Protective function of sclerosing cholangitis on IBD
Bedke T, Stumme F, Tomczak M, Steglich B, Jia R, Bohmann S, Wittek A, Kempski J, Göke E, Böttcher M, Reher D, Franke A, Lennartz M, Clauditz T, Sauter G, Fründt T, Weidemann S, Tiegs G, Schramm C, Gagliani N, Pelczar P, Huber S
GUT. 2024;73(8):1292-1301.

The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
Behler-Janbeck F, Baranowsky A, Schinke T, Jaeckstein M, Worthmann A, Fuh M, Gunasekaran K, Tiegs G, Amling M, Schinke T, Heeren J
FRONT ENDOCRINOL. 2024;15:1392418.

Editorial: Tumor and immune cell interactions in the formation of organ-specific metastasis
Gewalt T, Diehl L, Meder L
FRONT ONCOL. 2024;14:1373308.

CD44 expression on murine hepatic stellate cells promotes the induction of monocytic and polymorphonuclear myeloid-derived suppressor cells
Hagenstein J, Burkhardt S, Sprezyna P, Tasika E, Tiegs G, Diehl L
J LEUKOCYTE BIOL. 2024;116(1):177-185.

The ST2+ Treg/amphiregulin axis protects from immune-mediated hepatitis
Wachtendorf S, Fitriasari J, Ochel A, Heinrich F, Westendorf A, Tiegs G, Neumann K
FRONT IMMUNOL. 2024;15:1351405.

Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Genduso S, Freytag V, Schetler D, Kirchner L, Schiecke A, Maar H, Wicklein D, Gebauer F, Bröker K, Stürken C, Milde-Langosch K, Oliveira-Ferrer L, Ricklefs F, Ewald F, Wolters-Eisfeld G, Riecken K, Unrau L, Krause L, Bohnenberger H, Offermann A, Perner S, Sebens S, Lamszus K, Diehl L, Linder S, Jücker M, Schumacher U, Lange T
J HEMATOL ONCOL. 2023;16(1):.

Transcriptional and Clonal Characterization of Cytotoxic T Cells in Crescentic Glomerulonephritis
Mueller A, Zhao Y, Cicek H, Paust H, Sivayoganathan A, Linke A, Wegscheid C, Wiech T, Huber T, Meyer-Schwesinger C, Bonn S, Prinz I, Panzer U, Tiegs G, Krebs C, Neumann K
J AM SOC NEPHROL. 2023;34(6):1003-1018.

CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
Paust H, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel J, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel U, Steinmetz O, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer M, Hoxha E, Stahl R, Huber T, Bonn S, Meyer-Schwesinger C, Wiech T, Turner J, Becher B, Krebs C, Panzer U
SCI TRANSL MED. 2023;15(687):.

Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury
Riedel J, Robben L, Paust H, Zhao Y, Asada N, Song N, Peters A, Kaffke A, Borchers A, Tiegs G, Seifert L, Tomas N, Hoxha E, Wenzel U, Huber T, Wiech T, Turner J, Krebs C, Panzer U
JCI INSIGHT. 2023;8(1):.

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells
Ziegler A, Fittje P, Müller L, Ahrenstorf A, Hagemann K, Hagen S, Hess L, Niehrs A, Poch T, Ravichandran G, Löbl S, Padoan B, Brias S, Hennesen J, Richard M, Richert L, Peine S, Oldhafer K, Fischer L, Schramm C, Martrus G, Bunders M, Altfeld M, Lunemann S
FRONT IMMUNOL. 2023;14:.

The ADP-Ribosylation Factor 4d Restricts Regulatory T-Cell Induction via Control of IL-2 Availability
Geers B, Hagenstein J, Endig J, Ulrich H, Fleig L, Sprezyna P, Mikulec J, Heukamp L, Tiegs G, Diehl L
CELLS-BASEL. 2022;11(17):.

HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis
Groneberg M, Hoenow S, Marggraff C, Fehling H, Metwally N, Hansen C, Bruchhaus I, Tiegs G, Sellau J, Lotter H
J HEPATOL. 2022;76(1):160-173.

Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz O, Diehl L, Tiegs G, Neumann K
CELLS-BASEL. 2022;11(9):.

The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses
Melderis S, Warkotsch M, Dang J, Hagenstein J, Ehnold L, Herrnstadt G, Niehus C, Feindt F, Kylies D, Puelles V, Berasain C, Avila M, Neumann K, Tiegs G, Huber T, Tharaux P, Steinmetz O
J AUTOIMMUN. 2022;129:.

Conventional NK Cells and Type 1 Innate Lymphoid Cells Do Not Influence Pathogenesis of Experimental Glomerulonephritis
Rickassel C, Gnirck A, Shaikh N, Adamiak V, Waterhölter A, Tanriver Y, Neumann K, Huber T, Gasteiger G, Panzer U, Turner J
J IMMUNOL. 2022;208(7):1585-1594.

