;129(6):925-7.

Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
Torchia J, Picard D, Lafay-Cousin L, Hawkins C, Kim S, Letourneau L, Ra Y, Ho K, Chan T, Sin-Chan P, Dunham C, Yip S, Ng H, Lu J, Albrecht S, Pimentel J, Chan J, Somers G, Zielenska M, Faria C, Roque L, Baskin B, Birks D, Foreman N, Strother D, Klekner A, Garami M, Hauser P, Hortobágyi T, Bognár L, Wilson B, Hukin J, Carret A, Van Meter T, Nakamura H, Toledano H, Fried I, Fults D, Wataya T, Fryer C, Eisenstat D, Scheineman K, Johnston D, Michaud J, Zelcer S, Hammond R, Ramsay D, Fleming A, Lulla R, Fangusaro J, Sirachainan N, Larbcharoensub N, Hongeng S, Barakzai M, Montpetit A, Stephens D, Grundy R, Schüller U, Nicolaides T, Tihan T, Phillips J, Taylor M, Rutka J, Dirks P, Bader G, Warmuth-Metz M, Rutkowski S, Pietsch T, Judkins A, Jabado N, Bouffet E, Huang A
LANCET ONCOL. 2015;16(5):569-82.

Incidence, Trends, and Survival of Children With Embryonal Tumors
Tulla M, Berthold F, Graf N, Rutkowski S, von Schweinitz D, Spix C, Kaatsch P
PEDIATRICS. 2015;136(3):e623-32.

Metastatic medulloblastoma in adults: outcome of patients treated according to the HIT2000 protocol
von Bueren A, Friedrich C, von Hoff K, Kwiecien R, Müller K, Pietsch T, Warmuth-Metz M, Hau P, Benesch M, Kuehl J, Kortmann R, Rutkowski S
EUR J CANCER. 2015;51(16):2434-43.

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia
Wojtuszkiewicz A, Peters G, van Woerden N, Dubbelman B, Escherich G, Schmiegelow K, Sonneveld E, Pieters R, van de Ven P, Jansen G, Assaraf Y, Kaspers G, Cloos J
HEMATOL ONCOL. 2015;8:61.

Standardization of Good Manufacturing Practice-compliant production of bone marrow-derived human mesenchymal stromal cells for immunotherapeutic applications
Wuchter P, Bieback K, Schrezenmeier H, Bornhäuser M, Müller L, Bönig H, Wagner W, Meisel R, Pavel P, Tonn T, Lang P, Müller I, Renner M, Malcherek G, Saffrich R, Buss E, Horn P, Rojewski M, Schmitt A, Ho A, Sanzenbacher R, Schmitt M
CYTOTHERAPY. 2015;17(2):128-139.

2014

Germline de novo mutations and linkage markers vs. DNA sequencing for carrier detection in von Willebrand disease
Ahmad F, Oyen F, Jan R, Budde U, Schneppenheim R, Saxena R
HAEMOPHILIA. 2014;20(4):e311-e317.

EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion
Ariës I, Jerchel I, van den Dungen R, van den Berk L, Boer J, Horstmann M, Escherich G, Pieters R, den Boer M
LEUKEMIA. 2014;28(9):1828-1837.

Clinical and genetic features of rhabdoid tumors of the heart registered with the European Rhabdoid Registry (EU-RHAB)
Bartelheim K, Sumerauer D, Behrends U, Kodetova D, Kucera F, Leuschner I, Neumayer P, Oyen F, Rübe C, Siebert R, Schneppenheim R, Seeringer A, Vasovcak P, Frühwald M
CANCER GENET-NY. 2014;207(9):379-83.

High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB)
Benesch M, Bartelheim K, Fleischhack G, Gruhn B, Schlegel P, Witt O, Stachel K, Hauch H, Urban C, Quehenberger F, Massimino M, Pietsch T, Hasselblatt M, Giangaspero F, Kordes U, Schneppenheim R, Hauser P, Klingebiel T, Frühwald M
BONE MARROW TRANSPL. 2014;49(3):370-5.

Hemophagocytic lymphohistiocytosis in imported pediatric visceral leishmaniasis in a nonendemic area
Bode S, Bogdan C, Beutel K, Behnisch W, Greiner J, Henning S, Jorch N, Jankofsky M, Jakob M, Schmid I, Veelken N, Vraetz T, Janka G, Ehl S, Lehmberg K
J PEDIATR-US. 2014;165(1):147-153.e1.

Treatment of recurrent primitive neuroectodermal tumors (PNET) in children and adolescents with high-dose chemotherapy (HDC) and stem cell Support: results of the HITREZ 97 multicentre trial
Bode U, Zimmermann M, Moser O, Rutkowski S, Warmuth-Metz M, Pietsch T, Kortmann R, Faldum A, Fleischhack G
J NEURO-ONCOL. 2014;120(3):635-42.

von Willebrand disease type 2A phenotypes IIC, IID and IIE: A day in the life of shear-stressed mutant von Willebrand factor
Brehm M, Huck V, Aponte-Santamaría C, Obser T, Grässle S, Oyen F, Budde U, Schneppenheim S, Baldauf C, Gräter F, Schneider S, Schneppenheim R
THROMB HAEMOSTASIS. 2014;112(1):96-108.

Interactions of von Willebrand factor and ADAMTS13 in von Willebrand disease and thrombotic thrombocytopenic purpura
Budde U, Schneppenheim R
HAMOSTASEOLOGIE. 2014;34(3):215-25.

Acute lymphoblastic leukemia in children with Down Syndrome: a retrospective analysis from the Ponte di Legno study group
Buitenkamp T, Izraeli S, Zimmermann M, Forestier E, Heerema N, van den Heuvel-Eibrink M, Pieters R, Korbijn C, Silverman L, Schmiegelow K, Liang D, Horibe K, Arico M, Biondi A, Basso G, Rabin K, Schrappe M, Cario G, Mann G, Morak M, Panzer-Grümayer R, Mondelaers V, Lammens T, Cavé H, Stark B, Ganmore I, Moorman A, Vora A, Hunger S, Pui C, Mullighan C, Manabe A, Escherich G, Kowalczyk J, Whitlock J, Zwaan C
BLOOD. 2014;123(1):70-77.

Acquired hemophilia A and von Willebrand syndrome in a patient with late-onset systemic lupus erythematosus
Dicke C, Holstein K, Schneppenheim S, Dittmer R, Schneppenheim R, Bokemeyer C, Iking-Konert C, Budde U, Langer F
EXP HEMATOL ONCOL. 2014;3:21.

Adults with CNS primitive neuroectodermal tumors/pineoblastomas: results of multimodal treatment according to the pediatric HIT 2000 protocol
Friedrich C, Müller K, von Hoff K, Kwiecien R, Pietsch T, Warmuth-Metz M, Gerber N, Hau P, Kuehl J, Kortmann R, von Bueren A, Rutkowski S
J NEURO-ONCOL. 2014;116(3):567-575.

LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia
Frietsch J, Kastner C, Grunewald T, Schweigel H, Nollau P, Ziermann J, Clement J, La Rosée P, Hochhaus A, Butt E
ONCOTARGET. 2014;5(14):5257-71.

Identification of novel NOTCH1 mutations: increasing our knowledge of the NOTCH signaling pathway
Gallo Llorente L, Luther H, Schneppenheim R, Zimmermann M, Felice M, Horstmann M
PEDIATR BLOOD CANCER. 2014;61(5):788-96.

Recent developments and current concepts in medulloblastoma
Gerber N, Mynarek M, von Hoff K, Friedrich C, Resch A, Rutkowski S
CANCER TREAT REV. 2014;40(3):356-365.

Treatment of children with central nervous system primitive neuroectodermal tumors/pinealoblastomas in the prospective multicentric trial HIT 2000 using hyperfractionated radiation therapy followed by maintenance chemotherapy
Gerber N, von Hoff K, Resch A, Ottensmeier H, Kwiecien R, Faldum A, Matuschek C, Hornung D, Bremer M, Benesch M, Pietsch T, Warmuth-Metz M, Kuehl J, Rutkowski S, Kortmann R
INT J RADIAT ONCOL. 2014;89(4):863-71.

MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system
Gessi M, von Bueren A, Treszl A, Mühlen A, Hartmann W, Warmuth-Metz M, Rutkowski S, Pietsch T
NEURO-ONCOLOGY. 2014;16(7):924-932.

Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group
Gottardo N, Hansford J, McGlade J, Alvaro F, Ashley D, Bailey S, Baker D, Bourdeaut F, Cho Y, Clay M, Clifford S, Cohn R, Cole C, Dallas P, Downie P, Doz F, Ellison D, Endersby R, Fisher P, Hassall T, Heath J, Hii H, Jones D, Junckerstorff R, Kellie S, Kool M, Kotecha R, Lichter P, Laughton S, Lee S, McCowage G, Northcott P, Olson J, Packer R, Pfister S, Pietsch T, Pizer B, Pomeroy S, Remke M, Robinson G, Rutkowski S, Schoep T, Shelat A, Stewart C, Sullivan M, Taylor M, Wainwright B, Walwyn T, Weiss W, Williamson D, Gajjar A
ACTA NEUROPATHOL. 2014;127(2):189-201.

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps
Grässle S, Huck V, Pappelbaum K, Gorzelanny C, Aponte-Santamaría C, Baldauf C, Gräter F, Schneppenheim R, Obser T, Schneider S
ARTERIOSCL THROM VAS. 2014;34(7):1382-1389.

SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis
Hasselblatt M, Nagel I, Oyen F, Bartelheim K, Russell R, Schüller U, Junckerstorff R, Rosenblum M, Alassiri A, Rossi S, Schmid I, Gottardo N, Toledano H, Viscardi E, Balbin M, Witkowski L, Lu Q, Betts M, Foulkes W, Siebert R, Frühwald M, Schneppenheim R
ACTA NEUROPATHOL. 2014;128(3):453-6.

Inherited thrombotic thrombocytopenic purpura in children
Hassenpflug W, Budde U, Schneppenheim S, Schneppenheim R
SEMIN THROMB HEMOST. 2014;40(4):487-92.

Successful second ITI with factor IX and combined immunosuppressive therapy. A patient with severe haemophilia B and recurrence of a factor IX inhibitor
Holstein K, Schneppenheim R, Schrum J, Bokemeyer C, Langer F
HAMOSTASEOLOGIE. 2014;34 (4A):5-8.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing
Hovestadt V, Jones D, Picelli S, Wang W, Kool M, Northcott P, Sultan M, Stachurski K, Ryzhova M, Warnatz H, Ralser M, Brun S, Bunt J, Jäger N, Kleinheinz K, Erkek S, Weber U, Bartholomae C, von Kalle C, Lawerenz C, Eils J, Koster J, Versteeg R, Milde T, Witt O, Schmidt S, Wolf S, Pietsch T, Rutkowski S, Scheurlen W, Taylor M, Brors B, Felsberg J, Reifenberger G, Borkhardt A, Lehrach H, Wechsler-Reya R, Eils R, Yaspo M, Landgraf P, Korshunov A, Zapatka M, Radlwimmer B, Pfister S, Lichter P
NATURE. 2014;510(7506):537-541.

The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells
Hütz K, Mejías-Luque R, Farsakova K, Ogris M, Krebs S, Anton M, Vieth M, Schüller U, Schneider M, Blum H, Wagner E, Jung A, Gerhard M
CARCINOGENESIS. 2014;35(4):942-50.

Hemophagocytic lymphohistiocytosis: A serious challenge for every physician
Janka-Schaub G
VET CLIN PATH. 2014;214(6):318-9.

Hemophagocytic syndromes - An update
Janka-Schaub G, Lehmberg K
BLOOD REV. 2014;28(4):135-142.

Quality of survival and growth in children and young adults in the PNET4 European controlled trial of hyperfractionated versus conventional radiation therapy for standard-risk medulloblastoma
Kennedy C, Bull K, Chevignard M, Culliford D, Dörr H, Doz F, Kortmann R, Lannering B, Massimino M, Navajas Gutiérrez A, Rutkowski S, Spoudeas H, Calaminus G
INT J RADIAT ONCOL. 2014;88(2):292-300.

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1
Kerl K, Moreno N, Holsten T, Ahlfeld J, Mertins J, Hotfilder M, Kool M, Bartelheim K, Schleicher S, Handgretinger R, Schüller U, Meisterernst M, Frühwald M
INT J CANCER. 2014;135(4):989-95.

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Kool M, Jones D, Jäger N, Northcott P, Pugh T, Hovestadt V, Piro R, Esparza L, Markant S, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber U, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae C, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik A, Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford J, Grant G, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel J, Doz F, Delattre O, Bader G, McCabe M, Collins V, Kieran M, Cho Y, Pomeroy S, Witt O, Brors B, Taylor M, Schüller U, Korshunov A, Eils R, Wechsler-Reya R, Lichter P, Pfister S
CANCER CELL. 2014;25(3):393-405.

Favorable outcome of patients affected by rhabdoid tumors due to rhabdoid tumor predisposition syndrome (RTPS)
Kordes U, Bartelheim K, Modena P, Massimino M, Biassoni V, Reinhard H, Hasselblatt M, Schneppenheim R, Frühwald M
PEDIATR BLOOD CANCER. 2014;61(5):919-21.

The PML domain of PML-RARα blocks senescence to promote leukemia
Korf K, Wodrich H, Haschke A, Ocampo C, Harder L, Gieseke F, Pollmann A, Dierck K, Prall S, Staege H, Ma H, Horstmann M, Evans R, Sternsdorf T
P NATL ACAD SCI USA. 2014;111(33):12133-8.

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity
Korshunov A, Sturm D, Ryzhova M, Hovestadt V, Gessi M, Jones D, Remke M, Northcott P, Perry A, Picard D, Rosenblum M, Antonelli M, Aronica E, Schüller U, Hasselblatt M, Woehrer A, Zheludkova O, Kumirova E, Puget S, Taylor M, Giangaspero F, Peter Collins V, Deimling A, Lichter P, Huang A, Pietsch T, Pfister S, Kool M
ACTA NEUROPATHOL. 2014;128(2):279-89.

Platelet-free shear flow assay facilitates analysis of shear-dependent functions of VWF and ADAMTS13
Kraus E, Kraus K, Obser T, Oyen F, Klemm U, Schneppenheim R, Brehm M
THROMB RES. 2014;134(6):1285-1291.

Efficacious inhibition of Importin α/β-mediated nuclear import of human inositol phosphate multikinase
Kublun I, Ehm P, Brehm M, Nalaskowski M
BIOCHIMIE. 2014;102:117-23.

Characterisation of the p.A1461D mutation causing von Willebrand disease type 2B with severe thrombocytopenia, circulating giant platelets, and defective α-granule secretion
Langer F, Obser T, Oyen F, Spath B, Holstein K, Greinacher A, White J, Budde U, Bokemeyer C, Schneppenheim R
THROMB HAEMOSTASIS. 2014;111(4):777-779.

Treosulfan-based conditioning regimen for children and adolescents with hemophagocytic lymphohistiocytosis
Lehmberg K, Albert M, Beier R, Beutel K, Gruhn B, Kröger N, Meisel R, Schulz A, Stachel D, Woessmann W, Janka G, Müller I
HAEMATOLOGICA. 2014;99(1):180-4.

Determination of an appropriate cut-off value for ferritin in the diagnosis of hemophagocytic lymphohistiocytosis
Lehmberg K, McClain K, Janka-Schaub G, Allen C
PEDIATR BLOOD CANCER. 2014.

Brain iron quantification by MRI in mitochondrial membrane protein-associated neurodegeneration under iron-chelating therapy
Löbel U, Schweser F, Nickel M, Deistung A, Grosse R, Hagel C, Fiehler J, Schulz A, Hartig M, Reichenbach J, Kohlschütter A, Sedlacik J
ANN CLIN TRANSL NEUR. 2014;1(12):1041-6.

Therapie traumatischer Pankreasverletzungen im Kindesalter
Maier S, Reinshagen K, Kähler G, Wessel L
ZBL CHIR. 2014;139(3):266-70.

PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events
Mendes R, Sarmento L, Canté-Barrett K, Zuurbier L, Buijs-Gladdines J, Póvoa V, Smits W, Abecasis M, Yunes J, Sonneveld E, Horstmann M, Pieters R, Barata J, Meijerink J
BLOOD. 2014;124(4):567-78.

Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic Arthritis: a multinational, multicenter study of 362 patients
Minoia F, Davì S, Horne A, Demirkaya E, Bovis F, Li C, Lehmberg K, Weitzman S, Insalaco A, Wouters C, Shenoi S, Espada G, Ozen S, Anton J, Khubchandani R, Russo R, Pal P, Kasapcopur O, Miettunen P, Maritsi D, Merino R, Shakoory B, Alessio M, Chasnyk V, Sanner H, Gao Y, Huasong Z, Kitoh T, Avcin T, Fischbach M, Frosch M, Grom A, Huber A, Jelusic M, Sawhney S, Uziel Y, Ruperto N, Martini A, Cron R, Ravelli A
ARTHRITIS RHEUMATOL. 2014;66(11):3160-9.

Loss of Smarc proteins impairs cerebellar development
Moreno N, Schmidt C, Ahlfeld J, Pöschl J, Dittmar S, Pfister S, Kool M, Kerl K, Schüller U
J NEUROSCI. 2014;34(40):13486-91.

Postponed is not canceled: role of craniospinal radiation therapy in the management of recurrent infant medulloblastoma--an experience from the HIT-REZ 1997 & 2005 studies
Müller K, Mynarek M, Zwiener I, Siegler N, Zimmermann M, Christiansen H, Budach W, Henke G, Warmuth-Metz M, Pietsch T, von Hoff K, von Bueren A, Bode U, Rutkowski S, Kortmann R, Fleischhack G, Tippelt S
INT J RADIAT ONCOL. 2014;88(5):1019-1024.

Hochrisiko-Medulloblastom: Erfahrungen aus HIT2000
Mynarek M, von Hoff K, Kortmann R, Rutkowski S
2014. Klinische Pädiatrie. .

Medulloblastom mit niedrigem Risiko oder Standardrisiko: Die Studien PNET4 und PNET5
Mynarek M, von Hoff K, Kortmann R, Rutkowski S
2014. Klinische Pädiatrie. .

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Northcott P, Lee C, Zichner T, Stütz A, Erkek S, Kawauchi D, Shih D, Hovestadt V, Zapatka M, Sturm D, Jones D, Kool M, Remke M, Cavalli F, Zuyderduyn S, Bader G, VandenBerg S, Esparza L, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch C, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz H, Risch T, Yaspo M, Weber U, Bartholomae C, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann M, Ebinger M, Grimes H, Robinson G, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik A, von Deimling A, Witt O, Eils R, Gilbertson R, Korshunov A, Taylor M, Lichter P, Korbel J, Wechsler-Reya R, Pfister S
NATURE. 2014;511(7510):428-434.

Hypertrophic olivary degeneration with gadolinium enhancement after posterior fossa surgery in a child with medulloblastoma
Nowak J, Alkonyi B, Rutkowski S, Homola G, Warmuth-Metz M
CHILD NERV SYST. 2014;30(5):959-62.

MRI Characteristics of Ependymoblastoma: Results from 22 Centrally Reviewed Cases
Nowak J, Seidel C, Berg F, Pietsch T, Friedrich C, von Hoff K, Rutkowski S, Warmuth-Metz M
AM J NEURORADIOL. 2014;35(10):1996-2001.

Ependymoblastoma of the brainstem: MRI findings and differential diagnosis
Nowak J, Seidel C, Pietsch T, Friedrich C, von Hoff K, Rutkowski S, Warmuth-Metz M
PEDIATR BLOOD CANCER. 2014;61(6):1132-1134.

Cerebellar cortical lamination and foliation require cyclin A2
Otero J, Kalaszczynska I, Michowski W, Wong M, Gygli P, Gokozan H, Griveau A, Odajima J, Czeisler C, Catacutan F, Murnen A, Schüller U, Sicinski P, Rowitch D
DEV BIOL. 2014;385(2):328-39.

Performance evaluation and multicentre study of a von Willebrand factor activity assay based on GPIb binding in the absence of ristocetin
Patzke J, Budde U, Huber A, Méndez A, Muth H, Obser T, Peerschke E, Wilkens M, Schneppenheim R
BLOOD COAGUL FIBRIN. 2014;25(8):860-870.

Biopsy findings of symptomatic cerebral X-linked adrenoleucodystrophy and histological differentiation from multiple sclerosis
Pfeifenbring S, von Baumgarten L, Schüller U, Rosewich H, Thal D, Wirtz C, Hecht M, Terpolilli N, Brück W
NEUROPATH APPL NEURO. 2014;40(5):658-61.

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort
Pietsch T, Schmidt R, Remke M, Korshunov A, Hovestadt V, Jones D, Felsberg J, Kaulich K, Goschzik T, Kool M, Northcott P, von Hoff K, von Bueren A, Friedrich C, Mynarek M, Skladny H, Fleischhack G, Taylor M, Cremer F, Lichter P, Faldum A, Reifenberger G, Rutkowski S, Pfister S
ACTA NEUROPATHOL. 2014;128(1):137-149.

Wnt/β-catenin signaling inhibits the Shh pathway and impairs tumor growth in Shh-dependent medulloblastoma
Pöschl J, Bartels M, Ohli J, Bianchi E, Kuteykin-Teplyakov K, Grammel D, Ahlfeld J, Schüller U
ACTA NEUROPATHOL. 2014;127(4):605-7.

Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts
Pöschl J, Stark S, Neumann P, Gröbner S, Kawauchi D, Jones D, Northcott P, Lichter P, Pfister S, Kool M, Schüller U
ACTA NEUROPATHOL. 2014;128(1):123-36.

Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis
Ruland V, Hartung S, Kordes U, Wolff J, Paulus W, Hasselblatt M
GENE CHROMOSOME CANC. 2014;53(5):373-80.

Methylation of the hTERT promoter is frequent in choroid plexus tumors but not of independent prognostic value
Ruland V, Hartung S, Kordes U, Wolff J, Paulus W, Hasselblatt M
J NEURO-ONCOL. 2014;119(1):215-6.

Neuroonkologie
Rutkowski S, Hornung D, Kordes U, Kammler G, Hagel C, Löbel U, Ebinger M, Rössler J, Resch A, Linhart D
2014. Neuropädiatrie - Evidenzbasierte Therapie. Korinthenberg R, Panteliadis C, Hagel C (Hrsg.). 2. Aufl. München: Elsevier, .

Postmortem 31P magnetic resonance spectroscopy of the skeletal muscle: α-ATP/Pi ratio as a forensic tool?
Schmidt T, Wang Z, Keller S, Heinemann A, Acar S, Graessner J, Schoennagel B, Adam G, Fischer R, Yamamura J
FORENSIC SCI INT. 2014;242:172-6.

Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin C, Schröder B
BIOCHEM BIOPH RES CO. 2014;451(1):48-53.

Fetal blood flow velocimetry by phase-contrast MRI using a new triggering method and comparison with Doppler ultrasound in a sheep model: a pilot study
Schoennagel B, Remus C, Yamamura J, Kording F, de Sousa M, Hecher K, Fischer R, Ueberle F, Boehme M, Adam G, Kooijman H, Wedegärtner U
MAGN RESON MATER PHY. 2014;27(3):237-44.

Feasibility of intensive multimodal therapy in infants affected by rhabdoid tumors - experience of the EU-RHAB registry
Seeringer A, Bartelheim K, Kerl K, Hasselblatt M, Leuschner I, Rutkowski S, Timmermann B, Kortmann R, Koscielniak E, Schneppenheim R, Warmuth-Metz M, Gerß J, Siebert R, Graf N, Boos J, Frühwald M
KLIN PADIATR. 2014;226(3):143-148.

Synchronous congenital malignant rhabdoid tumor of the orbit and atypical teratoid/rhabdoid tumor--feasibility and efficacy of multimodal therapy in a long-term survivor
Seeringer A, Reinhard H, Hasselblatt M, Schneppenheim R, Siebert R, Bartelheim K, Leuschner I, Frühwald M
CANCER GENET-NY. 2014;207(9):429-33.

Cytogenetic prognostication within medulloblastoma subgroups
Shih D, Northcott P, Remke M, Korshunov A, Ramaswamy V, Kool M, Luu B, Yao Y, Wang X, Dubuc A, Garzia L, Peacock J, Mack S, Wu X, Rolider A, Morrissy A, Cavalli F, Jones D, Zitterbart K, Faria C, Schüller U, Kren L, Kumabe T, Tominaga T, Shin Ra Y, Garami M, Hauser P, Chan J, Robinson S, Bognár L, Klekner A, Saad A, Liau L, Albrecht S, Fontebasso A, Cinalli G, De Antonellis P, Zollo M, Cooper M, Thompson R, Bailey S, Lindsey J, Di Rocco C, Massimi L, Michiels E, Scherer S, Phillips J, Gupta N, Fan X, Muraszko K, Vibhakar R, Eberhart C, Fouladi M, Lach B, Jung S, Wechsler-Reya R, Fèvre-Montange M, Jouvet A, Jabado N, Pollack I, Weiss W, Lee J, Cho B, Kim S, Wang K, Leonard J, Rubin J, de Torres C, Lavarino C, Mora J, Cho Y, Tabori U, Olson J, Gajjar A, Packer R, Rutkowski S, Pomeroy S, French P, Kloosterhof N, Kros J, Van Meir E, Clifford S, Bourdeaut F, Delattre O, Doz F, Hawkins C, Malkin D, Grajkowska W, Perek-Polnik M, Bouffet E, Rutka J, Pfister S, Taylor M
J CLIN ONCOL. 2014;32(9):886-896.

Update on von Willebrand factor multimers: focus on high-molecular-weight multimers and their role in hemostasis
Stockschlaeder M, Schneppenheim R, Budde U
BLOOD COAGUL FIBRIN. 2014;25(3):206-16.

Therapie hereditärer Thrombozytopathien. Interdisziplinäre S2K-Leitlinie der Ständigen Kommission Pädiatrie der Gesellschaft für Thrombose- und Hämostaseforschung e. V
Streif W, Knöfler R, Eberl W, Andres O, Bakchoul T, Bergmann F, Beutel K, Dittmer R, Gehrisch S, Gottstein S, Halimeh S, Haselböck J, Hassenpflug W, Heine S, Holzhauer S, King S, Kirchmaier C, Krause M, Kreuz W, Lösche W, Mahnel R, Maurer M, Nimtz-Talaska A, Olivieri M, Rott H, Schambeck C, Schedel A, Schilling F, Schmugge M, Schneppenheim R, Scholz U, Scholz T, Schulze H, Siegemund A, Strauß G, Sykora K, Wermes C, Wiegering V, Wieland I, Zieger B, Zotz R
HAMOSTASEOLOGIE. 2014;34(4):269-75.

The transcription factor Cux1 in cerebellar granule cell development and medulloblastoma pathogenesis
Topka S, Glassmann A, Weisheit G, Schüller U, Schilling K
CEREBELLUM. 2014;13(6):698-712.

Significantly increased CD70 up regulation on TEL-AML positive B cell precursor acute lymphoblastic leukemia cells following CD40 stimulation
Troeger A, Glouchkova L, Ackermann B, Escherich G, Hanenberg H, Janka G, Roettgers S, Göbel U, Dilloo D
KLIN PADIATR. 2014;226(6-7):332-337.

Interference with pre-B-cell receptor signaling offers a therapeutic option for TCF3-rearranged childhood acute lymphoblastic leukemia
van der Veer A, van der Velden V, Willemse M, Hoogeveen P, Petricoin E, Beverloo H, Escherich G, Horstmann M, Pieters R, den Boer M
BLOOD CANCER J. 2014;4:e181.

Risikoadaptierte Behandlung von intrakraniellen Ependymomen: Ergebnisse von HIT2000 und Ausblick auf SIOP-Ependymoma II
von Hoff K, Mynarek M, Kortmann R, Rutkowski S
2014. Klinische Pädiatrie. .

Identifying molecular markers for the sensitive detection of residual atypical teratoid rhabdoid tumor cells
Vu-Han T, Frühwald M, Hasselblatt M, Kerl K, Nagel I, Obser T, Oyen F, Siebert R, Schneppenheim R
CANCER GENET-NY. 2014;207(9):390-397.

Subgroup-specific localization of human medulloblastoma based on pre-operative MRI
Wefers A, Warmuth-Metz M, Pöschl J, von Bueren A, Monoranu C, Seelos K, Peraud A, Tonn J, Koch A, Pietsch T, Herold-Mende C, Mawrin C, Schouten-van Meeteren A, van Vuurden D, von Hoff K, Rutkowski S, Pfister S, Kool M, Schüller U
ACTA NEUROPATHOL. 2014;127(6):931-3.

Dexamethasone released from cochlear implant coatings combined with a protein repellent hydrogel layer inhibits fibroblast proliferation
Wrzeszcz A, Dittrich B, Haamann D, Aliuos P, Klee D, Nolte I, Lenarz T, Reuter G
J BIOMED MATER RES A. 2014;102(2):442-54.

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma
Zhukova N, Ramaswamy V, Remke M, Martin D, Castelo-Branco P, Zhang C, Fraser M, Tse K, Poon R, Shih D, Baskin B, Ray P, Bouffet E, Dirks P, von Bueren A, Pfaff E, Korshunov A, Jones D, Northcott P, Kool M, Pugh T, Pomeroy S, Cho Y, Pietsch T, Gessi M, Rutkowski S, Bognár L, Cho B, Eberhart C, Conter C, Fouladi M, French P, Grajkowska W, Gupta N, Hauser P, Jabado N, Vasiljevic A, Jung S, Kim S, Klekner A, Kumabe T, Lach B, Leonard J, Liau L, Massimi L, Pollack I, Ra Y, Rubin J, Van Meir E, Wang K, Weiss W, Zitterbart K, Bristow R, Alman B, Hawkins C, Malkin D, Clifford S, Pfister S, Taylor M, Tabori U
ACTA NEUROPATHOL COM. 2014;2:174.

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors
Zuurbier L, Gutierrez A, Mullighan C, Canté-Barrett K, Gevaert A, de Rooi J, Li Y, Smits W, Buijs-Gladdines J, Sonneveld E, Look A, Horstmann M, Pieters R, Meijerink J
HAEMATOLOGICA. 2014;99(1):94-102.

