/bilder/forschung/ag-20steinmetz-202019_a_buehnenbild_contentseite.jpg)
/ag-steinmetz-2_contentbild.png)
/ag-steinmetz-1_contentbild.png)
Background
Glomerulonephritides are immune mediated diseases of the kidney, which often lead to end stage renal disease. Their pathophysiology is poorly understood and current therapeutic options are unsatisfying as they are unspecific and cause severe side effects. The search for new treatment modalities therefore is a priority for nephrologists worldwide.
The infiltration of leukocytes into the kidney is a typical finding in human and experimental glomerulonephritis. Among these, IFNy secreting T helper cells, termed Th1 and IL-17 secreting Th17 cells, are of special interest. We and others have shown that both Th1 and Th17 cell mediated immune responses are of central importance for initiation and progression of renal disease. While the pathogenic potency of Th1 and Th17 cells is well established, their regulation and counter regulation remains to be elucidated. Understanding T helper cell immunology is of special interest as Th1 and Th17 directed therapies have recently been introduced into clinical practice.Our research projects particularly address the following points:
1: Th1 and Th17 lineage specific regulatory T cells in glomerulonephritis
The potent pro-inflammatory Th1 and Th17 cells need to be tightly controlled by our immune system to avoid autoimmune disease. Central players of anti-inflammatory immune surveillance are the so called regulatory T cells. Very recent studies have suggested the concept of specialized regulatory T cells which specifically counter regulate Th1 and Th17 responses respectively. Currently we are characterizing these cells in acute and chronic glomerulonephritis. This is done by use of different knockout mice with gene deficiencies specifically in regulatory T cells. Also adoptive transfer models of sorted cells have been established.
2.: The role of biTregs in Glomerulonephritis
Recently we and others have discovered a new subset of T cells with both regulatory and pro-inflammatory properties. This intriguing novel lymphocyte population was shown to co-express the classical Treg transcription factor Foxp3 and the Th17 prototype transcription factor RORyt. Importantly, our studies could show that these RORyt+Foxp3+ cells constitute an independent and hitherto unrecognized cell population which differs from both classical Tregs and Th17 cells. Given their bi-functional nature (pro- and anti-inflammatory), we named this novel T cell lineage biTregs.
Currently, our group aims to further characterize the general properties of biTregs and investigate their role in glomerulonephritis. This is done by studies in various strains of knockout mice as well as biTreg reporter mouse strains. Furthermore, we investigate the potential role of biTregs in human autoimmune diseases as ANCA vasculitis and Lupus Erythematosus.
3: The dual role of IL-6 for generation of Th17 and Tr1 cells in glomerulonephrits
IL-6 is a pleiotropic cytokine which is central to the development of pro-inflammatory Th17 cells. However, accumulating evidence suggests that IL-6 is also critically involved in generation of anti-inflammatory type 1 regulatory T cells (Tr1). Recently, an IL-6 receptor antibody has been established for the treatment of various human autoimmune diseases. Studies in inflammatory renal disease are still lacking. We therefore analyse the effects of IL-6 blockade or deficiency on acute and chronic forms of experimental glomerulonephritis. This is done by use of general or leukocyte specific IL-6 signalling knockout mice as well as different blocking antibodies
Arbeitsgruppenleiter / PI
/steinmetzoliverdr_20150716_02_kontaktbild.jpg)
- Oberarzt
- Zentrum für Innere Medizin
- III. Medizinische Klinik und Poliklinik (Nephrologie/Rheumatologie/Endokrinologie)
- Facharzt für Innere Medizin und Nephrologie
Mitglieder / group members
Dr. med. Simon Melderis, MME (Postdoc)
Dr. med. Georg R. Herrnstadt (Postdoc)
Julia Hagenstein, M.sc. (wissenschaftliche Doktorandin)
Inken Holtze (BTA)
Christoph Niehus (medizinscher Doktorand)
Matthias Warkotsch (medizinischer Doktoran)
Frederic Feindt (medizinischer Doktorand)
Johannes Richter (medizinischer Doktorand)
Torben Ramcke (medizinischer Doktorand)
Publikationen
Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage
Bode M, Herrnstadt G, Dreher L, Ehnert N, Kirkerup P, Lindenmeyer M, Meyer-Schwesinger C, Ehmke H, Köhl J, Huber T, Krebs C, Steinmetz O, Wiech T, Wenzel U
HYPERTENSION. 2024;81(1):138-150.
