Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension
Remes A, Körbelin J, Arnold C, Rohwedder C, Heckmann M, Mairbauerl H, Frank D, Korff T, Frey N, Trepel M, Müller O
HUM GENE THER. 2022;33(17-18):959-967.

Non-productive angiogenesis disassembles Aß plaque-associated blood vessels
Alvarez-Vergara M, Rosales-Nieves A, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, Ortega-de San Luis C, Sanchez-Garcia M, Martin-Bornez M, Gómez-Gálvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena M, Bullones-Bolanos A, Davila J, Gonzalez-Martinez R, Trillo-Contreras J, Sanchez-Hidalgo A, Del Toro R, Scholl F, Herrera E, Trepel M, Körbelin J, Escudero L, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A
NAT COMMUN. 2021;12(1):.

Identification of New Adeno-Associated Virus 9 (AAV9) Capsid Variants Targeting the BALB/c Mouse Brain through Directed Evolution
Giannelli S, Luoni M, Conti E, Niro A, Trepel M, Körbelin J, Broccoli V
MOL THER. 2021;29(4):149-150.

Vascular Endothelial Cells: Heterogeneity and Targeting Approaches
Hennigs J, Matuszcak C, Trepel M, Körbelin J
CELLS-BASEL. 2021;10(10):2712.

Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors
Eichhoff A, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F
MOL THER-METH CLIN D. 2019;15:211-220.

Assessing the transduction profile of the brain-endothelial directed gene vector AAV-BR1
Körbelin J, Kleint M, Dogbevia G, Ohnmacht J, Trepel M, Schwaninger M
N-S ARCH PHARMACOL. 2018;(391):.

Lapatinib
Voigtländer M, Schneider-Merck T, Trepel M
Recent Results Cancer Res. 2018;211:19-44.

Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-KPolymorphism
Braig F, Kriegs M, Voigtlaender M, Habel B, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M
CANCER RES. 2017;77(5):1188-1199.

Gene Therapy Decreases Seizures in a Model of Incontinentia Pigmenti
Dogbevia G, Töllner K, Körbelin J, Bröer S, Ridder D, Grasshoff H, Brandt C, Wenzel J, Straub B, Trepel M, Löscher W, Schwaninger M
ANN NEUROL. 2017;82(1):93-104.

The role of B cell antigen receptors in mantle cell lymphoma
Fichtner M, Dreyling M, Binder M, Trepel M
J HEMATOL ONCOL. 2017;10(1):164.

Brain Endothelial-Targeted Gene Therapy in a Mouse Model of Incontinentia Pigmenti
Körbelin J, Dogbevia G, Töllner K, Bröer S, Ridder D, Grasshoff H, Brandt C, Straub B, Trepel M, Löscher W, Schwaninger M
MOL THER. 2017;25(5):256-257.

Optimization of design and production strategies for novel adeno-associated viral display peptide libraries
Körbelin J, Hunger A, Alawi M, Sieber T, Binder M, Trepel M
GENE THER. 2017;24(8):470-481.

Viral vector for the targeted transfer of genes in the brain and spinal cord
Körbelin J, Michelfelder S, Trepel M
2017.

How to successfully screen random AAV display peptide libraries in vivo
Körbelin J, Trepel M
HUM GENE THER METHOD. 2017;28(3):109-123.

Learning from the failures of drug discovery in B-cell non-Hodgkin lymphomas and perspectives for the future: chronic lymphocytic leukemia and diffuse large B-cell lymphoma as two ends of a spectrum in drug development
Kubuschok B, Trepel M
EXPERT OPIN DRUG DIS. 2017;12(7):733-745.

Complementarity determining region-independent recognition of a superantigen by B-cell antigen receptors of mantle cell lymphoma
Fichtner M, Spies E, Seismann H, Riecken K, Engels N, Gösch B, Dierlamm J, Gerull H, Nollau P, Klapper W, Dreyling M, Binder M, Trepel M
HAEMATOLOGICA. 2016;101(9):e378-81.

A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases
Körbelin J, Dogbevia G, Michelfelder S, Ridder D, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt J, Schwaninger M, Trepel M
EMBO MOL MED. 2016;8(6):609-25.

Vascular-targeted recombinant adeno-associated viral vectors for the treatment of rare diseases
Körbelin J, Schwaninger M, Trepel M
Rare Diseases. 2016;4(1):.

Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries
Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller O, Pasqualini R, Arap W, Kleinschmidt J, Trepel M
MOL THER. 2016;24(6):1050-61.

Combined modified en bloc corpectomy with replacement of the aorta in curative interdisciplinary treatment of a large osteosarcoma infiltrating the aorta
Pilger A, Tsilimparis N, Bockhorn M, Trepel M, Dreimann M
EUR SPINE J. 2016;25 (Suppl 1):58-62.

Validation of Nanobody and Antibody Based In Vivo Tumor Xenograft NIRF-imaging Experiments in Mice Using Ex Vivo Flow Cytometry and Microscopy
Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F
JOVE-J VIS EXP. 2015;(98):52462.

Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection
Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F
CONTRAST MEDIA MOL I. 2015;10(5):367-378.

Biomathematical description of synthetic peptide libraries
Sieber T, Hare E, Hofmann H, Trepel M
PLOS ONE. 2015;10(6):e0129200.

Comment on "Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins"
Spies E, Fichtner M, Müller F, Krasemann S, Illerhaus G, Glatzel M, Binder M, Trepel M
J IMMUNOL. 2015;195(10):4549-50.

Erratum for "Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors"
Trepel M, Körbelin J, Spies E, Heckmann M, Hunger A, Fehse B, Katus H, Kleinschmidt J, Müller O, Michelfelder S
GENE THER. 2015;22(10):840-847.

Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors
Trepel M, Körbelin J, Spies E, Heckmann M, Hunger A, Fehse B, Katus H, Kleinschmidt J, Müller O, Michelfelder S
GENE THER. 2015;22(10):840-7.

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies
Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Nolte F
CONTRAST MEDIA MOL I. 2014;9(2):135-42.

Lapatinib
Nolting M, Schneider-Merck T, Trepel M
Recent Results Cancer Res. 2014;201:125-43.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia
Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M
INT J CANCER. 2014;135(10):2370-2379.

Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893)
Tachezy M, Gebauer F, Petersen C, Arnold D, Trepel M, Wegscheider K, Schafhausen P, Bockhorn M, Izbicki J, Yekebas E
BMC CANCER. 2014;14(1):411.

Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma
Thiele B, Kloster M, Alawi M, Indenbirken D, Trepel M, Grundhoff A, Binder M
BLOOD. 2014;123(23):3618-21.

Neue Peptide mit Spezifität für die Lunge
Trepel M, Körbelin J, Michelfelder S
2014.

CLL B-cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL.
Binder M, Müller F, Frick M, Wehr C, Simon F, Leistler B, Veelken H, Mertelsmann R, Trepel M
BLOOD. 2013;121(1):239-241.

High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer
Flammiger A, Weisbach L, Huland H, Tennstedt P, Simon R, Minner S, Bokemeyer C, Sauter G, Schlomm T, Trepel M
EUR J CANCER. 2013;49(6):1273-9.

Meningeosis neoplastica
Trepel M, Müller F
2013. Das Rote Buch: Hämatologie und Internistische Onkologie. EcoMed, 1067-1071.

Intratumoral T but not B lymphocytes are related to clinical outcome in prostate cancer
Flammiger A, Bayer F, Cirugeda-Kühnert A, Huland H, Tennstedt P, Simon R, Minner S, Bokemeyer C, Sauter G, Schlomm T, Trepel M
APMIS. 2012;120(11):901-8.

Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia.
Müller-Schmah C, Solari L, Weis R, Pfeifer D, Scheibenbogen C, Trepel M, May A, Engelhardt R, Lübbert M
ANN HEMATOL. 2012;91(1):27-32.

Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions
Naumer M, Ying Y, Michelfelder S, Reuter A, Trepel M, Müller O, Kleinschmidt J
HUM GENE THER. 2012;23(5):492-507.

Phenotypic detection of clonotypic B cells in multiple myeloma by specific immunoglobulin ligands reveals their rarity in multiple myeloma.
Trepel M, Martens V, Doll C, Rahlff J, Gösch B, Loges S, Binder M
PLOS ONE. 2012;7(2):31998.

Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors.
Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus H, Kleinschmidt J, Müller O
GENE THER. 2012;19(8):800-809.

Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model.
Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig H, Mertelsmann R, Trepel M
INT J CANCER. 2012;131(2):10-20.

