- Leitung Arbeitsgruppe Klinische Studien
- Wissenschaftliche Mitarbeiterin
Fachgebiete
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Medizinische Biometrie
Tätigkeitsschwerpunkte
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Arbeitsgebiet:
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- Klinische Studien
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- Statistische Beratung
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Methodische Schwerpunkte:
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- Überlebenszeitanalysen
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- Gemischte Modelle
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- Propensity Score Matching
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Klinische Schwerpunkte:
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- Kardiologie
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- Pneumologie
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- Tumormetastasierung
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Bevorzugte statistische Software:
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- STATA (advanced)
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- R
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- SAS
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- SPSS
Lebenslauf
Auszeichnungen
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2022
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Zertifikat „Biometrie in der Medizin“ der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS) und der Internationalen Biometrischen Gesellschaft, Deutsche Region (IBS-DR)
Publikationen
2024
Efficacy and safety of transcranial direct current stimulation to the ipsilesional motor cortex in subacute stroke (NETS): a multicenter, randomized, double-blind, placebo-controlled trial
LANCET REG HEALTH-EU. 2024;38:100825.
Relationship between ICD implantation volume and treatment parameters of patients receiving an ICD with remote monitoring
Butter C, Klein G, Grönefeld G, Böcker D, Suling A, Buchholz A, Felk A, Hauser T, Wegscheider K, Bänsch D
TECHNOL HEALTH CARE. 2024;32(3):1583-1593.
Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study
Fabritz L, Chua W, Cardoso V, Al-Taie C, Borof K, Suling A, Krause L, Kany S, Magnussen C, Wegscheider K, Breithardt G, Crijns H, Camm A, Gkoutos G, Ellinor P, Goette A, Schotten U, Wienhues-Thelen U, Zeller T, Schnabel R, Zapf A, Kirchhof P
CARDIOVASC RES. 2024;120(8):855-868.
Comparison of ante- and postmortem ventricular wall thickness using echocardiography and autopsy findings
Lohner L, Ondruschka B, Garland J, Tse R, Suling A, Sinning C
VIRCHOWS ARCH. 2024.
Is an intraoperative liver function assessment possible? Application of the 13C-methacetin-breath-test during major liver resections - a pilot study
Makridis G, Reese T, Zádori Z, Suling A, Stark M, Horling K, Brüning R, Schneider M, Beumer M, Oldhafer K
HPB. 2024;26(1):91-101.
2023
Psychological risk factors for Long COVID and their modification: study protocol of a three-arm, randomised controlled trial (SOMA.COV)
Engelmann P, Büchel C, Frommhold J, Klose H, Lohse A, Maehder K, Nestoriuc Y, Scherer M, Suling A, Toussaint A, Weigel A, Zapf A, Löwe B
BJPSYCH OPEN. 2023;9(6):e207.
Early rhythm-control therapy for atrial fibrillation in patients with a history of stroke: a subgroup analysis of the EAST-AFNET 4 trial
Jensen M, Suling A, Metzner A, Schnabel R, Borof K, Goette A, Haeusler K, Zapf A, Wegscheider K, Fabritz L, Diener H, Thomalla G, Kirchhof P
LANCET NEUROL. 2023;22(1):45-54.
Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial
Kany S, Al-Taie C, Roselli C, Pirruccello J, Borof K, Reinbold C, Suling A, Krause L, Reissmann B, Schnabel R, Zeller T, Zapf A, Wegscheider K, Fabritz L, Ellinor P, Kirchhof P
CARDIOVASC RES. 2023;119(9):1799-1810.
Heart weight must not be measured before dissection during autopsies
Lohner L, Sinning C, Suling A, Tse R, Garland J, Ondruschka B
INT J LEGAL MED. 2023;137(6):1751–1755.
2022
A multicenter, randomized, double-blind, placebo-controlled trial to test efficacy and safety of transcranial direct current stimulation to the motor cortex after stroke (NETS): study protocol
NEUROL RES PRACT. 2022;4(1):14.