TNF in the liver:targeting a central player in inflammation
Tiegs G, Horst A
SEMIN IMMUNOPATHOL. 2022;44(4):445-459.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang H, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria C, Bernardo D, Boardman D, Borger J, Böttcher C, Brockmann L, Burns M, Busch D, Cameron G, Cammarata I, Cassotta A, Chang Y, Chirdo F, Christakou E, Čičin-Šain L, Cook L, Corbett A, Cornelis R, Cosmi L, Davey M, De Biasi S, De Simone G, Del Zotto G, Delacher M, Di Rosa F, Santo J, Diefenbach A, Dong J, Dörner T, Dress R, Dutertre C, Eckle S, Eede P, Evrard M, Falk C, Feuerer M, Fillatreau S, Fiz-Lopez A, Follo M, Foulds G, Fröbel J, Gagliani N, Galletti G, Gangaev A, Garbi N, Garrote J, Geginat J, Gherardin N, Gibellini L, Ginhoux F, Godfrey D, Gruarin P, Haftmann C, Hansmann L, Harpur C, Hayday A, Heine G, Hernández D, Herrmann M, Hoelsken O, Huang Q, Huber S, Huber J, Huehn J, Hundemer M, Hwang W, Iannacone M, Ivison S, Jäck H, Jani P, Keller B, Kessler N, Ketelaars S, Knop L, Knopf J, Koay H, Kobow K, Kriegsmann K, Kristyanto H, Krueger A, Kuehne J, Kunze-Schumacher H, Kvistborg P, Kwok I, Latorre D, Lenz D, Levings M, Lino A, Liotta F, Long H, Lugli E, MacDonald K, Maggi L, Maini M, Mair F, Manta C, Manz R, Mashreghi M, Mazzoni A, McCluskey J, Mei H, Melchers F, Melzer S, Mielenz D, Monin L, Moretta L, Multhoff G, Muñoz L, Muñoz-Ruiz M, Muscate F, Natalini A, Neumann K, Ng L, Niedobitek A, Niemz J, Almeida L, Notarbartolo S, Ostendorf L, Pallett L, Patel A, Percin G, Peruzzi G, Pinti M, Pockley A, Pracht K, Prinz I, Pujol-Autonell I, Pulvirenti N, Quatrini L, Quinn K, Radbruch H, Rhys H, Rodrigo M, Romagnani C, Saggau C, Sakaguchi S, Sallusto F, Sanderink L, Sandrock I, Schauer C, Scheffold A, Scherer H, Schiemann M, Schildberg F, Schober K, Schoen J, Schuh W, Schüler T, Schulz A, Schulz S, Schulze J, Simonetti S, Singh J, Sitnik K, Stark R, Starossom S, Stehle C, Szelinski F, Tan L, Tarnok A, Tornack J, Tree T, van Beek J, van de Veen W, van Gisbergen K, Vasco C, Verheyden N, von Borstel A, Ward-Hartstonge K, Warnatz K, Waskow C, Wiedemann A, Wilharm A, Wing J, Wirz O, Wittner J, Yang J, Yang J
EUR J IMMUNOL. 2021;51(12):2708-3145.

Antigen presentation, autoantibody production, and therapeutic targets in autoimmune liver disease
Horst A, Kumashie K, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2021;18(1):92-111.

Comparison of Resistance Spectra after First and Second Line Osimertinib Treatment Detected by Liquid Biopsy
Jóri B, Schatz S, Kaller L, Kah B, Roeper J, Ramdani H, Diehl L, Hoffknecht P, Grohé C, Griesinger F, Tiemann M, Heukamp L, Falk M
CANCERS. 2021;13(12):.

Notch1 Deficiency Induces Tumor Cell Accumulation Inside the Bronchiolar Lumen and Increases TAZ Expression in an Autochthonous Kras LSL-G12V Driven Lung Cancer Mouse Model
Meder L, Florin A, Ozretić L, Nill M, Koker M, Meemboor S, Radtke F, Diehl L, Ullrich R, Odenthal M, Büttner R, Heukamp L
PATHOL ONCOL RES. 2021;27:.

Immune regulation in renal inflammation
Neumann K, Tiegs G
CELL TISSUE RES. 2021;385(2):305-322.

Immune related endonucleases and GTPases are not associated with tumor response in patients with advanced non-small cell lung cancer treated with checkpoint inhibitors
Ramdani H, Falk M, Heukamp L, Schatz S, Tiemann M, Wesseler C, Diehl L, Schuuring E, Groen H, Griesinger F
PATHOL RES PRACT. 2021;227:.

Smad7 Deficiency in Myeloid Cells Does Not Affect Liver Injury, Inflammation or Fibrosis after Chronic CCl4 Exposure in Mice
Unrau L, Endig J, Goltz D, Sprezyna P, Ulrich H, Hagenstein J, Geers B, Kaftan K, Heukamp L, Tiegs G, Diehl L
INT J MOL SCI. 2021;22(21):.

Antimicrobial peptides in patients with anorexia nervosa: comparison with healthy controls and the impact of weight gain
Bendix M, Stephan M, Nöhre M, Wünsch-Leiteritz W, Schmidt H, Tiegs G, Harder J, de Zwaan M
SCI REP-UK. 2020;10(1):22223.

The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells
Hess L, Martrus G, Ziegler A, Langeneckert A, Salzberger W, Goebels H, Sagebiel A, Hagen S, Poch T, Ravichandran G, Koch M, Schramm C, Oldhafer K, Fischer L, Tiegs G, Richert L, Bunders M, Lunemann S, Altfeld M
HEPATOL COMMUN. 2020;4(3):409-424.

Glioma escape signature and clonal development under immune pressure
Maire C, Mohme M, Bockmayr M, Fita K, Riecken K, Börnigen D, Alawi M, Failla A, Kolbe K, Zapf S, Holz M, Neumann K, Dührsen L, Lange T, Fehse B, Westphal M, Lamszus K
J CLIN INVEST. 2020;130(10):5257-5271.

Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells
Melderis S, Hagenstein J, Warkotsch M, Dang J, Herrnstadt G, Niehus C, Neumann K, Panzer U, Berasain C, Avila M, Tharaux P, Tiegs G, Steinmetz O
J AM SOC NEPHROL. 2020;31(9):1996-2012.

ALCAM contributes to brain metastasis formation in non-small-cell lung cancer through interaction with the vascular endothelium
Münsterberg J, Loreth D, Brylka L, Werner S, Karbanova J, Gandrass M, Schneegans S, Besler K, Hamester F, Robador J, Bauer A, Werner Schneider S, Wrage M, Lamszus K, Matschke J, Vashist Y, Uzunoglu G, Steurer S, Horst A, Oliveira-Ferrer L, Glatzel M, Schinke T, Corbeil D, Pantel K, Maire C, Wikman H
NEURO-ONCOLOGY. 2020;22(7):955-966.

Neurogenic tachykinin mechanisms in experimental nephritis of rats
Rodionova K, Hilgers K, Paulus E, Tiegs G, Ott C, Schmieder R, Schiffer M, Amann K, Veelken R, Ditting T
PFLUG ARCH EUR J PHY. 2020;472(12):1705-1717.