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Engesser J, Khatri R, Schaub D, Zhao Y, Paust H, Sultana Z, Asada N, Riedel J, Sivayoganathan V, Peters A, Kaffke A, Jauch-Speer S, Goldbeck-Strieder T, Puelles V, Wenzel U, Steinmetz O, Hoxha E, Turner J, Mittrücker H, Wiech T, Huber T, Bonn S, Krebs C, Panzer U
NAT COMMUN. 2024;15(1):8220.
The CCR6/CCL20 Axis Expands RORγt+ Tregs to Protect from Glomerulonephritis
Herrnstadt G, Niehus C, Ramcke T, Hagenstein J, Ehnold L, Nosko A, Warkotsch M, Feindt F, Melderis S, Paust H, Sivayoganathan V, Jauch-Speer S, Wong M, Indenbirken D, Krebs C, Huber T, Panzer U, Puelles V, Kluger M, Steinmetz O
KIDNEY INT. 2023;104(1):74-89.
CD4+ T cells produce GM-CSF and drive immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12
Paust H, Song N, De Feo D, Asada N, Tuzlak S, Zhao Y, Riedel J, Hellmig M, Sivayoganathan A, Peters A, Kaffke A, Borchers A, Wenzel U, Steinmetz O, Tiegs G, Meister E, Mack M, Kurts C, von Vietinghoff S, Lindenmeyer M, Hoxha E, Stahl R, Huber T, Bonn S, Meyer-Schwesinger C, Wiech T, Turner J, Becher B, Krebs C, Panzer U
SCI TRANSL MED. 2023;15(687):.
Leishmania infantum reactivation with secondary IgA nephropathy
Grewe I, Brehm T, Kreuels B, Steinmetz O, Dumoulin B, Asemissen A, Tappe D, Ramharter M, Schmiedel S
J TRAVEL MED. 2022;29(7):.
Nierenbeteiligung bei Kollagenosen
Herrnstadt G, Holzer M, Steinmetz O, Kötter I, Melderis S
Z RHEUMATOL. 2022;81(10):829-844.
Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells
Linke A, Cicek H, Müller A, Meyer-Schwesinger C, Melderis S, Wiech T, Wegscheid C, Ridder J, Steinmetz O, Diehl L, Tiegs G, Neumann K
CELLS-BASEL. 2022;11(9):.
The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses
Melderis S, Warkotsch M, Dang J, Hagenstein J, Ehnold L, Herrnstadt G, Niehus C, Feindt F, Kylies D, Puelles V, Berasain C, Avila M, Neumann K, Tiegs G, Huber T, Tharaux P, Steinmetz O
J AUTOIMMUN. 2022;129:.
Sarkoidose als Paradebeispiel einer granulomatösen Erkrankung
Oqueka T, Galow S, Simon M, Weidmann A, Stübiger N, Zengin-Sahm E, Sinning C, Krusche M, Ruffer N, Steurer S, Schick-Bengardt X, Sebode M, Horst L, Steinmetz O, Melderis S, Rosenkranz S, Möller K, Jantke H, Klose H
Z RHEUMATOL. 2022;81(7):535-548.
Neutralization of IL-6 inhibits formation of autoreactive TH17 cells but does not prevent loss of renal function in experimental autoimmune glomerulonephritis
Brede K, Schmid J, Steinmetz O, Panzer U, Klinge S, Mittrücker H
IMMUNOL LETT. 2021;236:51-60.
The role of Treg subtypes in glomerulonephritis
Herrnstadt G, Steinmetz O
CELL TISSUE RES. 2021;385(2):293–304.
Lack of Evidence for an Association between Previous HEV Genotype-3 Exposure and Glomerulonephritis in General
Pischke S, Tamanaei S, Mader M, Wiesch J, Petersen-Benz C, Haddad M, Addo M, Schmidt T, Huber T, Krebs C, Steinmetz O, Turner J, Hoxha E, Horvatits T
PATHOGENS. 2021;11(1):.
Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells
Melderis S, Hagenstein J, Warkotsch M, Dang J, Herrnstadt G, Niehus C, Neumann K, Panzer U, Berasain C, Avila M, Tharaux P, Tiegs G, Steinmetz O
J AM SOC NEPHROL. 2020;31(9):1996-2012.
A Novel Role for IL-6 Receptor Classic Signaling: Induction of RORγt+Foxp3+ Tregs with Enhanced Suppressive Capacity
Hagenstein J, Melderis S, Nosko A, Warkotsch M, Richter J, Ramcke T, Herrnstadt G, Scheller J, Yan I, Mittrücker H, Kluger M, Steinmetz O
J AM SOC NEPHROL. 2019;30(8):1439-1453.