B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia.
Binder M, Müller F, Jackst A, Lechenne B, Pantic M, Bacher U, Zu Eulenburg C, Veelken H, Mertelsmann R, Pasqualini R, Arap W, Trepel M
CANCER-AM CANCER SOC. 2011;117(9):1891-1900.

Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.
Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller O, Kleinschmidt J, Trepel M
PLOS ONE. 2011;6(8):23101.

Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients
Staquicini F, Cardó-Vila M, Kolonin M, Trepel M, Edwards J, Nunes D, Sergeeva A, Efstathiou E, Sun J, Almeida N, Tu S, Botz G, Wallace M, O'Connell D, Krajewski S, Gershenwald J, Molldrem J, Flamm A, Koivunen E, Pentz R, Dias-Neto E, Setubal J, Cahill D, Troncoso P, Do K, Logothetis C, Sidman R, Pasqualini R, Arap W
P NATL ACAD SCI USA. 2011;108(46):18637-42.

Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells
Binder M, Léchenne B, Ummanni R, Scharf C, Balabanov S, Trusch M, Schlüter H, Braren I, Spillner E, Trepel M
PLOS ONE. 2010;5(12):e15992.

Novel cytotoxic vectors based on adeno-associated virus
Kohlschütter J, Michelfelder S, Trepel M
Toxins. 2010;2(12):2754-68.

Lapatinib.
Schneider-Merck T, Trepel M
Recent Results Cancer Res. 2010;184:45-59.

Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library
Ying Y, Müller O, Goehringer C, Leuchs B, Trepel M, Katus H, Kleinschmidt J
GENE THER. 2010;17(8):980-90.

Drugs targeting integrins for cancer therapy
Binder M, Trepel M
EXPERT OPIN DRUG DIS. 2009;4(3):229-41.

Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries
Michelfelder S, Kohlschütter J, Skorupa A, Pfennings S, Müller O, Kleinschmidt J, Trepel M
PLOS ONE. 2009;4(4):e5122.

Adeno-associated viral vectors and their redirection to cell-type specific receptors.
Michelfelder S, Trepel M
ADV GENET. 2009;67:29-60.

Lapatinib
Schneider-Merck T, Trepel M
2009. Small Molecules in Oncology: (Recent Results in Cancer Research). Springer Verl: 45-59.

A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.
Trepel M, Stoneham C, Eleftherohorinou H, Mazarakis N, Pasqualini R, Arap W, Hajitou A
MOL CANCER THER. 2009;8(8):2383-2391.

Meeting report: innovations in prostate cancer research.
Arap W, Trepel M, Zetter B, Pasqualini R
CANCER RES. 2008;68(3):635-638.

Drug delivery in acute myeloid leukemia
Kohlschütter J, Michelfelder S, Trepel M
EXPERT OPIN DRUG DEL. 2008;5(6):653-63.

Chapter 4. Screening phage-display Peptide libraries for vascular targeted peptides
Trepel M, Pasqualini R, Arap W
METHOD ENZYMOL. 2008;445:83-106.

Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab
Binder M, Vögtle F, Michelfelder S, Müller F, Illerhaus G, Sundararajan S, Mertelsmann R, Trepel M
CANCER RES. 2007;67(8):3518-23.

Design and construction of targeted AAVP vectors for mammalian cell transduction
Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani J, Alauddin M, Pasqualini R, Arap W
NAT PROTOC. 2007;2(3):523-31.

Leukemia-targeting ligands isolated from phage-display peptide libraries
Jäger S, Jahnke A, Wilmes T, Adebahr S, Vögtle F, Delima-Hahn E, Pfeifer D, Berg T, Lübbert M, Trepel M
LEUKEMIA. 2007;21(3):411-20.

Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy.
Michelfelder S, Lee M, DeLima-Hahn E, Wilmes T, Kaul F, Müller O, Kleinschmidt J, Trepel M
EXP HEMATOL. 2007;35(12):1766-1776.

Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU.
Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani J, Alauddin M
NAT PROTOC. 2007;2(2):416-423.

The epitope recognized by rituximab
Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M
BLOOD. 2006;108(6):1975-8.

A hybrid vector for ligand-directed tumor targeting and molecular imaging
Hajitou A, Trepel M, Lilley C, Soghomonyan S, Alauddin M, Marini F, Restel B, Ozawa M, Moya C, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman M, Gelovani J, Pasqualini R, Arap W
CELL. 2006;125(2):385-98.

Isolation of targeted AAV2 vectors from novel virus display libraries
Waterkamp D, Müller O, Ying Y, Trepel M, Kleinschmidt J
J GENE MED. 2006;8(11):1307-19.

Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection
Yao V, Ozawa M, Trepel M, Arap W, McDonald D, Pasqualini R
AM J PATHOL. 2005;166(2):625-36.

Aminopeptidase A is a functional target in angiogenic blood vessels
Marchiò S, Lahdenranta J, Schlingemann R, Valdembri D, Wesseling P, Arap M, Hajitou A, Ozawa M, Trepel M, Giordano R, Nanus D, Dijkman H, Oosterwijk E, Sidman R, Cooper M, Bussolino F, Pasqualini R, Arap W
CANCER CELL. 2004;5(2):151-62.

Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature
Müller C, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lübbert M
EUR J HAEMATOL. 2004;73(1):62-6.

Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors
Müller O, Kaul F, Weitzman M, Pasqualini R, Arap W, Kleinschmidt J, Trepel M
NAT BIOTECHNOL. 2003;21(9):1040-6.

Peptides targeting caspase inhibitors
Tamm I, Trepel M, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed J, Pasqualini R
J BIOL CHEM. 2003;278(16):14401-5.

Steps toward mapping the human vasculature by phage display
Arap W, Kolonin M, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano R, Mintz P, Ardelt P, Yao V, Vidal C, Chen L, Flamm A, Valtanen H, Weavind L, Hicks M, Pollock R, Botz G, Bucana C, Koivunen E, Cahill D, Troncoso P, Baggerly K, Pentz R, Do K, Logothetis C, Pasqualini R
NAT MED. 2002;8(2):121-7.

Severe cold hemagglutinin disease (CHD) successfully treated with rituximab
Engelhardt M, Jakob A, Ruter B, Trepel M, Hirsch F, Lübbert M
BLOOD. 2002;100(5):1922-3.

In vivo phage display and vascular heterogeneity: implications for targeted medicine
Trepel M, Arap W, Pasqualini R
CURR OPIN CHEM BIOL. 2002;6(3):399-404.

Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids
Grifman M, Trepel M, Speece P, Gilbert L, Arap W, Pasqualini R, Weitzman M
MOL THER. 2001;3(6):964-75.

Modulation of the immune response by systemic targeting of antigens to lymph nodes
Trepel M, Arap W, Pasqualini R
CANCER RES. 2001;61(22):8110-2.

Exploring vascular heterogeneity for gene therapy targeting
Trepel M, Arap W, Pasqualini R
GENE THER. 2000;7(24):2059-60.

Molecular adaptors for vascular-targeted adenoviral gene delivery
Trepel M, Grifman M, Weitzman M, Pasqualini R
HUM GENE THER. 2000;11(14):1971-81.

Potentiation of treosulfan toxicity by the glutathione-depleting agent buthionine sulfoximine in human malignant glioma cells: the role of bcl-2
Reber U, Wüllner U, Trepel M, Baumgart S, Seyfried J, Klockgether T, Dichgans J, Weller M
BIOCHEM PHARMACOL. 1998;55(3):349-59.

Chemosensitivity of human malignant glioma: modulation by p53 gene transfer
Trepel M, Groscurth P, Malipiero U, Gulbins E, Dichgans J, Weller M
J NEURO-ONCOL. 1998;39(1):19-32.

Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics
Roth W, Fontana A, Trepel M, Reed J, Dichgans J, Weller M
CANCER IMMUNOL IMMUN. 1997;44(1):55-63.

A new look at the role of p53 in leukemia cell sensitivity to chemotherapy
Trepel M, Scheding S, Groscurth P, Horny H, Malipiero U, Brugger W, Dichgans J, Weller M
LEUKEMIA. 1997;11(11):1842-9.

Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53
Weller M, Trepel M, Grimmel C, Schabet M, Bremen D, Krajewski S, Reed J
NEUROL RES. 1997;19(5):459-70.

Voluntary facial palsy with a pontine lesion
Trepel M, Weller M, Dichgans J, Petersen D
J NEUROL NEUROSUR PS. 1996;61(5):531-3.

The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo
Kolbinger W, Trepel M, Beyer J, Pilgrim C, Reisert I
BRAIN RES. 1991;544(2):349-52.

Letzte Aktualisierung aus dem FIS: 17.11.2024 - 23:34 Uhr