Afferent Renal Innervation in Anti Thy1.1 Nephritis in Rats
Rodionova K, Veelken R, Hilgers K, Paulus E, Linz P, Fischer M, Schenker M, Reeh P, Tiegs G, Ott C, Schmieder R, Schiffer M, Amann K, Ditting T
AM J PHYSIOL-RENAL. 2020;319(5):F822-F832.

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC
Roeper J, Falk M, Chalaris-Rißmann A, Lueers A, Ramdani H, Wedeken K, Stropiep U, Diehl L, Tiemann M, Heukamp L, Otto-Sobotka F, Griesinger F
ONCOTARGET. 2020;11(3):250-264.

Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer
Schatz S, Falk M, Jóri B, Ramdani H, Schmidt S, Willing E, Menon R, Groen H, Diehl L, Kröger M, Wesseler C, Griesinger F, Hoffknecht P, Tiemann M, Heukamp L
CANCERS. 2020;12(6):.

Pioglitazone-Mediated Peroxisome Proliferator-Activated Receptor γ Activation Aggravates Murine Immune-Mediated Hepatitis
Schulte R, Wohlleber D, Unrau L, Geers B, Metzger C, Erhardt A, Tiegs G, van Rooijen N, Heukamp L, Klotz L, Knolle P, Diehl L
INT J MOL SCI. 2020;21(7):.

Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
Steinmann S, Schoedsack M, Heinrich F, Breda P, Ochel A, Tiegs G, Neumann K
SCI REP-UK. 2020;10(1):1071.

Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver
Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K, Sass G, Tiegs G
SCI REP-UK. 2019;9(1):4232.

Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T cell responses
Breda P, Wiech T, Meyer-Schwesinger C, Grahammer F, Huber T, Panzer U, Tiegs G, Neumann K
AM J PHYSIOL-RENAL. 2019;317(1):F77-F89.

IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responses
Busse M, Campe K, Nowak D, Schumacher A, Plenagl S, Langwisch S, Tiegs G, Reinhold A, Zenclussen A
SCI REP-UK. 2019;9(1):9335.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza A, Chang H, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace W, Aghaeepour N, Akdis M, Allez M, Almeida L, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari C, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman D, Bogdan C, Borger J, Borsellino G, Boulais P, Bradford J, Brenner D, Brinkman R, Brooks A, Busch D, Büscher M, Bushnell T, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell S, Casola S, Cassatella M, Cavani A, Celada A, Chatenoud L, Chattopadhyay P, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo F, Cook L, Cooke A, Cooper A, Corbett A, Cosma A, Cosmi L, Coulie P, Cumano A, Cvetkovic L, Dang V, Dang-Heine C, Davey M, Davies D, De Biasi S, Del Zotto G, Dela Cruz G, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo J, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress R, Dudziak D, Dustin M, Dutertre C, Ebner F, Eckle S, Edinger M, Eede P, Ehrhardt G, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk C, Fehniger T, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds G, Frehse B, Frenette P, Frischbutter S, Fritzsche W, Galbraith D, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli R, Geginat J, Gerner W, Gherardin N, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey D, Goettlinger C, González-Navajas J, Goodyear C, Gori A, Grogan J, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur C, Hartmann S, Hauser A, Hauser A, Haviland D, Hedley D, Hernández D, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston J, Hoyer B, Huang B, Huang F, Huber J, Huehn J, Hundemer M, Hunter C, Hwang W, Iannone A, Ingelfinger F, Ivison S, Jäck H, Jani P, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann S, Keller B, Ketelaars S, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay H, Kobow K, Kolls J, Kong W, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold M, Leung L, Levings M, Lino A, Liotta F, Litwin V, Liu Y, Ljunggren H, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke A, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker H, Maggi L, Maguire O, Mair F, Mair K, Mantovani A, Manz R, Marshall A, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli A, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire H, McInnes I, Mei H, Melchers F, Melzer S, Mielenz D, Miller S, Mills K, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann T, Müller S, Multhoff G, Muñoz L, Münz C, Nakayama T, Nasi M, Neumann K, Ng L, Niedobitek A, Nourshargh S, Núñez G, O'Connor J, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl W, Piconese S, Pinti M, Pockley A, Podolska M, Poon Z, Pracht K, Prinz I, Pucillo C, Quataert S, Quatrini L, Quinn K, Radbruch H, Radstake T, Rahmig S, Rahn H, Rajwa B, Ravichandran G, Raz Y, Rebhahn J, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal E, Richter L, Rico L, Riddell A, Rieger A, Robinson J, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz R, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer H, Schiemann M, Schildberg F, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz A, Schulz S, Scottá C, Scott-Algara D, Sester D, Shankey T, Silva-Santos B, Simon A, Sitnik K, Sozzani S, Speiser D, Spidlen J, Stahlberg A, Stall A, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree T, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier R, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk H, von Borstel A, von Volkmann K, Waisman A, Walker R, Wallace P, Wang S, Wang X, Ward M, Ward-Hartstonge K, Warnatz K, Warnes G, Warth S, Waskow C, Watson J, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson R, Willimsky G, Wing J, Winkelmann R, Winkler T, Wirz O, Wong A, Wurst P, Yang J, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler S, Zielinski C, Zimmermann J, Zychlinsky A
EUR J IMMUNOL. 2019;49(10):1457-1973.

Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells
Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, Heukamp L, Tiegs G, Diehl L
INT J MOL SCI. 2019;20(22):.

Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
Horst A, Tiegs G, Diehl L
FRONT IMMUNOL. 2019;10:2670.

CCL21-expression and accumulation of CCR7 NK cells in livers of patients with primary sclerosing cholangitis
Langeneckert A, Lunemann S, Martrus G, Salzberger W, Hess L, Ziegler A, Poch T, Ravichandran G, Matschl U, Bosse J, Tiegs G, Fischer L, Koch M, Herkel J, Oldhafer K, Schramm C, Altfeld M
EUR J IMMUNOL. 2019;49(5):758-769.