Progrediente Luftnot und Schwäche bei einer 61-jährigen Patientin
Mahmud M, Schnoor U, Steinmetz O
INTERNIST. 2019;60(2):186-192.
Bevacizumab-associated glomerular microangiopathy
Person F, Rinschen M, Brix S, Wulf S, Noriega M, Fehrle W, Schmitz J, Schwarz A, Ivanyi P, Steinmetz O, Reinhard L, Hoxha E, Zipfel P, Bräsen J, Wiech T
MODERN PATHOL. 2019;32(5):684-700.
Pharmacokinetics of meropenem in septic patients on sustained low-efficiency dialysis: a population pharamcokinetic study
Braune S, König C, Roberts J, Nierhaus A, Steinmetz O, Baehr M, Kluge S, Langebrake C
CRIT CARE. 2018;22(1):25-34.
Organisation of lymphocytic infiltrates in ANCA-associated glomerulonephritis
Brix S, Noriega M, Herden E, Goldmann B, Langbehn U, Busch M, Jabs W, Steinmetz O, Panzer U, Huber T, Stahl R, Wiech T
HISTOPATHOLOGY. 2018;72(7):1093-1101.
IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN
Diefenhardt P, Nosko A, Kluger M, Richter J, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell R, Stahl R, Steinmetz O
J AM SOC NEPHROL. 2018;29(7):1825-1837.
Kreatininanstieg in der Frühphase nach Nierentransplantation: Es muss nicht immer Abstoßung sein …
Kluger M, Person F, Wenzel U, Steinmetz O
NEPHROLOGE. 2018;13(1):37-40.
IL-17C/IL-17 Receptor E Signaling in CD4 T Cells Promotes T17 Cell-Driven Glomerular Inflammation
Krohn S, Nies J, Kapffer S, Schmidt T, Riedel J, Kaffke A, Peters A, Steinmetz O, Krebs C, Turner J, Brix S, Paust H, Stahl R, Panzer U
J AM SOC NEPHROL. 2018;29(4):1210-1222.
Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells
Lücke K, Yan I, Krohn S, Volmari A, Klinge S, Schmid J, Schumacher V, Steinmetz O, Rose-John S, Mittrücker H
PLOS ONE. 2018;13(8):e0203395.
Lupusnephritis
Melderis S, Wiech T, Iking-Konert C, Steinmetz O
Z RHEUMATOL. 2018;77(7):593-608.
RORγt expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses
Kluger M, Nosko A, Ramcke T, Goerke B, Meyer M, Wegscheid C, Luig M, Tiegs G, Stahl R, Steinmetz O
CLIN EXP IMMUNOL. 2017;188(1):63-78.
Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis
König C, Braune S, Roberts J, Nierhaus A, Steinmetz O, Baehr M, Frey O, Langebrake C, Kluge S
J ANTIMICROB CHEMOTH. 2017;72(5):1433-1440.
T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN
Nosko A, Kluger M, Diefenhardt P, Melderis S, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2017;28(1):185-196.
Akutes Nierenversagen bei einer 75-jährigen Patientin mit High-output-Ileostoma
Teege S, Wiech T, Steinmetz O
INTERNIST. 2017;58(5):507-511.
A Mechanism for Cancer-Associated Membranous Nephropathy
Hoxha E, Wiech T, Stahl P, Zahner G, Tomas N, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz O, Panzer U, Harendza S, Stahl R
NEW ENGL J MED. 2016;374(20):1995-6.
Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Nosko A, Goerke B, Luig M, Meyer M, Turner J, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
KIDNEY INT. 2016;89(1):158-166.
The Authors Reply to Letter to the Editor (Kidder D), referring to: Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus
Kluger M, Melderis S, Steinmetz O
KIDNEY INT. 2016;90(1):222-3.
RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN
Kluger M, Meyer M, Nosko A, Goerke B, Luig M, Wegscheid C, Tiegs G, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2016;27(2):454-465.
Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch C, Mittrücker H, Steinhoff U, Stockinger B, Perez L, Wenzel U, Janneck M, Steinmetz O, Gagliani N, Stahl R, Huber S, Turner J, Panzer U
IMMUNITY. 2016;45(5):1078-1092.
CD4+ T Cell Fate in Glomerulonephritis: A Tale of Th1, Th17, and Novel Treg Subtypes
Krebs C, Steinmetz O
MEDIAT INFLAMM. 2016;2016:.