2013

Sox2 requirement in sonic hedgehog-associated medulloblastoma
Ahlfeld J, Favaro R, Pagella P, Kretzschmar H, Nicolis S, Schüller U
CANCER RES. 2013;73(12):3796-807.

Phenotypic and molecular characterisation of type 3 von Willebrand disease in a cohort of Indian patients
Ahmad F, Budde U, Jan R, Oyen F, Kannan M, Saxena R, Schneppenheim R
THROMB HAEMOSTASIS. 2013;109(4):652-60.

Characterisation of mutations and molecular studies of type 2 von Willebrand disease.
Ahmad F, Jan R, Kannan M, Obser T, Hassan M, Oyen F, Budde U, Saxena R, Schneppenheim R
THROMB HAEMOSTASIS. 2013;109(1):39-46.

PGK1 as predictor of CXCR4 expression, bone marrow metastases and survival in neuroblastoma
Ameis H, Drenckhan A, Loga K, Escherich G, Wenke K, Izbicki J, Reinshagen K, Gros S
PLOS ONE. 2013;8(12):e83701.

Allo-SCT using BU, CY and melphalan for children with AML in second CR
Beier R, Albert M, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster F, Schrauder A, Strahm B, Sykora K, Wössmann W, Zimmermann M, Sauer M
BONE MARROW TRANSPL. 2013;48(5):651-6.

Primary intracranial soft tissue sarcoma in children and adolescents: a cooperative analysis of the European CWS and HIT study groups
Benesch M, von Bueren A, Dantonello T, von Hoff K, Pietsch T, Leuschner I, Claviez A, Bierbach U, Kropshofer G, Korinthenberg R, Graf N, Suttorp M, Kortmann R, Friedrich C, von der Weid N, Kaatsch P, Klingebiel T, Koscielniak E, Rutkowski S
J NEURO-ONCOL. 2013;111(3):337-345.

Fulminant Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis.
Bohne S, Kentouche K, Petersen I, Fritzenwanger M, Pletz M, Lehmberg K, Paul L, Guntinas-Lichius O
LARYNGOSCOPE. 2013;123(2):362-365.

Incidence and prognostic relevance of genetic variations in T-cell lymphoblastic lymphoma in childhood and adolescence
Bonn B, Rohde M, Zimmermann M, Krieger D, Oschlies I, Niggli F, Wrobel G, Attarbaschi A, Escherich G, Klapper W, Reiter A, Burkhardt B
BLOOD. 2013;121(16):3153-60.

Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.
D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths G, Zur Stadt U, Bulfone-Paus S
EUR J IMMUNOL. 2013;43(1):194-208.

Use of allogeneic hematopoietic stem-cell transplantation based on minimal residual disease response improves outcomes for children with relapsed acute lymphoblastic leukemia in the intermediate-risk group
Eckert C, Henze G, Seeger K, Hagedorn N, Mann G, Panzer-Grümayer R, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Schrauder A, Escherich G, Sramkova L, Niggli F, Hitzler J, von Stackelberg A
J CLIN ONCOL. 2013;31(21):2736-42.

Minimal residual disease after induction is the strongest predictor of prognosis in intermediate risk relapsed acute lymphoblastic leukaemia - long-term results of trial ALL-REZ BFM P95/96.
Eckert C, von Stackelberg A, Seeger K, Groeneveld T, Peters C, Klingebiel T, Borkhardt A, Schrappe M, Escherich G, Henze G
EUR J CANCER. 2013;49(6):1346-1355.

VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease
Eikenboom J, Federici A, Dirven R, Castaman G, Rodeghiero F, Budde U, Schneppenheim R, Batlle J, Canciani M, Goudemand J, Peake I, Goodeve A
BLOOD. 2013;121(12):2336-9.

Identification of a homozygous Cys410Ser mutation in the von Willebrand factor D2 domain causing type 2A(IIC) von Willebrand disease phenotype in an Iranian patient
Enayat M, Ravanbod S, Rassoulzadegan M, Jazebi M, Ala F, Budde U, Schneppenheim S, Obser T, Schneppenheim R
HAEMOPHILIA. 2013;19(4):e261-4.

Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03.
Escherich G, Zimmermann M, Janka-Schaub G
PEDIATR BLOOD CANCER. 2013;60(2):254-257.

Clofarabine in combination with pegylated asparaginase in the frontline treatment of childhood acute lymphoblastic leukaemia: a feasibility report from the CoALL 08-09 trial
Escherich G, Zur Stadt U, Zimmermann M, Horstmann M
BRIT J HAEMATOL. 2013;163(2):240-7.

Treatment of young children with CNS-primitive neuroectodermal tumors/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy.
Friedrich C, von Bueren A, von Hoff K, Gerber N, Ottensmeier H, Deinlein F, Benesch M, Kwiecien R, Pietsch T, Warmuth-Metz M, Faldum A, Kuehl J, Kortmann R, Rutkowski S
NEURO-ONCOLOGY. 2013;15(2):224-234.

Treatment of adult nonmetastatic medulloblastoma patients according to the paediatric HIT 2000 protocol: a prospective observational multicentre study
Friedrich C, von Bueren A, von Hoff K, Kwiecien R, Pietsch T, Warmuth-Metz M, Hau P, Deinlein F, Kuehl J, Kortmann R, Rutkowski S
EUR J CANCER. 2013;49(4):893-903.

Distinct role of von Willebrand factor triplet bands in glycoprotein Ib-dependent platelet adhesion and thrombus formation under flow
Fuchs B, de Witt S, Solecka B, Kröning M, Obser T, Cosemans J, Schneppenheim R, Heemskerk J, Kannicht C
SEMIN THROMB HEMOST. 2013;39(3):306-14.

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation
Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Müller I
EUR J IMMUNOL. 2013;43(10):2741-9.

Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1
Gödeke J, Maier S, Eichenmüller M, Müller-Höcker J, von Schweinitz D, Kappler R
NUTR CANCER. 2013;65(8):1200-7.

Syntaxin binding mechanism and disease-causing mutations in Munc18-2
Hackmann Y, Graham S, Ehl S, Höning S, Lehmberg K, Aricò M, Owen D, Griffiths G
P NATL ACAD SCI USA. 2013;110(47):E4482-91.

Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression
Hagel C, Treszl A, Fehlert J, Harder J, von Haxthausen F, Kern M, von Bueren A, Kordes U
J NEURO-ONCOL. 2013;112(2):191-7.

Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia
Harder L, Eschenburg G, Zech A, Kriebitzsch N, Otto B, Streichert T, Behlich A, Dierck K, Klingler B, Hansen A, Stanulla M, Zimmermann M, Kremmer E, Stocking C, Horstmann M
J EXP MED. 2013;210(11):2289-304.

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells
Hartsink-Segers S, Exalto C, Allen M, Williamson D, Clifford S, Horstmann M, Caron H, Pieters R, Den Boer M
HAEMATOLOGICA. 2013;98(10):1539-46.

Fatal neurological side-effects with necrosis of spinal cord following nelarabine treatment in a child with relapsed T-cell acute lymphoblastic leukemia
Hartz B, Löbel U, Hagel C, Escherich G
AM J HEMATOL. 2013;88(12):1096-7.

High-resolution genomic analysis suggests the absence of recurrent genomic alterations other than SMARCB1 aberrations in atypical teratoid/rhabdoid tumors.
Hasselblatt M, Isken S, Linge A, Eikmeier K, Jeibmann A, Oyen F, Nagel I, Richter J, Bartelheim K, Kordes U, Schneppenheim R, Frühwald M, Siebert R, Paulus W
GENE CHROMOSOME CANC. 2013;52(2):185-190.

Grating-based X-ray phase-contrast tomography of atherosclerotic plaque at high photon energies
Hetterich H, Fill S, Herzen J, Willner M, Zanette I, Weitkamp T, Rack A, Schüller U, Sadeghi M, Brandl R, Adam-Neumair S, Reiser M, Pfeiffer F, Bamberg F, Saam T
Z MED PHYS. 2013;23(3):194-203.

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Höchst B, Schildberg F, Sauerborn P, Gäbel Y, Gevensleben H, Goltz D, Heukamp L, Türler A, Ballmaier M, Gieseke F, Müller I, Kalff J, Kurts C, Knolle P, Diehl L
J HEPATOL. 2013;59(3):528-35.

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays
Hovestadt V, Remke M, Kool M, Pietsch T, Northcott P, Fischer R, Cavalli F, Ramaswamy V, Zapatka M, Reifenberger G, Rutkowski S, Schick M, Bewerunge-Hudler M, Korshunov A, Lichter P, Taylor M, Pfister S, Jones D
ACTA NEUROPATHOL. 2013;125(6):913-6.

Hemophagocytic lymphohistiocytosis - pathogenesis and treatment
Janka-Schaub G, Lehmberg K
HEMATOL-AM SOC HEMAT. 2013;2013:605-11.

The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2
Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, Frei-Jones M, Gahl W, Gochuico B, Griese M, Griffiths G, Janka-Schaub G, Klein C, Kögl T, Kurnik K, Lehmberg K, Maul-Pavicic A, Mumford A, Pace D, Parvaneh N, Rezaei N, de Saint Basile G, Schmitt-Graeff A, Schwarz K, Karasu G, Zieger B, zur Stadt U, Aichele P, Ehl S
BLOOD. 2013;121(15):2943-51.

Phenotypic and genotypic characterization of 10 Finnish patients with von Willebrand disease type 3: discovery of two main mutations
Jokela V, Lassila R, Szanto T, Joutsi-Korhonen L, Armstrong E, Oyen F, Schneppenheim S, Schneppenheim R
HAEMOPHILIA. 2013;19(6):e344-8.

Pregnancy in Upshaw-Schulman syndrome
Kentouche K, Voigt A, Schleussner E, Schneppenheim R, Budde U, Beck J, Stefańska-Windyga E, Windyga J
HAMOSTASEOLOGIE. 2013;33(2):144-8.

Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy
Kerl K, Holsten T, Frühwald M
PEDIATR HEMAT ONCOL. 2013;30(7):587-604.

Hemophagocytic lymphohistiocytosis in syntaxin-11-deficient mice: T-cell exhaustion limits fatal disease
Kögl T, Müller J, Jessen B, Schmitt-Graeff A, Janka-Schaub G, Ehl S, zur Stadt U, Aichele P
BLOOD. 2013;121(4):604-13.

Juvenile metachromatic leukodystrophy 10 years post transplant compared with a non-transplanted cohort
Krägeloh-Mann I, Groeschel S, Kehrer C, Opherk K, Nägele T, Handgretinger R, Müller I
BONE MARROW TRANSPL. 2013;48(3):369-75.

Denosumab: a potential new and innovative treatment option for aneurysmal bone cysts
Lange T, Stehling C, Fröhlich B, Klingenhöfer M, Kunkel P, Schneppenheim R, Escherich G, Gosheger G, Hardes J, Jürgens H, Schulte T
EUR SPINE J. 2013;22(6):1417-22.

Diagnostic evaluation of patients with suspected haemophagocytic lymphohistiocytosis.
Lehmberg K, Ehl S
BRIT J HAEMATOL. 2013;160(3):275-287.

Administration of recombinant erythropoietin alone does not improve the phenotype in iron refractory iron deficiency anemia patients.
Lehmberg K, Grosse R, Muckenthaler M, Altamura S, Nielsen P, Schmid H, Graubner U, Oyen F, Zeller W, Schneppenheim R, Janka-Schaub G
ANN HEMATOL. 2013;92(3):387-394.

Differentiating macrophage activation syndrome in systemic juvenile idiopathic arthritis from other forms of hemophagocytic lymphohistiocytosis
Lehmberg K, Pink I, zu Eulenburg C, Beutel K, Maul-Pavicic A, Janka-Schaub G
J PEDIATR-US. 2013;162(6):1245-51.

Exponential size distribution of von Willebrand factor
Lippok S, Obser T, Müller J, Stierle V, Benoit M, Budde U, Schneppenheim R, Rädler J
BIOPHYS J. 2013;105(5):1208-16.

Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials
Mannuccio Mannucci P, Kyrle P, Schulman S, Di Paola J, Schneppenheim R, Cox Gill J
BLOOD TRANSFUS-ITALY. 2013;11(4):533-40.

Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry
Mansouri Taleghani M, von Krogh A, Fujimura Y, George J, Hrachovinová I, Knöbl P, Quist-Paulsen P, Schneppenheim R, Lämmle B, Kremer Hovinga J
HAMOSTASEOLOGIE. 2013;33(2):138-43.

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes.
Marsh R, Rao K, Satwani P, Lehmberg K, Müller I, Li D, Kim M, Fischer A, Latour S, Sedlacek P, Barlogis V, Hamamoto K, Kanegane H, Milanovich S, Margolis D, Dimmock D, Casper J, Douglas D, Amrolia P, Veys P, Kumar A, Jordan M, Bleesing J, Filipovich A
BLOOD. 2013;121(6):877-883.

Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients.
Meyer C, Zur Stadt U, Escherich G, Hofmann J, Binato R, Barbosa T, Emerenciano M, Pombo-de-Oliveira M, Horstmann M, Marschalek R
AM J BLOOD RES. 2013;3(2):165-173.

Outcomes of treatment for relapsed acute lymphoblastic leukaemia in children with Down syndrome
Meyr F, Escherich G, Mann G, Klingebiel T, Kulozik A, Rossig C, Schrappe M, Henze G, von Stackelberg A, Hitzler J
BRIT J HAEMATOL. 2013;162(1):98-106.

What's in a name? Intracranial peripheral primitive neuroectodermal tumors and CNS primitive neuroectodermal tumors are not the same
Müller K, Diez B, Muggeri A, Pietsch T, Friedrich C, Rutkowski S, von Hoff K, von Bueren A, Zwiener I, Bruns F
STRAHLENTHER ONKOL. 2013;189(5):372-9.

Outcome of allogeneic SCT in patients with chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy.
Oyekunle A, Zander A, Binder M, Ayuketang F, Zabelina T, Christopeit M, Stübig T, Alchalby H, Schafhausen P, Lellek H, Wolschke C, Müller I, Bacher U, Kröger N
ANN HEMATOL. 2013;92(4):487-496.

Ultralarge von Willebrand factor fibers mediate luminal Staphylococcus aureus adhesion to an intact endothelial cell layer under shear stress
Pappelbaum K, Gorzelanny C, Grässle S, Suckau J, Laschke M, Bischoff M, Bauer C, Schorpp-Kistner M, Weidenmaier C, Schneppenheim R, Obser T, Sinha B, Schneider S
CIRCULATION. 2013;128(1):50-9.

Constitutive activation of β-catenin in neural progenitors results in disrupted proliferation and migration of neurons within the central nervous system
Pöschl J, Grammel D, Dorostkar M, Kretzschmar H, Schüller U
DEV BIOL. 2013;374(2):319-32.

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis
Ramaswamy V, Remke M, Bouffet E, Faria C, Perreault S, Cho Y, Shih D, Luu B, Dubuc A, Northcott P, Schüller U, Gururangan S, McLendon R, Bigner D, Fouladi M, Ligon K, Pomeroy S, Dunn S, Triscott J, Jabado N, Fontebasso A, Jones D, Kool M, Karajannis M, Gardner S, Zagzag D, Nunes S, Pimentel J, Mora J, Lipp E, Walter A, Ryzhova M, Zheludkova O, Kumirova E, Alshami J, Croul S, Rutka J, Hawkins C, Tabori U, Codispoti K, Packer R, Pfister S, Korshunov A, Taylor M
LANCET ONCOL. 2013;14(12):1200-7.

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma
Remke M, Hering E, Gerber N, Kool M, Sturm D, Rickert C, Gerß J, Schulz S, Hielscher T, Hasselblatt M, Jeibmann A, Hans V, Ramaswamy V, Taylor M, Pietsch T, Rutkowski S, Korshunov A, Monoranu C, Frühwald M
CHILD NERV SYST. 2013;29(8):1253-62.

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma
Remke M, Ramaswamy V, Peacock J, Shih D, Koelsche C, Northcott P, Hill N, Cavalli F, Kool M, Wang X, Mack S, Barszczyk M, Morrissy A, Wu X, Agnihotri S, Luu B, Jones D, Garzia L, Dubuc A, Zhukova N, Vanner R, Kros J, French P, Van Meir E, Vibhakar R, Zitterbart K, Chan J, Bognár L, Klekner A, Lach B, Jung S, Saad A, Liau L, Albrecht S, Zollo M, Cooper M, Thompson R, Delattre O, Bourdeaut F, Doz F, Garami M, Hauser P, Carlotti C, Van Meter T, Massimi L, Fults D, Pomeroy S, Kumabe T, Ra Y, Leonard J, Elbabaa S, Mora J, Rubin J, Cho Y, McLendon R, Bigner D, Eberhart C, Fouladi M, Wechsler-Reya R, Faria C, Croul S, Huang A, Bouffet E, Hawkins C, Dirks P, Weiss W, Schüller U, Pollack I, Rutkowski S, Meyronet D, Jouvet A, Fèvre-Montange M, Jabado N, Perek-Polnik M, Grajkowska W, Kim S, Rutka J, Malkin D, Tabori U, Pfister S, Korshunov A, von Deimling A, Taylor M
ACTA NEUROPATHOL. 2013;126(6):917-29.

Sequential decisions on FAS sequencing guided by biomarkers in patients with lymphoproliferation and autoimmune cytopenia
Rensing-Ehl A, Janda A, Lorenz M, Gladstone B, Fuchs I, Abinun M, Albert M, Butler K, Cant A, Cseh A, Ebinger M, Goldacker S, Hambleton S, Hebart H, Houet L, Kentouche K, Kühnle I, Lehmberg K, Mejstrikova E, Niemeyer C, Minkov M, Neth O, Dückers G, Owens S, Rösler J, Schilling F, Schuster V, Seidel M, Smisek P, Sukova M, Svec P, Wiesel T, Gathmann B, Schwarz K, Vach W, Ehl S, Speckmann C
HAEMATOLOGICA. 2013;98(12):1948-55.

Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia
Richards S, Pui C, Gayon P
PEDIATR BLOOD CANCER. 2013;60(2):185-95.

Effective childhood cancer Treatment: the impact of large scale clinical trials in Germany and Austria
Rossig C, Juergens H, Schrappe M, Moericke A, Henze G, von Stackelberg A, Reinhardt D, Burkhardt B, Woessmann W, Zimmermann M, Gadner H, Mann G, Schellong G, Mauz-Koerholz C, Dirksen U, Bielack S, Berthold F, Graf N, Rutkowski S, Calaminus G, Kaatsch P, Creutzig U
PEDIATR BLOOD CANCER. 2013;60(10):1574-81.

Translation of atherosclerotic plaque phase-contrast CT imaging from synchrotron radiation to a conventional lab-based X-ray source
Saam T, Herzen J, Hetterich H, Fill S, Willner M, Stockmar M, Achterhold K, Zanette I, Weitkamp T, Schüller U, Auweter S, Adam-Neumair S, Nikolaou K, Reiser M, Pfeiffer F, Bamberg F
PLOS ONE. 2013;8(9):e73513.

Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia
Sanin V, Heeß C, Kretzschmar H, Schüller U
NEUROPATH APPL NEURO. 2013;39(5):510-8.

A very rare cancer in Down Syndrome: medulloblastoma. Epidemiological data from 13 countries
Satgé D, Stiller C, Rutkowski S, von Bueren A, Lacour B, Sommelet D, Nishi M, Massimino M, Garré M, Moreno F, Hasle H, Jakab Z, Greenberg M, von der Weid N, Kuehni C, Zurriaga O, Vicente M, Peris-Bonet R, Benesch M, Vekemans M, Sullivan S, Rickert C
J NEURO-ONCOL. 2013;112(1):107-14.

Second malignant neoplasms after treatment of childhood acute lymphoblastic leukemia
Schmiegelow K, Levinsen M, Attarbaschi A, Baruchel A, Devidas M, Escherich G, Gibson B, Heydrich C, Horibe K, Ishida Y, Liang D, Locatelli F, Michel G, Pieters R, Piette C, Pui C, Raimondi S, Silverman L, Stanulla M, Stark B, Winick N, Valsecchi M
J CLIN ONCOL. 2013;31(19):2469-76.

BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia
Schoennagel B, Yamamura J, Fischer R, de Sousa M, Weyhmiller M, Birkelbach M, Kooijman H, Adam G, Wedegärtner U
J MAGN RESON IMAGING. 2013.

Eisenquantifizierung mittels MRT bei Eisenüberladung
Schönnagel B, Fischer R, Nielsen P, Grosse R, Adam G, Yamamura J
ROFO-FORTSCHR RONTG. 2013;185(7):621-7.

X-linked inhibitor of apoptosis (XIAP) deficiency: the spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis
Speckmann C, Lehmberg K, Albert M, Damgaard R, Fritsch M, Gyrd-Hansen M, Rensing-Ehl A, Vraetz T, Grimbacher B, Salzer U, Fuchs I, Ufheil H, Belohradsky B, Hassan A, Cale C, Elawad M, Strahm B, Schibli S, Lauten M, Kohl M, Meerpohl J, Rodeck B, Kolb R, Eberl W, Soerensen J, von Bernuth H, Lorenz M, Schwarz K, zur Stadt U, Ehl S
CLIN IMMUNOL. 2013;149(1):133-41.

Pediatric Acute Lymphoblastic Leukemia: Efficacy and safety of recombinant E. coli-asparaginase in infants (less than one year of age) with acute lymphoblastic leukemia
van der Sluis I, Möricke A, Escherich G, von Stackelberg A, Holter W, Klingebiel T, Flotho C, Legien S, Tissing W, Bierings M, Guimbal-Schmolck C, Pichlmeier U, Kühnel H, Pieters R
HAEMATOLOGICA. 2013;98(11):1697-701.

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL
van der Veer A, Waanders E, Pieters R, Willemse M, Van Reijmersdal S, Russell L, Harrison C, Evans W, van der Velden V, Hoogerbrugge P, Van Leeuwen F, Escherich G, Horstmann M, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman H, Sonneveld E, Kuiper R, Den Boer M
BLOOD. 2013;122(15):2622-9.

Clinical phenotype and functional analysis of a rare XIAP/BIRC4 mutation
Vieth S, Ammann S, Schwarz K, Härtel C, Schultz C, Lehmberg K, Lauten M
KLIN PADIATR. 2013;225(6):343-6.

Infantile malignant brain tumors
von Hoff K, Rutkowski S
2013. Tumors of the pediatric central nervous system. Keating R, Tait Goodrich J, Packer R (Hrsg.). 2.. Aufl. New York: Georg Thieme Verlag KG, .

Challenges with defining response to antitumor agents in pediatric neuro-oncology: a report from the response assessment in pediatric neuro-oncology (RAPNO) working group
Warren K, Poussaint T, Vezina G, Hargrave D, Packer R, Goldman S, Wen P, Pollack I, Zurakowski D, Kun L, Prados M, Rutkowski S, Kieran M
PEDIATR BLOOD CANCER. 2013;60(9):1397-401.

Funktionalisierung des Trägermaterials von Cochlea-Implantaten mittels Dexamethason und Hydrogel: Effekt auf Bindegewebe in vitro und in vivo im Meerschweinchen
Wrzeszcz A
2013.

Spiral ganglion neuron quantification in the guinea pig cochlea using Confocal Laser Scanning Microscopy compared to embedding methods
Wrzeszcz A, Reuter G, Nolte I, Lenarz T, Scheper V
HEARING RES. 2013;306:145-55.

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma
Zhukova N, Ramaswamy V, Remke M, Pfaff E, Shih D, Martin D, Castelo-Branco P, Baskin B, Ray P, Bouffet E, von Bueren A, Jones D, Northcott P, Kool M, Sturm D, Pugh T, Pomeroy S, Cho Y, Pietsch T, Gessi M, Rutkowski S, Bognar L, Klekner A, Cho B, Kim S, Wang K, Eberhart C, Fevre-Montange M, Fouladi M, French P, Kros M, Grajkowska W, Gupta N, Weiss W, Hauser P, Jabado N, Jouvet A, Jung S, Kumabe T, Lach B, Leonard J, Rubin J, Liau L, Massimi L, Pollack I, Shin Ra Y, Van Meir E, Zitterbart K, Schüller U, Hill R, Lindsey J, Schwalbe E, Bailey S, Ellison D, Hawkins C, Malkin D, Clifford S, Korshunov A, Pfister S, Taylor M, Tabori U
J CLIN ONCOL. 2013;31(23):2927-35.

2012

ALDH1A1 is a marker of astrocytic differentiation during brain development and correlates with better survival in glioblastoma patients
Adam S, Schnell O, Pöschl J, Eigenbrod S, Kretzschmar H, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(6):788-97.

Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas
Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A
PANCREAS. 2012;41(2):222-9.

Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study.
Biondi A, Schrappe M, Paola D, Castor A, Lucchini G, Gandemer V, Pieters R, Stary J, Escherich G, Campbell M, Li C, Vora A, Aricò M, Röttgers S, Saha V, Valsecchi M
LANCET ONCOL. 2012;13(9):936-945.

Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.
Bode S, Lehmberg K, Maul-Pavicic A, Vraetz T, Janka-Schaub G, Zur Stadt U, Ehl S
ARTHRITIS RES THER. 2012;14(3):213.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Brauer H, Strauss J, Wegner W, Müller-Tidow C, Horstmann M, Jücker M
CELL SIGNAL. 2012;24(11):2095-2101.

A prospective evaluation of degranulation assays in the rapid diagnosis of familial hemophagocytic syndromes.
Bryceson Y, Pende D, Maul-Pavicic A, Gilmour K, Ufheil H, Vraetz T, Chiang S, Marcenaro S, Meazza R, Bondzio I, Walshe D, Janka-Schaub G, Lehmberg K, Beutel K, Zur Stadt U, Binder N, Arico M, Moretta L, Henter J, Ehl S
BLOOD. 2012;119(12):2754-2763.

Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.
Castaman G, Giacomelli S, Jacobi P, Obser T, Budde U, Rodeghiero F, Schneppenheim R, Haberichter S
J THROMB HAEMOST. 2012;10(5):951-958.

Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial.
Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A, Boelens J, Hewitt A, Schrum J, Schulz A, Müller I, Stein J, Wynn R, Greil J, Sykora K, Matthes-Martin S, Führer M, O'Meara A, Toporski J, Sedlacek P, Schlegel P, Ehlert K, Fasth A, Winiarski J, Arvidson J, Mauz-Körholz C, Ozsahin H, Schrauder A, Bader P, Massaro J, D'Agostino R, Hoyle M, Iacobelli M, Debatin K, Peters C, Dini G
LANCET. 2012;379(9823):1301-1309.

Caspofungin as antifungal prophylaxis in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective analysis.
Döring M, Hartmann U, Erbacher A, Lang P, Handgretinger R, Müller I
BMC INFECT DIS. 2012;12:151.

Analysis of posaconazole as oral antifungal prophylaxis in pediatric patients under 12 years of age following allogeneic stem cell transplantation.
Döring M, Müller C, Johann P, Erbacher A, Kimmig A, Schwarze C, Lang P, Handgretinger R, Müller I
BMC INFECT DIS. 2012;12:263.

Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia.
Döring M, Zierl A, Mezger M, Lang P, Handgretinger R, Müller I
Case reports in transplantation. 2012;2012:672923.

Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
Ellinghaus E, Stanulla M, Richter G, Ellinghaus D, Te Kronnie G, Cario G, Cazzaniga G, Horstmann M, Panzer Grümayer R, Cavé H, Trka J, Cinek O, Teigler-Schlegel A, ElSharawy A, Häsler R, Nebel A, Meissner B, Bartram T, Lescai F, Franceschi C, Giordan M, Nürnberg P, Heinzow B, Zimmermann M, Schreiber S, Schrappe M, Franke A
LEUKEMIA. 2012;26(5):902-909.

Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons.
Frick A, Grammel D, Schmidt F, Pöschl J, Priller M, Pagella P, von Bueren A, André O, Peraud A, Tonn J, Rutkowski S, Rutkowski S, Kretzschmar H, Schüller U
GLIA. 2012;60(5):820-832.

A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma.
Gerber N, von Hoff K, von Bueren A, Treulieb W, Treulieb W, Deinlein F, Benesch M, Zwiener I, Soerensen N, Warmuth-Metz M, Pietsch T, Mittler U, Kuehl J, Kortmann R, Rutkowski S, Rutkowski S
EUR J CANCER. 2012;48(13):2028-2036.

p53 expression predicts dismal outcome for medulloblastoma patients with metastatic disease.
Gessi M, von Bueren A, Rutkowski S, Rutkowski S, Pietsch T
J NEURO-ONCOL. 2012;106(1):135-141.

Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts.
Gieseke F, Mang P, Viebahn S, Sonntag I, Kruchen A, Erbacher A, Pfeiffer M, Handgretinger R, Müller I
EUR J IMMUNOL. 2012;42(8):2176-2186.

Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.
Grammel D, Warmuth-Metz M, von Bueren A, André O, Kool M, Pietsch T, Kretzschmar H, Rutkowski S, Rutkowski S, Pfister S, Schüller U
ACTA NEUROPATHOL. 2012;123(4):601-614.

Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature.
Grunewald T, Greulich N, Kontny U, Frühwald M, Rutkowski S, Kordes U, Scheurlen W, Schmidt W, Stachel D, Metzler M, Mittler U, Graf N, Benesch M, Burdach S
KLIN PADIATR. 2012;224(3):124-131.

Familial and acquired hemophagocytic lymphohistiocytosis.
Janka-Schaub G
ANNU REV MED. 2012;63:233-246.