Human liver-derived CXCR6+ NK cells are predominantly educated through NKG2A and show reduced cytokine production
Lunemann S, Langeneckert A, Martrus G, Hess L, Salzberger W, Ziegler A, Löbl S, Poch T, Ravichandran G, Sauter J, Schmidt A, Schramm C, Oldhafer K, Altfeld M, Körner C
J LEUKOCYTE BIOL. 2019;105(6):1331-1340.

The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis
Neumann K, Ostmann A, Breda P, Ochel A, Tacke F, Paust H, Panzer U, Tiegs G
SCI REP-UK. 2019;9:2038.

Type 2 Innate Lymphoid Cells in Liver and Gut: From Current Knowledge to Future Perspectives
Ochel A, Tiegs G, Neumann K
INT J MOL SCI. 2019;20(8):.

Interferon-γ-dependent immune responses contribute to the pathogenesis of sclerosing cholangitis in mice
Ravichandran G, Neumann K, Berkhout L, Weidemann S, Langeneckert A, Schwinge D, Poch T, Huber S, Schiller B, Hess L, Ziegler A, Oldhafer K, Barikbin R, Schramm C, Altfeld M, Tiegs G
J HEPATOL. 2019;71(4):773-782.

Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy
Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, Horst A, Sturm A, de la Motte C, Fiocchi C
INFLAMM BOWEL DIS. 2019;25(2):294-305.

Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2 mice
Barikbin R, Berkhout L, Bolik J, Schmidt-Arras D, Ernst T, Ittrich H, Adam G, Parplys A, Casar C, Krech T, Karimi K, Sass G, Tiegs G
SCI REP-UK. 2018;8(1):16238.

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN
Diefenhardt P, Nosko A, Kluger M, Richter J, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell R, Stahl R, Steinmetz O
J AM SOC NEPHROL. 2018;29(7):1825-1837.

CEACAM1 in Liver Injury, Metabolic and Immune Regulation
Horst A, Najjar S, Wagener C, Tiegs G
INT J MOL SCI. 2018;19(10):3110.

Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
Horst A, Wegscheid C, Schaefers C, Schiller B, Neumann K, Lunemann S, Langeneckert A, Oldhafer K, Weiler-Normann C, Lang K, Singer B, Altfeld M, Diehl L, Tiegs G
HEPATOLOGY. 2018;68(1):200-214.

NLRP3 Inflammasome and IL-33: Novel Players in Sterile Liver Inflammation
Neumann K, Schiller B, Tiegs G
INT J MOL SCI. 2018;19(9):2732.

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production
Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp L, Knolle P, Kolanus W, Diehl L
SCI REP-UK. 2018;8(1):16123.

Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort
Bremer L, Goletzke J, Wiessner C, Pagenkemper M, Gehbauer C, Becher H, Tolosa E, Hecher K, Arck P, Diemert A, Tiegs G
EBIOMEDICINE. 2017;26:146-151.

Pregnancy-Related Immune Adaptation Promotes the Emergence of Highly Virulent H1N1 Influenza Virus Strains in Allogenically Pregnant Mice
Engels G, Hierweger A, Hoffmann J, Thieme R, Thiele S, Bertram S, Dreier C, Resa-Infante P, Jacobsen H, Thiele K, Alawi M, Indenbirken D, Grundhoff A, Siebels S, Fischer N, Stojanovska V, Muzzio D, Jensen F, Karimi K, Mittrücker H, Arck P, Gabriel G
CELL HOST MICROBE. 2017;21(3):321-333.

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination
Heine A, Flores C, Gevensleben H, Diehl L, Heikenwälder M, Ringelhan M, Janssen K, Nitsche U, Garbi N, Brossart P, Knolle P, Kurts C, Höchst B
ONCOIMMUNOLOGY. 2017;6(8):e1338995.

Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Kah J, Volz T, Lütgehetmann M, Groth A, Lohse A, Tiegs G, Sass G, Dandri-Petersen M
LIVER INT. 2017;37(8):1128-1137.

A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury
Kleinschmidt D, Giannou A, McGee H, Kempski J, Steglich B, Huber F, Ernst T, Shiri A, Wegscheid C, Tasika E, Hübener P, Huber P, Bedke T, Steffens N, Agalioti T, Fuchs T, Noll J, Lotter H, Tiegs G, Lohse A, Axelrod J, Galun E, Flavell R, Gagliani N, Huber S
J IMMUNOL. 2017;199(12):4078-4090.

RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses
Kluger M, Nosko A, Ramcke T, Goerke B, Meyer M, Wegscheid C, Luig M, Tiegs G, Stahl R, Steinmetz O
CLIN EXP IMMUNOL. 2017;188(1):63-78.

A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
Neumann K, Karimi K, Meiners J, Voetlause R, Steinmann S, Dammermann W, Lüth S, Asghari F, Wegscheid C, Horst A, Tiegs G
J IMMUNOL. 2017;198(1):128-137.

T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN
Nosko A, Kluger M, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2017;28(1):185-196.

Immunology of hepatic diseases during pregnancy
Bremer L, Schramm C, Tiegs G
SEMIN IMMUNOPATHOL. 2016;38(6):669-685.

CD103+ Kidney Dendritic Cells Protect against Crescentic GN by Maintaining IL-10-Producing Regulatory T Cells
Evers B, Engel D, Böhner A, Tittel A, Krause T, Heuser C, Garbi N, Kastenmüller W, Mack M, Tiegs G, Panzer U, Boor P, Ludwig-Portugall I, Kurts C
J AM SOC NEPHROL. 2016;27(11):3368-3382.

Khaya grandifoliola C.DC: a potential source of active ingredients against hepatitis C virus in vitro
Galani B, Sahuc M, Sass G, Njayou F, Loscher C, Mkounga P, Deloison G, Brodin P, Rouillé Y, Tiegs G, Séron K, Moundipa P
ARCH VIROL. 2016;161(5):1169-81.

Loss of the LIM-only protein Fhl2 impairs inflammatory reaction and scar formation after cardiac ischemia leading to better hemodynamic performance
Goltz D, Hittetiya K, Gevensleben H, Kirfel J, Diehl L, Meyer R, Büttner R
LIFE SCI. 2016;151:348-58.