Incidence and risk factors of mental disorders in the elderly: The European MentDis_ICF65+ study
Andreas S, Schulz H, Volkert J, Lüdemann J, Dehoust M, Sehner S, Suling A, Wegscheider K, Ausín B, Canuto A, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Belén Santos-Olmo A, Shalev A, Weber K, Wittchen H, Härter M
AUST NZ J PSYCHIAT. 2022;56(5):551-559.
Association of NT-proBNP and hs-cTnT with Imaging Markers of Diastolic Dysfunction and Focal Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Chevalier C, Wendner M, Suling A, Cavus E, Muellerleile K, Lund G, Kirchhof P, Patten M
LIFE-BASEL. 2022;12(8):.
Attaining sinus rhythm mediates improved outcome with early rhythm control therapy of atrial fibrillation: the EAST - AFNET 4 trial
Eckardt L, Sehner S, Suling A, Borof K, Breithardt G, Crijns H, Goette A, Wegscheider K, Zapf A, Camm J, Metzner A, Kirchhof P
EUR HEART J. 2022;43(40):4127-4144.
Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial
Metzner A, Suling A, Brandes A, Breithardt G, Camm A, Crijns H, Eckardt L, Elvan A, Goette A, Haegeli L, Heidbuchel H, Kautzner J, Kuck K, Mont L, Ng A, Szumowski L, Themistoclakis S, van Gelder I, Vardas P, Wegscheider K, Willems S, Kirchhof P
EUROPACE. 2022;24(4):552-564.
Corrigendum to: Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST-AFNET 4 trial
Metzner A, Suling A, Brandes A, Breithardt G, Camm A, Crijns H, Eckardt L, Elvan A, Goette A, Haegeli L, Heidbuchel H, Kautzner J, Kuck K, Mont L, Ng G, Szumowski L, Themistoclakis S, van Gelder I, Vardas P, Wegscheider K, Willems S, Kirchhof P
EUROPACE. 2022;24(4):564.
CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo
Oh-Hohenhorst S, Tilki D, Ahlers A, Suling A, Hahn O, Tennstedt P, Matuszcak C, Maar H, Labitzky V, Hanika S, Starzonek S, Baumgart S, Johnsen S, Kluth M, Sirma H, Simon R, Sauter G, Huland H, Schumacher U, Lange T
CANCER GENE THER. 2022;29(1):49-61.
Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study
Tamisier R, Pepin J, Cowie M, Wegscheider K, Vettorazzi E, Suling A, Angermann C, d'Ortho M, Erdmann E, Simonds A, Somers V, Teschler H, Lévy P, Woehrle H
J SLEEP RES. 2022;31(6):e13694.
Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial
Willems S, Borof K, Brandes A, Breithardt G, Camm A, Crijns H, Eckardt L, Gessler N, Goette A, Haegeli L, Heidbuchel H, Kautzner J, Ng G, Schnabel R, Suling A, Szumowski L, Themistoclakis S, Vardas P, van Gelder I, Wegscheider K, Kirchhof P
EUR HEART J. 2022;43(12):1219-1230.
2021
„Coronavirus-disease-2019“-Pandemie aus nephrologischer Perspektive
Hoxha E, Suling A, Turner J, Haubitz M, Floege J, Huber T, Galle J
INTERNIST. 2021;62(7):718-724.
COVID-19 Prevalence and Mortality in Chronic Dialysis Patients
Hoxha E, Suling A, Turner J, Haubitz M, Floege J, Huber T, Galle J
DTSCH ARZTEBL INT. 2021;118(11):195-196.
Early Rhythm Control Therapy in Patients with Atrial Fibrillation and Heart Failure
Rillig A, Magnussen C, Ozga A, Suling A, Brandes A, Breithardt G, Camm A, Crijns H, Eckardt L, Elvan A, Goette A, Gulizia M, Haegeli L, Heidbuchel H, Kuck K, Ng A, Szumowski L, van Gelder I, Wegscheider K, Kirchhof P
CIRCULATION. 2021;144(11):845-858.