Dissecting the genomic complexity underlying medulloblastoma.
Jones D, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, Cho Y, Pugh T, Hovestadt V, Stütz A, Rausch T, Warnatz H, Ryzhova M, Bender S, Sturm D, Pleier S, Cin H, Pfaff E, Sieber L, Wittmann A, Remke M, Witt H, Hutter S, Tzaridis T, Weischenfeldt J, Raeder B, Avci M, Amstislavskiy V, Zapatka M, Weber U, Wang Q, Lasitschka B, Bartholomae C, Schmidt M, von Kalle C, Ast V, Lawerenz C, Eils J, Kabbe R, Benes V, van Sluis P, Koster J, Volckmann R, Shih D, Betts M, Russell R, Coco S, Tonini G, Schüller U, Hans V, Graf N, Kim Y, Monoranu C, Roggendorf W, Unterberg A, Herold-Mende C, Milde T, Kulozik A, von Deimling A, Witt O, Maass E, Rössler J, Ebinger M, Schuhmann M, Frühwald M, Hasselblatt M, Jabado N, Rutkowski S, von Bueren A, André O, Williamson D, Clifford S, McCabe M, Collins V, Wolf S, Wiemann S, Lehrach H, Brors B, Scheurlen W, Felsberg J, Reifenberger G, Northcott P, Taylor M, Meyerson M, Pomeroy S, Yaspo M, Korbel J, Korshunov A, Eils R, Pfister S, Lichter P
NATURE. 2012;488(7409):100-105.

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Kool M, Korshunov A, Remke M, Jones D, Schlanstein M, Northcott P, Cho Y, Koster J, Antoinette S, van Vuurden D, Clifford S, Pietsch T, von Bueren A, Rutkowski S, Rutkowski S, McCabe M, Collins V, Bäcklund M, Haberler C, Bourdeaut F, Delattre O, Doz F, Ellison D, Gilbertson R, Pomeroy S, Taylor M, Lichter P, Pfister S
ACTA NEUROPATHOL. 2012;123(4):473-484.

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)
Korshunov A, Ryzhova M, Jones D, Northcott P, van Sluis P, Volckmann R, Koster J, Versteeg R, Cowdrey C, Perry A, Picard D, Rosenblum M, Giangaspero F, Aronica E, Schüller U, Hasselblatt M, Collins V, Deimling A, Lichter P, Huang A, Pfister S, Kool M
ACTA NEUROPATHOL. 2012;124(6):875-81.

Low values of 5-hydroxymethylcytosine (5hmC), the "sixth base," are associated with anaplasia in human brain tumors
Kraus T, Globisch D, Wagner M, Eigenbrod S, Widmann D, Münzel M, Müller M, Pfaffeneder T, Hackner B, Feiden W, Schüller U, Carell T, Kretzschmar H
INT J CANCER. 2012;131(7):1577-90.

Loss of TP53 expression in immortalized choroid plexus epithelial cells results in increased resistance to anticancer agents
Krzyzankova M, Mertsch S, Koos B, Jeibmann A, Kruse A, Kordes U, Frühwald M, Wolff J, Paulus W, Hasselblatt M
J NEURO-ONCOL. 2012;109(3):449-55.

Basic biology and clinical application of multipotent mesenchymal stromal cells: from bench to bedside.
Kuçi S, Henschler R, Müller I, Biagi E, Meisel R
Stem Cells Int. 2012;2012:185943.

Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial.
Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C, Taylor R, Gandola L, Björk-Eriksson T, Giralt J, Oldenburger F, Pietsch T, Figarella-Branger D, Robson K, Forni M, Clifford S, Warmuth-Metz M, von Hoff K, Faldum A, Mosseri V, Kortmann R
J CLIN ONCOL. 2012;30(26):3187-3193.

Variant alleles of cytokine genes influence risk and clinical course of Langerhans cell histiocytosis.
Lehrnbecher T, Salzmann-Manrique E, Soerensen J, Beutel K, Janka-Schaub G, Gadner H, Minkov M
BRIT J HAEMATOL. 2012;156(1):138-141.

Distinct mutations in STXBP2 are associated with variable clinical presentations in patients with familial hemophagocytic lymphohistiocytosis type 5 (FHL5)
Pagel J, Beutel K, Lehmberg K, Koch F, Maul-Pavicic A, Rohlfs A, Al-Jefri A, Beier R, Lilian B, Ehlert K, Gross-Wieltsch U, Jorch N, Kremens B, Pekrun A, Sparber-Sauer M, Mejstrikova E, Wawer A, Ehl S, Zur Stadt U, Janka-Schaub G
BLOOD. 2012;119(25):6016-6024.

Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
Pauli S, Steinemann D, Dittmann K, Wienands J, Shoukier M, Möschner M, Burfeind P, Manukjan G, Göhring G, Escherich G
AM J MED GENET A. 2012;158A(3):652-658.

IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT.
Pfeiffer M, Schumm M, Müller I, Handgretinger R, Lang P
LEUKEMIA. 2012;26(11):2435-2439.

Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome.
Ronceray L, Pötschger U, Janka-Schaub G, Gadner H, Minkov M, Hematology G, Group O
J PEDIATR-US. 2012;161(1):123-129.

DWI of the brain: postmortal DWI of the brain in comparison with in vivo data.
Schmidt T, Fischer R, Acar S, Lorenzen M, Heinemann A, Wedegärtner U, Adam G, Yamamura J
FORENSIC SCI INT. 2012;220(1-3):180-183.

Letter to the editor
Schnell O, Pöschl J, Tonn J, Schüller U
BRAIN PATHOL. 2012;22(5):724.

Outcomes after induction failure in childhood acute lymphoblastic leukemia.
Schrappe M, Hunger S, Pui C, Saha V, Gaynon P, Baruchel A, Conter V, Otten J, Ohara A, Versluys A, Escherich G, Heyman M, Silverman L, Horibe K, Mann G, Camitta B, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M
NEW ENGL J MED. 2012;366(15):1371-1381.

Fatal EBV infection and variable clinical manifestations in an XLP-1 pedigree - rapid diagnosis of primary immunodeficiencies may save lives.
Sperl D, Benesch M, Urban C, Lackner H, Sovinz P, Speicher M, Uhrig S, Schwarzbraun T, Schwinger W, Zur Stadt U, Beutel K, Janka-Schaub G, Scarpatetti M, Seidel M
KLIN PADIATR. 2012;224(6):386-389.

Molecular subgroups of medulloblastoma: the current consensus.
Taylor M, Northcott P, Korshunov A, Remke M, Cho Y, Clifford S, Eberhart C, Parsons D, Rutkowski S, Gajjar A, Ellison D, Lichter P, Gilbertson R, Pomeroy S, Kool M, Pfister S
ACTA NEUROPATHOL. 2012;123(4):465-472.

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice.
Terziyska N, Catarina C, Groiss V, Schneider K, Farkasova K, Ogris M, Wagner E, Ehrhardt H, Brentjens R, Zur Stadt U, Horstmann M, Quintanilla-Martinez L, Jeremias I
PLOS ONE. 2012;7(12):52798.

Risk factors for early death in children with haemophagocytic lymphohistiocytosis.
Trottestam H, Berglöf E, Horne A, Onelöv E, Beutel K, Lehmberg K, Sieni E, Silfverberg T, Aricò M, Janka-Schaub G, Henter J
ACTA PAEDIATR. 2012;101(3):313-318.

A young man with symptomatic epilepsy and right hemianopia: family affair
von Baumgarten L, Pfeifenbring S, Terpolilli N, Schüller U, Jahn K, Opherk C, Freilinger T
NEUROLOGY. 2012;79(19):2008-9.

CNS PNET molecular subgroups with distinct clinical features.
von Bueren A, André O
LANCET ONCOL. 2012;13(8):753-754.

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis.
von Bueren A, André O, Hagel C, Hagel C, Cai H, Remke M, Hasselblatt M, Feuerstein B, Pernet S, Delattre O, Rutkowski S, Rutkowski S, Pfister S, Baudis M
J NEURO-ONCOL. 2012;109(2):415-423.

Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours.
von Bueren A, Bacolod M, Hagel C, Heinimann K, Fedier A, Kordes U, Pietsch T, Koster J, Grotzer M, Friedman H, Marra G, Kool M, Rutkowski S
BRIT J CANCER. 2012;107(8):1399-1408.

Medulloblastoma.
von Hoff K, Rutkowski S
CURR TREAT OPTION NE. 2012;14(4):416-426.

Quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using amplicon-fusion-site polymerase chain reaction (AFS-PCR).
Weber A, Taube S, Zur Stadt U, Horstmann M, Krohn K, Bradtke J, Teigler-Schlegel A, Leiblein S, Christiansen H
EXP HEMATOL ONCOL. 2012;1(1):33.

Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database.
Wolff B, Ng A, Roth D, Parthey K, Warmuth-Metz M, Eyrich M, Kordes U, Kortmann R, Pietsch T, Kramm C, Wolff J
J NEURO-ONCOL. 2012;107(1):139-146.

CPT SIOP
Wolff J, Hasselblatt M, Hartung S, Powell M, Garami M, Traunecker H, Thall P, Mahajan A, Kordes U, Sumerauer D
J NEURO-ONCOL. 2012;14:i153.

The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.
Zuurbier L, Petricoin E, Vuerhard M, Calvert V, Kooi C, Buijs-Gladdines J, Smits W, Sonneveld E, Veerman A, Kamps W, Horstmann M, Pieters R, Meijerink J
HAEMATOLOGICA. 2012;97(9):1405-1413.

2011

Primary central nervous system primitive neuroectodermal tumors (CNS-PNETs) of the spinal cord in children: four cases from the German HIT database with a critical review of the literature.
Benesch M, Sperl D, von Bueren A, André O, von Hoff K, von Hoff K, Warmuth-Metz M, Ferrari R, Lassay L, Kortmann R, Rutkowski S, Rutkowski S
J NEURO-ONCOL. 2011;104(1):279-286.

Promising therapy results for lymphoid malignancies in children with chromosomal breakage syndromes (Ataxia teleangiectasia or Nijmegen-breakage syndrome): a retrospective survey.
Bienemann K, Burkhardt B, Modlich S, Meyer U, Möricke A, Bienemann K, Mauz-Körholz C, Escherich G, Zimmermann M, Körholz D, Janka-Schaub G, Schrappe M, Reiter A, Borkhardt A
BRIT J HAEMATOL. 2011;155(4):468-476.

Glioblastoma in childhood – Treatment and outcome of 7 patients
Burkhardt T, Emami P, Kordes U, Matschke J, Regelsberger J, Westphal M, Kammler G
2011. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). .

A complex karyotype in an atypical teratoid/rhabdoid tumor: case report and review of the literature.
Coccé M, Lubieniecki F, Kordes U, Alderete D, Gallego M
J NEURO-ONCOL. 2011;104(1):375-380.

Meta-analysis of randomised trials comparing thiopurines in childhood acute lymphoblastic leukaemia.
Escherich G, Richards S, Stork L, Vora A
LEUKEMIA. 2011;25(6):953-959.

The long-term impact of in vitro drug sensitivity on risk stratification and treatment outcome in acute lymphoblastic leukemia of childhood (CoALL 06-97).
Escherich G, Troeger A, Gobel U, Graubner U, Pekrun A, Jorch N, Kaspers G, Zimmermann M, Zur Stadt U, Kazemir K, Pieters R, Horstmann M, Denboer M, Janka-Schaub G
HAEMATOLOGICA. 2011;96(6):854-862.

Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006.
Gerber N, von Hoff K, von Bueren A, Treulieb W, Treulieb W, Warmuth-Metz M, Pietsch T, Soerensen N, Faldum A, Emser A, Schlegel P, Deinlein F, Rutkowski S, Rutkowski S
J NEURO-ONCOL. 2011;102(3):459-469.

Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
Gómez-Barrena E, Rosset P, Müller I, Giordano R, Bunu C, Layrolle P, Konttinen Y, Luyten F
J CELL MOL MED. 2011;15(6):1266-1286.

Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression.
Hasselblatt M, Gesk S, Oyen F, Rossi S, Viscardi E, Giangaspero F, Giannini C, Judkins A, Frühwald M, Obser T, Schneppenheim R, Siebert R, Paulus W
AM J SURG PATHOL. 2011;35(6):933-935.

SV40 and p53 as team players in childhood lymphoproliferative disorders.
Heinsohn S, Scholz R, Kabisch H
INT J ONCOL. 2011;38(5):1307-1317.

Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.
Homminga I, Pieters R, Langerak A, Rooi d, Johan J, Stubbs A, Verstegen M, Vuerhard M, Buijs-Gladdines J, Kooi C, Klous P, van Vlierberghe P, Ferrando A, Cayuela J, Verhaaf B, Horstmann M, Horstmann M, de Haas V, Wiekmeijer A, Pike-Overzet K, Staal F, de Laat W, Soulier J, Sigaux F, Meijerink J
CANCER CELL. 2011;19(4):484-497.

Subtle differences in CTL cytotoxicity determine susceptibility to hemophagocytic lymphohistiocytosis in mice and humans with Chediak-Higashi syndrome.
Jessen B, Maul-Pavicic A, Ufheil H, Vraetz T, Enders A, Lehmberg K, Längler A, Gross-Wieltsch U, Bay A, Kaya Z, Bryceson Y, Koscielniak E, Badawy S, Davies G, Hufnagel M, Schmitt-Graeff A, Aichele P, Zur Stadt U, Schwarz K, Ehl S
BLOOD. 2011;118(17):4620-4629.

Ectopic craniopharyngioma.
Kordes U, Flitsch J, Hagel C, Goebell E, Schwarz R, Herberhold T, von Bueren A, Rutkowski S, Müller H
KLIN PADIATR. 2011;223(3):176-177.

SIOP-CPT-2000 update
Kordes U, Kutluk T, Hasselblatt M, Pietsch A, Thall P, Wolff J
2011. 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH). .

Parvovirus B19 infection and autoimmune hepatitis in a child with sickle cell anemia.
Kordes U, Schneppenheim R, Briem-Richter A, Scherpe S, Schäfer H
PEDIATR BLOOD CANCER. 2011;56(2):323-324.

Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors
Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar H, Schüller U
MOL CELL BIOL. 2011;31(16):3326-38.

Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè M, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
CRIT REV ONCOL HEMAT. 2011;79(41):65-83.

Common large partial VWF gene deletion does not cause alloantibody formation in the Hungarian type 3 von Willebrand disease population.
Mohl A, Boda Z, Jager R, Losonczy H, Marosi A, Masszi T, Nagy E, Nemes L, Obser T, Oyen F, Radványi G, Schlammadinger [, Szélessy Z, Várkonyi A, Vezendy K, Vilimi B, Schneppenheim R, Bodó I
J THROMB HAEMOST. 2011;9(5):945-952.

Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature.
Müller K, Zwiener I, Welker H, Maass E, Bongartz R, Berthold F, Pietsch T, Warmuth-Metz M, von Bueren A, Rutkowski S
STRAHLENTHER ONKOL. 2011;187(11):757-762.

The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.
Oehler C, von Bueren A, André O, Furmanova P, Broggini-Tenzer A, Rutkowski S, Rutkowski S, Frei K, Grotzer M, Pruschy M
NEURO-ONCOLOGY. 2011;13(9):1000-1010.

High-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma--a systematic review.
Peinemann F, Kröger N, Bartel C, Grouven U, Pittler M, Erttmann R, Kulig M
PLOS ONE. 2011;6(2):17127.

An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia.
Perez-Becker R, Szczepanowski M, Leuschner I, Janka-Schaub G, Gokel M, Imschweiler T, Völpel S, Niehues T, Klapper W
PEDIATR BLOOD CANCER. 2011;56(5):859-862.

Increased cyclosporine concentrations in the absence of cyclosporine administration.
Peter A, Shipkova M, Wieland E, Schleicher E, Müller I
CLIN CHEM. 2011;57(5):670-673.

Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Pöschl J, Lorenz A, Hartmann W, von Bueren A, Kool M, Li S, Peraud A, Tonn J, Herms J, Xiang M, Rutkowski S, Kretzschmar H, Schüller U
ONCOGENE. 2011;30(47):4721-4730.

Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
Priller M, Pöschl J, Abrão L, von Bueren A, Cho Y, Rutkowski S, Kretzschmar H, Schüller U
CLIN CANCER RES. 2011;17(21):6791-801.

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.
Remke M, Hielscher T, Korshunov A, Northcott P, Bender S, Kool M, Westermann F, Benner A, Cin H, Ryzhova M, Sturm D, Witt H, Haag D, Toedt G, Wittmann A, Schöttler A, von Bueren A, André O, Rutkowski S, Rutkowski S, Scheurlen W, Kulozik A, Taylor M, Lichter P, Pfister S
J CLIN ONCOL. 2011;29(29):3852-3861.

Characterisation of two novel large F8 deletions in patients with severe haemophilia A and factor VIII inhibitors.
Roth L, Marschalek R, Oldenburg J, Oyen F, Schneppenheim R
THROMB HAEMOSTASIS. 2011;105(2):279-284.

The pathophysiology of von Willebrand disease: therapeutic implications.
Schneppenheim R
THROMB RES. 2011;128 Suppl 1:3-7.

Regulation der primären Hämostase durch von-Willebrand-Faktor und ADAMTS13
Schneppenheim R, Budde U
HAMOSTASEOLOGIE. 2011;31(4):275-80.

[Von Willebrand factor and ADAMTS13 balancing primary haemostasis].
Schneppenheim R, Budde U
HAMOSTASEOLOGIE. 2011;31(4):275-280.

von Willebrand factor: the complex molecular genetics of a multidomain and multifunctional protein.
Schneppenheim R, Budde U
J THROMB HAEMOST. 2011;9 Suppl 1:209-215.

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3.
Sieni E, Cetica V, Santoro A, Beutel K, Mastrodicasa E, Meeths M, Ciambotti B, Brugnolo F, Zur Stadt U, Pende D, Moretta L, Griffiths G, Henter J, Janka-Schaub G, Aricò M
J MED GENET. 2011;48(5):343-352.

A comparison between two semi-quantitative bleeding scales for the diagnosis and assessment of bleeding severity in type 1 von Willebrand disease.
Tosetto A, Rodeghiero F, Castaman G, Goodeve A, Federici A, Batlle J, Meyer D, Goudemand J, Eikenboom J, Schneppenheim R, Budde U, Ingerslev J, Lethagen S, Hill F, Peake I
HAEMOPHILIA. 2011;17(1):165-166.

Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.
Trottestam H, Horne A, Aricò M, Egeler R, Filipovich A, Gadner H, Imashuku S, Ladisch S, Webb D, Janka-Schaub G, Henter J, Society H
BLOOD. 2011;118(17):4577-4584.

Severe phototoxicity associated with long-term voriconazole treatment.
Vöhringer S, Schrum J, Ott H, Höger P
J DTSCH DERMATOL GES. 2011;9(4):274-276.

c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients.
von Bueren A, André O, Oehler C, von Hoff K, von Hoff K, Pruschy M, Seifert B, Gerber N, Warmuth-Metz M, Stearns D, Eberhart C, Rutkowski S, Rutkowski S, Grotzer M
BMC CANCER. 2011;11:74.

Late complete remission of supratentorial primitive neuroectodermal tumor (CNS-PNET) after multiple relapses.
von Bueren A, André O, Warmuth-Metz M, Schlegel P, Soerensen N, Krauss J, Roggendorf W, Pietsch T, Feiden W, Graf N, Pohl F, Flentje M, Rutkowski S, Rutkowski S
PEDIATR BLOOD CANCER. 2011;56(3):503-505.

Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology.
von Bueren A, von Hoff K, von Hoff K, Pietsch T, Gerber N, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, Krauss J, Kuehl J, Rutkowski S, Rutkowski S
NEURO-ONCOLOGY. 2011;13(6):669-679.

Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database.
von Hoff K, Hinkes B, Dannenmann-Stern E, von Bueren A, André O, Warmuth-Metz M, Soerensen N, Emser A, Zwiener I, Schlegel P, Kuehl J, Frühwald M, Kortmann R, Rutkowski S, Rutkowski S
PEDIATR BLOOD CANCER. 2011;57(6):978-985.

Outcome of children and adolescents with relapsed acute lymphoblastic leukaemia and non-response to salvage protocol therapy: a retrospective analysis of the ALL-REZ BFM Study Group.
von Stackelberg A, Völzke E, Kühl J, Seeger K, Schrauder A, Escherich G, Henze G, Tallen G, Group A
EUR J CANCER. 2011;47(1):90-97.

Recurrence in childhood medulloblastoma.
Warmuth-Metz M, Blashofer S, von Bueren A, von Hoff K, von Hoff K, Bison B, Pohl F, Kortmann R, Rutkowski S, Rutkowski S
J NEURO-ONCOL. 2011;103(3):705-711.

Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases.
Wernicke C, Grunewald T, Juenger H, Kuci S, Kuci Z, Koehl U, Müller I, Doering M, Peters C, Lawitschka A, Kolb H, Bader P, Burdach S, von Luettichau I
Int Arch Med. 2011;4(1):27.

TH1 predominance is associated with improved survival in pediatric medulloblastoma patients
Wiegering V, Eyrich M, Rutkowski S, Wölfl M, Schlegel P, Winkler B
CANCER IMMUNOL IMMUN. 2011;60(5):693-703.

High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D Pilot study.
Wolff J, Kortmann R, Wolff B, Pietsch T, Peters O, Schmid H, Rutkowski S, Warmuth-Metz M, Kramm C
J NEURO-ONCOL. 2011;102(3):433-442.

Pancreatic exocrine function and cardiac iron in patients with iron overload and with thalassemia.
Yamamura J, Grosse R, Jarisch A, Janka-Schaub G, Nielsen P, Adam G, Fischer R
PEDIATR BLOOD CANCER. 2011;57(4):674-676.

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia.
Zenatti P, Ribeiro D, Li W, Zuurbier L, Silva M, Paganin M, Tritapoe J, Hixon J, Silveira A, Cardoso B, Sarmento L, Correia N, Toribio M, Kobarg J, Horstmann M, Pieters R, Brandalise S, Ferrando A, Meijerink J, Durum S, Yunes J, Barata J
NAT GENET. 2011;43(10):932-939.

2010

Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours.
Ardon H, Steven D, Frank V, Claes L, Kramm C, Rutkowski S, Wolff J, Gool V, Stefaan W
PEDIATR BLOOD CANCER. 2010;54(4):519-525.

Clinical outcome of children with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia treated between 1995 and 2005.
Aricò M, Schrappe M, Hunger S, Carroll W, Conter V, Galimberti S, Manabe A, Saha V, Baruchel A, Vettenranta K, Horibe K, Benoit Y, Pieters R, Escherich G, Silverman L, Pui C, Valsecchi M
J CLIN ONCOL. 2010;28(31):4755-4761.

Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database.
Benesch M, Weber-Mzell D, Gerber N, von Hoff K, Deinlein F, Krauss J, Warmuth-Metz M, Kortmann R, Pietsch T, Driever P, Quehenberger F, Urban C, Rutkowski S
J NEUROSURG-PEDIATR. 2010;6(2):137-144.

Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl.
Calaminus G, Göbel U, Schrum J, Wittkugel O, Westphal M, Timmermann B
KLIN PADIATR. 2010;222(3):175-179.

Homozygous type 2N R854W von Willebrand factor is poorly secreted and causes a severe von Willebrand disease phenotype.
Castaman G, Giacomelli S, Jacobi P, Obser T, Budde U, Rodeghiero F, Haberichter S, Schneppenheim R
J THROMB HAEMOST. 2010;8(9):2011-2016.

Homozygous type 2N R854W von Willebrand factor is poorly secreted and causes a severe von Willebrand disease phenotype
Castaman G, Giacomelli S, Jacobi P, Obser T, Budde U, Rodeghiero F, Haberichter S, Schneppenheim R
J THROMB HAEMOST. 2010;8(9):2011-6.

Validation of a rapid test (VWF-LIA) for the quantitative determination of von Willebrand factor antigen in type 1 von Willebrand disease diagnosis within the European multicenter study MCMDM-1VWD.
Castaman G, Tosetto A, Cappelletti A, Goodeve A, Federici A, Batlle J, Meyer D, Goudemand J, Eikenboom J, Schneppenheim R, Budde U, Ingerslev J, Lethagen S, Hill F, Peake I, Rodeghiero F
THROMB RES. 2010;126(3):227-231.

The impact of bleeding history, von Willebrand factor and PFA-100(®) on the diagnosis of type 1 von Willebrand disease: results from the European study MCMDM-1VWD.
Castaman G, Tosetto A, Goodeve A, Federici A, Lethagen S, Ulrich B, Batlle J, Meyer D, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Habart D, Hill F, Peake I, Rodeghiero F
BRIT J HAEMATOL. 2010;151(3):245-251.

STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5.
Cetica V, Santoro A, Gilmour K, Sieni E, Beutel K, Pende D, Marcenaro S, Koch F, Grieve S, Wheeler R, Zhao F, Zur Stadt U, Griffiths G, Aricò M
J MED GENET. 2010;47(9):595-600.

A FOXO-Pak1 transcriptional pathway controls neuronal polarity
de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih D, Rowitch D, Brunet A, Bonni A
GENE DEV. 2010;24(8):799-813.

Systematic review of the addition of vincristine plus steroid pulses in maintenance treatment for childhood acute lymphoblastic leukaemia - an individual patient data meta-analysis involving 5,659 children
Eden T, Pieters R, Yetgin S, Olcay L, Dibar E, Conter V, Masera G, Valsecchi M, Dacou-Voutetakis C, Henze G, Loening L, Schrappe M, von Stackelberg A, Zimmermann M, Attarbaschi A, Gadner H, Mann G, Brandalise S, Carroll W, Devidas M, Gaynon P, Hunger S, Nachman J, Janka-Schaub G, Stary J, Gelber R, Bierings M, Kamps W, Otten J, Suciu S, Viana M, Baruchel A, Ortega J, Magyarosy E, Perez C, Steinberg D, Tsurusawa M, Zintl F, Matsuzaki A, Lilleyman J, Richards S, Steinherz P, Kochupillai V, de Toledo J, Appelbaum F, Campbel M, Cheng C, Pei D, Pui C, Kukure P, Nakazawa S, Elphinstone T, Evans V, Gettins L, Hicks C, MacKinnon L, Morris P, Wade R, Wise C
BRIT J HAEMATOL. 2010;149(5):722-733.

Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97.
Escherich G, Horstmann M, Zimmermann M, Janka-Schaub G
LEUKEMIA. 2010;24(2):298-308.

Non-cerebellar primitive neuroectodermal tumors (PNET): summary of the Milan consensus and state of the art workshop on marrow ablative chemotherapy with hematopoietic cell rescue for malignant brain tumors of childhood and adolescents.
Fangusaro J, Massimino M, Rutkowski S, Gururangan S
PEDIATR BLOOD CANCER. 2010;54(4):638-640.

Ongoing remission after intensive ALL-type chemotherapy in pediatric intestinal T-cell lymphoma.
Friedrich C, Schrum J, Chott A, Janka-Schaub G, Kabisch H
PEDIATR BLOOD CANCER. 2010;54(4):610-612.

The mutation N528S in the von Willebrand factor (VWF) propeptide causes defective multimerization and storage of VWF.
Haberichter S, Ulrich B, Obser T, Schneppenheim S, Wermes C, Schneppenheim R
BLOOD. 2010;115(22):4580-4587.

Polymorphic variation within the VWF gene contributes to the failure to detect mutations in patients historically diagnosed with type 1 von Willebrand disease from the MCMDM-1VWD cohort.
Hampshire D, Burghel G, Goudemand J, Bouvet L, Eikenboom J, Schneppenheim R, Ulrich B, Peake I, Goodeve A
HAEMATOLOGICA. 2010;95(12):2163-2165.

Dexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastoma
Heine V, Priller M, Ling J, Rowitch D, Schüller U
CANCER RES. 2010;70(13):5220-5.

von Willebrand factor variant p.Arg924Gln marks an allele associated with reduced von Willebrand factor and factor VIII levels
Hickson N, Hampshire D, Winship P, Goudemand J, Schneppenheim R, Budde U, Castaman G, Rodeghiero F, Federici A, James P, Peake I, Eikenboom J, Goodeve A
J THROMB HAEMOST. 2010;8(9):1986-1993.

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
Holzwarth C, Vaegler M, Gieseke F, Pfister S, Handgretinger R, Kerst G, Müller I
BMC CELL BIOL. 2010;11:11.

Difficulties in diagnosing congenital thrombotic thrombocytopenic purpura.
Klukowska A, Niewiadomska E, Ulrich B, Oyen F, Schneppenheim R
J PEDIAT HEMATOL ONC. 2010;32(2):103-107.

Neonatal cholestasis and glucose-6-P-dehydrogenase deficiency.
Kordes U, Briem-Richter A, Santer R, Schäfer H, Singer D, Sonntag J, Steuerwald U, Schneppenheim R, Janka-Schaub G
PEDIATR BLOOD CANCER. 2010;54(5):758-760.

Neonatal cholestasis in glucose-6-phosphate dehydrogenase deficiency.
Kordes U, Briem-Richter A, Santer R, Schäfer H, Singer D, Sonntag J, Steuerwald U, Schneppenheim R, Janka-Schaub G
PEDIATR BLOOD CANCER. 2010;54(5):758-766.

Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor.
Kordes U, Gesk S, Frühwald M, Graf N, Leuschner I, Hasselblatt M, Jeibmann A, Oyen F, Peters O, Pietsch T, Siebert R, Schneppenheim R
GENE CHROMOSOME CANC. 2010;49(2):176-181.

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification.
Korshunov A, Remke M, Werft W, Benner A, Ryzhova M, Witt H, Sturm D, Wittmann A, Schöttler A, Felsberg J, Reifenberger G, Rutkowski S, Scheurlen W, Kulozik A, von Deimling A, Lichter P, Pfister S
J CLIN ONCOL. 2010;28(18):3054-3060.

Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study.
Mann G, Attarbaschi A, Schrappe M, Paola D, Peters C, Hann I, Giulio D, Felice M, Lausen B, Leblanc T, Szczepanski T, Ferster A, Janka-Schaub G, Rubnitz J, Silverman Lewis B, Stary J, Campbell M, Li C, Suppiah R, Biondi A, Vora A, Valsecchi M, Pieters R, Group I
BLOOD. 2010;116(15):2644-2650.

Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia.
Meinhardt A, Burkhardt B, Zimmermann M, Borkhardt A, Kontny U, Klingebiel T, Berthold F, Janka-Schaub G, Klein C, Kabickova E, Klapper W, Attarbaschi A, Schrappe M, Reiter A, Group B
J CLIN ONCOL. 2010;28(19):3115-3121.

Loss of SMARCB1/INI1 expression in poorly differentiated chordomas.
Mobley B, McKenney J, Bangs C, Callahan K, Yeom K, Schneppenheim R, Hayden M, Cherry A, Gokden M, Edwards M, Fisher P, Vogel H
ACTA NEUROPATHOL. 2010;120(6):745-753.

Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Müller-Tidow C, Klein H, Hascher A, Isken F, Tickenbrock L, Thoennissen N, Agrawal-Singh S, Tschanter P, Disselhoff C, Wang Y, Becker A, Thiede C, Ehninger G, Zur Stadt U, Koschmieder S, Seidl M, Müller F, Schmitz W, Schlenke P, McClelland M, Berdel W, Dugas M, Serve H, Leukemia S
BLOOD. 2010;116(18):3564-3571.

Laboratory diagnosis of von Willebrand disease.
Patzke J, Schneppenheim R
HAMOSTASEOLOGIE. 2010;30(4):203-206.

Subacute herpes simplex encephalitis presenting as relapsing encephalitis
Peters N, Fesl G, Theil D, Schüller U, Birnbaum T, Brückmann H, Noachtar S
J NEUROL. 2010;257(5):843-5.

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.
Pfaff E, Remke M, Sturm D, Benner A, Witt H, Till M, von Bueren A, André O, Wittmann A, Schöttler A, Jorch N, Graf N, Kulozik A, Witt O, Scheurlen W, Rutkowski S, Rutkowski S, Taylor M, Tabori U, Lichter P, Korshunov A, Pfister S
J CLIN ONCOL. 2010;28(35):5188-5196.

Giant cell arteritis of the Basal cerebral arteries: correlation of MRI, dsa, and histopathology
Pfefferkorn T, Schüller U, Cyran C, Hüfner K, Fesl G, Seelos K, Dichgans M, Pfister H, Nikolaou K, Kretzschmar H, Saam T
NEUROLOGY. 2010;74(20):1651-3.

A 76-year-old woman with paraplegia
Rémi J, Pfefferkorn T, König F, Lassmann H, Brück W, Holtmannspötter M, Straube A, Kretzschmar H, Schüller U
BRAIN PATHOL. 2010;20(2):507-10.

Atypical familial hemophagocytic lymphohistiocytosis due to mutations in UNC13D and STXBP2 overlaps with primary immunodeficiency diseases
Rohr J, Beutel K, Maul-Pavicic A, Vraetz T, Thiel J, Warnatz K, Bondzio I, Gross-Wieltsch U, Schündeln M, Schütz B, Woessmann W, Groll A, Strahm B, Pagel J, Speckmann C, Janka-Schaub G, Griffiths G, Schwarz K, Zur Stadt U, Ehl S
HAEMATOLOGICA. 2010;95(12):2080-2087.

Chronic inflammatory bowel disease as key manifestation of atypical ARTEMIS deficiency
Rohr J, Pannicke U, Döring M, Schmitt-Graeff A, Wiech E, Busch A, Speckmann C, Müller I, Lang P, Handgretinger R, Fisch P, Schwarz K, Ehl S
J CLIN IMMUNOL. 2010;30(2):314-20.

Medulloblastoma in young children.
Rutkowski S, Cohen B, Finlay J, Luksch R, Ridola V, Valteau-Couanet D, Hara J, Garre M, Grill J
PEDIATR BLOOD CANCER. 2010;54(4):635-637.

Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis.
Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison D, Garre M, Biassoni V, Grundy R, Finlay J, Dhall G, Raquin M, Grill J
J CLIN ONCOL. 2010;28(33):4961-4968.

Neue Aspekte der MRT-Bildgebung zur Diagnostik der Großgefäßvaskulitiden sowie der primären Angiitis des zentralen Nervensystems
Saam T, Habs M, Cyran C, Grimm J, Pfefferkorn T, Schüller U, Reiser M, Nikolaou K
RADIOLOGE. 2010;50(10):861-71.

Using ImageJ for the quantitative analysis of flow-based adhesion assays in real-time under physiologic flow conditions.
Sascha M, Klinkhardt U, Schneppenheim R, Harder S
PLATELETS. 2010;21(1):60-66.

Germline nonsense mutation and somatic inactivation of SMARCA4/BRG1 in a family with rhabdoid tumor predisposition syndrome.
Schneppenheim R, Frühwald M, Gesk S, Hasselblatt M, Jeibmann A, Kordes U, Kreuz M, Leuschner I, Subero M, Obser T, Oyen F, Oyen F, Vater I, Siebert R
AM J HUM GENET. 2010;86(2):279-284.

A cluster of mutations in the D3 domain of von Willebrand factor correlates with a distinct subgroup of von Willebrand disease: type 2A/IIE.
Schneppenheim R, Michiels J, Obser T, Oyen F, Pieconka A, Schneppenheim S, Will K, Zieger B, Ulrich B
BLOOD. 2010;115(23):4894-4901.

Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.
Shalaby T, von Bueren A, André O, Hürlimann M, Fiaschetti G, Castelletti D, Masayuki T, Nagasawa K, Arcaro A, Jelesarov I, Shin-ya K, Grotzer M
MOL CANCER THER. 2010;9(1):167-179.

Cerebellar stem cells act as medulloblastoma-initiating cells in a mouse model and a neural stem cell signature characterizes a subset of human medulloblastomas
Sutter R, Shakhova O, Bhagat H, Behesti H, Sutter C, Penkar S, Santuccione A, Bernays R, Heppner F, Schüller U, Grotzer M, Moch H, Schraml P, Marino S
ONCOGENE. 2010;29(12):1845-56.

Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-of-relapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90.
Tallen G, Ratei R, Mann G, Kaspers G, Niggli F, Karachunsky A, Ebell W, Escherich G, Schrappe M, Klingebiel T, Fengler R, Henze G, von Stackelberg A
J CLIN ONCOL. 2010;28(14):2339-2347.

Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors.
von Hoff K, Hartmann W, von Bueren A, Oscar A, Gerber N, Grotzer M, Rutkowski S, Rutkowski S
PEDIATR BLOOD CANCER. 2010;54(3):369-376.

Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol.
Wolff J, Driever P, Erdlenbruch B, Kortmann R, Rutkowski S, Pietsch T, Parker C, Metz M, Gnekow A, Kramm C
CANCER-AM CANCER SOC. 2010;116(3):705-712.

[28-year old female patient with respiratory insufficiency, elevated liver enzymes, pancytopenia and fever].
Wolschke C, Fiedler W, Habermann C, Janka-Schaub G, Kluge S
INTERNIST. 2010;51(11):1434-1438.

Distribution of cardiac iron measured by magnetic resonance imaging (MRI)-R*2.
Yamamura J, Grosse R, Graessner J, Janka-Schaub G, Adam G, Fischer R
J MAGN RESON IMAGING. 2010;32(5):1104-1109.

Severe bleeding diathesis associated with moderate thrombocytopenia - diagnostic workup of seven family members with type 2B von Willebrand's disease.
Zdziarska J, Iwaniec T, Skotnicki A, Musia J, Schneppenheim R, Budde U, Kentouche K
HAEMOPHILIA. 2010;16(6):958-962.

NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.
Zuurbier L, Homminga I, Calvert V, Te Winkel M, Buijs-Gladdines J, Kooi C, Smits W, Sonneveld E, Veerman A, Kamps W, Horstmann M, Petricoin E, Pieters R, Meijerink J
LEUKEMIA. 2010;24(12):2014-2022.

2009

Fatal Epstein-Barr virus infection in a case of familial hemophagocytic lymphohistiocytosis with syntaxin-11 mutation.
Albayrak M, Kaya Z, Yilmaz-Keskin E, Zur Stadt U, Koçak U, Gürsel T
TURKISH J PEDIATR. 2009;51(4):371-374.

Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group.
Bader P, Kreyenberg H, Henze G, Eckert C, Reising M, Willasch A, Barth A, Borkhardt A, Peters C, Handgretinger R, Sykora K, Holter W, Kabisch H, Klingebiel T, von Stackelberg A
J CLIN ONCOL. 2009;27(3):377-384.

Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
Battula V, Treml S, Bareiss P, Gieseke F, Roelofs H, de Zwart P, Müller I, Schewe B, Skutella T, Fibbe W, Kanz L, Bühring H
HAEMATOLOGICA. 2009;94(2):173-84.

Infection of T lymphocytes in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children of non-Asian origin.
Beutel K, Gross-Wieltsch U, Wiesel T, Zur Stadt U, Janka-Schaub G, Wagner H
PEDIATR BLOOD CANCER. 2009;53(2):184-190.

ITI with high-dose FIX and combined immunosuppressive therapy in a patient with severe haemophilia B and inhibitor.
Beutel K, Hauch H, Rischewski J, Kordes U, Schneppenheim J, Schneppenheim R
HAMOSTASEOLOGIE. 2009;29(2):155-157.

Infection of T lymphocytes in non-Asian patients with epstein-barr virus-associated hemophagocytic-response.
Beutel K, Janka-Schaub G
PEDIATR BLOOD CANCER. 2009.

Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008.
Brüggemann M, Schrauder A, Raff T, Pfeifer H, Dworzak M, Ottmann O, Asnafi V, Baruchel A, Bassan R, Benoit Y, Biondi A, Cavé H, Dombret H, Fielding A, Foà R, Gökbuget N, Goldstone A, Goulden N, Henze G, Hoelzer D, Janka-Schaub G, Macintyre E, Pieters R, Rambaldi A, Ribera J, Schmiegelow K, Spinelli O, Stary J, von Stackelberg A, Kneba M, Schrappe M, van Dongen J
LEUKEMIA. 2009.

Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.
Bug S, Dürig J, Oyen F, Klein-Hitpass L, Martin-Subero J, Harder L, Baudis M, Arnold N, Kordes U, Dührsen U, Schneppenheim R, Siebert R
CANCER GENET-NY. 2009;192(1):44-47.

Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure.
Claus R, Bockmeyer C, Ulrich B, Kentouche K, Sossdorf M, Hilberg T, Schneppenheim R, Reinhart K, Bauer M, Brunkhorst F, Lösche W
THROMB HAEMOSTASIS. 2009;101(2):239-247.

Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.
Dedes K, Dedes I, Imesch P, von Bueren A, André O, Fink D, Fedier A
ANTI-CANCER DRUG. 2009;20(5):321-333.

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study.
Den B, Monique L, Slegtenhorst v, Marjon [, Menezes D, Renée X, Cheok [, Meyling H, Buijs-Gladdines [, Jessica G, Peters [, Susan T, Zutven V, Laura J, Beverloo [, Berna H, Spek V, Peter J, Escherich G, Gaby [, Horstmann M, Martin A, Janka-Schaub G, Gritta E, Kamps [, Willem A, Evans [, William E, Pieters [, Rob [
LANCET ONCOL. 2009;10(2):125-134.

Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare.
Eberl W, Budde U, Bentele K, Christen H, Knapp R, Mey A, Schneppenheim R
HAMOSTASEOLOGIE. 2009;29(2):137-142.

Expression of 14 von Willebrand factor mutations identified in patients with type 1 von Willebrand disease from the MCMDM-1VWD study
Eikenboom J, Hilbert L, Ribba A, Hommais A, Habart D, Messenger S, Al-Buhairan A, Guilliatt A, Lester W, Mazurier C, Meyer D, Fressinaud E, Budde U, Will K, Schneppenheim R, Obser T, Marggraf O, Eckert E, Castaman G, Rodeghiero F, Federici A, Batlle J, Goudemand J, Ingerslev J, Lethagen S, Hill F, Peake I, Goodeve A
J THROMB HAEMOST. 2009;7(8):1304-12.

Expression of fourteen von Willebrand factor mutations identified in patients with type 1 von Willebrand disease from the MCMDM-1VWD study.
Eikenboom J, Hilbert L, Ribba A, Hommais A, Habart D, Messenger S, Al-Buhairan A, Guilliatt A, Lester W, Mazurier C, Meyer D, Fressinaud E, Budde U, Will K, Schneppenheim R, Obser T, Marggraf O, Eckert E, Castaman G, Rodeghiero F, Federici A, Batlle J, Goudemand J, Ingerslev J, Lethagen S, Oyen F, Peake I, Goodeve A
J THROMB HAEMOST. 2009.

Dendritic cells: functional aspects of glycosylation and lectins
Erbacher A, Gieseke F, Handgretinger R, Müller I
HUM IMMUNOL. 2009;70(5):308-12.

Diffusion-driven device for a high-resolution dose-response profiling of combination chemotherapy
Ganser A, Roth G, van Galen J, Hilderink J, Wammes J, Müller I, van Leeuwen F, Wiesmüller K, Brock R
ANAL CHEM. 2009;81(13):5233-40.

The CD70/CD27 pathway is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia.
Glouchkova L, Ackermann B, Zibert A, Meisel R, Siepermann M, Janka-Schaub G, Goebel U, Troeger A, Dilloo D
J IMMUNOL. 2009;182(1):718-725.

Second allogeneic stem cell transplantation in myeloid malignancies.
Hartwig M, Ocheni S, Asenova S, Wiedemann B, Zabelina T, Ayuketang Ayuk F, Kabisch H, Erttmann R, Kröger N, Zander A, Bacher U
ACTA HAEMATOL-BASEL. 2009;122(4):185-192.

Cribriform neuroepithelial tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis.
Hasselblatt M, Oyen F, Gesk S, Kordes U, Brigitte W, Bergmann M, Schmid H, Frühwald M, Schneppenheim R, Siebert R, Paulus W
J NEUROPATH EXP NEUR. 2009;68(12):1249-1255.

Evaluation of SV40 in osteosarcoma and healthy population: a Hungarian-German study.
Heinsohn S, Szendroi M, Bielack S, Zur Stadt U, Kabisch H
ONCOL REP. 2009;21(2):289-297.

Hemophagocytic lymphohistiocytosis: when the immune system runs amok.
Janka-Schaub G
KLIN PADIATR. 2009;221(5):278-285.

Case-control study on the therapy of childhood cancer and the occurrence of second malignant neoplasms in Germany.
Kaatsch P, Reinisch I, Spix C, Berthold F, Janka-Schaub G, Mergenthaler A, Michaelis J, Blettner M
CANCER CAUSE CONTROL. 2009;20(6):965-980.

Neuroonkologie
Kammler G, Kordes U, Hornung D, LINHART D, Hagel C
2009. Neuropädiatrie - Evidenzbasierte Therapie. Elsevier: 215-239.

HLA-mismatched unrelated donors as an alternative graft source for allogeneic stem cell transplantation after antithymocyte globulin-containing conditioning regimen.
Kröger N, Zabelina T, Binder T, Ayuketang Ayuk F, Bacher U, Amtsfeld G, Lellek H, Schrum J, Erttmann R, Eiermann T, Zander A
BIOL BLOOD MARROW TR. 2009;15(4):454-462.

Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro
Langer H, Stellos K, Steingen C, Froihofer A, Schönberger T, Krämer B, Bigalke B, May A, Seizer P, Müller I, Gieseke F, Siegel-Axel D, Meuth S, Schmidt A, Wendel H, Müller I, Bloch W, Gawaz M
J MOL CELL CARDIOL. 2009;47(2):315-25.

Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome.
Lehmberg K, Rohr J, Schneppenheim R, Sommerfeld K, Janka-Schaub G
ACTA PAEDIATR. 2009;98(5):769-770, 912-914.

Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol.
Linden v, Marieke H, Valsecchi M, Paola D, Janka-Schaub G, Janka G, Leblanc T, Felice M, Andrea B, Campbell M, Hann I, Rubnitz J, Stary J, Szczepanski T, Vora A, Ferster A, Hovi L, Silverman L, Pieters R
BLOOD. 2009;114(18):3764-3768.

Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia.
Lönnerholm G, Valsecchi M, Paola D, Schrappe M, Hovi L, Campbell M, Mann G, Janka-Schaub G, Li C, Stary J, Hann I, Pieters R
PEDIATR BLOOD CANCER. 2009;52(5):596-601.

Heterozygous missense protein S mutation in a young boy with incomplete tetraplegia.
Mauz-Koerholz C, Müller T, Kunze C, Schneppenheim R, Bernstaedt M, Koerholz D
KLIN PADIATR. 2009;221(3):180.

Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations.
Meeths M, Bryceson Y, Rudd E, Zheng C, Wood S, Ramme K, Beutel K, Hasle H, Heilmann C, Hultenby K, Ljunggren H, Fadeel B, Nordenskjöld M, Henter J
PEDIATR BLOOD CANCER. 2009.

New insights to the MLL recombinome of acute leukemias.
Meyer C, Kowarz E, Hofmann J, Renneville A, Zuna J, Trka J, Ben Abdelali R, Macintyre E, De Braekeleer E, De Braekeleer M, Delabesse E, de Oliveira M, Cavé H, Clappier E, van Dongen J, Balgobind B, van den Heuvel-Eibrink M, Beverloo H, Panzer-Grümayer R, Teigler-Schlegel A, Harbott J, Kjeldsen E, Schnittger S, Koehl U, Gruhn B, Heidenreich O, Chan L, Yip S, Krzywinski M, Eckert C, Möricke A, Schrappe M, Alonso C, Schäfer B, Krauter J, Lee D, Zur Stadt U, Te Kronnie G, Sutton R, Izraeli S, Trakhtenbrot L, Lo Nigro L, Tsaur G, Fechina L, Szczepanski T, Strehl S, Ilencikova D, Molkentin M, Burmeister T, Dingermann T, Klingebiel T, Marschalek R
LEUKEMIA. 2009;23(8):1490-1499.

Italian Society of Hematology guidelines for thalassemia and non-invasive iron measurements.
Nielsen P, Engelhardt R, Grosse R, Janka-Schaub G, Harmatz P, Fischer R
HAEMATOLOGICA. 2009;94(2):294-296.

Allogeneic blood SCT for children with Hurler's syndrome: results from the German multicenter approach MPS-HCT 2005.
Sauer M, Meissner B, Fuchs D, Gruhn B, Kabisch H, Erttmann R, Suttorp M, Beilken A, Luecke T, Welte K, Grigull L, Sykora K
BONE MARROW TRANSPL. 2009;43(5):375-381.

Basic research and clinical applications of non-hematopoietic stem cells, 4-5 April 2008, Tubingen, Germany
Schäfer R, Dominici M, Müller I, Horwitz E, Asahara T, Bulte J, Bieback K, Le Blanc K, Bühring H, Capogrossi M, Dazzi F, Gorodetsky R, Henschler R, Handgretinger R, Kajstura J, Kluger P, Lange C, Luettichau I, Mertsching H, Schrezenmeier H, Sievert K, Strunk D, Verfaillie C, Northoff H
CYTOTHERAPY. 2009;11(2):245-55.

Molecular analysis and clinical aspects of four patients with Chédiak-Higashi syndrome (CHS).
Scherber E, Beutel K, Ganschow R, Schulz A, Janka-Schaub G, Zur Stadt U
CLIN GENET. 2009.

Paediatric haemostaseology.
Schneppenheim R
HAMOSTASEOLOGIE. 2009;29(2):133.

Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis.
Schneppenheim R, Baldauf C, Stacklies W, Obser T, Pieconka A, Schneppenheim S, Budde U, Zhou J, Gräter F
J THROMB HAEMOST. 2009;7(12):2096-2105.

Response to DDAVP in children with von Willebrand disease type 2.
Schneppenheim R, Budde U, Beutel K, Hassenpflug W, Hauch H, Obser T, Oyen F, Schneppenheim S, Schrum J
HAMOSTASEOLOGIE. 2009;29(2):143-148.

The problem of novel FVIII missense mutations for haemophilia A genetic counseling.
Schneppenheim R, Schröder J, Obser T, Oyen F, Schneppenheim S, Oldenburg J
HAMOSTASEOLOGIE. 2009;29(2):158-160.

Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation.
Sparber-Sauer M, Hönig M, Schulz A, Zur Stadt U, Schütz C, Debatin K, Friedrich W
BONE MARROW TRANSPL. 2009;44(6):333-338.

Hemophagocytic lymphohistiocytosis and Kawasaki disease: Combined manifestation and differential diagnosis.
Titze U, Janka-Schaub G, Schneider E, Prall F, Haffner D, Classen C
PEDIATR BLOOD CANCER. 2009;53(3):493-495.

WT1 mutations in T-ALL.
Tosello V, Mansour M, Barnes K, Paganin M, Sulis M, Jenkinson S, Allen C, Gale R, Linch D, Palomero T, Real P, Murty V, Yao X, Richards S, Goldstone A, Rowe J, Basso G, Wiernik P, Paietta E, Pieters R, Horstmann M, Meijerink J, Ferrando A
BLOOD. 2009;114(5):1038-1045.

Treatment of the X-linked lymphoproliferative, Griscelli and Chédiak-Higashi syndromes by HLH directed therapy.
Trottestam H, Beutel K, Meeths M, Carlsen N, Heilmann C, Pasi S, Webb D, Hasle H, Henter J
PEDIATR BLOOD CANCER. 2009;52(2):268-272.

A novel type 2A von Willebrand factor mutation (V1499E) associated with variable clinical expression.
van Den H, Esther [, Laat d, Bas [, Eckmann [, Carel M, Michiels [, Jan J, Schneppenheim R, Reinhard [, Ulrich B, Mourik v, Jan A, Versteegh [, Florens G
J PEDIAT HEMATOL ONC. 2009;31(4):277-280.

RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.
von Bueren A, André O, Shalaby T, Oehler-Jänne C, Arnold L, Stearns D, Eberhart C, Arcaro A, Pruschy M, Grotzer M
BMC CANCER. 2009;9:10.

Dose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91.
von Bueren A, von Hoff K, Benesch M, Rutkowski S
KLIN PADIATR. 2009;221(6):396-397.

Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91
von Hoff K, Hinkes B, Gerber N, Deinlein F, Mittler U, Urban C, Benesch M, Warmuth-Metz M, Soerensen N, Zwiener I, Goette H, Schlegel P, Pietsch T, Kortmann R, Kuehl J, Rutkowski S
EUR J CANCER. 2009;45(7):1209-17.

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11
zur Stadt U, Rohr J, Seifert W, Koch F, Grieve S, Pagel J, Strauss J, Kasper B, Nürnberg G, Becker C, Maul-Pavicic A, Beutel K, Janka G, Griffiths G, Ehl S, Hennies H
AM J HUM GENET. 2009;85(4):482-492.

2008

Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors.
Ayuketang Ayuk F, Diyachenko G, Zabelina T, Panse J, Wolschke C, Eiermann T, Binder T, Fehse B, Erttmann R, Kabisch H, Bacher U, Kröger N, Zander A
EXP HEMATOL. 2008;36(8):1047-1054.

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis.
Balgobind [, Brian V, Vlierberghe V, Pieter [, van Den O, Ans M, Beverloo [, Berna H, Terlouw-Kromosoeto [, Joan N, Wering v, Elisabeth R, Reinhardt [, Dirk [, Horstmann M, Martin [, Kaspers [, Gertjan J, Pieters [, Rob [, Zwaan [, Michel C, Heuvel-Eibrink V, Marry M, Meijerink [, Jules P
BLOOD. 2008;111(8):4322-4328.

Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected].
Bhojwani D, Kang H, Menezes R, Yang W, Sather H, Moskowitz N, Min D, Potter J, Harvey R, Hunger S, Seibel N, Raetz E, Pieters R, Horstmann M, Relling M, den Boer M, Willman C, Carroll W
J CLIN ONCOL. 2008;26(27):4376-4384.

Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor.
Bockmeyer C, Claus R, Budde U, Kentouche K, Schneppenheim R, Lösche W, Reinhart K, Brunkhorst F
HAEMATOLOGICA. 2008;93(1):137-140.

Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.
Boller D, Schramm A, Doepfner K, Shalaby T, von Bueren A, André O, Eggert A, Grotzer M, Arcaro A
CLIN CANCER RES. 2008;14(4):1172-1181.

Secondary malignant neoplasms after intensive treatment of relapsed acute lymphoblastic leukaemia in childhood.
Borgmann A, Zinn C, Hartmann R, Herold R, Kaatsch P, Escherich G, Möricke A, Henze G, von Stackelberg A
EUR J CANCER. 2008;44(2):257-268.

Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD).
Budde U, Schneppenheim R, Eikenboom J, Goodeve A, Will K, Drewke E, Castaman G, Rodeghiero F, Federici A, Batlle J, Pérez A, Meyer D, Mazurier C, Goudemand J, Ingerslev J, Habart D, Vorlova Z, Holmberg L, Lethagen S, Pasi J, Hill F, Peake I
J THROMB HAEMOST. 2008;6(5):762-771.

Response to desmopressin is influenced by the genotype and phenotype in type 1 von Willebrand disease (VWD): results from the European Study MCMDM-1VWD.
Castaman G, Lethagen S, Federici A, Tosetto A, Goodeve A, Budde U, Batlle J, Meyer D, Mazurier C, Fressinaud E, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Pasi J, Hill F, Peake I, Rodeghiero F
BLOOD. 2008;111(7):3531-3539.

Treatment of neuroblastoma with human natural antibodies.
Erttmann R
AUTOIMMUN REV. 2008;7(6):496-500.

Lack of Thy1 (CD90) expression in neuroblastomas is correlated with impaired survival.
Fiegel H, Kaifi J, Quaas A, Varol E, Krickhahn A, Metzger R, Sauter G, Till H, Izbicki J, Erttmann R, Kluth D
PEDIATR SURG INT. 2008;24(1):101-105.

Midkine is highly expressed in neuroblastoma tissues.
Fiegel H, Kaifi J, Wachowiak R, Quaas A, Aridome K, Ichihara-Tanaka K, Muramatsu T, Metzger R, Izbicki J, Erttmann R, Kluth D, Till H
PEDIATR SURG INT. 2008;24(12):1355-1359.

Analysis of the CC chemokine receptor 5Delta32 polymorphism in pediatric liver transplant recipients.
Fischer-Maas L, Schneppenheim R, Oyen F, Grabhorn E, Briem-Richter A, Fischer L, Ganschow R
PEDIATR TRANSPLANT. 2008;12(7):769-772.

Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors
Fuchs J, Seitz G, Ellerkamp V, Dietz K, Bosk A, Müller I, Warmann S, Schäfer J
J SURG ONCOL. 2008;17(4):323-30.

Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia.
Graubner U, Porzig S, Jorch N, Kolb R, Wessalowski R, Escherich G, Janka-Schaub G
PEDIATR BLOOD CANCER. 2008;50(2):259-263.

Genetic defects in von Willebrand disease type 3 in Indian and Greek patients.
Gupta P, Saxena R, Adamtziki E, Budde U, Oyen F, Obser T, Schneppenheim R
BLOOD CELL MOL DIS. 2008;41(2):219-222.

Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD).
Haberichter S, Castaman G, Budde U, Peake I, Goodeve A, Rodeghiero F, Federici A, Batlle J, Meyer D, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill F, Montgomery R
BLOOD. 2008;111(10):4979-4985.

Emergence of linezolid resistance in a methicillin resistant Staphylococcus aureus strain.
Hentschke M, Saager B, Horstkotte M, Scherpe S, Wolters M, Kabisch H, Grosse R, Heisig P, Aepfelbacher M, Rohde H
INFECTION. 2008;36(1):85-87.

Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis.
Horne A, Trottestam H, Aricò M, Egeler R, Filipovich A, Gadner H, Imashuku S, Ladisch S, Webb D, Janka-Schaub G, Henter J
BRIT J HAEMATOL. 2008;140(3):327-335.

Impaired capacity for acute endogenous fibrinolysis in smokers is restored by ascorbic acid.
Kähler J, Koeke K, Karstens M, Schneppenheim R, Meinertz T, Heitzer T
FREE RADICAL BIO MED. 2008;44(3):315-321.

WT1 protein expression in childhood acute leukemia
Kerst G, Bergold N, Gieseke F, Coustan-Smith E, Lang P, Kalinova M, Handgretinger R, Trka J, Müller I
AM J HEMATOL. 2008;83(5):382-6.

WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase
Kerst G, Bergold N, Viebahn S, Gieseke F, Kalinova M, Trka J, Handgretinger R, Müller I
LEUKEMIA RES. 2008;32(9):1393-9.

Drug delivery in acute myeloid leukemia
Kohlschütter J, Michelfelder S, Trepel M
EXPERT OPIN DRUG DEL. 2008;5(6):653-63.

Successful donor-lymphocyte infusion for extreme immune-hemolysis following unrelated BMT in a patient with X-linked chronic granulomatous disease and McLeod phenotype.
Kordes U, Binder T, Eiermann T, Hassenpflug-Diedrich B, Hassan M, Beutel K, Nagy M, Kabisch H, Schneppenheim R
BONE MARROW TRANSPL. 2008;42(3):219-220.

Efficient in vitro generation of adult multipotent cells from mobilized peripheral blood CD133+ cells
Kuçi S, Kuçi Z, Schmid S, Seitz G, Müller I, Dufke A, Leimig T, Murti G, Jurecic R, Schumm M, Lang P, Bruchelt G, Bader P, Klingebiel T, Niethammer D, Handgretinger R
CELL PROLIFERAT. 2008;41(1):12-27.

Non-surgical management of advanced cardiac lymphoma.
Lilje C, Thiel C, Weil J, Schrum J, Stork A
J PEDIATR-US. 2008;152(3):440.

Reactivations in multisystem Langerhans cell histiocytosis: data of the international LCH registry.
Minkov M, Steiner M, Pötschger U, Aricò M, Braier J, Donadieu J, Grois N, Henter J, Janka-Schaub G, McClain K, Weitzman S, Windebank K, Ladisch S, Gadner H
J PEDIATR-US. 2008;153(5):1-2, 700-705.

An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary.
Mohl A, Marschalek R, Masszi T, Nagy E, Obser T, Oyen F, Sallai K, Bodó I, Schneppenheim R
J THROMB HAEMOST. 2008;6(10):1729-1735.

Mesenchymal stem cell therapy for degenerative inflammatory disorders
Müller I, Lymperi S, Dazzi F
CURR OPIN ORGAN TRAN. 2008;13(6):639-44.

Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis
Müller I, Vaegler M, Holzwarth C, Tzaribatchev N, Pfister S, Schütt B, Reize P, Greil J, Handgretinger R, Rudert M
LEUKEMIA. 2008;22(11):2054-61.

EBV reactivation and post transplant lymphoproliferative disorders following allogeneic SCT.
Ocheni S, Kröger N, Zabelina T, Sobottka I, Ayuketang Ayuk F, Wolschke C, Muth A, Lellek H, Petersen L, Erttmann R, Kabisch H, Zander A, Bacher U
BONE MARROW TRANSPL. 2008;42(3):181-186.