Plasticity of Th17 Cells in Autoimmune Kidney Diseases
Krebs C, Turner J, Paust H, Kapffer S, Koyro T, Krohn S, Ufer F, Friese M, Flavell R, Stockinger B, Steinmetz O, Stahl R, Huber S, Panzer U
J IMMUNOL. 2016;197(2):449-57.
CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN
Paust H, Riedel J, Krebs C, Turner J, Brix S, Krohn S, Velden J, Wiech T, Kaffke A, Peters A, Bennstein S, Kapffer S, Meyer-Schwesinger C, Wegscheid C, Tiegs G, Thaiss F, Mittrücker H, Steinmetz O, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(7):1933-42.
IL-17F Promotes Tissue Injury in Autoimmune Kidney Diseases
Riedel J, Paust H, Krohn S, Turner J, Kluger M, Steinmetz O, Krebs C, Stahl R, Panzer U
J AM SOC NEPHROL. 2016;27(12):3666-3677.
CXCL5 drives neutrophil recruitment in TH17-mediated GN
Disteldorf E, Krebs C, Paust H, Turner J, Nouailles G, Tittel A, Meyer-Schwesinger C, Stege G, Brix S, Velden J, Wiech T, Helmchen U, Steinmetz O, Peters A, Bennstein S, Kaffke A, Llanto C, Lira S, Mittrücker H, Stahl R, Kurts C, Kaufmann S, Panzer U
J AM SOC NEPHROL. 2015;26(1):55-66.
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN
Luig M, Kluger M, Goerke B, Meyer M, Nosko A, Yan I, Scheller J, Mittrücker H, Rose-John S, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2015;26(7):1597-1607.
Function of the Th17/interleukin-17A immune response in murine lupus nephritis
Schmidt T, Paust H, Krebs C, Turner J, Kaffke A, Bennstein S, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz O, Mittrücker H, Stahl R, Panzer U
ARTHRITIS RHEUMATOL. 2015;67(2):475-87.
Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation
Chan A, Alikhan M, Odobasic D, Gan P, Khouri M, Steinmetz O, Mansell A, Kitching A, Holdsworth S, Summers S
AM J PATHOL. 2014;184(5):1411-1418.
Stat3 Programs Th17-Specific Regulatory T Cells to Control GN
Kluger M, Luig M, Wegscheid C, Goerke B, Paust H, Brix S, Yan I, Mittrücker H, Hagl B, Renner E, Tiegs G, Wiech T, Stahl R, Panzer U, Steinmetz O
J AM SOC NEPHROL. 2014;25(6):1291-302.
B-cell-derived IL-10 does not vitally contribute to the clinical course of glomerulonephritis
Kluger M, Ostmann A, Luig M, Meyer M, Goerke B, Paust H, Meyer-Schwesinger C, Stahl R, Panzer U, Tiegs G, Steinmetz O
EUR J IMMUNOL. 2014;44(3):683-693.
Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane
Summers S, Odobasic D, Khouri M, Steinmetz O, Yang Y, Holdsworth S, Kitching A
CLIN EXP IMMUNOL. 2014;176(3):341-350.
Plasticity of Th17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses.
Hirota K, Turner J, Villa M, Duarte J, Demengeot J, Steinmetz O, Stockinger B
NAT IMMUNOL. 2013;14(4):372-379.
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling
Hoge J, Yan I, Jänner N, Schumacher V, Chalaris A, Steinmetz O, Engel D, Scheller J, Rose-John S, Mittrücker H
J IMMUNOL. 2013;190(2):703-11.
MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN
Krebs C, Kapffer S, Paust H, Schmidt T, Bennstein S, Peters A, Stege G, Brix S, Meyer-Schwesinger C, Müller R, Turner J, Steinmetz O, Wolf G, Stahl R, Panzer U
J AM SOC NEPHROL. 2013;24(12):1955-65.
Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis.
Paust H, Turner J, Riedel J, Disteldorf E, Peters A, Schmidt T, Krebs C, Velden J, Mittrücker H, Steinmetz O, Stahl R, Panzer U
KIDNEY INT. 2012;82(1):72-83.
Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel J, Paust H, Turner J, Tittel A, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker H, Garbi N, Stahl R, Steinmetz O, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(12):1987-2000.
IL-17A production by renal γδ T cells promotes kidney injury in crescentic GN.
