Adeno-associated virus-based gene therapy treats inflammatory kidney disease in mice
Wu G, Liu S, Hagenstein J, Alawi M, Hengel F, Schaper M, Akyüz N, Liao Z, Wanner N, Tomas N, Failla A, Dierlamm J, Körbelin J, Lu S, Huber T
J CLIN INVEST. 2024;134(17):.

EBV and 1q Gains Affect Gene and miRNA Expression in Burkitt Lymphoma
Akyüz N, Janjetovic S, Ghandili S, Bokemeyer C, Dierlamm J
VIRUSES-BASEL. 2023;15(9):.

Molecular monitoring of T-cell kinetics and migration in severe neurotoxicity after real-world CD19-specific chimeric antigen receptor-T cell therapy
Berger S, Fehse B, Akyüz N, Geffken M, Wolschke C, Janson D, Gagelmann N, Luther M, Wichmann D, Frenzel C, Thayssen G, Alegiani A, Badbaran A, Zeschke S, Dierlamm J, Kröger N, Ayuk F
HAEMATOLOGICA. 2023;108(2):444-456.

Non-Random Pattern of Integration for Epstein-Barr Virus with Preference for Gene-Poor Genomic Chromosomal Regions into the Genome of Burkitt Lymphoma Cell Lines
Janjetovic S, Hinke J, Balachandran S, Akyüz N, Behrmann P, Bokemeyer C, Dierlamm J, Murga Penas E
VIRUSES-BASEL. 2022;14(1):.

Molecular- and cytogenetic characterization of the IGH associated t(1;14) in a nodal marginal zone B-cell lymphoma case
Akyüz N, Penas E, Janjetovic S, Loges S, Bokemeyer C, Dierlamm J
LEUKEMIA LYMPHOMA. 2021;62(14):3526-3530.

Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma
Mohme M, Maire C, Geumann U, Schliffke S, Dührsen L, Fita K, Akyüz N, Binder M, Westphal M, Guenther C, Lamszus K, Hermann F, Schmidt N
CLIN CANCER RES. 2020;26(11):2626-2639.

Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide
Mährle T, Akyüz N, Fuchs P, Bonzanni N, Simnica D, Germing U, Asemissen A, Jann J, Nolte F, Hofmann W, Nowak D, Binder M
HAEMATOLOGICA. 2019;104(7):1355-1364.

T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model
Schliffke S, Carambia A, Akyüz N, Thiele B, Herkel J, Binder M
J NEUROIMMUNOL. 2019;332:49-56.

T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors
Simnica D, Akyüz N, Schliffke S, Mohme M, V Wenserski L, Mährle T, Fanchi L, