Truncated mini LRP1 transports cargo from luminal to basolateral side across the blood brain barrier
Fritzen L, Wienken K, Wagner L, Kurtyka M, Vogel K, Körbelin J, Weggen S, Fricker G, Pietrzik C
FLUIDS BARRIERS CNS. 2024;21(1):74.

New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets
Giannelli S, Luoni M, Iannielli A, Middeldorp J, Philippens I, Bido S, Körbelin J, Broccoli V
ISCIENCE. 2024;27(5):109777.

Gene therapy targeting the blood-brain barrier
Körbelin J, Arrulo A, Schwaninger M
VITAM HORM. 2024;126:191-217.

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes
Sharma S, Cheema M, Reeson P, Narayana K, Boghozian R, Cota A, Brosschot T, FitzPatrick R, Körbelin J, Reynolds L, Brown C
NAT METAB. 2024 [Epub ahead of print].

Microglia targeting by adeno-associated viral vectors
Stamataki M, Rissiek B, Magnus T, Körbelin J
FRONT IMMUNOL. 2024;15:1425892.

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging
Todorov-Völgyi K, González-Gallego J, Müller S, Beaufort N, Malik R, Schifferer M, Todorov M, Crusius D, Robinson S, Schmidt A, Körbelin J, Bareyre F, Ertürk A, Haass C, Simons M, Paquet D, Lichtenthaler S, Dichgans M
NATURE AGING. 2024;4(4):595-612.

Perivascular neurons instruct 3D vascular lattice formation via neurovascular contact
Toma K, Zhao M, Zhang S, Wang F, Graham H, Zou J, Modgil S, Shang W, Tsai N, Cai Z, Liu L, Hong G, Kriegstein A, Hu Y, Körbelin J, Zhang R, Liao Y, Kim T, Ye X, Duan X
CELL. 2024;187(11):2767-2784.e23.

Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice
Wu G, Liu S, Hagenstein J, Alawi M, Hengel F, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas N, Failla A, Dierlamm J, Körbelin J, Lu S, Huber T
J CLIN INVEST. 2024;134(17):.

Antigen recognition detains CD8+ T cells at the blood-brain barrier and contributes to its breakdown
Aydin S, Pareja J, Schallenberg V, Klopstein A, Gruber T, Page N, Bouillet E, Blanchard N, Liblau R, Körbelin J, Schwaninger M, Johnson A, Schenk M, Deutsch U, Merkler D, Engelhardt B
NAT COMMUN. 2023;14(1):.

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension
Isobe S, Nair R, Kang H, Wang L, Moonen J, Shinohara T, Cao A, Taylor S, Otsuki S, Marciano D, Harper R, Adil M, Zhang C, Lago-Docampo M, Körbelin J, Engreitz J, Snyder M, Rabinovitch M
NAT COMMUN. 2023;14(1):.

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS
Johann L, Soldati S, Müller K, Lampe J, Marini F, Klein M, Schramm E, Ries N, Schelmbauer C, Palagi I, Karram K, Assmann J, Khan M, Wenzel J, Schmidt M, Körbelin J, Schlüter D, van Loo G, Bopp T, Engelhardt B, Schwaninger M, Waisman A
J CLIN INVEST. 2023;133(24):.

Transcription factors in the pathogenesis of pulmonary arterial hypertension-Current knowledge and therapeutic potential
Körbelin J, Matuszcak C, Runge J, Harbaum L, Klose H, Hennigs J
FRONT CARDIOVASC MED. 2023;9:1036096.

A novel strategy for delivering Niemann-Pick type C2 proteins across the blood-brain barrier using the brain endothelial-specific AAV-BR1 virus
Rasmussen C, Hede E, Routhe L, Körbelin J, Helgudottir S, Thomsen L, Schwaninger M, Burkhart A, Moos T
J NEUROCHEM. 2023;164(1):6-28.

Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
Ren J, Huang Y, Ren Y, Tu T, Qiu B, Ai D, Bi Z, Bai X, Li F, Li J, Chen X, Feng Z, Guo Z, Lei J, Tian A, Cui Z, Lindner V, Adams R, Wang Y, Zhao F, Körbelin J, Sun W, Wang Y, Zhang H, Hong T, Ge W
BRAIN. 2023;146(9):3634-3647.

Short regulatory DNA sequences to target brain endothelial cells for gene therapy
Graßhoff H, Müller-Fielitz H, Dogbevia G, Körbelin J, Bannach J, Vahldieck C, Kusche-Vihrog K, Jöhren O, Müller O, Nogueiras R, Prevot V, Schwaninger M
J CEREBR BLOOD F MET. 2022;42(1):104-120.

Respiratory muscle dysfunction in long-COVID patients
Hennigs J, Huwe M, Hennigs A, Oqueka T, Simon M, Harbaum L, Körbelin J, Schmiedel S, Schulze Zur Wiesch J, Addo M, Kluge S, Klose H
INFECTION. 2022;50(5):1391-1397.

AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43
Ivanova E, Corona C, Eleftheriou C, Stout R, Körbelin J, Sagdullaev B
J COMP NEUROL. 2022;530(8):1302-1317.

The HDL particle composition determines its antitumor activity in pancreatic cancer
Oberle R, Kührer K, Österreicher T, Weber F, Steinbauer S, Udonta F, Wroblewski M, Ben-Batalla I, Hassl I, Körbelin J, Unseld M, Jauhiainen M, Plochberger B, Röhrl C, Hengstschläger M, Loges S, Stangl H
LIFE SCI ALLIANCE. 2022;5(9):.

Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension
Remes A, Körbelin J, Arnold C, Rohwedder C, Heckmann M, Mairbauerl H, Frank D, Korff T, Frey N, Trepel M, Müller O
HUM GENE THER. 2022;33(17-18):959-967.

Identification of New AAV9 Engineered Capsids Targeting Mouse and Monkey Brains Through a Directed Evolution Approach in BALB/c Mice
Serena G, Luoni M, Bellinazzi B, Martin T, Körbelin J, Broccoli V
MOL THER. 2022;30(4):209-210.

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency
Sundaram S, Arrulo Pereira A, Müller-Fielitz H, Köpke H, De Angelis M, Müller T, Heuer H, Körbelin J, Krohn M, Mittag J, Nogueiras R, Prevot V, Schwaninger M
BRAIN. 2022;145(12):4264-4274.

The Alzheimer's risk factor CD2AP drives defects across the cerebrovascular network
Vandal M, Gunn C, Institoris A, Bourassa P, Korin B, Lee S, Mishra R, Peringod G, Hirai S, Jiang Y, Belzil C, Reveret L, Tremblay C, Hashem M, Nicola W, Körbelin J, Dunn J, Braun A, Bennett D, Shaw A, Gordon G, Calon F, Nguyen M
J CEREBR BLOOD F MET. 2022;42(1_SUPPL):286-287.

The SARS-CoV-2 main protease induces capillary cell death by cleaving NEMO in brain endothelial cells
Wenzel J, Lampe J, Muller-Fielitz H, Schuster R, Zille M, Körbelin J, Sauve F, Franz J, Stadelmann C, Trottein F, Glatzel M, Prevot V, Schwaninger M
J CEREBR BLOOD F MET. 2022;42(1_SUPPL):35.

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
Alvarez-Vergara M, Rosales-Nieves A, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, Ortega-de San Luis C, Sanchez-Garcia M, Martin-Bornez M, Gómez-Gálvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena M, Bullones-Bolanos A, Davila J, Gonzalez-Martinez R, Trillo-Contreras J, Sanchez-Hidalgo A, Del Toro R, Scholl F, Herrera E, Trepel M, Körbelin J, Escudero L, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A
NAT COMMUN. 2021;12(1):.

Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin-dependent vascular remodeling
Chen D, Sun N, Chen X, Gong J, Yuan S, Hu Z, Lu N, Körbelin J, Fukunaga K, Liu Q, Lu Y, Han F
J CLIN INVEST. 2021;131(4):.

Identification of New Adeno-Associated Virus 9 (AAV9) Capsid Variants Targeting the BALB/c Mouse Brain through Directed Evolution
Giannelli S, Luoni M, Conti E, Niro A, Trepel M, Körbelin J, Broccoli V
MOL THER. 2021;29(4):149-150.

PPARγ-p53-Mediated Vasculoregenerative Program to Reverse Pulmonary Hypertension
Hennigs J, Cao A, Li C, Shi M, Mienert J, Miyagawa K, Körbelin J, Marciano D, Chen P, Roughley M, Elliott M, Harper R, Bill M, Chappell J, Moonen J, Diebold I, Wang L, Snyder M, Rabinovitch M
CIRC RES. 2021;128(3):401-418.

Vascular Endothelial Cells: Heterogeneity and Targeting Approaches
Hennigs J, Matuszcak C, Trepel M, Körbelin J
CELLS-BASEL. 2021;10(10):2712.

Inactivation of Adeno-Associated Viral Vectors by Oxidant-Based Disinfectants
Korte J, Mienert J, Hennigs J, Körbelin J
HUM GENE THER. 2021;32(13-14):771-781.

Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair
Mehina E, Taylor S, Boghozian R, White E, Choi S, Cheema M, Korbelin J, Brown C
SCI ADV. 2021;7(34):.

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
Nikolakopoulou A, Wang Y, Ma Q, Sagare A, Montagne A, Huuskonen M, Rege S, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic B
J EXP MED. 2021;218(4):.

Selective Endothelial Hyperactivation of Oncogenic KRAS Induces Brain Arteriovenous Malformations in Mice
Park E, Kim S, Huang S, Yoo J, Körbelin J, Lee T, Kaur B, Dash P, Chen P, Kim E
ANN NEUROL. 2021;89(5):926-941.

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism
Ren A, Snellings D, Su Y, Hong C, Castro M, Tang A, Detter M, Hobson N, Girard R, Romanos S, Lightle R, Moore T, Shenkar R, Benavides C, Beaman M, Mueller-Fielitz H, Chen M, Mericko P, Yang J, Sung D, Lawton M, Ruppert M, Schwaninger M, Körbelin J, Potente M, Awad I, Marchuk D, Kahn M
NATURE. 2021;594(7862):271-276.

The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner J, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho C, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen H, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M
NAT NEUROSCI. 2021;24(11):1522-1533.

Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension
Santisteban M, Ahn S, Lane D, Faraco G, Garcia-Bonilla L, Racchumi G, Poon C, Schaeffer S, Segarra S, Körbelin J, Anrather J, Iadecola C
HYPERTENSION. 2020;76(3):795-807.

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors
Eichhoff A, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F
MOL THER-METH CLIN D. 2019;15:211-220.

Gene therapy to the blood-brain barrier with resulting protein secretion as a strategy for treatment of NPC2 disease
Hede E, Heegaard C, Körbelin J, Schwaninger M, Moos T, Burkhart A
HUM GENE THER. 2019;2019(30):.

The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension
Hennigs J, Lüneburg N, Stage A, Schmitz M, Körbelin J, Harbaum L, Matuszcak C, Mienert J, Bokemeyer C, Böger R, Kiefmann R, Klose H
PURINERG SIGNAL. 2019;15(3):299-311.

Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4
Tan C, Lu N, Wang C, Chen D, Sun N, Lyu H, Körbelin J, Shi W, Fukunaga K, Lu Y, Han F
NEURON. 2019;101(5):920-937.e13.

Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1
Yousef H, Czupalla C, Lee D, Chen M, Burke A, Zera K, Zandstra J, Berber E, Lehallier B, Mathur V, Nair R, Bonanno L, Yang A, Peterson T, Hadeiba H, Merkel T, Körbelin J, Schwaninger M, Buckwalter M, Quake S, Butcher E, Wyss-Coray T
NAT MED. 2019;25(6):988-1000.

Novel Gene Therapy Approaches for Whole Brain Delivery of the Lysosomal Gcase Enzyme for Wide Protection from Alpha-Synuclein Toxic Aggregates
Broccoli V, Ordozza G, Bido S, Valtorta M, Morabito G, Körbelin J, Cacellieri C, Giannelli S
MOL THER. 2018;26(5 Suppl.):131-131.

Assessing the transduction profile of the brain-endothelial directed gene vector AAV-BR1
Körbelin J, Kleint M, Dogbevia G, Ohnmacht J, Trepel M, Schwaninger M
N-S ARCH PHARMACOL. 2018;(391):.

Gene Therapy Decreases Seizures in a Model of Incontinentia Pigmenti
Dogbevia G, Töllner K, Körbelin J, Bröer S, Ridder D, Grasshoff H, Brandt C, Wenzel J, Straub B, Trepel M, Löscher W, Schwaninger M
ANN NEUROL. 2017;82(1):93-104.

Brain Endothelial-Targeted Gene Therapy in a Mouse Model of Incontinentia Pigmenti
Körbelin J, Dogbevia G, Töllner K, Bröer S, Ridder D, Grasshoff H, Brandt C, Straub B, Trepel M, Löscher W, Schwaninger M
MOL THER. 2017;25(5):256-257.

Optimization of design and production strategies for novel adeno-associated viral display peptide libraries
Körbelin J, Hunger A, Alawi M, Sieber T, Binder M, Trepel M
GENE THER. 2017;24(8):470-481.

Viral vector for the targeted transfer of genes in the brain and spinal cord
Körbelin J, Michelfelder S, Trepel M
2017.

How to successfully screen random AAV display peptide libraries in vivo
Körbelin J, Trepel M
HUM GENE THER METHOD. 2017;28(3):109-123.

Genetic manipulation of brain endothelial cells in vivo
Assmann J, Körbelin J, Schwaninger M
BBA-MOL BASIS DIS. 2016;1862(3):381-94.

A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
Körbelin J, Dogbevia G, Michelfelder S, Ridder D, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt J, Schwaninger M, Trepel M
EMBO MOL MED. 2016;8(6):609-25.

Vascular-targeted recombinant adeno-associated viral vectors for the treatment of rare diseases
Körbelin J, Schwaninger M, Trepel M
Rare Diseases. 2016;4(1):.

Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries
Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller O, Pasqualini R, Arap W, Kleinschmidt J, Trepel M
MOL THER. 2016;24(6):1050-61.

Erratum for "Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors"
Trepel M, Körbelin J, Spies E, Heckmann M, Hunger A, Fehse B, Katus H, Kleinschmidt J, Müller O, Michelfelder S
GENE THER. 2015;22(10):840-847.

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors
Trepel M, Körbelin J, Spies E, Heckmann M, Hunger A, Fehse B, Katus H, Kleinschmidt J, Müller O, Michelfelder S
GENE THER. 2015;22(10):840-7.

Neue Peptide mit Spezifität für die Lunge
Trepel M, Körbelin J, Michelfelder S
2014.

The complete sequence of tobacco mosaic virus isolate Ohio V reveals a high accumulation of silent mutations in all open reading frames
Körbelin J, Willingmann P, Adam G, Heinze C
ARCH VIROL. 2012;157(2):387-9.

Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.
Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller O, Kleinschmidt J, Trepel M
PLOS ONE. 2011;6(8):23101.

Letzte Aktualisierung aus dem FIS: 22.11.2024 - 23:34 Uhr