Temperature sensitivity of phospho-Ser(473)-PKB/AKT.
Oehler-Jänne C, von Bueren A, André O, Vuong V, Hollenstein A, Grotzer M, Pruschy M
BIOCHEM BIOPH RES CO. 2008;375(3):399-404.

The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia.
Pieter V, van Grotel M, Tchinda J, Lee C, Beverloo H, Spek v, Peter J, Stubbs A, Cools J, Nagata K, Fornerod M, Horstmann M, Horstmann M, Wering v, Elisabeth R, Soulier J, Pieters R, Meijerink J
BLOOD. 2008;111(9):4668-4680.

[Inborn and acquired von Willebrand disease]
Schneppenheim R, Budde U
HAMOSTASEOLOGIE. 2008;28(5):312-319.

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
Schüller U, Heine V, Mao J, Kho A, Dillon A, Han Y, Huillard E, Sun T, Ligon A, Qian Y, Ma Q, Alvarez-Buylla A, McMahon A, Rowitch D, Ligon K
CANCER CELL. 2008;14(2):123-34.

Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas
Schüller U, Ruiter M, Herms J, Kretzschmar H, Grasbon-Frodl E
ACTA NEUROPATHOL. 2008;115(3):367-8.

Review and update of the use of urokinase in the prevention and management of CVAD-related complications in pediatric oncology patients.
Simon A, Udo B, Lieber K, Beutel K, Fleischhack G
AM J INFECT CONTROL. 2008;36(1):54-58.

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations.
Trizzino A, Zur Stadt U, Ueda I, Risma K, Janka G, Ishii E, Beutel K, Sumegi J, Cannella S, Pende D, Mian A, Henter J, Janka-Schaub G, Santoro A, Filipovich A, Aricò M
J MED GENET. 2008;45(1):15-21.

High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95.
Troeger A, Glouchkova L, Ackermann B, Escherich G, Meisel R, Hanenberg H, Boer d, Monique L, Janka-Schaub G, Janka-Schaub G, Goebel U, Laws H, Dilloo D
BLOOD. 2008;112(4):1028-1034.

Reduced expression and defective modulation of TNF receptor/ligand family molecules on proB-ALL blasts.
Troeger A, Glouchkova L, Escherich G, Siepermann M, Hanenberg H, Janka-Schaub G, Göbel U, Ackermann B, Dilloo D
KLIN PADIATR. 2008;220(6):353-357.

Mesenchymal stromal cells: a novel treatment option for steroid-induced avascular osteonecrosis
Tzaribachev N, Vaegler M, Schaefer J, Reize P, Rudert M, Handgretinger R, Müller I
CAN MED ASSOC J. 2008;10(3):232-4.

Erythrocytapheresis: Do Not Forget a Useful Therapy!
Ullrich H, Fischer R, Grosse R, Kordes U, Schubert C, Altstadt B, Andreu G
TRANSFUS MED HEMOTH. 2008;35(1):24-30.

Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia.
Van Vlierberghe P, Beverloo H, Buijs-Gladdines J, van Wering E, Horstmann M, Pieters R, Meijerink J
LEUKEMIA. 2008;22(7):1434-1437.

Cooperative genetic defects in TLX3 rearranged pediatric T-ALL.
Van Vlierberghe P, Homminga I, Zuurbier L, Gladdines-Buijs J, van Wering E, Horstmann M, Beverloo H, Pieters R, Meijerink J
LEUKEMIA. 2008;22(4):762-770.

Impairment of intellectual functions after surgery and posterior fossa irradiation in children with ependymoma is related to age and neurologic complications
von Hoff K, Kieffer V, Habrand J, Kalifa C, Dellatolas G, Grill J
BMC CANCER. 2008;8:15.

High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.
von Stackelberg A, Hartmann R, Bührer C, Fengler R, Janka-Schaub G, Reiter A, Mann G, Schmiegelow K, Ratei R, Klingebiel T, Ritter J, Henze G
BLOOD. 2008;111(5):2573-2580.

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Yang Z, Ellis T, Markant S, Read T, Kessler J, Bourboulas M, Schüller U, Machold R, Fishell G, Rowitch D, Wainwright B, Wechsler-Reya R
CANCER CELL. 2008;14(2):135-45.

2007

DNA methylation of tumor suppressor genes in clinical remission predicts the relapse risk in acute myeloid leukemia.
Agrawal S, Unterberg M, Koschmieder S, Zur Stadt U, Brunnberg U, Verbeek W, Büchner T, Berdel W, Serve H, Müller-Tidow C
CANCER RES. 2007;67(3):1370-1377.

Insulin-like factor 3 levels in cord blood and serum from children: effects of age, postnatal hypothalamic-pituitary-gonadal axis activation, and cryptorchidism
Bay K, Virtanen H, Hartung S, Ivell R, Main K, Skakkebaek N, Andersson A, Toppari J
J CLIN ENDOCR METAB. 2007;92(10):4020-7.

Recent developments in iron chelation therapy.
Cario H, Janka-Schaub G, Janssen G, Jarisch A, Strauss G, Kohne E
KLIN PADIATR. 2007;219(3):158-165.

Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells.
D'cunja J, Shalaby T, Rivera P, von Bueren A, Patti R, Heppner F, Arcaro A, Rorke-Adams L, Phillips P, Grotzer M
EUR J CANCER. 2007;43(10):1581-1589.

Daunorubicin-induced cell kill with 1-hour versus 24-hour infusions: a randomized comparison in children with newly diagnosed acute lymphoblastic leukemia.
Escherich G, Göbel U, Jorch N, Spaar H, Janka-Schaub G
KLIN PADIATR. 2007;219(3):134-138.

The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells.
Fedier A, Dedes K, Imesch P, von Bueren A, Andre O, Fink D
INT J ONCOL. 2007;31(3):633-641.

Plexin-B2 controls the development of cerebellar granule cells
Friedel R, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M, Chédotal A
J NEUROSCI. 2007;27(14):3921-32.

Identification of a novel candidate splice site mutation (0874 + 1G > A) in a type 3 von Willebrand disease patient
Gadisseur A, Vrelust I, Vangenechten I, Schneppenheim R, Van der Planken M
THROMB HAEMOSTASIS. 2007;98(2):464-6.

Thrombotic microangiopathy in a 17-year-old Patient: TTP, HUS or a bit of both?
Gerth J, Busch M, Oyen F, Schneppenheim R, Keller T, Budde U, Groene H, Wolf G
CLIN NEPHROL. 2007;68(6):405-411.

Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNgammaR1 signaling and IDO expression
Gieseke F, Schütt B, Viebahn S, Koscielniak E, Friedrich W, Handgretinger R, Müller I
BLOOD. 2007;110(6):2197-200.

Phenotype and genotype of a cohort of families historically diagnosed with type 1 von Willebrand disease in the European study, Molecular and Clinical Markers for the Diagnosis and Management of Type 1 von Willebrand Disease (MCMDM-1VWD)
Goodeve A, Eikenboom J, Castaman G, Rodeghiero F, Federici A, Batlle J, Meyer D, Mazurier C, Goudemand J, Schneppenheim R, Budde U, Ingerslev J, Habart D, Vorlova Z, Holmberg L, Lethagen S, Pasi J, Hill F, Hashemi Soteh M, Baronciani L, Hallden C, Guilliatt A, Lester W, Peake I
BLOOD. 2007;109(1):112-21.

Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma.
Grotzer M, von Hoff K, von Bueren A, Shalaby T, Hartmann W, Warmuth-Metz M, Emser A, Kortmann R, Kuehl J, Pietsch T, Rutkowski S
KLIN PADIATR. 2007;219(6):312-317.

Submicroscopic bone marrow involvement in isolated extramedullary relapses in childhood acute lymphoblastic leukemia: a more precise definition of "isolated" and its possible clinical implications, a collaborative study of the Resistant Disease Committee of the International BFM study group.
Hagedorn N, Acquaviva C, Fronkova E, von Stackelberg A, Barth A, Zur Stadt U, Schrauder A, Trka J, Gaspar N, Seeger K, Henze G, Cavé H, Eckert C
BLOOD. 2007;110(12):4022-4029.

Feasibility and outcome of reduced-intensity conditioning in haploidentical transplantation
Handgretinger R, Chen X, Pfeiffer M, Müller I, Feuchtinger T, Hale G, Lang P
ANN NY ACAD SCI. 2007;1106:279-89.

Determination of the prognostic value of loss of heterozygosity at the retinoblastoma gene in osteosarcoma.
Heinsohn S, Evermann U, Zur Stadt U, Bielack S, Kabisch H
INT J ONCOL. 2007;30(5):1205-1214.

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Henter J, Horne A, Aricó M, Egeler R, Filipovich A, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka-Schaub G
PEDIATR BLOOD CANCER. 2007;48(2):124-131.

Symptoms of OTC deficiency but not DMD in a female carrier of an Xp21.1 deletion including the genes for dystrophin and OTC
Jakubiczka S, Bettecken T, Mohnike K, Schneppenheim R, Stumm M, Tönnies H, Volleth M, Wieacker P
EUR J PEDIATR. 2007;166(7):743-5.

Familial and acquired hemophagocytic lymphohistiocytosis.
Janka-Schaub G
EUR J PEDIATR. 2007;166(2):95-109.

Hemophagocytic syndromes.
Janka-Schaub G
BLOOD REV. 2007;21(5):245-253.

Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas
Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer C, Wiestler O, Birchmeier W, Behrens J, Pietsch T
INT J CANCER. 2007;121(2):284-91.

Almost normal cognitive function in patients during therapy for childhood acute lymphoblastic leukemia without cranial irradiation according to ALL-BFM 95 and COALL 06-97 protocols: results of an Austrian-German multicenter longitudinal study and implications for follow-up.
Krappmann P, Paulides M, Stöhr W, Ittner E, Plattig B, Nickel P, Lackner H, Schrappe M, Janka-Schaub G, Beck J, Langer T
PEDIATR HEMAT ONCOL. 2007;24(2):101-109.

Retransplantation with stem cells from mismatched related donors after graft rejection in pediatric patients
Lang P, Müller I, Greil J, Bader P, Schumm M, Pfeiffer M, Hoelle W, Klingebiel T, Heinzelmann F, Belka C, Schlegel P, Kremens B, Woessmann W, Handgretinger R
BLOOD CELL MOL DIS. 2007;40(1):33-9.

From neonates to adolescents--the diagnostic significance of pitted erythrocytes in hyposplenic and asplenic children.
Lehmberg K, Steinhausen B, Janka-Schaub G
KLIN PADIATR. 2007;219(6):339-342.

Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura
Manea M, Kristoffersson A, Schneppenheim R, Saleem M, Mathieson P, Mörgelin M, Björk P, Holmberg L, Karpman D
BRIT J HAEMATOL. 2007;138(5):651-62.

Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy.
Meister N, Shalaby T, von Bueren A, Rivera P, Patti R, Oehler C, Pruschy M, Grotzer M
EUR J CANCER. 2007;43(12):1833-1841.

Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Metzner A, Horstmann M, Fehse B, Ortmeyer G, Niemeyer C, Stocking C, Mayr G, Jücker M
GENE THER. 2007;14(8):699-703.

Application of multipotent mesenchymal stromal cells in pediatric patients following allogeneic stem cell transplantation
Müller I, Kordowich S, Holzwarth C, Isensee G, Lang P, Neunhoeffer F, Dominici M, Greil J, Handgretinger R
BLOOD CELL MOL DIS. 2007;40(1):25-32.

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia.
Nachman J, Heerema N, Sather H, Camitta B, Forestier E, Harrison C, Dastugue N, Schrappe M, Pui C, Basso G, Silverman L, Janka-Schaub G
BLOOD. 2007;110(4):1112-1115.

A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.
Pieters R, Schrappe M, Paola D, Hann I, Giulio D, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka-Schaub G, Rubnitz J, Silverman L, Stary J, Campbell M, Li C, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi M
LANCET. 2007;370(9583):240-250.

Cloning and characterization of dihydrofolate reductase from a facultative alkaliphilic and halotolerant bacillus strain
Redecke L, Brehm M, Bredehorst R
EXTREMOPHILES. 2007;11(1):75-83.

Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.
Rutkowski S, von Bueren A, von Hoff K, Hartmann W, Shalaby T, Deinlein F, Warmuth-Metz M, Soerensen N, Emser A, Udo B, Mittler U, Urban C, Benesch M, Kortmann R, Schlegel P, Kuehl J, Pietsch T, Grotzer M
CLIN CANCER RES. 2007;13(9):2651-2657.

Accessibility and quality of secondary care rheumatology services for people with inflammatory arthritis: a regional survey.
Sandhu R, Treharne G, Justice E, Jordan A, Saravana S, Obrenovic K, Erb N, Kitas G, Rowe I
CLIN MED. 2007;7(6):579-584.

Progress in characterization, preparation and clinical applications of non-hematopoietic stem cells, 29-30 September 2006, Tübingen, Germany
Schäfer R, Dominici M, Müller I, Dazzi F, Bieback K, Godthardt K, Le Blanc K, Meisel R, Pochampally R, Richter R, Skutella T, Steinhoff G, Mitterberger M, Wendel H, Wiskirchen J, Handgretinger R, Northoff H
CYTOTHERAPY. 2007;9(4):397-405.

A common 253-kb deletion involving VWF and TMEM16B in German and Italian patients with severe von Willebrand disease type 3.
Schneppenheim R, Castaman G, Federici A, Kreuz W, Marschalek R, Oldenburg J, Oyen F, Budde U
J THROMB HAEMOST. 2007;5(4):722-728.

Beta-catenin function is required for cerebellar morphogenesis
Schüller U, Rowitch D
BRAIN RES. 2007;1140:161-9.

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors
Schüller U, Zhao Q, Godinho S, Heine V, Medema R, Pellman D, Rowitch D
MOL CELL BIOL. 2007;27(23):8259-70.

Impact of plasma von Willebrand factor levels in the diagnosis of type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1VWD)
Tosetto A, Rodeghiero F, Castaman G, Bernardi M, Bertoncello K, Goodeve A, Federici A, Batlle J, Meyer D, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Budde U, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill F, Peake I
J THROMB HAEMOST. 2007;5(4):715-21.

Polypharmacy among people with rheumatoid arthritis: the role of age, disease duration and comorbidity.
Treharne G, Douglas K, Iwaszko J, Panoulas V, Hale E, Mitton D, Piper H, Erb N, Kitas G
MUSCULOSKELET CARE. 2007;5(4):175-190.

High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia.
Troeger A, Gudowius S, Escherich G, Boer d, Monique L, Glouchkova L, Ackermann B, Meisel R, Laws H, Groeger M, Wessalowski R, Willers R, Harbott J, Pieters R, Janka-Schaub G, Janka-Schaub G, Hanenberg H, Dilloo D
BRIT J HAEMATOL. 2007;139(3):450-457.

Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL.
Troeger A, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub G, Schulze-Osthoff K, Dilloo D
BLOOD. 2007;110(1):384-387.

Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia.
Troeger A, Siepermann M, Escherich G, Meisel R, Willers R, Gudowius S, Moritz T, Laws H, Hanenberg H, Goebel U, Janka-Schaub G, Mahotka C, Dilloo D
HAEMATOLOGICA. 2007;92(8):1043-1050.

Role of survivin splice variants in pediatric acute precursor B lymphoblastic leukemia.
Tröger A, Siepermann M, Mahotka C, Wethkamp N, Bülle H, Laws H, Escherich G, Janka-Schaub G, Göbel U, Dilloo D
KLIN PADIATR. 2007;219(3):127-133.

Analysis of minimal residual disease by Ig/TCR gene rearrangements: guidelines for interpretation of real-time quantitative PCR data.
van der Velden V, Cazzaniga G, Schrauder A, Hancock J, Bader P, Panzer-Grumayer E, Flohr T, Sutton R, Cave H, Madsen H, Cayuela J, Trka J, Eckert C, Foroni L, Zur Stadt U, Beldjord K, Raff T, van der Schoot C, van Dongen J
LEUKEMIA. 2007;21(4):604-611.

Salbutamol exhibits androgenic activity in vitro.
von Bueren A, André O, Ma R, Schlumpf M, Lichtensteiger W
BRIT J SPORT MED. 2007;41(12):874-878.

Anti-proliferative activity of the quassinoid NBT-272 in childhood medulloblastoma cells.
von Bueren A, André O, Shalaby T, Rajtarova J, Stearns D, Eberhart C, Helson L, Arcaro A, Grotzer M
BMC CANCER. 2007;7:19.

2006

Laboratory testing for von Willebrand disease: contribution of multimer analysis to diagnosis and classification
Budde U, Pieconka A, Will K, Schneppenheim R
SEMIN THROMB HEMOST. 2006;32(5):514-21.

A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia.
Cappellini M, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, Aydinok Y, Kattamis A, Kilinc Y, Porter J, Capra M, Galanello R, Fattoum S, Drelichman G, Magnano C, Verissimo M, Athanassiou-Metaxa M, Giardina P, Kourakli-Symeonidis A, Janka-Schaub G, Coates T, Vermylen C, Olivieri N, Thuret I, Opitz H, Ressayre-Djaffer C, Marks P, Alberti D
BLOOD. 2006;107(9):3455-3462.

Comparable results in patients with acute lymphoblastic leukemia after related and unrelated stem cell transplantation.
Dahlke J, Kröger N, Zabelina T, Ayuketang Ayuk F, Wolschke C, Renges H, Krüger W, Kruell A, Hinke A, Erttmann R, Kabisch H, Zander A
BONE MARROW TRANSPL. 2006;37(2):155-163.

Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.
Dierck K, Machida K, Voigt A, Thimm J, Horstmann M, Fiedler W, Mayer B, Nollau P
NAT METHODS. 2006;3(9):737-744.

Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents: a prognostically unfavorable but curable disease.
Distelmaier F, Calaminus G, Harms D, Sträter R, Kordes U, Fleischhack G, Göbel U, Schneider D
CANCER-AM CANCER SOC. 2006;107(9):2298-2306.

Linkage analysis in families diagnosed with type 1 von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 VWD
Eikenboom J, Van Marion V, Putter H, Goodeve A, Rodeghiero F, Castaman G, Federici A, Batlle J, Meyer D, Mazurier C, Goudemand J, Schneppenheim R, Budde U, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill F, Peake I
J THROMB HAEMOST. 2006;4(4):774-82.

Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome.
Frühwald M, Hasselblatt M, Wirth S, Köhler G, Schneppenheim R, Subero J, Siebert R, Kordes U, Jürgens H, Vormoor J
PEDIATR BLOOD CANCER. 2006;47(3):273-278.

Risk factors for diabetes insipidus in langerhans cell histiocytosis.
Grois N, Pötschger U, Prosch H, Minkov M, Arico M, Braier J, Henter J, Janka-Schaub G, Ladisch S, Ritter J, Steiner M, Unger E, Gadner H
PEDIATR BLOOD CANCER. 2006;46(2):228-233.

Treatment with caspofungin in immunocompromised paediatric patients: a multicentre survey.
Groll A, Attarbaschi A, Schuster F, Herzog N, Grigull L, Dworzak M, Beutel K, Laws H, Lehrnbecher T
J ANTIMICROB CHEMOTH. 2006;57(3):527-535.

The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study of patients treated according to DCOG or COALL protocols.
Grotel v, Martine [, Meijerink [, Jules P, Beverloo [, Berna H, Langerak [, Anton W, Buys-Gladdines [, Jessica G, Schneider [, Pauline [, Poulsen [, Tim S, Den B, Monique L, Horstmann M, Martin [, Kamps [, Willem A, Veerman [, Anjo J, Wering v, Elisabeth R, Noesel v, Max M, Pieters [, Rob [
HAEMATOLOGICA. 2006;91(9):1212-1221.

Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.
Hassenpflug W, Ulrich B, Obser T, Angerhaus D, Drewke E, Schneppenheim S, Schneppenheim R
BLOOD. 2006;107(6):2339-2345.

Expression of the outcome predictor in acute leukemia 1 (OPAL1) gene is not an independent prognostic factor in patients treated according to COALL or St Jude protocols.
Holleman A, Boer d, Monique L, Cheok M, Kazemier K, Pei D, Janka-Schaub G, Janka-Schaub G, Göbel U, Graubner U, Pui C, Evans W, Pieters R
BLOOD. 2006;108(6):1984-1990.

The expression of 70 apoptosis genes in relation to lineage, genetic subtype, cellular drug resistance, and outcome in childhood acute lymphoblastic leukemia.
Holleman A, Boer d, Monique L, Menezes d, Renée X, Cheok M, Janka-Schaub G, Kazemier K, Janka-Schaub G, Göbel U, Graubner U, Evans W, Pieters R
BLOOD. 2006;107(2):769-776.

In vitro sensitivity and cross-resistance to deoxynucleoside analogs in childhood acute leukemia.
Hubeek I, Peters G, Broekhuizen R, Zwaan C, Kaaijk P, Wering v, Elisabeth S, Gibson B, Janka-Schaub G, Janka-Schaub G, Boer d, Monique L, Pieters R, Kaspers G
HAEMATOLOGICA. 2006;91(1):17-23.

Increased alpha2,6-sialylation of surface proteins on tolerogenic, immature dendritic cells and regulatory T cells
Jenner J, Kerst G, Handgretinger R, Müller I
EXP HEMATOL. 2006;34(9):1212-8.

von Willebrand factor-cleaving protease (ADAMTS13) in the course of stem cell transplantation
Kentouche K, Zintl F, Angerhaus D, Fuchs D, Hermann J, Schneppenheim R, Budde U
SEMIN THROMB HEMOST. 2006;32(2):98-104.

RETRACTED: Modified high-performance liquid chromatographic conditions for determination of inosine 5'-monophosphate dehydrogenase activity inerythrocytes.
Khalil P, Erb N, Khalil M, Escherich G, Janka-Schaub G
J Pharmacol Toxicol Methods. 2006.

Validation and application of a high-performance liquid chromatographic-based assay for determination of the inosine 5'-monophosphate dehydrogenase activity in erythrocytes.
Khalil P, Erb N, Khalil M, Escherich G, Janka-Schaub G
J CHROMATOGR B. 2006;842(1):1-7.

Expression of SOX9 and SOX10 in central neuroepithelial tumor.
Kordes U, Hagel C
J NEURO-ONCOL. 2006;80(2):151-155.

Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples.
Kunz F, Shalaby T, Lang D, von Bueren A, Hainfellner J, Slavc I, Tabatabai G, Grotzer M
NEUROPATHOLOGY. 2006;26(5):393-399.

Haploidentical stem cell transplantation in patients with pediatric solid tumors: preliminary results of a pilot study and analysis of graft versus tumor effects
Lang P, Pfeiffer M, Müller I, Schumm M, Ebinger M, Koscielniak E, Feuchtinger T, Föll J, Martin D, Handgretinger R
KLIN PADIATR. 2006;218(6):321-6.

Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate
Mahood I, McKinnell C, Walker M, Hallmark N, Scott H, Fisher J, Rivas A, Hartung S, Ivell R, Mason J, Sharpe R
INT J ANDROL. 2006;29(1):148-54; discussion 181-5.

Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia.
Meier M, Den B, Meijerink [, Broekhuis [, Passier [, Wering v, Janka-Schaub G, Pieters R
LEUKEMIA. 2006;20(8):1377-1384.

In vitro analysis of multipotent mesenchymal stromal cells as potential cellular therapeutics in neurometabolic diseases in pediatric patients
Müller I, Kustermann-Kuhn B, Holzwarth C, Isensee G, Vaegler M, Harzer K, Krägeloh-Mann I, Handgretinger R, Bruchelt G
EXP HEMATOL. 2006;34(10):1413-9.

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor
Sadler J, Budde U, Eikenboom J, Favaloro E, Hill F, Holmberg L, Ingerslev J, Lee C, Lillicrap D, Mannucci P, Mazurier C, Meyer D, Nichols W, Nishino M, Peake I, Rodeghiero F, Schneppenheim R, Ruggeri Z, Srivastava A, Montgomery R, Federici A
J THROMB HAEMOST. 2006;4(10):2103-14.

Thrombosis in infants and children
Schneppenheim R, Greiner J
HEMATOL-AM SOC HEMAT. 2006;86-96.

A common origin of the 4143insA ADAMTS13 mutation.
Schneppenheim R, Hovinga K, Johanna A, Becker T, Ulrich B, Karpman D, Brockhaus W, Hrachovinová I, Oyen F, Oyen F, Rittich S, von Rosen J, Tjønnfjord G, Pimanda J, Wienker T, Lämmle B
THROMB HAEMOSTASIS. 2006;96(1):3-6.

Cerebellar 'transcriptome' reveals cell-type and stage-specific expression during postnatal development and tumorigenesis
Schüller U, Kho A, Zhao Q, Ma Q, Rowitch D
MOL CELL NEUROSCI. 2006;33(3):247-59.

Diagnosis and treatment of catheter-related infections in paediatric oncology: an update.
Simon A, Bode U, Beutel K
CLIN MICROBIOL INFEC. 2006;12(7):606-620.

Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia.
Stam [, Den B, Passier [, Janka-Schaub G, Sallan [, Armstrong [, Pieters R
LEUKEMIA. 2006;20(2):264-271.

Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome.
Stams [, Beverloo [, Den B, Menezes d, Stigter [, Drunen v, Ramakers-van-Woerden [, Loonen [, Wering v, Janka-Schaub G, Pieters R
LEUKEMIA. 2006;20(3):410-416.

Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients
Tefs K, Gueorguieva M, Klammt J, Allen C, Aktas D, Anlar F, Aydogdu S, Brown D, Ciftci E, Contarini P, Dempfle C, Dostalek M, Eisert S, Gökbuget A, Günhan O, Hidayat A, Hügle B, Isikoglu M, Irkec M, Joss S, Klebe S, Kneppo C, Kurtulus I, Mehta R, Ornek K, Schneppenheim R, Seregard S, Sweeney E, Turtschi S, Veres G, Zeitler P, Ziegler M, Schuster V
BLOOD. 2006;108(9):3021-6.

A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD)
Tosetto A, Rodeghiero F, Castaman G, Goodeve A, Federici A, Batlle J, Meyer D, Fressinaud E, Mazurier C, Goudemand J, Eikenboom J, Schneppenheim R, Budde U, Ingerslev J, Vorlova Z, Habart D, Holmberg L, Lethagen S, Pasi J, Hill F, Peake I
J THROMB HAEMOST. 2006;4(4):766-73.

Intracranial hemorrhage in a term newborn with severe von Willebrand disease type 3 associated with sinus venous thrombosis.
Wetzstein V, Ulrich B, Oyen F, Ding X, Herrmann J, Liebig B, Schneppenheim R
HAEMATOLOGICA. 2006;91(12):60.

Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.
Zur Stadt U, Beutel K, Kolberg S, Schneppenheim R, Kabisch H, Janka G, Hennies H
HUM MUTAT. 2006;27(1):62-68.

2005

The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29--30, 2005.
Aricó M, Baruchel A, Bertrand Y, Biondi A, Conter V, Eden T, Gadner H, Gaynon P, Horibe K, Hunger S, Janka-Schaub G, Masera G, Nachman J, Pieters R, Schrappe M, Schmiegelow K, Valsecchi M, Pui C
LEUKEMIA. 2005;19(7):1145-1152.

Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells.
Bardenheuer W, Lehmberg K, Rattmann I, Brueckner A, Schneider A, Sorg U, Seeber S, Moritz T, Flasshove M
LEUKEMIA. 2005;19(12):2281-2288.

Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial.
Berthold F, Boos J, Burdach S, Erttmann R, Henze G, Hermann J, Klingebiel T, Kremens B, Schilling F, Schrappe M, Simon T, Hero B
LANCET ONCOL. 2005;6(9):649-658.

[Diagnostics and management of central venous line infections in pediatric cancer patients]
Beutel K, Simon A
KLIN PADIATR. 2005;217(1):91-100.

Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor
De Gendt K, Atanassova N, Tan K, de França L, Parreira G, McKinnell C, Sharpe R, Saunders P, Mason J, Hartung S, Ivell R, Denolet E, Verhoeven G
ENDOCRINOLOGY. 2005;146(9):4117-26.

Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.
Einsiedel H, von Stackelberg A, Hartmann R, Fengler R, Schrappe M, Janka-Schaub G, Mann G, Hählen K, Göbel U, Klingebiel T, Ludwig W, Henze G
J CLIN ONCOL. 2005;23(31):7942-7950.

Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival.
Führer M, Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, Friedrich W, Ebell W, Borkhardt A, Bender-Goetze C
BLOOD. 2005;106(6):2102-2104.

Haemophilia A: from mutation analysis to new therapies
Graw J, Brackmann H, Oldenburg J, Schneppenheim R, Spannagl M, Schwaab R
NAT GENET. 2005;6(6):488-501.

Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.
Grosse R, Lund U, Caruso V, Fischer R, Janka-Schaub G, Magnano C, Engelhardt R, Dürken M, Nielsen P
ANN NY ACAD SCI. 2005;1054:429-432.

Gene conversions are a common cause of von Willebrand disease.
Gupta P, Adamtziki E, Budde U, Jaiprakash M, Kumar H, Harbeck-Seu A, Kannan M, Oyen F, Obser T, Wedekind I, Saxena R, Schneppenheim R
BRIT J HAEMATOL. 2005;130(5):752-758.

Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
Hartmann W, Koch A, Brune H, Waha A, Schüller U, Dani I, Denkhaus D, Langmann W, Bode U, Wiestler O, Schilling K, Pietsch T
AM J PATHOL. 2005;166(4):1153-62.

Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes.
Hellwinkel O, Müller J, Pollmann A, Kabisch H
J GENE MED. 2005;7(4):407-419.

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia.
Holleman A, Boer d, Monique L, Kazemier K, Beverloo H, Janka-Schaub G, Anne R, Janka-Schaub G, Pieters R
BLOOD. 2005;106(5):1817-1823.

Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis.
Horne A, Janka-Schaub G, Maarten Egeler R, Gadner H, Imashuku S, Ladisch S, Locatelli F, Montgomery S, Webb D, Winiarski J, Filipovich A, Henter J
BRIT J HAEMATOL. 2005;129(5):622-630.

Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance.
Horne A, Zheng C, Lorenz I, Löfstedt M, Montgomery S, Janka-Schaub G, Henter J, Marion Schneider E
BRIT J HAEMATOL. 2005;129(5):658-666.

Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Horstmann M, Hassenpflug W, Udo Z, Escherich G, Janka-Schaub G, Kabisch H
HAEMATOLOGICA. 2005;90(12):1701-1703.

Correlation of bFGF expression in renal cell cancer with clinical and histopathological features by tissue microarray analysis and measurement of serum levels
Horstmann M, Merseburger A, von der Heyde E, Serth J, Wegener G, Mengel M, Feil G, Hennenlotter J, Nagele U, Anastasiadis A, Bokemeyer C, Stenzl A, Kuczyk M
J CANCER RES CLIN. 2005;131(11):715-22.

Insulin-like factor 3 - where are we now?
Ivell R, Hartung S, Anand-Ivell R
ANN NY ACAD SCI. 2005;1041:486-96.

Hemophagocytic lymphohistiocytosis
Janka-Schaub G
HEMATOLOGY. 2005;10 Suppl 1:104-7.

Familial and acquired hemophagocytic lymphohistiocytosis.
Janka-Schaub G, Udo Z
HEMATOL-AM SOC HEMAT. 2005;82-88.

Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR
Kerst G, Kreyenberg H, Roth C, Well C, Dietz K, Coustan-Smith E, Campana D, Koscielniak E, Niemeyer C, Schlegel P, Müller I, Niethammer D, Bader P
BRIT J HAEMATOL. 2005;128(6):774-82.

Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.
Khalil M, Erb N, Khalil P, Escherich G, Janka-Schaub G
J CHROMATOGR B. 2005;821(1):105-111.

Elevated expression of Wnt antagonists is a common event in hepatoblastomas
Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton K, Fuchs S, von Schweinitz D, Pietsch T
CLIN CANCER RES. 2005;11(12):4295-304.

Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.
Kordes U, Cheng Y, Scotting P
DEV BRAIN RES. 2005;157(2):209-213.

A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study
Lang P, Schumm M, Greil J, Bader P, Klingebiel T, Müller I, Feuchtinger T, Pfeiffer M, Schlegel P, Niethammer D, Handgretinger R
KLIN PADIATR. 2005;217(6):334-8.

Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
Lugthart S, Cheok M, Boer d, Monique L, Yang W, Holleman A, Cheng C, Pui C, Janka-Schaub G, Janka-Schaub G, Pieters R, Evans W
CANCER CELL. 2005;7(4):375-386.

Hämophilie B (Faktor-IX-Mangel) mit begleitender Faktor-XII-Erniedrigung bei einem Mischlingskater
Lutze G, Kutschmann K, Fürst K, Schneppenheim R
BERL MUNCH TIERARZTL. 2005;118(5-6):255-60.

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate
McKinnell C, Sharpe R, Mahood K, Hallmark N, Scott H, Ivell R, Staub C, Jégou B, Haag F, Koch-Nolte F, Hartung S
ENDOCRINOLOGY. 2005;146(10):4536-44.

Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia.
Meier M, den Boer M, Hall A, Irving J, Passier M, Minto L, van Wering E, Janka-Schaub G, Pieters R
LEUKEMIA. 2005;19(11):1887-1895.

Long-term treatment with deferiprone in a L1 veteran.
Meo A, Ruggeri A, Rosa L, Angela M, Kordes U, Kordes U, Fischer R
EUR J HAEMATOL. 2005;74(6):523-525.

Langerhans cell histiocytosis in neonates.
Minkov M, Prosch H, Steiner M, Grois N, Pötschger U, Kaatsch P, Janka-Schaub G, Gadner H
PEDIATR BLOOD CANCER. 2005;45(6):802-807.

Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia
Mühlhausen C, Schneppenheim R, Budde U, Merkel M, Muschol N, Ullrich K, Santer R
J INHERIT METAB DIS. 2005;28(6):945-950.

Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
Schilbach K, Kerst G, Walter S, Eyrich M, Wernet D, Handgretinger R, Xie W, Rammensee H, Müller I, Bühring H, Niethammer D
BLOOD. 2005;106(1):144-9.

The evolving classification of von Willebrand disease
Schneppenheim R
BLOOD COAGUL FIBRIN. 2005;16 Suppl 1:S3-S10.

Angeborenes und erworbenes von-Willebrand-Syndrom
Schneppenheim R, Barthels M, Budde U
HAMOSTASEOLOGIE. 2005;25(4):367-75.

Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update
Schneppenheim R, Budde U
SEMIN HEMATOL. 2005;42(1):15-28.

Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
Schüller U, Koch A, Hartmann W, Garrè M, Goodyer C, Cama A, Sörensen N, Wiestler O, Pietsch T
INT J CANCER. 2005;117(1):82-9.

[Viral infections in pediatric cancer patients]
Schuster F, Simon A, Laws H, Beutel K, Groll A, Jäger G, Schuster V
KLIN PADIATR. 2005;217(1):67-84.

[Bacterial infections in pediatric cancer patients]
Simon A, Beutel K, Marklein G, Fleischhack G
KLIN PADIATR. 2005;217(1):17-36.

Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.
Stam R, Boer d, Monique L, Schneider P, Horstmann M, Horstmann M, Beverloo H, van der Voort E, Valsecchi M, de Lorenzo P, Sallan S, Armstrong S, Pieters R
BLOOD. 2005;106(7):2484-2490.

Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.
Stams W, Boer d, Monique L, Holleman A, Appel I, Beverloo H, Janka-Schaub G, Elisabeth R, Janka-Schaub G, Evans W, Pieters R
BLOOD. 2005;105(11):4223-4225.

Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.
Stams [, Wendy A, Den B, Monique L, Beverloo [, Berna H, Kazemier [, Karin M, Wering v, Elisabeth R, Janka-Schaub G, Gritta E, Pieters [, Rob [
HAEMATOLOGICA. 2005;90(12):1697-1699.

Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia.
Stams [, Wendy A, Den B, Monique L, Beverloo [, Berna H, Meijerink [, Jules P, Wering v, Elisabeth R, Janka-Schaub G, Gritta E, Pieters [, Rob [
CLIN CANCER RES. 2005;11(8):2974-2980.

Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.
Udo Z, Schmidt S, Kasper B, Beutel K, Diler A, Henter J, Kabisch H, Schneppenheim R, Nürnberg P, Janka-Schaub G, Hennies H
HUM MOL GENET. 2005;14(6):827-834.

Ligands for the peroxisome proliferator-activated receptor-gamma have inhibitory effects on growth of human neuroblastoma cells in vitro.
Valentiner U, Carlsson M, Erttmann R, Hildebrandt H, Schumacher U
TOXICOLOGY. 2005;213(1-2):157-168.

DHPLC based fraction collection of TCR-gamma rearrangements in childhood ALL: direct sequencing of products amplified by a single or a multiplex PCR approach.
Zur Stadt U, Isbarn H, Schneppenheim R, Kabisch H
INT J ONCOL. 2005;27(2):547-552.

2004

Diagnose der thrombotisch-thrombozytopenischen Purpura
Budde U, Angerhaus D, Obser T, Schneppenheim R
HAMOSTASEOLOGIE. 2004;24(1):65-70.

Standardisierte Diagnostik des von-Willebrand-Syndroms
Budde U, Drewke E, Will K, Schneppenheim R
HAMOSTASEOLOGIE. 2004;24(1):12-26.

Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF.
Du J, Widlund H, Horstmann M, Ramaswamy S, Ross K, Huber W, Nishimura E, Golub T, Fisher D
CANCER CELL. 2004;6(6):565-576.

[Thrombotic thrombocytopenic purpura in childhood]
Hassenpflug W, Angerhaus D, Budde U, Obser T, Schneppenheim R
HAMOSTASEOLOGIE. 2004;24(1):71-76.

Thrombotisch-thrombozytopenische Purpura im Kindesalter
Hassenpflug W, Angerhaus D, Budde U, Obser T, Schneppenheim R
HAMOSTASEOLOGIE. 2004;24(1):71-6.

Permanent consequences in Langerhans cell histiocytosis patients: a pilot study from the Histiocyte Society-Late Effects Study Group.
Haupt R, Nanduri V, Calevo M, Bernstrand C, Braier J, Broadbent V, Rey G, McClain K, Janka-Schaub G, Egeler R
PEDIATR BLOOD CANCER. 2004;42(5):438-444.

Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome.
Heerema N, Harbott J, Galimberti S, Camitta B, Gaynon P, Janka-Schaub G, Kamps W, Basso G, Pui C, Schrappe M, Auclerc M, Carroll A, Conter V, Harrison C, Pullen J, Raimondi S C, Richards S, Riehm H, Sather H, Shuster J, Silverman L, Valsecchi M, Aricò M
LEUKEMIA. 2004;18(4):693-702.

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment.
Holleman A, Cheok M, Boer d, Monique L, Yang W, Veerman A, Kazemier K, Pei D, Cheng C, Pui C, Janka-Schaub G, Janka-Schaub G, Pieters R, Evans W
NEW ENGL J MED. 2004;351(6):533-542.

Modern management of children with haemophagocytic lymphohistiocytosis.
Janka-Schaub G, Schneider E
BRIT J HAEMATOL. 2004;124(1):4-14.

Gingivitis as probable source of a thoracic actinomycosis due to Actinomyces israelii and Actinobacillus actinomycetemcomitans.
Kordes U, Beutel K, Cachovan G, Schäfer H, Helmke K, Sobottka I
ARCH DIS CHILD. 2004;89(10):895.

Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)
Licht C, Stapenhorst L, Simon T, Budde U, Schneppenheim R, Hoppe B
KIDNEY INT. 2004;66(3):955-8.

Glycosylation and lectins-examples of immunesurveillance and immune evasion
Müller I, Jenner J, Handgretinger R, Riberdy J, Kerst G
HISTOL HISTOPATHOL. 2004;19(2):527-33.

Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation
Otto M, Barfield R, Iyengar R, Gatewood J, Müller I, Holladay M, Houston J, Leung W, Handgretinger R
J IMMUNOTHER. 2004;28(1):73-8.

Limited specificity of promoter constructs for gene therapy in osteosarcoma.
Pollmann A, Kabisch H, Block A, Müller J, Hellwinkel O
INT J MOL MED. 2004;14(4):737-742.

Molekulare Genetik des von-Willebrand-Syndroms
Schneppenheim R
HAMOSTASEOLOGIE. 2004;24(1):37-43.

Recombinant expression of mutations causing von Willebrand disease type Normandy: characterization of a combined defect of factor VIII binding and multimerization.
Schneppenheim R, Lenk H, Obser T, Oldenburg J, Oyen F, Schneppenheim S, Schwaab R, Will K, Budde U
THROMB HAEMOSTASIS. 2004;92(1):36-41.

Severe ADAMTS-13 deficiency in childhood.
Schneppenheim R, Ulrich B, Hassenpflug W, Obser T
SEMIN HEMATOL. 2004;41(1):83-89.

Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma
Schüller U, Schober F, Kretzschmar H, Herms J
NEUROPATH APPL NEURO. 2004;30(5):513-21.

Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein.
Stam [, van Den H, Den B, Ebus [, Janka-Schaub G, Allen [, Pieters R
LEUKEMIA. 2004;18(1):78-83.

A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype.
Udo Z, Beutel K, Weber B, Kabisch H, Schneppenheim R, Janka-Schaub G
BLOOD. 2004;104(6):1910.

In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype.
Woerden R, Beverloo [, Veerman [, Camitta [, Loonen [, Wering v, Slater [, Harbott J, Den B, Ludwig [, Haas [, Janka-Schaub G, Pieters R
LEUKEMIA. 2004;18(3):521-529.

2003

Patient stratification based on prednisolone-vincristine-asparaginase resistance profiles in children with acute lymphoblastic leukemia.
Den B, Harms [, Pieters R, Kazemier [, Gobel U, Körholz D, Graubner U, Haas [, Jorch N, Spaar [, Kaspers [, Kamps [, Does V, Berg V, Wering V, Janka-Schaub G, Janka-Schaub [
J CLIN ONCOL. 2003;21(17):3262-3268.

MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma.
Du J, Miller A, Widlund H, Horstmann M, Ramaswamy S, Fisher D
AM J PATHOL. 2003;163(1):333-343.

High-performance liquid chromatographic assay of metabolites of thioguanine and mercaptopurine in capillary blood.
Erb N, Haverland U, Harms D, Escherich G, Janka-Schaub G
J CHROMATOGR B. 2003;796(1):87-94.

Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis.
Ericson K, Fadeel B, Andersson M, Gudmundsson G, Gürgey A, Yalman N, Janka-Schaub G, Nordenskjöld M, Henter J
HUM GENET. 2003;112(1):98-99.

Large-scale isolation of CD133+ progenitor cells from G-CSF mobilized peripheral blood stem cells
Gordon P, Leimig T, Babarin-Dorner A, Houston J, Holladay M, Mueller I, Geiger T, Handgretinger R
BONE MARROW TRANSPL. 2003;31(1):17-22.

Thioguanine offers no advantage over mercaptopurine in maintenance treatment of childhood ALL: results of the randomized trial COALL-92.
Harms D, Göbel U, Spaar H, Graubner U, Jorch N, Gutjahr P, Janka-Schaub G
BLOOD. 2003;102(8):2736-2740.

Congenital dyserythropoietic anemia type II: epidemiology, clinical appearance, and prognosis based on long-term observation.
Heimpel H, Anselstetter V, Chrobak L, Denecke J, Einsiedler B, Gallmeier K, Griesshammer A, Marquardt T, Janka-Schaub G, Kron M, Kohne E
BLOOD. 2003;102(13):4576-4581.

Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia.
Holleman A, Boer d, Monique L, Janka-Schaub G, Janka-Schaub G, Pieters R
BLOOD. 2003;102(13):4541-4546.

Infantile cobalamin deficiency with cerebral lactate accumulation and sustained choline depletion.
Horstmann M, Neumaier-Probst E, Lukacs Z, Steinfeld R, Ullrich K, Kohlschütter A
NEUROPEDIATRICS. 2003;34(5):261-264.

The molecular basis of cryptorchidism
Ivell R, Hartung S
MOL HUM REPROD. 2003;9(4):175-81.

Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.
Kaaijk P, Kaspers G, Van Wering E, Broekema G, Loonen A, Hählen K, Schmiegelow K, Janka-Schaub G, Henze G, Creutzig U, Veerman A
BRIT J CANCER. 2003;88(5):775-781.

Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis
Müller I, Pfister S, Grohs U, Zweigner J, Handgretinger R, Niethammer D, Bruchelt G
CANCER RES. 2003;63(8):1772-5.

Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases.
Nielsen P, Fischer R, Buggisch P, Janka-Schaub G
BRIT J HAEMATOL. 2003;123(5):952-953.

Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements.
Pui C, Chessells J, Camitta B, Baruchel A, Biondi A, Boyett J, Carroll A, Eden O, Evans W, Gadner H, Harbott J, Harms D, Harrison C, Harrison P, Heerema N, Janka-Schaub G, Kamps W, Masera G, Pullen J, Raimondi S C, Richards S, Riehm H, Sallan S, Sather H, Shuster J, Silverman L, Valsecchi M, Vilmer E, Zhou Y, Gaynon P, Schrappe M
LEUKEMIA. 2003;17(4):700-706.

Children may not benefit from neuroblastoma screening at 1 year of age. Updated results of the population based controlled trial in Germany.
Schilling F, Spix C, Berthold F, Erttmann R, Sander J, Treuner J, Michaelis J
CANCER LETT. 2003;197(1-2):19-28.

Natural killer deficiency: a minor or major factor in the manifestation of hemophagocytic lymphohistiocytosis?
Schneider E, Lorenz I, Walther P, Janka-Schaub G
J PEDIAT HEMATOL ONC. 2003;25(9):680-683.

von Willebrand factor cleaving protease and ADAMTS13 mutations in childhood TTP.
Schneppenheim R, Ulrich B, Oyen F, Angerhaus D, Aumann V, Drewke E, Hassenpflug W, Häberle J, Kentouche K, Kohne E, Kurnik K, Müller-Wiefel D, Obser T, Santer R, Sykora K
BLOOD. 2003;101(5):1845-1850.

Lead-time and overdiagnosis estimation in neuroblastoma screening.
Spix C, Michaelis J, Berthold F, Erttmann R, Sander J, Schilling F
STAT MED. 2003;22(18):2877-2892.

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia.
Stam R, Boer d, Monique L, Meijerink J, Ebus M, Peters G, Janka-Schaub G, Janka-Schaub G, Armstrong S, Korsmeyer S, Pieters R
BLOOD. 2003;101(4):1270-1276.

Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL.
Stams [, Wendy A, Den B, Monique L, Beverloo [, Berna H, Meijerink [, Jules P, Stigter [, Rolinda L, Wering v, Elisabeth R, Janka-Schaub G, Gritta E, Slater [, Rosalyn [, Pieters [, Rob [
BLOOD. 2003;101(7):2743-2747.

Rapid LightCycler assay for identification of the perforin codon 374 Trp --> stop mutation in patients and families with hemophagocytic lymphohistiocytosis (HLH).
Udo Z, Kabisch H, Janka-Schaub G, Schneider E
Med Pediatr Oncol. 2003;41(1):26-29.

2% Hämophilie-A-Patienten ohne Mutation im FVIII-Gen
Uen C, Oldenburg J, Schröder J, Brackmann H, Schramm W, Schwaab R, Schneppenheim R, Graw J
HAMOSTASEOLOGIE. 2003;23(1):1-5.

Identification and characterisation of clonal incomplete T-cell-receptor Vdelta2-Ddelta3/Ddelta2-Ddelta3 rearrangements by denaturing high-performance liquid chromatography and subsequent fragment collection: implications for minimal residual disease monitoring in childhood acute lymphoblastic leukemia
zur Stadt U, Eckert C, Rischewski J, Michael K, Golta S, Müller M, Schneppenheim R, Kabisch H
J CHROMATOGR B. 2003;792(2):287-98.

2002

Infant acute lymphoblastic leukemia - combined cytogenetic, immunophenotypical and molecular analysis of 77 cases.
Borkhardt A, Wuchter C, Viehmann S, Pils S, Teigler-Schlegel A, Stanulla M, Zimmermann M, Ludwig W, Janka-Schaub G, Schrappe M, Harbott J
LEUKEMIA. 2002;16(9):1685-1690.

Laboratory diagnosis of congenital von Willebrand disease
Budde U, Drewke E, Mainusch K, Schneppenheim R
SEMIN THROMB HEMOST. 2002;28(2):173-90.

Pretreatment prognostic factors and treatment results in children with hepatoblastoma: a report from the German Cooperative Pediatric Liver Tumor Study HB 94.
Fuchs J, Rydzynski J, Dietrich V, Udo B, Hecker H, Weinel P, Bürger D, Harms D, Erttmann R, Oldhafer K, Mildenberger H
CANCER-AM CANCER SOC. 2002;95(1):172-182.

A large-scale method for T cell depletion: towards graft engineering of mobilized peripheral blood stem cells
Gordon P, Leimig T, Mueller I, Babarin-Dorner A, Holladay M, Houston J, Kerst G, Geiger T, Handgretinger R
BONE MARROW TRANSPL. 2002;30(2):69-74.

[Unrelated donor stem cell transplantation in children: low toxicity using a GvHD-prophylaxis regimen with CSA, MTX, metronidazole,iv-immunoglobulin and ATG]
Graf Finckenstein F, Zabelina T, Dürken M, Dahlke J, Kröger N, Krüger W, Janka-Schaub G, Erttmann R, Zander A, Kabisch H
KLIN PADIATR. 2002;214(4):206-211.

In vitro glucocorticoid resistance in childhood leukemia correlates with receptor affinity determined at 37 degrees C, but not with affinity determined at room temperature.
Haarman [, Kaspers [, Pieters R, Rottier [, Den B, Janka-Schaub G, Veerman [
LEUKEMIA. 2002;16(9):1882-1884.

Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation.
Henter J, Samuelsson-Horne A, Aricò M, Egeler R, Elinder G, Filipovich A, Gadner H, Imashuku S, Komp D, Ladisch S, Webb D, Janka-Schaub G
BLOOD. 2002;100(7):2367-2373.

Remission of thrombotic thrombocytopenic purpura in a patient with compound heterozygous deficiency of von Willebrand factor-cleaving protease by infusion of solvent/detergent plasma
Kentouche K, Budde U, Furlan M, Scharfe V, Schneppenheim R, Zintl F
ACTA PAEDIATR. 2002;91(10):1056-9.

11 hemophilia A patients without mutations in the factor VIII encoding gene
Klopp N, Oldenburg J, Uen C, Schneppenheim R, Graw J
THROMB HAEMOSTASIS. 2002;88(2):357-60.

Homozygous Factor V Leiden mutation in sickle cell anaemia.
Kordes U, Janka-Schaub G, Schneppenheim R
BRIT J HAEMATOL. 2002;116(1):236.

In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors.
Kröger N, Zabelina T, Krüger W, Renges H, Stute N, Rischewski J, Sonnenberg S, Ayuk F, Ayuketang Ayuk F, Schade U, Fiegel H, Erttmann R, Löliger C, Zander A
BONE MARROW TRANSPL. 2002;29(8):683-689.

Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.
Kröger N, Zabelina T, Renges H, Krüger W, Kordes U, Rischewski J, Schrum J, Horstmann M, Ayuketang Ayuk F, Erttmann R, Kabisch H, Zander A
ANN HEMATOL. 2002;81(11):627-631.

Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability.
McGill G, Horstmann M, Widlund H, Du J, Motyckova G, Nishimura E, Lin Y, Ramaswamy S, Avery W, Ding H, Jordan S, Jackson I, Korsmeyer S, Golub T, Fisher D
CELL. 2002;109(6):707-718.

[SQUID-biosusceptometry in iron overloaded patients with hematologic diseases]
Nielsen P, Kordes U, Fischer R, Engelhardt R, Janka-Schaub G
KLIN PADIATR. 2002;214(4):218-222.

In vitro drug resistance profile of Philadelphia positive acute lymphoblastic leukemia is heterogeneous and related to age: a report of the Dutch and German Leukemia Study Groups.
Ramakers-van Woerden N, Pieters R, Hoelzer D, Slater R, den Boer M, Loonen A, Harbott J, Janka-Schaub G, Ludwig W, Ossenkoppele G, van Wering E, Veerman A
Med Pediatr Oncol. 2002;38(6):379-386.

Neuroblastoma screening at one year of age.
Schilling F, Spix C, Berthold F, Erttmann R, Fehse N, Hero B, Klein G, Sander J, Schwarz K, Treuner J, Zorn U, Michaelis J
NEW ENGL J MED. 2002;346(14):1047-1053.

Hemophagocytic lymphohistiocytosis is associated with deficiencies of cellular cytolysis but normal expression of transcripts relevant to killer-cell-induced apoptosis.
Schneider E, Lorenz I, Müller-Rosenberger M, Steinbach G, Kron M, Janka-Schaub G
BLOOD. 2002;100(8):2891-2898.

Prenatal diagnosis of perforin gene mutations in familial hemophagocytic lymphohistiocytosis (FHLH).
Udo Z, Pruggmayer M, Jung H, Henter J, Schneider M, Kabisch H, Janka-Schaub G
PRENATAL DIAG. 2002;22(1):80-81.

Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
Widlund H, Horstmann M, Price E, Cui J, Lessnick S, Wu M, He X, Fisher D
J CELL BIOL. 2002;158(6):1079-87.

Different drug sensitivity profiles of acute myeloid and lymphoblastic leukemia and normal peripheral blood mononuclear cells in children with and without Down syndrome.
Zwaan C, Kaspers G, Pieters R, Hählen K, Janka-Schaub G, Zantwijk v, Christina H, Huismans D, de Vries E, Rots M, Peters G, Jansen G, Creutzig U, Veerman A
BLOOD. 2002;99(1):245-251.

2001

Familial hemophagocytic lymphohistiocytosis: how late can the onset be?
Allen M, De Fusco C, Legrand F, Clementi R, Conter V, Danesino C, Janka-Schaub G, Aricò M
HAEMATOLOGICA. 2001;86(5):499-503.

Von Willebrand factor and von Willebrand disease
Budde U, Schneppenheim R
Reviews in clinical and experimental hematology. 2001;5(4):335-68; quiz following 431.

Six novel mutations in the PRF1 gene in children with haemophagocytic lymphohistiocytosis.
Clementi R, Zur Stadt U, Savoldi G, Varoitto S, Conter V, De Fusco C, Notarangelo L, Schneider M, Klersy C, Janka-Schaub G, Danesino C, Aricò M
J MED GENET. 2001;38(9):643-646.

Bone marrow transplantation in hemophagocytic lymphohistiocytosis.
Dürken M, Finckenstein F, Janka-Schaub G
LEUKEMIA LYMPHOMA. 2001;41(1-2):89-95.

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis.
Göransdotter Ericson K, Fadeel B, Nilsson-Ardnor S, Söderhäll C, Samuelsson A, Janka G, Schneider M, Gürgey A, Yalman N, Révész T, Egeler R, Jahnukainen K, Storm-Mathiesen I, Haraldsson A, Poole J, Janka-Schaub G, Nordenskjöld M, Henter J
AM J HUM GENET. 2001;68(3):590-597.

A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome.
Kröger N, Schetelig J, Zabelina T, Krüger W, Renges H, Stute N, Schrum J, Kabisch H, Siegert W, Zander A
BONE MARROW TRANSPL. 2001;28(7):643-647.

Anti-thymocyte-globulin as part of the preparative regimen prevents graft failure and severe graft versus host disease (GvHD) in allogeneic stem cell transplantation from unrelated donors.
Kröger N, Zabelina T, Krüger W, Renges H, Stute N, Dürken M, Graf von Finkenstein F, Erttmann R, Kabisch H, Schafhausen P, Jaburg N, Löliger C, Zander A
ANN HEMATOL. 2001;80(4):209-215.

Patient cytomegalovirus seropositivity with or without reactivation is the most important prognostic factor for survival and treatment-related mortality in stem cell transplantation from unrelated donors using pretransplant in vivo T-cell depletion with anti-thymocyte globulin.
Kröger N, Zabelina T, Krüger W, Renges H, Stute N, Schrum J, Kabisch H, Schafhausen P, Jaburg N, Löliger C, Schäfer P, Hinke A, Zander A
BRIT J HAEMATOL. 2001;113(4):1060-1071.

Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family.
Motyckova G, Weilbaecher K, Horstmann M, Rieman D, Fisher D, Fisher D
P NATL ACAD SCI USA. 2001;98(10):5798-5803.

Noncutaneous varicella-zoster virus (VZV) infection with fatal liver failure in a child with acute lymphoblastic leukemia (ALL)
Müller I, Aepinus C, Beck R, Bültmann B, Niethammer D, Klingebiel T
Med Pediatr Oncol. 2001;37(2):145-7.

Familial Williams-Beuren syndrome showing varying clinical expression
Pankau R, Siebert R, Kautza M, Schneppenheim R, Gosch A, Wessel A, Partsch C
Am J Med Genet. 2001;98(4):324-9.

Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86.
Paulussen M, Ahrens S, Dunst J, Winkelmann W, Exner G, Kotz R, Amann G, Dockhorn-Dworniczak B, Harms D, Müller-Weihrich S, Welte K, Kornhuber B, Janka-Schaub G, Göbel U, Treuner J, Voûte P, Zoubek A, Gadner H, Jürgens H
J CLIN ONCOL. 2001;19(6):1818-1829.

In vitro drug resistance and prognostic impact of p16INK4A/P15INK4B deletions in childhood T-cell acute lymphoblastic leukaemia.
Ramakers-van Woerden N, Pieters R, Slater R, Loonen A, Beverloo H, van Drunen E, Heyman M, Moreno T, Rots M, van Wering E, Kamps W, Janka-Schaub G, Veerman A
BRIT J HAEMATOL. 2001;112(3):680-690.

Screening strategies for a highly polymorphic gene: DHPLC analysis of the Fanconi anemia group A gene
Rischewski J, Schneppenheim R
J BIOCHEM BIOPH METH. 2001;47(1-2):53-64.

Expression and characterization of von Willebrand factor dimerization defects in different types of von Willebrand disease.
Schneppenheim R, Budde U, Obser T, Brassard J, Mainusch K, Ruggeri Z, Schneppenheim S, Schwaab R, Oldenburg J
BLOOD. 2001;97(7):2059-2066.

A molecular approach to the classification of von Willebrand disease
Schneppenheim R, Budde U, Ruggeri Z
BEST PRACT RES CL HA. 2001;14(2):281-98.

Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex
Schüller U, Lamp E, Schilling M
HISTOCHEM CELL BIOL. 2001;116(2):149-59.

Short-pulse B-non-Hodgkin lymphoma-type chemotherapy is efficacious treatment for pediatric anaplastic large cell lymphoma: a report of the Berlin-Frankfurt-Münster Group Trial NHL-BFM 90.
Seidemann K, Tiemann M, Schrappe M, Yakisan E, Simonitsch I, Janka-Schaub G, Dörffel W, Zimmermann M, Mann G, Gadner H, Parwaresch R, Riehm H, Reiter A
BLOOD. 2001;97(12):3699-3706.

Quantification and facilitated comparison of von Willebrand factor multimer patterns by densitometry
Studt J, Budde U, Schneppenheim R, Eisert R, von Depka Prondzinski M, Ganser A, Barthels M
AM J CLIN PATHOL. 2001;116(4):567-74.

Successful treatment of Pseudomonas aeruginosa respiratory tract infection with a sugar solution--a case report on a lectin based therapeutic principle
von Bismarck P, Schneppenheim R, Schumacher U
KLIN PADIATR. 2001;213(5):285-7.

MRD at the end of induction therapy in childhood acute lymphoblastic leukemia: outcome prediction strongly depends on the therapeutic regimen.
Zur Stadt U, Harms D, Schlüter S, Schrappe M, Goebel U, Spaar H, Janka-Schaub G, Kabisch H
LEUKEMIA. 2001;15(2):283-285.

Denaturing HPLC for identification of clonal T-cell receptor gamma rearrangements in newly diagnosed acute lymphoblastic leukemia
zur Stadt U, Rischewski J, Schneppenheim R, Kabisch H
CLIN CHEM. 2001;47(11):2003-11.