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib
Heine A, Schilling J, Grünwald B, Krüger A, Gevensleben H, Held S, Garbi N, Kurts C, Brossart P, Knolle P, Diehl L, Höchst B
CANCER IMMUNOL IMMUN. 2016;65(3):273-82.

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells
Horst A, Neumann K, Diehl L, Tiegs G
CELL MOL IMMUNOL. 2016;13(3):277-292.

Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
KIDNEY INT. 2016;89(1):158-166.

RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2016;27(2):454-465.

The Limonoids TS3 and Rubescin E Induce Apoptosis in Human Hepatoma Cell Lines and Interfere with NF-κB Signaling
Lange N, Tontsa A, Wegscheid C, Mkounga P, Nkengfack A, Loscher C, Sass G, Tiegs G
PLOS ONE. 2016;11(8):e0160843.

A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis
Müller M, Wetzel S, Köhn-Gaone J, Chalupsky K, Lüllmann-Rauch R, Barikbin R, Bergmann J, Wöhner B, Zbodakova O, Leuschner I, Martin G, Tiegs G, Rose-John S, Sedlacek R, Tirnitz-Parker J, Saftig P, Schmidt-Arras D
ONCOTARGET. 2016;7(14):17431-41.

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.

CEACAM1 controls the EMT switch in murine mammary carcinoma in vitro and in vivo
Wegwitz F, Lenfert E, Gerstel D, von Ehrenstein L, Einhoff J, Schmidt G, Logsdon M, Brandner J, Tiegs G, Beauchemin N, Wagener C, Deppert W, Horst A
ONCOTARGET. 2016;7(39):63730-63746.

STATs:An Old Story, Yet Mesmerizing: An Old Story, Yet Mesmerizing
Abroun S, Saki N, Ahmadvand M, Asghari F, Salari F, Rahim F
Cell J. 2015;17(3):395-411.

Quantitative Trait Locus Analysis Implicates CD4⁺/CD44high Memory T Cells in the Pathogenesis of Murine Autoimmune Pancreatitis
Bischof J, Müller S, Borufka L, Asghari F, Möller S, Holzhüter S, Nizze H, Ibrahim S, Jaster R
PLOS ONE. 2015;10(9):e0136298.

Acetaminophen/Paracetamol: A history of errors, failures and false decisions
Brune K, Renner B, Tiegs G
EUR J PAIN. 2015;19(7):953-965.

Immunomodulation by splenectomy or by FTY720 protects the heart against ischemia reperfusion injury
Goltz D, Huss S, Ramadori E, Büttner R, Diehl L, Meyer R
CLIN EXP PHARMACOL P. 2015;42(11):1168-77.

Differential induction of Ly6G and Ly6C positive myeloid derived suppressor cells in chronic kidney and liver inflammation and fibrosis
Höchst B, Mikulec J, Baccega T, Metzger C, Welz M, Peusquens J, Tacke F, Knolle P, Kurts C, Diehl L, Ludwig-Portugall I
PLOS ONE. 2015;10(3):Art. e0119662.

Activation of Cell Surface Bound 20S Proteasome Inhibits Vascular Cell Growth and Arteriogenesis
Ito W, Lund N, Zhang Z, Buck F, Lellek H, Horst A, Machens H, Schunkert H, Schaper W, Meinertz T
BIOMED RES INT . 2015;2015:719316.

Sharpin Controls Osteogenic Differentiation of Mesenchymal Bone Marrow Cells
Jeschke A, Catala-Lehnen P, Sieber S, Bickert T, Schweizer M, Koehne T, Wintges K, Marshall R, Mautner A, Duchstein L, Otto B, Horst A, Amling M, Kreienkamp H, Schinke T
J IMMUNOL. 2015;195(8):3675-84.

Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity
Karimi K, Karimi Y, Chan J, Boudreau J, Basset J, Chew M, Reid S, Bramson J, Wan Y, Ashkar A
INNATE IMMUN-LONDON. 2015;21(6):626-34.

Prenatal acetaminophen induces liver toxicity in dams, reduces fetal liver stem cells, and increases airway inflammation in adult offspring
Karimi K, Keßler T, Thiele K, Ramisch K, Erhardt A, Hübener P, Barikbin R, Arck P, Tiegs G
J HEPATOL. 2015;62(5):1085-91.

Mechanisms of Osteopontin-mediated effects on chronic hepatic inflammation and cancer
Loscher C
2015.

Inside Cover: Microdomain Formation Controls Spatiotemporal Dynamics of Cell-Surface Glycoproteins (ChemBioChem 14/2015)
Möckl L, Horst A, Kolbe K, Lindhorst T, Bräuchle C
CHEMBIOCHEM. 2015;16(14):1966.

Microdomain Formation Controls Spatiotemporal Dynamics of Cell-Surface Glycoproteins
Möckl L, Horst A, Kolbe K, Lindhorst T, Bräuchle C
CHEMBIOCHEM. 2015;16(14):2023-8.

Testosterone Suppresses Hepatic Inflammation by the Downregulation of IL-17, CXCL-9, and CXCL-10 in a Mouse Model of Experimental Acute Cholangitis
Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
J IMMUNOL. 2015;194(6):2522-30.

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation
Solano M, Kowal M, O'Rourke G, Horst A, Modest K, Plösch T, Barikbin R, Remus C, Berger R, Jago C, Ho H, Sass G, Parker V, Lydon J, DeMayo F, Hecher K, Karimi K, Arck P
J CLIN INVEST. 2015;125(4):1726-38.

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis
Stoyanov E, Ludwig G, Mizrahi L, Olam D, Schnitzer-Perlman T, Tasika E, Sass G, Tiegs G, Jiang Y, Nie T, Kohler J, Schinazi R, Vertino P, Cedar H, Galun E, Goldenberg D
ONCOTARGET. 2015;6(13):11047-60.

Prenatal Acetaminophen Affects Maternal Immune and Endocrine Adaptation to Pregnancy, Induces Placental Damage, and Impairs Fetal Development in Mice
Thiele K, Solano M, Huber S, Flavell R, Kessler T, Barikbin R, Jung R, Karimi K, Tiegs G, Arck P
AM J PATHOL. 2015;185(10):2805-2818.