Pharmacological rhythm versus rate control in patients with atrial fibrillation and heart failure: the CASTLE-AF trial
Zhao Y, Krupadev V, Dagher L, Mahnkopf C, Sohns C, Sehner S, Suling A, Sanders P, Boersma L, Schunkert H, Wegscheider K, Brachmann J, Marrouche N
J INTERV CARD ELECTR. 2021;61(3):609-615.
2020
Quality of life, level of functioning, and its relationship with mental and physical disorders in the elderly: results from the MentDis_ICF65+ study
Grassi L, Caruso R, Da Ronch C, Härter M, Schulz H, Volkert J, Dehoust M, Sehner S, Suling A, Wegscheider K, Ausín B, Canuto A, Muñoz M, Crawford M, Hershkovitz Y, Quirk A, Rotenstein O, Santos-Olmo A, Shalev A, Strehle J, Weber K, Wittchen H, Andreas S, Belvederi Murri M, Zerbinati L, Nanni M
HEALTH QUAL LIFE OUT. 2020;18(1):61.
Who is shocked and who survives? A multi-state analysis of the NORDIC ICD trial
Gronefeld G, Buchholz A, Boecker D, Klein G, Butter C, Suling A, Felk A, Hauser T, Baensch D, Wegscheider K
EUR HEART J. 2020;41(2):.
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation
Kirchhof P, Camm A, Goette A, Brandes A, Eckardt L, Elvan A, Fetsch T, van Gelder I, Haase D, Haegeli L, Hamann F, Heidbüchel H, Hindricks G, Kautzner J, Kuck K, Mont L, Ng G, Rekosz J, Schoen N, Schotten U, Suling A, Taggeselle J, Themistoclakis S, Vettorazzi E, Vardas P, Wegscheider K, Willems S, Crijns H, Breithardt G
NEW ENGL J MED. 2020;383(14):1305-1316.
The Use of Bovine Xenogeneic Bone Graft for Dega Pelvic Osteotomy in Children with Hip Dysplasia: A Retrospective Study of 147 Treated Hips
Stiel N, Moritz M, Babin K, Suling A, Rupprecht M, Beil F, Stuecker R, Spiro A
J CLIN MED. 2020;9(7):.
Temporomandibular joint involvement in patients with juvenile idiopathic arthritis: a retrospective chart review
von Schuckmann L, Klotsche J, Suling A, Kahl-Nieke B, Foeldvari I
SCAND J RHEUMATOL. 2020;49(4):271-280.
2019
Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
Andreas S, Dehoust M, Volkert J, Schulz H, Sehner S, Suling A, Wegscheider K, Ausín B, Canuto A, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Belén Santos-Olmo A, Shalev A, Weber K, Wittchen H, Härter M
PLOS ONE. 2019;14(11):e0224871.
The role of meaning in life in community-dwelling older adults with depression and relationship to other risk factors
Volkert J, Härter M, Dehoust M, Ausín B, Canuto A, Da Ronch C, Suling A, Grassi L, Munoz M, Santos-Olmo A, Sehner S, Weber K, Wegscheider K, Wittchen H, Schulz H, Andreas S
AGING MENT HEALTH. 2019;23(1):100-106.
2018
Anxiety Disorders in Old Age: Psychiatric Comorbidities, Quality of Life, and Prevalence According to Age, Gender, and Country
Canuto A, Weber K, Baertschi M, Andreas S, Volkert J, Dehoust M, Sehner S, Suling A, Wegscheider K, Ausín B, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Santos-Olmo A, Shalev A, Strehle J, Wittchen H, Schulz H, Härter M
AM J GERIAT PSYCHIAT. 2018;26(2):174-185.
Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy
Ernst A, Putscher A, Samatov T, Suling A, Galatenko V, Shkurnikov M, Knyazev E, Tonevitsky A, Haalck T, Lange T, Maar H, Schröder-Schwarz J, Riecken K, Schumacher U, Wicklein D
PLOS ONE. 2018;13(2):e0192525.
Nationwide Routine-Data Analysis of Sex Differences in Outcome of Acute Myocardial Infarction
Freisinger E, Sehner S, Malyar N, Suling A, Reinecke H, Wegscheider K
CLIN CARDIOL. 2018;41(8):1013-1021.
Alcohol use, abuse and dependence in an older European population: Results from the MentDis_ICF65+ study
Muñoz M, Ausín B, Santos-Olmo A, Härter M, Volkert J, Schulz H, Sehner S, Dehoust M, Suling A, Wegscheider K, Canuto A, Crawford M, Grassi L, Da Ronch C, Hershkovitz Y, Quirk A, Rotenstein O, Shalev A, Strehle J, Weber K, Wittchen H, Andreas S
PLOS ONE. 2018;13(4):e0196574.
Participation of elderly gynecological cancer patients in clinical trials
Prieske K, Trillsch F, Oskay-Özcelik G, Chekerov R, Bleich C, Oliveira-Ferrer L, Grimm D, Kuerti S, Mueller V, Suling A, Schmalfeldt B, Sehouli J, Mahner S, Woelber L
ARCH GYNECOL OBSTET. 2018;298(4):797-804.
Functional donor site morbidity longer than one year after fibula free flap: A prospective biomechanical analysis
Rendenbach C, Rashad A, Hansen L, Kohlmeier C, Dyck M, Suling A, Assaf A, Amling M, Heiland M, Wikner J, Riecke B, Kreutzer K
MICROSURG. 2018;38(4):395-401.
Predisposing, enabling, and need factors of service utilization in the elderly with mental health problems
Volkert J, Andreas S, Härter M, Dehoust M, Sehner S, Suling A, Ausín B, Canuto A, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Santos-Olmo A, Shalev A, Strehle J, Weber K, Wegscheider K, Wittchen H, Schulz H
INT PSYCHOGERIATR. 2018;30(7):1027-1037.
CEACAM1 promotes melanoma metastasis and is involved in the regulation of the EMT associated gene network in melanoma cells
Wicklein D, Otto B, Suling A, Elies E, Lüers G, Lange T, Feldhaus S, Maar H, Schröder-Schwarz J, Brunner G, Wagener C, Schumacher U
SCI REP-UK. 2018;8:11893.
2017
Prevalence of mental disorders in elderly people: the European MentDis_ICF65+ study
Andreas S, Schulz H, Volkert J, Dehoust M, Sehner S, Suling A, Ausín B, Canuto A, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Santos-Olmo A, Shalev A, Strehle J, Weber K, Wegscheider K, Wittchen H, Härter M
BRIT J PSYCHIAT. 2017;210(2):125-131.
Phenotyping of Sleep-Disordered Breathing in Patients With Chronic Heart Failure With Reduced Ejection Fraction-the SchlaHF Registry
Arzt M, Oldenburg O, Graml A, Erdmann E, Teschler H, Wegscheider K, Suling A, Woehrle H
J AM HEART ASSOC. 2017;6(12):.
Prevalence and correlates of somatoform disorders in the elderly: Results of a European study.
Dehoust M, Schulz H, Härter M, Volkert J, Sehner S, Drabik A, Wegscheider K, Canuto A, Weber K, Crawford M, Quirk A, Grassi L, DaRonch C, Munoz M, Ausin B, Santos-Olmo A, Shalev A, Rotenstein O, Hershkowitz Y, Strehle J, Wittchen H, Andreas S
INT J METH PSYCH RES. 2017;26(1): Art. e1550 .
Sella turcica measurements on lateral cephalograms of patients with neurofibromatosis type 1
Friedrich R, Baumann J, Suling A, Scheuer H, Scheuer H
GMS INTERDISCIP PLAS. 2017;6:UNSP 5.