2000

Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia.
Aricò M, Valsecchi M, Camitta B, Schrappe M, Chessells J, Baruchel A, Gaynon P, Silverman L, Janka-Schaub G, Kamps W, Pui C, Masera G
NEW ENGL J MED. 2000;342(14):998-1006.

An additional unique candidate mutation (G2470A; M740I) in the original families with von Willebrand disease type 2 M Vicenza and the G3864A (R1205H) mutation
Castaman G, Missiaglia E, Federici A, Schneppenheim R, Rodeghiero F
THROMB HAEMOSTASIS. 2000;84(2):350-1.

Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease
Hahn A, Claviez A, Brinkmann G, Altermatt H, Schneppenheim R, Stephani U
NEUROPEDIATRICS. 2000;31(1):42-4.

Co-operative study group for childhood acute lymphoblastic leukemia (COALL): long-term follow-up of trials 82, 85, 89 and 92.
Harms D, Janka-Schaub G
LEUKEMIA. 2000;14(12):2234-2239.

Hereditary fructose intolerance and alpha(1) antitrypsin deficiency
Hillebrand G, Schneppenheim R, Oldigs H, Santer R
ARCH DIS CHILD. 2000;83(1):72-3.

Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells.
Kordes U, Krappmann D, Heissmeyer V, Ludwig W, Scheidereit C
LEUKEMIA. 2000;14(3):399-402.

Dose-dependent effect of etoposide in combination with busulfan plus cyclophosphamide as conditioning for stem cell transplantation in patients with acute myeloid leukemia.
Kröger N, Zabelina T, Sonnenberg S, Krüger W, Renges H, Stute N, Finkenstein F, Mayer U, Holstein K, Fiedler W, Colberg H, Sonnen R, Kuse R, Braumann D, Metzner B, Del Valle F, Erttmann R, Kabisch H, Zander A
BONE MARROW TRANSPL. 2000;26(7):711-716.

Using SQUID biomagnetic liver susceptometry in the treatment of thalassemia and other iron loading diseases.
Nielsen P, Engelhardt R, Duerken M, Janka-Schaub G, Fischer R
Transfus Sci. 2000;23(3):257-258.

Williams-Beuren syndrome 35 years after the diagnosis in one of the first Beuren patients
Pankau R, Partsch C, Gosch A, Siebert R, Schneider M, Schneppenheim R, Winter M, Wessel A
Am J Med Genet. 2000;91(4):322-4.

TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia.
Ramakers-van Woerden N, Pieters R, Loonen A, Hubeek I, van Drunen E, Beverloo H, Slater R, Harbott J, Seyfarth J, van Wering E, Hählen K, Schmiegelow K, Janka-Schaub G, Veerman A
BLOOD. 2000;96(3):1094-1099.

The common deletion 657del5 in the Nibrin gene is not a major risk factor for B or T cell non-Hodgkin lymphoma in a pediatric population.
Rischewski J, Bismarck P, Kabisch H, Janka-Schaub G, Obser T, Schneppenheim R
LEUKEMIA. 2000;14(8):1528-1529.

A heterozygous frameshift mutation in the Fanconi anemia C gene in familial T-ALL and secondary malignancy
Rischewski J, Clausen H, Leber V, Niemeyer C, Ritter J, Schindler D, Schneppenheim R
KLIN PADIATR. 2000;212(4):174-6.

Methotrexate resistance in relapsed childhood acute lymphoblastic leukaemia.
Rots M, Pieters R, Peters G, Noordhuis P, Van Zantwijk C, Henze G, Janka-Schaub G, Veerman A, Jansen G
BRIT J HAEMATOL. 2000;109(3):629-634.

Molecular analysis in glycogen storage disease 1 non-A: DHPLC detection of the highly prevalent exon 8 mutations of the G6PT1 gene in German patients.
Santer R, Rischewski J, Block G, Kinner M, Wendel U, Schaub J, Schneppenheim R
HUM MUTAT. 2000;16(2):177.

Population-based and controlled study to evaluate neuroblastoma screening at one year of age in Germany: interim results.
Schilling F, Berthold F, Erttmann R, Michaelis J, Spix C, Sander J, Schwarz K, Treuner J
Med Pediatr Oncol. 2000;35(6):701-704.

Von Willebrand Disease type 2M "Vicenza" in Italian and German patients: identification of the first candidate mutation (G3864A; R1205H) in 8 families
Schneppenheim R, Federici A, Budde U, Castaman G, Drewke E, Krey S, Mannucci P, Riesen G, Rodeghiero F, Zieger B, Zimmermann R
THROMB HAEMOSTASIS. 2000;83(1):136-40.

Long-term results of large prospective trials in childhood acute lymphoblastic leukemia.
Schrappe M, Camitta B, Pui C, Eden T, Gaynon P, Gustafsson G, Janka-Schaub G, Kamps W, Masera G, Sallan S, Tsuchida M, Vilmer E
LEUKEMIA. 2000;14(12):2193-2194.

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.
Wu M, Hemesath T, Takemoto C, Horstmann M, Wells A, Price E, Fisher D, Fisher D
GENE DEV. 2000;14(3):301-312.

[Minimal residual disease analysis in acute lymphoblastic leukemia of childhood within the framework of COALL Study: results of an induction therapy without asparaginase]
Zur Stadt U, Harms D, Schlüter S, Jorch N, Spaar H, Nürnberger W, Völpel S, Gutjahr P, Schrappe M, Janka-Schaub G, Kabisch H
KLIN PADIATR. 2000;212(4):169-173.

Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia.
Zwaan C, Kaspers G, Pieters R, Ramakers-Van Woerden N, den Boer M, Wünsche R, Rottier M, Hählen K, van Wering E, Janka-Schaub G, Creutzig U, Veerman A
BLOOD. 2000;96(8):2879-2886.

1999

Intracerebral hemorrhage as a late complication after CNS treatment of childhood lymphoma
Claviez A, Neubauer B, Link J, Schneppenheim R
KLIN PADIATR. 1999;210(6):406-8.

Human natural immunoglobulin M antibodies induce apoptosis of human neuroblastoma cells by binding to a Mr 260,000 antigen.
David K, Ollert M, Vollmert C, Heiligtag S, Eickhoff B, Erttmann R, Bredehorst R, Vogel C
CANCER RES. 1999;59(15):3768-3775.

Myeloid antigen co-expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance.
Den Boer M, Kapaun P, Pieters R, Kazemier K, Janka-Schaub G, Veerman A
BRIT J HAEMATOL. 1999;105(4):876-882.

Different expression of glutathione S-transferase alpha, mu and pi in childhood acute lymphoblastic and myeloid leukaemia.
Den Boer M, Pieters R, Kazemier K, Janka-Schaub G, Henze G, Creutzig U, Kaspers G, Kearns P, Hall A, Pearson A, Veerman A
BRIT J HAEMATOL. 1999;104(2):321-327.

Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia.
Den Boer M, Pieters R, Kazemier K, Janka-Schaub G, Henze G, Veerman A
LEUKEMIA. 1999;13(12):2023-2030.

Linkage of familial hemophagocytic lymphohistiocytosis to 10q21-22 and evidence for heterogeneity.
Dufourcq-Lagelouse R, Jabado N, Le Deist F, Stéphan J, Souillet G, Bruin M, Vilmer E, Schneider M, Janka-Schaub G, Fischer A, de Saint Basile G
AM J HUM GENET. 1999;64(1):172-179.

Improved outcome in haemophagocytic lymphohistiocytosis after bone marrow transplantation from related and unrelated donors: a single-centre experience of 12 patients.
Dürken M, Horstmann M, Bieling P, Erttmann R, Kabisch H, Löliger C, Schneider E, Hellwege H, Krüger W, Kröger N, Zander A, Janka G
BRIT J HAEMATOL. 1999;106(4):1052-1058.

Assessment of iron stores in children with transfusion siderosis by biomagnetic liver susceptometry.
Fischer R, Tiemann C, Engelhardt R, Nielsen P, Dürken M, Gabbe E, Janka-Schaub G
AM J HEMATOL. 1999;60(4):289-299.

Analysis of treatment efficiency of carboplatin and etoposide in combination with radical surgery in advanced and recurrent childhood hepatoblastoma: a report of the German Cooperative Pediatric Liver Tumor Study HB 89 and HB 94.
Fuchs J, Bode U, von Schweinitz D, Weinel P, Erttmann R, Harms D, Mildenberger H
KLIN PADIATR. 1999;211(4):305-309.

[In vitro drug resistance as independent prognostic factor in the study COALL-O5-92 Treatment of childhood acute lymphoblastic leukemia; two-tiered classification of treatments based on accepted risk criteria and drug sensitivity profiles in study COALL-06-97]
Janka-Schaub G, Harms D, den Boer M, Veerman A, Pieters R
KLIN PADIATR. 1999;211(4):233-238.

Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.
Krappmann D, Emmerich F, Kordes U, Scharschmidt E, Dörken B, Scheidereit C
ONCOGENE. 1999;18(4):943-953.

Early infections in patients undergoing bone marrow or blood stem cell transplantation--a 7 year single centre investigation of 409 cases.
Krüger W, Rüssmann B, Kröger N, Salomon C, Ekopf N, Elsner H, Kaulfers P, Mack D, Fuchs N, Dürken M, Kabisch H, Erttmann R, Zander A
BONE MARROW TRANSPL. 1999;23(6):589-597.

A classification based on T cell selection-related phenotypes identifies a subgroup of childhood T-ALL with favorable outcome in the COALL studies.
Niehues T, Kapaun P, Harms D, Burdach S, Kramm C, Körholz D, Janka-Schaub G, Göbel U
LEUKEMIA. 1999;13(4):614-617.

Longitudinal evaluation of growth, puberty, and bone maturation in children with Williams syndrome
Partsch C, Dreyer G, Gosch A, Winter M, Schneppenheim R, Wessel A, Pankau R
J PEDIATR-US. 1999;134(1):82-9.

A 2-year-old boy with recurrent severe bleeding: von Willebrand type 2B and ITP--or von Willebrand type 2B alone?
Rauch R, Budde U, Schneppenheim R, Ries M, Girisch M, Klinge J
EUR J PEDIATR. 1999;158 Suppl 3:S171-3.

Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Rots M, Pieters R, Peters G, van Zantwijk C, Mauritz R, Noordhuis P, Willey J, Hählen K, Creutzig U, Janka-Schaub G, Kaspers G, Veerman A, Jansen G
BLOOD. 1999;94(9):3121-3128.

[Natural human IgM-antibodies in neuroblastoma therapy: preliminary findings of a phase I/II clinical trial]
Schmitt C, David K, Hiller J, Schrum J, Bredehorst R, Vogel C, Löliger C, Erttmann R
KLIN PADIATR. 1999;211(4):314-318.

Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow.
Zander A, Zabelina T, Kröger N, Renges H, Krüger W, Löliger C, Dürken M, Stockschläder M, de Wit M, Wacker-Backhaus G, Bielack S, Jaburg N, Rüssmann B, Erttmann R, Kabisch H
BONE MARROW TRANSPL. 1999;23(9):889-893.

1998

The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia.
den Boer M, Pieters R, Kazemier K, Janka-Schaub G, Henze G, Veerman A
LEUKEMIA. 1998;12(6):912-920.

Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia.
den Boer M, Pieters R, Kazemier K, Rottier M, Zwaan C, Kaspers G, Janka-Schaub G, Henze G, Creutzig U, Scheper R, Veerman A
BLOOD. 1998;91(6):2092-2098.

[Treatment of hemophagocytic lymphohistiocytosis, HLH, with bone marrow transplantation]
Dürken M, Schneider E, Blütters-Sawatzki R, Stollmann-Gibbels B, Janka-Schaub G, Bretz R, Körholz D, Probst E, Holsten-Griffin H, Harps E, Zander A, Janka G
KLIN PADIATR. 1998;210(4):180-184.

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine.
Erb N, Harms D, Janka-Schaub G
CANCER CHEMOTH PHARM. 1998;42(4):266-272.

10 years' neuroblastoma screening in Europe: preliminary results of a clinical and biological review from the Study Group for Evaluation of Neuroblastoma Screening in Europe (SENSE).
Erttmann R, Tafese T, Berthold F, Kerbl R, Mann J, Parker L, Schilling F, Ambros P, Christiansen H, Favrot M, Kabisch H, Hero B, Philip T
EUR J CANCER. 1998;34(9):1391-1397.

Relapse and clonal disease in children with aplastic anemia (AA) after immunosuppressive therapy (IST): the SAA 94 experience. German/Austrian Pediatric Aplastic Anemia Working Group.
Führer M, Burdach S, Ebell W, Gadner H, Haas R, Harbott J, Janka-Schaub G, Klingebiel T, Kremens B, Niemeyer C, Rampf U, Reiter A, Ritter J, Schulz A, Walther U, Zeidler C, Bender-Götze C
KLIN PADIATR. 1998;210(4):173-179.

Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis.
Henter J, Aricò M, Janka-Schaub G, Imashuku S, Janka G
HEMATOL ONCOL CLIN N. 1998;12(2):417-433.

Ins405AsnPro mutation in the von Willebrand factor propeptide in recessive type 2A (IIC) von Willebrand's disease
Holmberg L, Karpman D, Isaksson C, Kristoffersson A, Lethagen S, Schneppenheim R
THROMB HAEMOSTASIS. 1998;79(4):718-22.

Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis.
Janka G, Imashuku S, Janka-Schaub G, Schneider M, Henter J
HEMATOL ONCOL CLIN N. 1998;12(2):435-444.

Treatment and long-term outcome of pineal nongerminomatous germ cell tumors.
Knappe U, Bentele K, Horstmann M, Herrmann H
PEDIATR NEUROSURG. 1998;28(5):241-245.

Busulfan, cyclophosphamide and etoposide as high-dose conditioning therapy in patients with malignant lymphoma and prior dose-limiting radiation therapy.
Kröger N, Hoffknecht M, Hänel M, Krüger W, Zeller W, Stockschläder M, de Wit M, Weh H, Kabisch H, Erttmann R, Zander A
BONE MARROW TRANSPL. 1998;21(12):1171-1175.

Intensified conditioning regimen in bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia.
Kröger N, Krüger W, Wacker-Backhaus G, Hegewisch-Becker S, Stockschläder M, Fuchs N, Rüssmann B, Renges H, Dürken M, Bielack S, de Wit M, Schuch G, Bartels H, Braumann D, Kuse R, Kabisch H, Erttmann R, Zander A
BONE MARROW TRANSPL. 1998;22(11):1029-1033.

Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review)
Müller I, Niethammer D, Bruchelt G
INT J MOL MED. 1998;1(2):491-4.

Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia--implications for treatment of infants.
Pieters R, den Boer M, Durian M, Janka-Schaub G, Schmiegelow K, Kaspers G, van Wering E, Veerman A
LEUKEMIA. 1998;12(9):1344-1348.

Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden)
Pohl M, Zimmerhackl L, Heinen F, Sutor A, Schneppenheim R, Brandis M
J PEDIATR-US. 1998;132(1):159-61.

alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome.
Price E, Horstmann M, Wells A, Weilbaecher K, Takemoto C, Landis M, Fisher D
J BIOL CHEM. 1998;273(49):33042-33047.

Detection of hyperdiploid karyotypes (>50 chromosomes) in childhood acute lymphoblastic leukemia (ALL) using fluorescence in situ hybridization (FISH).
Ritterbach J, Hiddemann W, Beck J, Schrappe M, Janka-Schaub G, Ludwig W, Harbott J, Lampert F
LEUKEMIA. 1998;12(3):427-433.

Fanconi-Bickel syndrome--a congenital defect of the liver-type facilitative glucose transporter. SSIEM Award. Society for the Study of Inborn Errors of Metabolism
Santer R, Schneppenheim R, Dombrowski A, Götze H, Steinmann B, Schaub J
J INHERIT METAB DIS. 1998;21(3):191-194.

1997

Thiopurine biology and pharmacology.
Aarbakke J, Janka-Schaub G, Elion G
TRENDS PHARMACOL SCI. 1997;18(1):3-7.

Transcription of tal-1, a putative oncogene playing an important role in childhood T-ALL, can be shown in normal peripheral blood cells by a highly sensitive RT-PCR assay.
Anderegg B, Horstmann M, Ernst M, Kabisch H
PEDIATR HEMAT ONCOL. 1997;14(4):349-358.

Effects of anti-tal-1 oligodeoxynucleotides in T-ALL cell lines.
Anderegg B, Horstmann M, Kabisch H
CANCER GENE THER. 1997;4(2):84-90.

Expression of a 260 kDa neuroblastoma surface antigen, the target of cytotoxic natural human IgM: correlation to MYCN amplification and effects of retinoic acid.
David K, Ehrhardt A, Ollert M, Erttmann R, Bredehorst R, Vogel C
EUR J CANCER. 1997;33(12):1937-1941.

Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society.
Favara B, Feller A, Pauli M, Jaffe E, Weiss L, Arico M, Bucsky P, Egeler R, Elinder G, Gadner H, Gresik M, Henter J, Imashuku S, Janka-Schaub G, Jaffe R, Ladisch S, Nezelof C, Pritchard J
Med Pediatr Oncol. 1997;29(3):157-166.

Factors influencing the haematological recovery after allogeneic bone marrow transplantation in leukaemia patients treated with methotrexate-containing GVHD prophylaxis: a single-centre experience.
Hassan H, Krog C, Stockschläder M, Schleimer B, Zeller W, Krüger W, Erttmann R, Zander A
ANTICANCER RES. 1997;17(1):589-599.

Factors influencing haematological recovery after allogeneic bone marrow transplantation in leukaemia patients treated with methotrexate-containing GVHD prophylaxis. A single-centre experience.
Hassan H, Krog C, Stockschläder M, Zeller W, Krüger W, Erttmann R, Zander A
SUPPORT CARE CANCER. 1997;5(4):299-306.

HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. HLH study Group of the Histiocyte Society.
Henter J, Aricò M, Egeler R, Elinder G, Favara B, Filipovich A, Gadner H, Imashuku S, Janka-Schaub G, Komp D, Ladisch S, Webb D
Med Pediatr Oncol. 1997;28(5):342-347.

Late manifestation of diabetes insipidus in "pure" cutaneous Langerhans cell histiocytosis.
Hoeger P, Janka-Schaub G, Mensing H
EUR J PEDIATR. 1997;156(7):524-527.

Frequent reduction or loss of DCC gene expression in human osteosarcoma.
Horstmann M, Pösl M, Scholz R, Anderegg B, Simon P, Baumgaertl K, Delling G, Kabisch H
BRIT J CANCER. 1997;75(9):1309-1317.

Antimycotic therapy with liposomal amphotericin-B for patients undergoing bone marrow or peripheral blood stem cell transplantation.
Krüger W, Stockschläder M, Sobottka I, Betker R, De Wit M, Kröger N, Grimm J, Arland M, Fiedler W, Erttmann R, Zander A
LEUKEMIA LYMPHOMA. 1997;24(5-6):491-499.

APC resistance in childhood thromboembolism: diagnosis and clinical aspects
Nowak-Göttl U, Schneppenheim R, Vielhaber H
SEMIN THROMB HEMOST. 1997;23(3):253-8.

Arginine506 to glutamin mutation in the factor V gene in infancy and childhood: evidence of fibrinolytic impairment
Nowak-Göttl U, Vielhaber H, Grohmann J, Schneppenheim R, Koch H
EUR J PEDIATR. 1997;156(3):195-8.

Mechanisms of in vivo anti-neuroblastoma activity of human natural IgM.
Ollert M, David K, Vollmert C, Juhl H, Erttmann R, Bredehorst R, Vogel C
EUR J CANCER. 1997;33(12):1942-1948.

Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology.
von Schweinitz D, Byrd D, Hecker H, Weinel P, Bode U, Bürger D, Erttmann R, Harms D, Mildenberger H
EUR J CANCER. 1997;33(8):1243-1249.

High dose chemotherapy with busulfan, cyclophosphamide, and etoposide as conditioning regimen for allogeneic bone marrow transplantation for patients with acute myeloid leukemia in first complete remission.
Zander A, Berger C, Kröger N, Stockshläder M, Krüger W, Horstmann M, Grimm J, Zeller W, Kabisch H, Erttmann R, Schönrock P, Kuse R, Braumann D, Illiger H, Fiedler W, de Witt M, Hossfeld K, Weh H
CLIN CANCER RES. 1997;3(12 Pt 2):2671-2675.

1996

Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry. FHL Study Group of the Histiocyte Society.
Aricò M, Janka G, Fischer A, Henter J, Blanche S, Janka-Schaub G, Martinetti M, Rusca M
LEUKEMIA. 1996;10(2):197-203.

Prevalence of factor V Leiden in children with thrombo-embolism
Aschka I, Aumann V, Bergmann F, Budde U, Eberl W, Eckhof-Donovan S, Krey S, Nowak-Göttl U, Schobess R, Sutor A, Wendisch J, Schneppenheim R
EUR J PEDIATR. 1996;155(12):1009-14.

The recurrence patterns of stages I, II and III neuroblastoma: experience with 77 relapsing patients.
Berthold F, Hero B, Breu H, Christiansen H, Erttmann R, Gnekow A, Herrmann F, Klingebiel T, Lampert F, Müller-Weihrich S, Weinel P
ANN ONCOL. 1996;7(2):183-187.

Impact of scheduling on toxicity and clinical efficacy of doxorubicin: what do we know in the mid-nineties?
Bielack S, Erttmann R, Kempf-Bielack B, Winkler K
EUR J CANCER. 1996;32(10):1652-1660.

Peripheral blast counts at diagnosis of late isolated bone marrow relapse of childhood acute lymphoblastic leukemia predict response to salvage chemotherapy and outcome. Berlin-Frankfurt-Münster Relapse Study Group.
Bührer C, Hartmann R, Fengler R, Rath B, Schrappe M, Janka-Schaub G, Henze G
J CLIN ONCOL. 1996;14(10):2812-2817.

Hepatopathie bei Patienten mit Neuroblastom Stadium 4S
Claviez A, Hero B, Schneppenheim R, Berthold F
KLIN PADIATR. 1996;208(4):221-8.

Growth arrest of solid human neuroblastoma xenografts in nude rats by natural IgM from healthy humans.
David K, Ollert M, Juhl H, Vollmert C, Erttmann R, Vogel C, Bredehorst R
NAT MED. 1996;2(6):686-689.

Naturally occurring humoral cytotoxicity against neuroblastoma (NB) cells in healthy persons and NB patients.
Erttmann R, Schmitt C, Ollert M, David K, Bredehorst R, Vogel C
PEDIATR HEMAT ONCOL. 1996;13(6):545-548.

Comparison of the diagnostic and prognostic value of biological markers in neuroblastoma. Proposal for a common methodology of analysis. SENSE group.
Favrot M, Ambros P, Schilling F, Frappaz D, Combaret V, Berthold F, Dominici C, Erttmann R, Esteve J, Jenkner A, Kerbl R, Mann J, Mathieu P, Parker L, Powell J, Philip T
ANN ONCOL. 1996;7(6):607-611.

Pharmacokinetics of the 5HT3 receptor antagonist tropisetron in children.
Gaedicke G, Erttmann R, Henze G, Hartmann W, Drechsler S, Grass P, Faerber L, Kutz K
PEDIATR HEMAT ONCOL. 1996;13(5):405-416.

MLL/ENL fusion in congenital acute lymphoblastic leukemia with a unique t(11;18;19).
Horstmann M, Argyriou-Tirita A, Borkhardt A, Kabisch H, Kapaun P, Winkler K, Haas O
CANCER GENET-NY. 1996;88(2):103-109.

Early toxicity of intensified conditioning with etoposide combined with total body irradiation/cyclophosphamide or busulfan/cyclophosphamide in children undergoing autologous or allogeneic bone marrow transplantation.
Horstmann M, Kroschke G, Stockschläder M, Betker R, Krüger W, Erttmann R, Kabisch H, Zander A
PEDIATR HEMAT ONCOL. 1996;13(1):45-53.

Randomized comparison of rotational chemotherapy in high-risk acute lymphoblastic leukaemia of childhood--follow up after 9 years. Coall Study Group.
Janka-Schaub G, Harms D, Goebel U, Graubner U, Gutjahr P, Haas R, Juergens H, Spaar H, Winkler K
EUR J PEDIATR. 1996;155(8):640-648.

[Induction of multiple melanocytic nevus cell nevi in 2 children with malignant hematologic systemic diseases and chemotherapy-induced immunosuppression]
Jappe U, Abeck D, Janka-Schaub G, Gross G, Jakob T, Ring J
HAUTARZT. 1996;47(7):537-540.

Fatal outcome of disseminated candidosis after allogeneic bone marrow transplantation under treatment with liposomal and conventional amphotericin-B. A report of 4 cases with determination of the Mic values.
Krüger W, Sobottka I, Stockschläder M, Mross K, Hoffknecht M, Rüssmann B, Horstmann M, Betker R, Zander A
SCAND J INFECT DIS. 1996;28(3):313-316.

Inherited defects of the protein C anticoagulant system in childhood thrombo-embolism
Nowak-Göttl U, Auberger K, Göbel U, Kreuz W, Schneppenheim R, Vielhaber H, Zenz W, Zieger B
EUR J PEDIATR. 1996;155(11):921-7.

Resistance to activated protein C (APCR) in children with venous or arterial thromboembolism
Nowak-Göttl U, Koch H, Aschka I, Kohlhase B, Vielhaber H, Kurlemann G, Oleszcuk-Raschke K, Kehl H, Jürgens H, Schneppenheim R
BRIT J HAEMATOL. 1996;92(4):992-8.

APC resistance in neonates and infants: adjustment of the APTT-based method
Nowak-Göttl U, Kohlhase B, Vielhaber H, Aschka I, Schneppenheim R, Jürgens H
THROMB RES. 1996;81(6):665-70.

Normal human serum contains a natural IgM antibody cytotoxic for human neuroblastoma cells.
Ollert M, David K, Schmitt C, Hauenschild A, Bredehorst R, Erttmann R, Vogel C
P NATL ACAD SCI USA. 1996;93(9):4498-4503.

Incidence and clinical outcome of children with BCR/ABL-positive acute lymphoblastic leukemia (ALL). A prospective RT-PCR study based on 673 patients enrolled in the German pediatric multicenter therapy trials ALL-BFM-90 and CoALL-05-92.
Schlieben S, Borkhardt A, Reinisch I, Ritterbach J, Janssen J, Ratei R, Schrappe M, Repp R, Zimmermann M, Kabisch H, Janka-Schaub G, Bartram C, Ludwig W, Riehm H, Lampert F, Harbott J
LEUKEMIA. 1996;10(6):957-963.

Von Willebrand disease
Schneppenheim R
EUR J PEDIATR. 1996;155(9):751-2.

Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease
Schneppenheim R, Brassard J, Krey S, Budde U, Kunicki T, Holmberg L, Ware J, Ruggeri Z
P NATL ACAD SCI USA. 1996;93(8):3581-6.

Results of a screening for von Willebrand disease type 2N in patients with suspected haemophilia A or von Willebrand disease type 1
Schneppenheim R, Budde U, Krey S, Drewke E, Bergmann F, Lechler E, Oldenburg J, Schwaab R
THROMB HAEMOSTASIS. 1996;76(4):598-602.

Use of cryopreserved bone marrow in unrelated allogeneic transplantation.
Stockschläder M, Krüger W, Tom Dieck A, Horstmann M, Altnöder M, Löliger C, Fiedler W, Hoffknecht M, Erttmann R, Zander A
BONE MARROW TRANSPL. 1996;17(2):197-199.

Geographic distribution and origin of CFTR mutations in Germany
Tümmler B, Storrs T, Dziadek V, Dörk T, Meitinger T, Golla A, Bertele-Harms R, Harms H, Schröder E, Claass A, Rutjes J, Schneppenheim R, Bauer I, Breuel K, Stuhrmann M, Schmidtke J, Lindner M, Eigel A, Horst J, Kaiser R, Lentze M, Schmidt K, von der Hardt H, Estivill X
HUM GENET. 1996;97(6):727-31.

1995

Structurally modified anthracyclines retain activity in a cell line with simultaneous typical and atypical multidrug resistance.
Bielack S, Kallenbach K, Looft G, Erttmann R, Winkler K
ANTICANCER RES. 1995;15(4):1279-1284.

First case of disseminated Mycobacterium avium infection following chemotherapy for childhood acute myeloid leukemia
Claass A, Claviez A, Westphal E, Rüsch-Gerdes S, Schneppenheim R
INFECTION. 1995;23(5):301-2.

Cyclophosphamide/antithymocyte globulin conditioning of patients with severe aplastic anemia transplanted with bone marrow from HLA-identical related donors
Horstmann M, Stockschläder M, Kabisch H, Zander A
BLOOD. 1995;85(5):1404-5.

Cyclophosphamide/antithymocyte globulin conditioning of patients with severe aplastic anemia for marrow transplantation from HLA-matched siblings: preliminary results.
Horstmann M, Stockschläder M, Krüger W, Hoffknecht M, Betker R, Kabisch H, Zander A
ANN HEMATOL. 1995;71(2):77-81.

Experience with liposomal Amphotericin-B in 60 patients undergoing high-dose therapy and bone marrow or peripheral blood stem cell transplantation.
Krüger W, Stockschläder M, Rüssmann B, Berger C, Hoffknecht M, Sobottka I, Kohlschütter B, Kroschke G, Kröger N, Horstmann M
BRIT J HAEMATOL. 1995;91(3):684-690.

Liver iron stores in patients with secondary haemosiderosis under iron chelation therapy with deferoxamine or deferiprone.
Nielsen P, Fischer R, Engelhardt R, Tondüry P, Gabbe E, Janka-Schaub G
BRIT J HAEMATOL. 1995;91(4):827-833.

Identification of a candidate missense mutation in a family with von Willebrand disease type IIC
Schneppenheim R, Thomas K, Krey S, Budde U, Jessat U, Sutor A, Zieger B
HUM GENET. 1995;95(6):681-6.

Von Willebrand disease in childhood
Schneppenheim R, Thomas K, Sutor A
SEMIN THROMB HEMOST. 1995;21(3):261-75.

Complete resection before development of drug resistance is essential for survival from advanced hepatoblastoma--a report from the German Cooperative Pediatric Liver Tumor Study HB-89.
von Schweinitz D, Hecker H, Harms D, Bode U, Weinel P, Bürger D, Erttmann R, Mildenberger H
J PEDIATR SURG. 1995;30(6):845-852.