Immunological in vivo effects of B7-H1 deficiency
Bazhin A, von Ahn K, Maier C, Soltek S, Serba S, Diehl L, Werner J, Karakhanova S
IMMUNOL LETT. 2014;162(2 Pt B):273-86.

Hepatocytes induce Foxp3⁺ regulatory T cells by Notch signaling
Burghardt S, Claass B, Erhardt A, Karimi K, Tiegs G
J LEUKOCYTE BIOL. 2014;96(4):571-7.

Anti-hepatitis C virus activity of crude extract and fractions of Entada africana in genotype 1b replicon systems
Galani Tietcheu B, Sass G, Njayou N, Mkounga P, Tiegs G, Moundipa P
AM J CHINESE MED. 2014;42(4):853-68.

Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1
Heckt T, Bickert T, Jeschke A, Seitz S, Schulze J, Ito W, Zimmermann W, Amling M, Schinke T, Horst A, Keller J
PLOS ONE. 2014;9(12):e114360.

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time
Kaczmarek J, Homsi Y, van Üüm J, Metzger C, Knolle P, Kolanus W, Lang T, Diehl L
PLOS ONE. 2014;9(6):e99574.

Stat3 Programs Th17-Specific Regulatory T Cells to Control GN
Kluger M, Luig M, Wegscheid C, Goerke B, Paust H, Brix S, Yan I, Mittrücker H, Hagl B, Renner E, Tiegs G, Wiech T, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2014;25(6):1291-302.

B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis
Kluger M, Ostmann A, Luig M, Meyer M, Goerke B, Paust H, Meyer-Schwesinger C, Stahl R, Panzer U, Tiegs G, Steinmetz O
EUR J IMMUNOL. 2014;44(3):683-693.

Identification of HO-1/CO-induced tumor protective genes in HCC
Loscher C, Barikbin R, Schildgen J, Wulf J, Tiegs G, Sass G
2014. Zeitschrift für Gastroenterologie. .

CEACAM1 confers resistance toward oxygen-induced vessel damage in a mouse model of retinopathy of prematurity
Ludewig P, Flachsbarth K, Wegscheid C, Tiegs G, Richard G, Wagener C, Bartsch U, Horst A
INVEST OPHTH VIS SCI. 2014;55(12):7950-7960.

Cross-sectional study of 168 patients with hepatorenal tyrosinaemia and implications for clinical practice
Mayorandan S, Meyer U, Gokcay G, Segarra N, de Baulny H, van Spronsen F, Zeman J, de Laet C, Spiekerkoetter U, Thimm E, Maiorana A, Dionisi-Vici C, Moeslinger D, Brunner-Krainz M, Lotz-Havla A, Cocho de Juan J, Couce Pico M, Santer R, Scholl-Bürgi S, Mandel H, Bliksrud Y, Freisinger P, Aldamiz-Echevarria L, Hochuli M, Gautschi M, Endig J, Jordan J, McKiernan P, Ernst S, Morlot S, Vogel A, Sander J, Das A
ORPHANET J RARE DIS. 2014;9:107.

Role of Blimp-1 in programing Th effector cells into IL-10 producers
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
J EXP MED. 2014;211(9):1807-19.

Binding of hepatitis B virus to its cellular receptor alters the expression profile of genes of bile acid metabolism
Oehler N, Volz T, Bhadra O, Kah J, Allweiss L, Giersch K, Bierwolf J, Riecken K, Pollok J, Lohse A, Fehse B, Petersen J, Urban S, Lütgehetmann M, Heeren J, Dandri M
HEPATOLOGY. 2014.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia
Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M
INT J CANCER. 2014;135(10):2370-2379.

New problems arising from old drugs: second-generation effects of acetaminophen
Tiegs G, Karimi K, Brune K, Arck P
EXPERT REV CLIN PHAR. 2014;7(5):655-62.

Hepatic CD141⁺IFNλ⁺ DC subset: one against all?
Wegscheid C, Karimi K, Tiegs G
J HEPATOL. 2014;60(1):9-11.

Matrix Conditions and KLF2-Dependent Induction of Heme Oxygenase-1 Modulate Inhibition of HCV Replication by Fluvastatin
Wüstenberg A, Kah J, Singethan K, Sirma H, Keller A, Perez Rosal S, Schrader J, Loscher C, Volz T, Bartenschlager R, Lohmann V, Protzer U, Dandri M, Lohse A, Tiegs G, Sass G
PLOS ONE. 2014;9(5):e96533.

Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity
Böttcher J, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Höchst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath M, Busch D, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze J, Diehl L, Knolle P
CELL REP. 2013;3(3):779-95.

Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, Chalaris A, Schmidt-Arras D, Rose-John S, Karimi K, Tiegs G
J IMMUNOL. 2013;191(11):5574-82.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells
Carambia A, Frenzel C, Bruns O, Schwinge D, Reimer R, Hohenberg H, Huber S, Tiegs G, Schramm C, Lohse A, Herkel J
J HEPATOL. 2013;58(1):112-8.

Increased expression of complement regulators CD55 and CD59 on peripheral blood cells in patients with EAHEC O104:H4 infection
Dammermann W, Schipper P, Ullrich S, Zimmermann-Fraedrich K, Schulze Zur Wiesch J, Fründt T, Tiegs G, Lohse A, Lüth S
PLOS ONE. 2013;8(9):e74880.

Prenatal stress enhances severity of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring via inflammatory pathways
Ho H, Lhotak S, Solano M, Karimi K, Pincus M, Austin R, Arck P
J DEV ORIG HLTH DIS. 2013;4(1):90-7.

Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model
König K, Meder L, Kröger C, Diehl L, Florin A, Rommerscheidt-Fuss U, Kahl P, Wardelmann E, Magin T, Buettner R, Heukamp L
PLOS ONE. 2013;8(3):e57996.

Inhibition of WNT signalling interferes with HCV replication
Loscher C, Keller A, Perez Rosal S, Lohmann V, Bartenschlager R, Tiegs G, Sass G
2013. Zeitschrift für Gastroenterologie. .