The effects of music therapy in patients with high-dose chemotherapy and stem cell support: a randomized pilot study
Tuinmann G, Preissler P, Böhmer H, Suling A, Bokemeyer C
PSYCHO-ONCOLOGY. 2017;26(3):377-384.
Early segmental relaxation abnormalities in hypertrophic cardiomyopathy for differential diagnostic of patients with left ventricular hypertrophy
Voigt C, Münch J, Avanesov M, Suling A, Witzel K, Lund G, Patten M
CLIN CARDIOL. 2017;40(11):1026-1032.
Study approach and field work procedures of the MentDis_ICF65+ project on the prevalence of mental disorders in the older adult European population
Volkert J, Härter M, Dehoust M, Schulz H, Sehner S, Suling A, Wegscheider K, Ausín B, Canuto A, Crawford M, Da Ronch C, Grassi L, Hershkovitz Y, Muñoz M, Quirk A, Rotenstein O, Santos-Olmo A, Shalev A, Strehle J, Weber K, Wittchen H, Andreas S
BMC PSYCHIATRY. 2017;17(1):366.
Adaptive servo ventilation for central sleep apnoea in heart failure:SERVE-HF on-treatment analysis.
Woehrle H, Cowie M, Eulenburg C, Suling A, Angermann C, d'Ortho M, Erdmann E, Levy P, Simonds A, Somers V, Zannad F, Teschler H, Wegscheider K
EUR RESPIR J. 2017;50(2):1601692.
2016
Prevalence and Predictors of Sleep-Disordered Breathing in Patients With Stable Chronic Heart Failure: The SchlaHF Registry
Arzt M, Woehrle H, Oldenburg O, Graml A, Suling A, Erdmann E, Teschler H, Wegscheider K
JACC-HEART FAIL. 2016;4(2):116-125.
Integrating patient reported measures as predictive parameters into decisionmaking about palliative chemotherapy: a pilot study
Creutzfeldt A, Suling A, Oechsle K, Mehnert A, Atanackovic D, Kripp M, Arnold D, Stein A, Quidde J
BMC PALLIAT CARE. 2016;15(1):25.
Serum Matrix Metalloproteinases as Quantitative Biomarkers for Myocardial Fibrosis and Sudden Cardiac Death Risk Stratification in Patients With Hypertrophic Cardiomyopathy
Münch J, Avanesov M, Bannas P, Säring D, Krämer E, Mearini G, Carrier L, Suling A, Lund G, Patten-Hamel M
J CARD FAIL. 2016;22(10):845-50.
Prospective biomechanical analysis of donor-site morbidity after fibula free flap
Rendenbach C, Kohlmeier C, Suling A, Assaf A, Catala-Lehnen P, Amling M, Heiland M, Riecke B
J CRANIO MAXILL SURG. 2016;44(2):155-9.
Prospective biomechanical evaluation of donor site morbidity after radial forearm free flap
Riecke B, Kohlmeier C, Assaf A, Wikner J, Drabik A, Catalá-Lehnen P, Heiland M, Rendenbach C
BRIT J ORAL MAX SURG. 2016;54(2):181-6.
Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer
zu Eulenburg C, Suling A, Neuser P, Reuss A, Canzler U, Fehm T, Luyten A, Hellriegel M, Woelber L, Mahner S
PLOS ONE. 2016;11(11):e0165705.
2015
Intra-operative defibrillation testing and clinical shock efficacy in patients with implantable cardioverter-defibrillators: the NORDIC ICD randomized clinical trial
Bänsch D, Bonnemeier H, Brandt J, Bode F, Svendsen J, Táborský M, Kuster S, Blomström-Lundqvist C, Felk A, Hauser T, Suling A, Wegscheider K
EUR HEART J. 2015;36(37):2500-2507.