Turner J, Krebs C, Tittel A, Paust H, Meyer-Schwesinger C, Bennstein S, Steinmetz O, Prinz I, Magnus T, Korn T, Stahl R, Kurts C, Panzer U
J AM SOC NEPHROL. 2012;23(9):1486-1495.
Protective role for CCR5 in murine lupus nephritis.
Turner J, Paust H, Mathey S, Bramke P, Krebs C, Steinmetz O, Velden J, Haag F, Stahl R, Panzer U
AM J PHYSIOL-RENAL. 2012;302(11):1503-1515.
Renal IL-17 expression in human ANCA-associated glomerulonephritis.
Velden J, Paust H, Hoxha E, Turner J, Steinmetz O, Wolf G, Jabs W, Özcan F, Beige J, Heering P, Schröder S, Kneißler U, Disteldorf E, Mittrücker H, Stahl R, Helmchen U, Panzer U
AM J PHYSIOL-RENAL. 2012;302(12):1663-1673.
An immunofluorescence test for phospholipase-A₂-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis.
Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl R
NEPHROL DIAL TRANSPL. 2011;26(8):2526-2532.
ISN Forefronts Symposium 2010 in Sylt, Germany: 'Induction and Resolution of Renal Inflammation'
Panzer U, Turner J, Steinmetz O, Kurts C, Johnson R, Stahl R
KIDNEY INT. 2011;79(8):807-813.
The Th17-Defining Transcription Factor ROR{gamma}t Promotes Glomerulonephritis.
Steinmetz O, Summers S, Gan P, Semple T, Holdsworth S, Kitching A
J AM SOC NEPHROL. 2011;22(3):472-483.
The Th17-defining transcription factor RORγt promotes glomerulonephritis
Steinmetz O, Summers S, Gan P, Semple T, Holdsworth S, Kitching A
J AM SOC NEPHROL. 2011;22(3):472-83.
Mast cells mediate acute kidney injury through the production of TNF.
Summers S, Chan J, Gan P, Dewage L, Nozaki Y, Steinmetz O, Nikolic-Paterson D, Kitching A, Holdsworth S
J AM SOC NEPHROL. 2011;22(12):2226-2236.
TLR2 induces Th17 myeloperoxidase autoimmunity, while TLR9 drives Th1 autoimmunity.
Summers S, Steinmetz O, Gan P, Ooi J, Odobasic D, Kitching A, Holdsworth S
ARTHRITIS RHEUMATOL. 2011.
Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.
Gan P, Steinmetz O, Tan D, O'Sullivan Kim M, Ooi J, Iwakura Y, Kitching A, Holdsworth S
J AM SOC NEPHROL. 2010;21(6):925-931.
Staying on top of things right from the start: the obsessive-compulsive disorder of regulatory T cells.
Steinmetz O, Turner J, Panzer U
J AM SOC NEPHROL. 2010;21(1):6-7.
TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.
Summers S, Hoi A, Steinmetz O, O'Sullivan K M, Ooi J, Odobasic D, Akira S, Kitching A, Holdsworth S
J AUTOIMMUN. 2010;35(4):291-298.
Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis.
Summers S, Steinmetz O, Ooi J, Gan P, O'Sullivan Kim M, Visvanathan K, Akira S, Kitching A, Holdsworth S
AM J PATHOL. 2010;177(5):2234-2244.
The Th17 immune response in renal inflammation.
Turner J, Paust H, Steinmetz O, Panzer U
KIDNEY INT. 2010;77(12):1070-1075.
CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner J, Paust H, Steinmetz O, Peters A, Riedel J, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker H, Tiegs G, Stahl R, Panzer U
J AM SOC NEPHROL. 2010;21(6):974-985.
Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.
Benndorf R, Krebs C, Hirsch-Hoffmann B, Schwedhelm E, Cieslar G, Schmidt-Haupt R, Steinmetz O, Meyer-Schwesinger C, Thaiss F, Haddad M, Fehr S, Heilmann A, Helmchen U, Hein L, Ehmke H, Stahl R, Böger R, Wenzel U
KIDNEY INT. 2009;75(10):1039-1049.
Resolution of renal inflammation: a new role for NF-kappaB1 (p50) in inflammatory kidney diseases.
Panzer U, Steinmetz O, Turner J, Meyer-Schwesinger C, von Ruffer C, Meyer T, Zahner G, Gómez-Guerrero C, Schmid R, Helmchen U, Moeckel G, Wolf G, Stahl R, Thaiss F
AM J PHYSIOL-RENAL. 2009.
The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis.
Paust H, Turner J, Steinmetz O, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker H, Stahl R, Panzer U
J AM SOC NEPHROL. 2009;20(5):969-979.