Regulatory T Cell-Derived IL-10 Ameliorates Crescentic GN.
Ostmann A, Paust H, Panzer U, Wegscheid C, Kapffer S, Huber S, Flavell R, Erhardt A, Tiegs G
J AM SOC NEPHROL. 2013;24(6):930-942.

Interstrain differences in chronic hepatitis and tumor development in a murine model of inflammation-mediated hepatocarcinogenesis
Potikha T, Stoyanov E, Pappo O, Frolov A, Mizrahi L, Olam D, Shnitzer-Perlman T, Weiss I, Barashi N, Peled A, Sass G, Tiegs G, Poirier F, Rabinovich G, Galun E, Goldenberg D
HEPATOLOGY. 2013;58(1):192-204.

Acetaminophen and pregnancy: short- and long-term consequences for mother and child
Thiele K, Kessler T, Arck P, Erhardt A, Tiegs G
J REPROD IMMUNOL. 2013;97(1):128-39.

Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5)
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J BONE MINER RES. 2013;28(10):2070-80.

Biology and bioinformatics of myeloma cell
Abroun S, Saki N, Fakher R, Asghari F
Laboratory hematology. 2012;18(4):30-41.

Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice
Barikbin R, Neureiter D, Wirth J, Erhardt A, Schwinge D, Kluwe J, Schramm C, Tiegs G, Sass G
HEPATOLOGY. 2012;55(2):553-562.

IL-33--a cytokine which balances on a knife's edge?
Erhardt A, Tiegs G
J HEPATOL. 2012;56(1):7-10.

Liver sinusoidal endothelial cells contribute to CD8 T cell tolerance toward circulating carcinoembryonic antigen in mice
Höchst B, Schildberg F, Böttcher J, Metzger C, Huss S, Türler A, Overhaus M, Knoblich A, Schneider B, Pantelis D, Kurts C, Kalff J, Knolle P, Diehl L
HEPATOLOGY. 2012;56(5):1924-33.

Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression.
Kah J, Wüstenberg A, Keller A, Sirma H, Montalbano R, Ocker M, Volz T, Dandri-Petersen M, Tiegs G, Sass G
ONCOL REP. 2012;28(3):1077-1083.

A Lactobacillus rhamnosus strain induces a heme oxygenase dependent increase in Foxp3+ regulatory T cells.
Karimi K, Kandiah N, Chau J, Bienenstock J, Forsythe P
PLOS ONE. 2012;7(10):47556.

Regulation of pregnancy maintenance and fetal survival in mice by CD27(low) mature NK cells.
Karimi K, Solano M, Ashkar A, Ho H, Steidle E, Karen-Anne M, Hecher K, Bienenstock J, Arck P
J MOL MED. 2012;90(9):1047-1057.

Induction of heme oxygenase 1 by HMG-CoA-Reductase inhibitors interferes with HCV replication
Loscher C, Wüstenberg A, Keller A, Lehmann E, Sirma H, Bartenschlager R, Lohmann V, Dandri-Petersen M, Tiegs G, Sass G
2012. Zeitschrift für Gastroenterologie. .

Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid
Neumann K, Kruse N, Szilagyi B, Erben U, Rudolph C, Flach A, Zeitz M, Hamann A, Klugewitz K
HEPATOLOGY. 2012;55(6):1976-84.

Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker H, Garbi N, Stahl R, Steinmetz O, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(12):1987-2000.

The multiple functions of heme oxygenase-1 in the liver.
Sass G, Barikbin R, Tiegs G
Z GASTROENTEROL. 2012;50(1):34-40.

Sharpin contributes to TNFα dependent NFκB activation and anti-apoptotic signalling in hepatocytes.
Sieber S, Lange N, Kollmorgen G, Erhardt A, Quaas A, Gontarewicz A, Sass G, Tiegs G, Kreienkamp H
PLOS ONE. 2012;7(1):29993.

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
Sprüssel A, Schulte J, Weber S, Necke M, Händschke K, Thor T, Pajtler K, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp L, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert J
LEUKEMIA. 2012;26(9):2039-51.

[Hepatology: from basic science to the clinic].
Thimme R, Tiegs G
Z GASTROENTEROL. 2012;50(1):19.

Preface. Inflammation and cancer.
Tiegs G
DIGEST DIS. 2012;30(5):443-444.

Neoplastic Bone Marrow Niche: Hematopoietic and Mesenchymal Stem Cells
Asghari F
Cell J. 2011;13(3):131-136.

Identification of quantitative trait loci for murine autoimmune pancreatitis
Asghari F, Fitzner B, Holzhüter S, Nizze H, de Castro Marques A, Müller S, Möller S, Ibrahim S, Jaster R
J MED GENET. 2011;48(8):557-62.

Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue
Doebis C, Menning A, Neumann K, Ghani S, Schlawe K, Lauer U, Hamann A, Huehn J, Syrbe U
IMMUNOL CELL BIOL. 2011;89(4):566-72.

CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
Erhardt A, Wegscheid C, Claaß B, Carambia A, Herkel J, Mittrücker H, Panzer U, Tiegs G
J IMMUNOL. 2011;186(9):5284-5293.

Transcription factor Fra-1 induces cholangitis and liver fibrosis.
Kireva T, Erhardt A, Tiegs G, Tilg H, Denk H, Haybaeck J, Aigner E, Moschen A, Distler J, Schett G, Zwerina J
HEPATOLOGY. 2011;53(4):1259-1269.

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
Mayer B, Rehberg M, Erhardt A, Wolf A, Reichel C, Kracht M, Krombach F, Tiegs G, Zahler S, Vollmar A, Fürst R
ARTERIOSCL THROM VAS. 2011;31(10):2240-2250.

Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Paust H, Ostmann A, Erhardt A, Turner J, Velden J, Mittrücker H, Sparwasser T, Panzer U, Tiegs G
KIDNEY INT. 2011;80(2):154-164.

Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT.
Sass G, Klinger N, Sirma H, Hashemolhosseini S, Hellerbrand C, Neureiter D, Wege H, Ocker M, Tiegs G
INT J ONCOL. 2011;39(2):433-442.

Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism
Schildberg F, Wojtalla A, Siegmund S, Endl E, Diehl L, Abdullah Z, Kurts C, Knolle P
HEPATOLOGY. 2011;54(1):262-72.

Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9.
Schmerwitz U, Sass G, Khandoga A, Joore J, Mayer B, Berberich N, Totzke F, Krombach F, Tiegs G, Zahler S, Vollmar A, Fürst R
ARTERIOSCL THROM VAS. 2011;31(2):280-288.

205 GLUCOSE-6-PHOSPHATE DEHYDROGENAZE ACTIVITY IN OVINE OOCYTES IS ASSOCIATED WITH PRE-IMPLANTATION EMBRYONIC DEVELOPMENT IN VITRO
Asghari F
REPROD FERT DEVELOP. 2010;23(1):201-202.

Tolerance induction in response to liver inflammation.
Erhardt A, Tiegs G
DIGEST DIS. 2010;28(1):86-92.

Virally infected mouse liver endothelial cells trigger CD8+ T-cell immunity
Kern M, Popov A, Scholz K, Schumak B, Djandji D, Limmer A, Eggle D, Sacher T, Zawatzky R, Holtappels R, Reddehase M, Hartmann G, Debey-Pascher S, Diehl L, Kalinke U, Koszinowski U, Schultze J, Knolle P
GASTROENTEROLOGY. 2010;138(1):336-46.

Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration
König K, Diehl L, Rommerscheidt-Fuss U, Golletz C, Quast T, Kahl P, Kolanus W, Knolle P, Buettner R, Heukamp L
J IMMUNOL. 2010;185(3):1466-75.

Immune-mediated liver injury.
Lohse A, Weiler-Normann C, Tiegs G
J HEPATOL. 2010;52:136-144.

Potent reducing effects of vitamin D3 on the frequency of apoptosis induced by arsenic trioxide in NB4 cell line
Mozdarani H, Asghari F
ARCH IRAN MED. 2010;13(1):26-33.

Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells
Schurich A, Berg M, Stabenow D, Böttcher J, Kern M, Schild H, Kurts C, Schuette V, Burgdorf S, Diehl L, Limmer A, Knolle P
J IMMUNOL. 2010;184(8):4107-14.

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.
Seifert U, Bialy L, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel P, Krüger E
CELL. 2010;142(4):613-624.

Immune tolerance: what is unique about the liver.
Tiegs G, Lohse A
J AUTOIMMUN. 2010;34:1-6.

CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner J, Paust H, Steinmetz O, Peters A, Riedel J, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker H, Tiegs G, Stahl R, Panzer U
J AM SOC NEPHROL. 2010;21(6):974-985.

High Resolution Mapping of Cia3: A Common Arthritis Quantitative Trait Loci in Different Species1
Asghari F
J IMMUNOL. 2009;182(5 ):3016-3023.

Pivotal Advance: Heme oxygenase 1 expression by human CD4+ T cells is not sufficient for their development of immunoregulatory capacity.
Biburger M, Theiner G, Schädle M, Schuler G, Tiegs G
J LEUKOCYTE BIOL. 2009.

Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences
Brázdová M, Quante T, Tögel L, Walter K, Loscher C, Tichý V, Cincárová L, Deppert W, Tolstonog G
NUCLEIC ACIDS RES. 2009;37(5):1486-500.

Do distinct populations of dorsal root ganglion neurons account for the sensory peptidergic innervation of the kidney?
Ditting T, Tiegs G, Rodionova K, Reeh P, Neuhuber W, Freisinger W, Veelken R
AM J PHYSIOL-RENAL. 2009;297(5):1427-1434.

Autonomous innervation in renal inflammatory disease-innocent bystander or active modulator?
Ditting T, Tiegs G, Veelken R
J MOL MED. 2009;87(9):865-870.

Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia.
Eberhardt M, Neeb L, Vogel E, Tiegs G, Reuter U, Messlinger K, Fischer M
NEUROPEPTIDES. 2009;43(6):483-489.

Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.
Haimerl F, Erhardt A, Sass G, Tiegs G
J BIOL CHEM. 2009;284(1):495-504.

A novel technique for selective NF-kappaB inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion.
Hoffmann F, Sass G, Zillies J, Zahler S, Tiegs G, Hartkorn A, Fuchs S, Wagner J, Winter G, Coester C, Gerbes A, Vollmar A
GUT. 2009;58(12):1670-1678.

The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice.
Kroeger I, Erhardt A, Abt D, Fischer M, Biburger M, Rau T, Neuhuber W, Tiegs G
J HEPATOL. 2009;51(2):342-353.

Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3- regulatory T cells suppressing autoimmune hepatitis
Kruse N, Neumann K, Schrage A, Derkow K, Schott E, Erben U, Kühl A, Loddenkemper C, Zeitz M, Hamann A, Klugewitz K
HEPATOLOGY. 2009;50(6):1904-13.

The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response.
Lehmann E, El-Tantawy W, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, Tiegs G, Sass G
HEPATOLOGY. 2009;51(2):398-404.

Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling
Linnemann C, Schildberg F, Schurich A, Diehl L, Hegenbarth S, Endl E, Lacher S, Müller C, Frey J, Simeoni L, Schraven B, Stabenow D, Knolle P
IMMUNOLOGY. 2009;128(1 Suppl):e728-37.

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Sharp F, Ruane D, Claaß B, Creagh E, Harris J, Malyala P, Singh M, O'Hagan D, Pétrilli V, Tschopp J, O'Neill L, Lavelle E
P NATL ACAD SCI USA. 2009;106(3):870-875.

Systemic antigen cross-presented by liver sinusoidal endothelial cells induces liver-specific CD8 T-cell retention and tolerization
von Oppen N, Schurich A, Hegenbarth S, Stabenow D, Tolba R, Weiskirchen R, Geerts A, Kolanus W, Knolle P, Diehl L
HEPATOLOGY. 2009;49(5):1664-72.

Letzte Aktualisierung aus dem FIS: 20.12.2024 - 23:32 Uhr