[Intraspinal metastasis of stage I anaplastic Wilms tumor]
Wiegel T, Grzyska U, Schwarz R, Escherich G
STRAHLENTHER ONKOL. 1995;171(5):296-299.

1994

Malignant histiocytosis and large cell anaplastic (Ki-1) lymphoma in childhood: guidelines for differential diagnosis--report of the Histiocyte Society.
Bucsky P, Favara B, Feller A, Nezelof C, Radzun H, Schlegelberger B, Janka-Schaub G
Med Pediatr Oncol. 1994;22(3):200-203.

The impact of EBV, proliferation rate, and Bcl-2 expression in Hodgkin's disease in childhood
Claviez A, Tiemann M, Peters J, Kreipe H, Schneppenheim R, Parwaresch R
ANN HEMATOL. 1994;68(2):61-6.

Relapse of MALT lymphoma associated with Helicobacter pylori after antibiotic treatment.
Horstmann M, Erttmann R, Winkler K
LANCET. 1994;343(8905):1098-1099.

Screening for neuroblastoma.
Schilling F, Erttmann R, Ambros P, Strehl S, Christiansen H, Kovar H, Kabisch H, Treuner J
LANCET. 1994;344(8930):1157-1158.

Genetic heterogeneity of severe von Willebrand disease type III in the German population
Schneppenheim R, Krey S, Bergmann F, Bock D, Budde U, Lange M, Linde R, Mittler U, Meili E, Mertes G
HUM GENET. 1994;94(6):640-52.

[Results of the HB-89 Study in treatment of malignant epithelial liver tumors in childhood and concept of a new HB-94 protocol]
von Schweinitz D, Bürger D, Bode U, Weinel P, Erttmann R, Hecker H, Mildenberger H
KLIN PADIATR. 1994;206(4):282-288.

1993

Intraarterial chemotherapy for osteosarcoma: does the result really justify the effort?
Bielack S, Bieling P, Erttmann R, Winkler K
Cancer Treat Res. 1993;62:85-92.

Phenylalanine, other large neutral amino acids and RNA catabolites as markers for protein biosynthesis in phenylketonuria.
Clemens P, Burmester J, Wiegand G, Prankel B, Halfmann E, Erb N, Müller-Wickop J
METABOLISM. 1993;42(4):531-532.

Extracellular purine nucleosides elevated in chronic recidiving central nervous injury by deranged metabolism in phenylketonuria.
Clemens P, Prankel B, Halfman E, Erb N, Müller-Wickop J
MED HYPOTHESES. 1993;41(3):287-288.

[BEP/VIP in children and adolescents with malignant non-testicular germ cell tumors. A comparison of the results of treatment of therapy studies MAKEI 83/86 and 89P/89]
Göbel U, Calaminus G, Teske C, Bamberg M, Bökkerink J, Haas R, Holschneider A, Janka-Schaub G, Jürgens H, Mittler U
KLIN PADIATR. 1993;205(4):231-240.

von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure
Holmberg L, Dent J, Schneppenheim R, Budde U, Ware J, Ruggeri Z
J CLIN INVEST. 1993;91(5):2169-77.

Reversal of multidrug resistance in Friend leukemia cells by dexniguldipine-HCl.
Reymann A, Looft G, Woermann C, Dietel M, Erttmann R
CANCER CHEMOTH PHARM. 1993;32(1):25-30.

1992

[Effect of dose intensity and therapy-induced leukocytopenia in intensive therapy on the prognosis of acute lymphatic leukemia in childhood. Results in 213 patients of the COALL-85 study]
Gobrecht O, Göbel U, Graubner U, Gutjahr P, Schöck V, Spaar H, Janka-Schaub G
KLIN PADIATR. 1992;204(4):230-235.

Infectious risks of Broviac catheters in children with neoplastic diseases: a matched pairs analysis.
Harms D, Görtitz I, Lambrecht W, Kabisch H, Erttmann R, Janka-Schaub G
PEDIATR INFECT DIS J. 1992;11(12):1014-1018.

Treatment of chronic neutropenia of childhood responsive to cyclosporin A in vitro and in vivo.
Janka-Schaub G, Raghavachar A, Rister M, Belohradsky B
INT J HEMATOL. 1992;55(2):157-163.

[Preoperative chemotherapy of nephroblastoma. Preliminary results of the SIOP-9/GPO therapy study]
Ludwig R, Weirich A, Pötter R, Harms D, Bürger D, Michaelis J, Erttmann R, Weinel P, Haas R, Ritter J
KLIN PADIATR. 1992;204(4):204-213.

[Early neuroblastoma detection in Germany. On the status of the Hamburg-Stuttgart cooperative pilot study]
Schilling F, Erttmann R, Dohrmann S, Erb N, Winkler K, Gross U, Treuner J
KLIN PADIATR. 1992;204(4):282-287.

1991

Neuroblastoma screening: arguments from retrospective analysis of three German neuroblastoma trials.
Berthold F, Hunneman D, Käser H, Harms D, Bertram U, Erttmann R, Schilling F, Treuner J, Zieschang J
J PEDIAT HEMATOL ONC. 1991;13(1):8-13.

Conserved cytostatic activity of aclarubicin in a doxorubicin selected Friend leukaemia cell line with multifactorial multidrug resistance.
Erttmann R, Münchmeyer M, Looft G, Winkler K
EUR J CANCER. 1991;27(8):1064.

Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM group.
Henze G, Fengler R, Hartmann R, Kornhuber B, Janka-Schaub G, Niethammer D, Riehm H
BLOOD. 1991;78(5):1166-1172.

[Familial hemophagocytic lymphohistiocytosis]
Hesse C, Hansmann M, Janka-Schaub G, Rontogianni D, Radzun H, Fischer R
Verh Dtsch Ges Pathol. 1991;75:200-204.

[Initial response to therapy as an important prognostic factor in acute lymphoblastic leukemia in childhood. COALL study group]
Janka-Schaub G, Stührk H, Kortüm B, Graubner U, Jürgens H, Spaar H, Schöck V, Dohrn B, Bahr R, Winkler K
KLIN PADIATR. 1991;203(4):231-235.

Discrepant results of different tests for antibodies to hepatitis C in children with malignant diseases and in patients on renal replacement therapy
Rautenberg P, Schneppenheim R, Leimenstoll G, Behnke H, Loose G
EUR J CLIN MICROBIOL. 1991;10(11):978-81.

Luminography--a new, highly sensitive visualization method for electrophoresis
Schneppenheim R, Budde U, Dahlmann N, Rautenberg P
ELECTROPHORESIS. 1991;12(5):367-72.

Seroprevalence and significance of antibodies to hepatitis C virus in pediatric patients with malignant diseases
Schneppenheim R, Rautenberg P, Behnke H, Vietor K
KLIN PADIATR. 1991;203(4):273-5.

1990

Luminographic detection of von Willebrand factor multimers in agarose gels and on nitrocellulose membranes
Budde U, Schneppenheim R, Plendl H, Dent J, Ruggeri Z, Zimmerman T
THROMB HAEMOSTASIS. 1990;63(2):312-5.

Risk of CNS relapse after systemic relapse of childhood acute lymphoblastic leukemia.
Fengler R, Hartmann R, Bode U, Janka-Schaub G, Jürgens H, Riehm H, Henze G
BLOOD TRANSFUS-ITALY. 1990;33:511-515.

Cytogenetics of childhood acute lymphoblastic leukemia in multicenter trials.
Harbott J, Ritterbach J, Janka-Schaub G, Ludwig W, Reiter A, Riehm H, Lampert F
BLOOD TRANSFUS-ITALY. 1990;33:451-458.

[Therapy of sickle cell crisis]
Janka-Schaub G
DEUT MED WOCHENSCHR. 1990;115(42):1611.

Improved prognosis for childhood acute lymphocytic leukemia with very high white blood cell count (greater than 100/nl) with rotation of non-cross-resistant drug combinations.
Janka-Schaub G, Goebel U, Graubner U, Haas R, Juergens H, Spaar H, Winkler K
BLOOD TRANSFUS-ITALY. 1990;33:489-493.

Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high-dose methotrexate, and ifosfamide on histologic tumor response in osteosarcoma (study COSS-86).
Winkler K, Bielack S, Delling G, Salzer-Kuntschik M, Kotz R, Greenshaw C, Jürgens H, Ritter J, Kusnierz-Glaz C, Erttmann R
CANCER-AM CANCER SOC. 1990;66(8):1703-1710.

1989

Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma. Cooperative Osteosarcoma Study Group COSS.
Bielack S, Erttmann R, Looft G, Purfürst C, Delling G, Winkler K, Landbeck G
CANCER CHEMOTH PHARM. 1989;24(6):376-380.

Doxorubicin: effect of different schedules on toxicity and anti-tumor efficacy.
Bielack S, Erttmann R, Winkler K, Landbeck G
Eur J Cancer Clin Oncol. 1989;25(5):873-882.

Natural killer cell function and interferon production in familial hemophagocytic lymphohistiocytosis.
Eife R, Janka-Schaub G, Belohradsky B, Holtmann H
PEDIATR HEMAT ONCOL. 1989;6(3):265-272.

[Anthracycline transport in sensitive and resistant leukemia cells]
Erttmann R, Erb N, Forcadell de Dios P, Neurath C, Looft G, Landbeck G
KLIN PADIATR. 1989;201(1):40-45.

An EcoRI polymorphism in the human von Willebrand factor (vWF) gene
Ewerhardt B, Ludwig M, Schwaab R, Schneppenheim R, Olek K
NUCLEIC ACIDS RES. 1989;17(13):5416.

[Intracranial germ cell tumors: analysis of the therapy study MAKEI 83/86 and changes in protocol for the follow-up study]
Göbel U, Bamberg M, Budach V, Haas R, Janka-Schaub G, Kühl J, Lenard H, Rister M, Spaar H
KLIN PADIATR. 1989;201(4):261-268.

[Non-testicular germ cell tumors: analysis of the therapy study MAKEI 83/86 anc changes in the protocol for the follow-up study]
Göbel U, Bamberg M, Haas R, Bökkerink J, Brämswig G, Calaminus G, Engert J, Gadner H, Havers W, Janka-Schaub G
KLIN PADIATR. 1989;201(4):247-260.

Familial hemophagocytic lymphohistiocytosis macrophages showing immunohistochemical properties of activated macrophages and T-accessory cells.
Hansmann M, Rontogianni D, Janka-Schaub G, Wacker H, Hinkeldey K, Radzun H
PEDIATR HEMAT ONCOL. 1989;6(3):237-246.

Familial hemophagocytic lymphohistiocytosis: diagnostic problems and differential diagnosis.
Janka-Schaub G
PEDIATR HEMAT ONCOL. 1989;6(3):219-225.

Familial hemophagocytic lymphohistiocytosis: therapy in the German experience.
Janka-Schaub G
PEDIATR HEMAT ONCOL. 1989;6(3):227-231.

1988

[Myeloablative chemo- and radiotherapy with autologous and allogenic bone marrow reconstitution in children with metastatic neuroblastoma]
Berthold F, Bender-Götze C, Dopfer R, Erttmann R, Haas R, Henze G, Körbling M, Riehm H, Rister M, Stollmann B
KLIN PADIATR. 1988;200(3):221-225.

[Antineoplastic effectiveness and toxicity of idarubicin (4-demethoxy-daunorubicin) in recurrent acute leukemias in childhood]
Erttmann R, Bode U, Erb N, Forcadell de Dios P, Gutjahr P, Haas R, Kuhn N, Siewert H, Landbeck G
KLIN PADIATR. 1988;200(3):200-204.

Pharmacokinetics of doxorubicin in man: dose and schedule dependence.
Erttmann R, Erb N, Steinhoff A, Landbeck G
J CANCER RES CLIN. 1988;114(5):509-513.

Long term doxorubicin cardiotoxicity in childhood: non-invasive evaluation of the contractile state and diastolic filling.
Hausdorf G, Morf G, Beron G, Erttmann R, Winkler K, Landbeck G, Keck E
Br Heart J. 1988;60(4):309-315.

Rapidly rotating combination chemotherapy in childhood acute lymphoblastic leukemia: preliminary results of a randomized comparison with conventional treatment.
Janka-Schaub G, Winkler K, Göbel U, Graubner U, Gutjahr P, Haas R, Jürgens H, Spaar J
LEUKEMIA. 1988;2(12):.

[The COALL-85 cooperative study for risk patients with acute lymphatic leukemia: initial results]
Janka-Schaub G, Winkler K, Göbel U, Graubner U, Schwenger M, Haas R, Jürgens H, Spaar J
KLIN PADIATR. 1988;200(3):171-176.

Luminography--an alternative assay for detection of von Willebrand factor multimers
Schneppenheim R, Plendl H, Budde U
THROMB HAEMOSTASIS. 1988;60(2):133-6.

Aplastic crisis caused by parvovirus B19 infection.
Schwarz T, Roggendorf M, Janka-Schaub G
EUR J CLIN MICROBIOL. 1988;7(1):87-88.

1987

[Langerhans cell histiocytosis in childhood--results of the DAL-HX 83 study]
Gadner H, Heitger A, Ritter J, Göbel U, Janka-Schaub G, Kühl J, Bode U, Spaar H
KLIN PADIATR. 1987;199(3):173-182.

Early intensification therapy in high-risk childhood acute lymphocytic leukemia: lack of benefit from high-dose methotrexate.
Janka-Schaub G, Winkler K, Juergens H, Goebel U
BLOOD TRANSFUS-ITALY. 1987;30:456-460.

Nachweis von Neuroblastomzellen im Knochenmark durch "Southern-Blot" und "In situ-Hybridisierung" mit Hilfe einer NMYC-DNS-Probe
Kabisch H, Heinsohn S, Milde-Langosch K, Löning T, Bartl S, Erttmann R, Landbeck G
MONATSSCHR KINDERH. 1987;135(4):210-213.

A luminescence Western blot with enhanced sensitivity for antibodies to human immunodeficiency virus
Schneppenheim R, Rautenberg P
EUR J CLIN MICROBIOL. 1987;6(1):49-51.

1986

A rapid chromatographic procedure for the determination of adriamycin, daunomycin and their 13-OH metabolites adriamycinol and daunomycinol.
Erb N, Erttmann R, Landbeck G
CANCER CHEMOTH PHARM. 1986;17(1):53-55.

Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
Erttmann R, Bielack S, Landbeck G
ONCOLOGY-BASEL. 1986;43(2):86-88.

[The pharmacokinetics of doxorubicin]
Erttmann R, Grandt M, Erb N, Garbrecht M, Landbeck G
KLIN PADIATR. 1986;198(3):271-276.

Intermediate-dose methotrexate in the treatment of childhood acute lymphocytic leukaemia: lack of benefit during maintenance therapy following intensive induction therapy.
Janka-Schaub G, Winkler K, Jürgens H, Goebel U, Gutjahr P, Spaar H
EUR J PEDIATR. 1986;145(1-2):14-17.

Detection of neuroblastoma cells in bone marrow by in situ hybridization.
Kabisch H, Heinsohn S, Milde K, Löning T, Bartl S, Erttmann R
EUR J PEDIATR. 1986;145(4):323-324.

Meta-iodobenzylguanidine scintigraphy in neuroblastoma--a comparison with conventional X-ray and ultrasound.
Müller-Gärtner H, Erttmann R, Helmke K
PEDIATR HEMAT ONCOL. 1986;3(2):97-109.

The age dependency of the creatinine-related concentration of ribonucleosides in human urine.
Müller-Wickop J, Lorenz H, Winkler K, Erb N
J Clin Chem Clin Biochem. 1986;24(12):993-999.

[Effect of a local surgical procedure on the incidence of metastases following neoadjuvant chemotherapy of osteosarcoma]
Winkler K, Beron G, Kotz R, Salzer-Kuntschik M, Beck J, Beck W, Brandeis W, Ebell W, Erttmann R, Göbel U
Z ORTHOP GRENZGEB. 1986;124(1):22-29.

1985

7-Hydroxy-methotrexate and clinical toxicity following high-dose methotrexate therapy.
Erttmann R, Bielack S, Landbeck G
J CANCER RES CLIN. 1985;109(1):86-88.

Kinetics of 7-hydroxy-methotrexate after high-dose methotrexate therapy.
Erttmann R, Bielack S, Landbeck G
CANCER CHEMOTH PHARM. 1985;15(2):101-104.

[Clinical significance of non-renal elimination mechanisms of methotrexate (MTX)]
Erttmann R, Gkanatsas A
MONATSSCHR KINDERH. 1985;133(8):516-519.

Effect of oral cholestyramine on the elimination of high-dose methotrexate.
Erttmann R, Landbeck G
J CANCER RES CLIN. 1985;110(1):48-50.

[The Munich study on the treatment of acute lymphoblastic leukemia in childhood (ALL 77-02)]
Graubner U, Haas R, Janka G, Janka-Schaub G, Kohne E, Rieber E
KLIN PADIATR. 1985;197(3):207-214.

[Scintigraphy with radioiodinated meta-iodobenzylguanidine in the diagnosis of neuroblastoma]
Müller-Gärtner H, Erttmann R, Helmke K
NUKLEARMED-NUCL MED. 1985;24(5-6):222-226.

An improved method for the simultaneous analysis of normal and modified urinary nucleosides and nucleobases by high performance liquid chromatography.
Sander G, Wieland J, Topp H, Heller-Schöch G, Erb N, Schöch G
CLIN CHIM ACTA. 1985;152(3):355-361.

1984

In vivo production of childhood acute lymphoblastic leukemia cells in relation to ploidy and immunological subtype.
Dörmer P, Janka-Schaub G, Lau B, Haas R, Janka G
LEUKEMIA RES. 1984;8(4):587-595.

Prolonged methotrexate infusions in children with acute leukemia in relapse and in remission and with medulloblastoma. Pharmacokinetics, toxicity and clinical results.
Janka-Schaub G, Mack R, Helmig M, Haas R, Bidlingmaier F
ONCOLOGY-BASEL. 1984;41(4):225-232.

Neoadjuvant chemotherapy for osteogenic sarcoma: results of a Cooperative German/Austrian study.
Winkler K, Beron G, Kotz R, Salzer-Kuntschik M, Beck J, Beck W, Brandeis W, Ebell W, Erttmann R, Göbel U
J CLIN ONCOL. 1984;2(6):617-624.

1983

Determination of aclacinomycin A by reversed-phase high-performance liquid chromatography.
Erttmann R
J CHROMATOGR A. 1983;277:433-435.

Pancreatic sonography in thalassemia major.
Erttmann R, Hausdorf G, Landbeck G
KLIN PADIATR. 1983;195(2):97-99.

[Intracranial metastasis in neuroblastoma]
Erttmann R, Heller M, Veelken N, Landbeck G
Z Kinderchir. 1983;38(5):333-335.

[Wiskott-Aldrich syndrome]
Erttmann R, Thöne I, Landbeck G
MONATSSCHR KINDERH. 1983;131(8):524-527.

[Treatment strategy in non-testicular malignant germ cell tumors in children and adolescents--concept of the MAKEI 83 cooperative therapeutic study of the Society for Pediatric Oncology]
Göbel U, Haas R, Harms D, Janka-Schaub G, Brämswig J, Jürgens H, Weissbach L, Faber P, Müller E
KLIN PADIATR. 1983;195(3):201-206.

[Malignant testicular tumors in children and adolescents: concept of the MAHO 82 cooperative therapeutic study of the Society for Pediatric Oncology]
Haas R, Brämswig J, Göbel U, Harms D, Janka-Schaub G, Weissbach L
KLIN PADIATR. 1983;195(3):196-200.

Therapy of acute lymphocytic leukemia in childhood with intermediate dose methotrexate and CNS irradiation. A report of the ALL 77-02 study group.
Haas R, Janka G, Janka-Schaub G, Kohne E, Netzel B
Blut. 1983;47(6):321-331.

[Invasive aspergillosis with an intrapulmonary fungus ball in childhood]
Hausdorf G, Erttmann R
KLIN PADIATR. 1983;195(2):129-132.

Familial hemophagocytic lymphohistiocytosis.
Janka-Schaub G
EUR J PEDIATR. 1983;140(3):221-230.

Multivariate analysis of urinary RNA catabolites in malignancies: cross-sectional and longitudinal studies.
Müller J, Erb N, Heller-Schöch G, Lorenz H, Winkler K, Schöch G
Recent Results Cancer Res. 1983;84:317-330.

Serological inhibition of graft versus host disease: recent results in 28 patients with leukemia.
Rodt H, Thierfelder S, Bender-Götze C, Dopfer R, Haas F, Janka-Schaub G, Kolb H, Link H, Netzel B, Niethammer D, Schüch K, Wilms K
BLOOD TRANSFUS-ITALY. 1983;28:92-96.

[COALL-80 therapy in the management of acute lymphoblastic leukemia in childhood--an interim report]
Winkler K, Beron G, Erttmann R, Jürgens H, Göbel U, Gutjahr P, Kabisch H, Kuhn N, Spaar H, Drescher J, Thomas P, Landbeck G
KLIN PADIATR. 1983;195(3):161-167.

Adjuvant chemotherapy in osteosarcoma - effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin. Preliminary results of the COSS 80 study.
Winkler K, Beron G, Kotz R, Salzer-Kuntschik M, Beck J, Beck W, Brandeis W, Ebell W, Erttmann R, Göbel U, Havers W, Henze G, Hinderfield L, Höcker P, Jobke A, Jürgens H, Kabisch H, Landbeck G, Preusser P, Prindull G, Ramach W, Ritter J, Sekera J, Treuner J, Wüst G
J CANCER RES CLIN. 1983;106:1-7.

1982

[Excretion of methylated nucleosides in the initial therapy phase in a case of anorexia nervosa]
Clemens P, Schöch G, Ziemer G, Altenhoff J, Erb N, Lorenz H, Müller J, Grüttner R
Padiatr Padol. 1982;17(2):157-163.

[Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy]
Haas R, Helmig F, Hausner H, Eife R, Devens K, Janka-Schaub G, Helmig M, Lampert F
ONKOLOGIE. 1982;5(2):60-66.

[So-called histiocytosis X and malignant histiocytosis]
Haas R, Janka-Schaub G, Helmig M, Meister P
ONKOLOGIE. 1982;5(1):4-12.

[Sonographic findings in malignant lymphoblastic T-cell lymphomas in childhood]
Hausdorf G, Erttmann R, Hübner C, Winkler K
ONKOLOGIE. 1982;5(6):284-288.

1981

[Medulloblastoma cerebelli in childhood--retrospective evaluation of diagnostic methods and therapy (author's transl)]
Berthold R, Janka-Schaub G, Lampert F
KLIN PADIATR. 1981;193(3):189-197.

[The cyanogenic glycosides of triticum, secale and sorghum.]
Erb N, Zinsmeister H, Nahrstedt A
PLANTA MED. 1981;41(1):84-89.

[Infections in children with leukaemia or malignant tumour treated with cytostatic agents: long-term study of 200 cases (author's transl)]
Goetz O, Peller P, Haas R, Janka-Schaub G
DEUT MED WOCHENSCHR. 1981;106(14):421-423.

[All 77-01 therapy study for treatment of acute lymphocytic leukemia in childhood (author's transl)]
Haas R, Janka-Schaub G, Netzel B, Helmig M
KLIN PADIATR. 1981;193(3):137-144.

Familial lymphohistiocytosis.
Janka-Schaub G, Belohradsky B, Däumling S, Müller-Höcker J, Meister P, Haas R
BLOOD TRANSFUS-ITALY. 1981;27:245-253.

Intravenous and subcutaneous desferrioxamine therapy in children with severe iron overload.
Janka-Schaub G, Möhring P, Helmig M, Haas R, Betke K
EUR J PEDIATR. 1981;137(3):285-290.

Microrheological aspects in extreme leukocytotic acute childhood leukemia.
Klose H, Kelson S, Janka-Schaub G, Schwarzbach K, Haas R, Betke K
Bibl Haematol. 1981;47:258-263.

[Initial treatment of acute childhood leukemia with extreme leukocytosis by blood exchange transfusion -- rheological aspects (author's transl)]
Klose H, Kelson S, Schwarzbach K, Janka-Schaub G, Netzel B, Haas R, Betke K
KLIN PADIATR. 1981;193(3):172-176.

[Bone marrow transplantation for aplastic anaemia (author's transl)]
Kolb H, Wündisch G, Spitzer I, Ochsler H, Stengel-Rutkowski L, Bender-Götze C, Albert E, Sauer H, Ledderose G, Brehm G, Jehn U, Eckstein R, Mempel W, Wilmanns W, Haas R, Helmig M, Netzel B, Belohradsky B, Janka-Schaub G, Rodt H, GrosseWWilde H, Thiel E, von Lieven H, Roloff R, Krimmel B, Bunde E, Wank R, Schendel D
Klin Wochenschr. 1981;59(7):325-342.

[Bone marrow transplantation in acute leukemias: antibody treatment for suppression of graft-versus-host disease (author's transl)]
Rodt H, Netzel B, Kolb H, Haas R, Wilms K, Bender-Götze C, Wernet P, Janka-Schaub G, Link H, Wilmanns W, Thierfelder S
Blut. 1981;43(2):113-118.

[Presentation of the cooperative study COALL-80 on treatment of childhood ALL (author's transl)]
Winkler K, Matzke E, Caspers S, Erttmann R, Grosch-Wörner I, Kabisch H, Müller J, Landbeck G
KLIN PADIATR. 1981;193(3):155-158.

1980

Effects of probenecid on plasma/tissue distribution of 14C-benzylpenicillin in rats.
Bergholz H, Erttmann R, Damm K
Experientia. 1980;36(3):333-334.

[Acute juvenile lymphoblastic leukemia]
Haas R, Janka-Schaub G, Helmig M, Netzel B
MMW Munch Med Wochenschr. 1980;122(9):301-304.

Antibody incubation of human marrow graft for prevention graft versus host disease.
Haas R, Janka-Schaub G, Netzel B, Rodt H, Thierfelder S, Helmig M, Eife R, Belohradsky B, Kolb H, Betke K
Blut. 1980;40(6):387-397.

The concept of antileukemic, autologous bone marrow transplantation in acute lymphoblastic leukemia.
Netzel B, Rodt H, Haas R, Janka-Schaub G, Thierfelder S
BLOOD TRANSFUS-ITALY. 1980;25:297-307.

Wolman's disease: clinical, biochemical and ultrastructural studies in an unusual case without striking adrenal calcification.
Schaub J, Janka G, Christomanou H, Sandhoff K, Permanetter W, Janka-Schaub G, Meister P
EUR J PEDIATR. 1980;135(1):45-53.

Total aganglionosis of the colon and Ondine's curse.
Stern M, Erttmann R, Hellwege H, Kuhn N
LANCET. 1980;1(8173):877-878.

[Radiation therapy of the renal tumor in children (author's transl)]
von Lieven H, Kurz S, Haas R, Janka-Schaub G, Devens K
Strahlentherapie. 1980;156(6):388-393.

1979

[Non-Hodgkin's lymphoma in children: improved prognosis through aggressive multiple drug combination and irradiation (author's transl)]
Janka-Schaub G, Lau B, Meister P, Lampert F, Haas R
KLIN PADIATR. 1979;191(1):40-46.

[High-dose methotrexate therapy in osteogenic sarcoma: plasma pharmakokinetics to predict toxicity (author's transl)]
Janka-Schaub G, Wiesner H, Bidlingmaier F, Haas R
Klin Wochenschr. 1979;57(8):411-416.

[Hydrocyanic acid content in cerals and cereal products]
Lehmann G, Zinsmeister H, Erb N, Neunhoeffer O
Z Ernahrungswiss. 1979;18(1):16-22.

Osteosarcoma: histological evaluation and grading.
Meister P, Konrad E, Lob G, Janka-Schaub G, Keyl W, Stürz H
ARCH ORTHOP TRAUM SU. 1979;94(2):91-98.

GVHD suppression by incubation of bone marrow grafts with anti-T-cell globulin: effect in the canine model and application to clinical bone marrow transplantation.
Rodt H, Kolb H, Netzel B, Rieder I, Janka-Schaub G, Belohradsky B, Haas R, Thierfelder S
TRANSPL P. 1979;11(1):962-966.

1978

[Juvenile rhabdomyosarcoma. Diagnosis and new therapeutic possibilities]
Haas R, Devens K, Helmig M, Janka-Schaub G, Klose H, Lampert F
ONKOLOGIE. 1978;1(4):142-148.

[Diagnostik significance of cell membrane markers in childhood ALL (author's transl)]
Haas R, Netzel B, Janka-Schaub G, Rodt H, Thiel E, Thierfelder S
KLIN PADIATR. 1978;190(5):446-452.

[Malignant juvenile bone tumors]
Janka-Schaub G
MED KLIN-INTENSIVMED. 1978;73(22):815-818.

Combination chemotherapy and radiotherapy for Hodgkin's disease in children.
Janka-Schaub G, Lau B, Haas R, von Lieven H, Lampert F
EUR J PEDIATR. 1978;127(4):287-292.

Lymphoblast cell size and prognosis in acute lymphoblastic leukemia in childhood.
Janka-Schaub G, Teige-Singer S, Haas R, Lau B
Blut. 1978;37(2):89-94.

[Abt-Letterer-Siwe disease. Diagnosis and therapy (author's transl)]
Wolff H, Janka-Schaub G
MONATSSCHR KINDERH. 1978;126(7):425-430.

1977

In vitro functions of lymphoid cells in untreated childhood acute lymphoblastic leukemia.
Eife R, Kopecky M, Lau B, Janka-Schaub G, Haas R, Lampert F
BLOOD TRANSFUS-ITALY. 1977;20:209-213.

[Neuroblastoma: paraneoplastic diseases and late complications (author's transl)]
Holschneider A, Geiger H, Bolkenius N, Janka-Schaub G, Lampert F
MONATSSCHR KINDERH. 1977;125(2):69-73.

1975

[Distrubances in glucose metabolism during diphenyhydantoin treatment in childhood]
Janka G, Toyka K, Janka-Schaub G, Förster C
Bibl Psychiatr. 1975;151:172-175.

Letzte Aktualisierung aus dem FIS: 21.12.2024 - 23:32 Uhr