Chemokines and B cells in renal inflammation and allograft rejection.
Steinmetz O, Stahl R, Panzer U
FRONT BIOSCI-LANDMRK. 2009;1:13-22.
CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
Steinmetz O, Turner J, Paust H, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer T, Helmchen U, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2009;183(7):4693-4704.
Th1 and Th17 cells induce proliferative glomerulonephritis.
Summers S, Steinmetz O, Li M, Kausman J, Semple T, Edgtton K, Borza D, Braley H, Holdsworth S, Kitching A
J AM SOC NEPHROL. 2009;20(12):2518-2524.
Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats.
Krebs C, Weber M, Steinmetz O, Meyer-Schwesinger C, Stahl R, Danser A, Garrelds I, van Goor H, Nguyen G, Müller D, Wenzel U
KIDNEY INT. 2008;74(6):823-824.
15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells
Panzer U, Zahner G, Wienberg U, Steinmetz O, Peters A, Turner J, Paust H, Wolf G, Stahl R, Schneider A
NEPHROL DIAL TRANSPL. 2008;23(12):3776-85.
Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis.
Steinmetz O, Velden J, Kneissler U, Marx M, Klein A, Helmchen U, Stahl R, Panzer U
KIDNEY INT. 2008;74(4):448-457.
CCR5 deficiency aggravates crescentic glomerulonephritis in mice.
Turner J, Paust H, Steinmetz O, Peters A, Meyer-Schwesinger C, Heymann F, Helmchen U, Fehr S, Horuk R, Wenzel U, Kurts C, Mittrücker H, Stahl R, Panzer U
J IMMUNOL. 2008;181(9):6546-6556.
Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats.
Krebs C, Hamming I, Sadaghiani S, Steinmetz O, Meyer-Schwesinger C, Fehr S, Stahl R, Garrelds I, Danser A, van Goor H, Contrepas A, Nguyen G, Wenzel U
KIDNEY INT. 2007;72(6):725-730.
Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.
Panzer U, Steinmetz O, Paust H, Meyer-Schwesinger C, Peters A, Turner J, Zahner G, Heymann F, Kurts C, Hopfer H, Helmchen U, Haag F, Schneider A, Stahl R
J AM SOC NEPHROL. 2007;18(7):2071-2084.
Acute cellular allograft rejection in homozygous CCR5 Delta32 patients after renal transplantation.
Steinmetz O, Fischereder M, Weiss M, Helmchen U, Stahl R, Panzer U
TRANSPLANTATION. 2007;84(4):559-561.
Rituximab removes intrarenal B cell clusters in patients with renal vascular allograft rejection.
Steinmetz O, Lange-Hüsken F, Turner J, Vernauer A, Helmchen U, Stahl R, Thaiss F, Panzer U
TRANSPLANTATION. 2007;84(7):842-850.
A pitfall of glomerular sieving: profibrotic and matrix proteins derive from the Bowman's capsule and not the glomerular tuft in rats with renovascular hypertension.
Steinmetz O, Panzer U, Fehr S, Meyer-Schwesinger C, Stahl R, Wenzel U
NEPHROL DIAL TRANSPL. 2007;22(10):3055-3060.
Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats.
Steinmetz O, Sadaghiani S, Panzer U, Krebs C, Meyer-Schwesinger C, Streichert T, Fehr S, Hamming I, van Goor H, Stahl R, Wenzel U
AM J PHYSIOL-RENAL. 2007;292(2):876-887.
Targeting of Th1-associated chemokine receptors CXCR3 and CCR5 as therapeutic strategy for inflammatory diseases.
Turner J, Steinmetz O, Stahl R, Panzer U
MINI-REV MED CHEM. 2007;7(11):1089-1096.
Enhanced expression of selenocysteine lyase in acute glomerulonephritis and its regulation by AP-1.
Jafari C, Panzer U, Steinmetz O, Zahner G, Stahl R, Harendza S
CELL MOL BIOL LETT. 2006;11(3):424-437.
Kidney diseases and chemokines.
Panzer U, Steinmetz O, Stahl R, Wolf G
CURR DRUG TARGETS. 2006;7(1):65-80.
Statin therapy in patients with chronic kidney disease: to use or not to use.
Steinmetz O, Panzer U, Stahl R, Wenzel U
EUR J CLIN INVEST. 2006;36(8):519-527.
Letzte Aktualisierung aus dem FIS: 24.12.2024 - 23:33 Uhr