Increased perfusion in normal appearing white matter in high inflammatory multiple sclerosis patients
Bester M, Forkert N, Stellmann J, Aly L, Drabik A, Young K, Heesen C, Fiehler J, Siemonsen S
PLOS ONE. 2015;10(3):e0119356.
Ipsilesional motor area size correlates with functional recovery after stroke: a 6-month follow-up longitudinal TMS motor mapping study
Freundlieb N, Philipp S, Drabik A, Gerloff C, Forkert N, Hummel F
RESTOR NEUROL NEUROS. 2015;33(2):221-31.
Surgical complications after kidney transplantation: different impacts of immunosuppression, graft function, patient variables, and surgical performance
Koch M, Kantas A, Ramcke K, Drabik A, Nashan B
CLIN TRANSPLANT. 2015;29(3):252-60.
Orthostatic blood pressure test for risk stratification in patients with hypertrophic cardiomyopathy
Münch J, Aydin A, Suling A, Voigt C, Blankenberg S, Patten M
PLOS ONE. 2015;10(6):e0131044.
Long-term biomechanical analysis of donor site morbidity after radial forearm free flap
Riecke B, Kohlmeier C, Kreiker H, Suling A, Assaf A, Wikner J, Hanken H, Heiland M, Gröbe A, Rendenbach C
J CRANIO MAXILL SURG. 2015;43(9):1776-1780.
Antwort auf den Kommentar von Jürgen Windeler, Stefan Lange zum Beitrag: Nutzenbewertung aus Sicht der Versorgungsforschung und der Epidemiologie. Bundesgesundheitsbl Gesundheitsforsch Gesundheitsschutz (2015): 298-307
Wegscheider K, Drabik A, Bleich C, Schulz H
BUNDESGESUNDHEITSBLA. 2015;58(6):634-635.
Nutzenbewertung aus Sicht der Versorgungsforschung und der Epidemiologie.
Wegscheider K, Drabik A, Bleich C, Schulz H
BUNDESGESUNDHEITSBLA. 2015;58(3):298-307.
Beyond the early stages insights from the ASSURE registry on bioresorbable vascular scaffolds
Wöhrle J, Naber C, Schmitz T, Schwencke C, Frey N, Butter C, Brachmann J, Ingwersen M, Suling A, Markovic S, Mathey D
EUROINTERVENTION. 2015;11(2):149-156.
2014
Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial
Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, Karg O, Laier-Groeneveld G, Nava S, Schönhofer B, Schucher B, Wegscheider K, Criée C, Welte T
LANCET RESP MED. 2014;2(9):698-705.
Zertifizierungen in der onkologischen Chirurgie: Bedeutung für die Wahl der Behandlungsstätte
Melling N, Drabik A, El Gammal A, Antonakis F, Darmann I, Izbicki J, Bockhorn M
CHIRURG. 2014;86(7):687-695.
Disease-Management-Programme - was wurde bisher erreicht?
Wegscheider K, Drabik A, Kaduszkiewicz H, Schäfer I, Bussche van den H
2014. Ergebnisverbesserung durch Qualitätsmanagement - Aktuelle Maßnahmen, Nachweise, Stand der Evaluierung. Jonitz G, Mansky T, Scriba P, Selbmann H (Hrsg.). 1. Aufl. Köln: Deutscher Ärzte-Verlag, 145-154.
2013
Effect of medical education on students' attitudes toward psychiatry and individuals with mental disorders
Hofmann M, Harendza S, Meyer J, Drabik A, Reimer J, Kuhnigk O
ACAD PSYCHIATR. 2013;37(6):380-4.
Physicians' radiation exposure in the catheterization lab: does the type of procedure matter?
Ingwersen M, Drabik A, Kulka U, Oestreicher U, Fricke S, Krankenberg H, Schwencke C, Mathey D
JACC-CARDIOVASC INTE. 2013;6(10):1095-102.
Letzte Aktualisierung aus dem FIS: 22.12.2024 - 23:36 Uhr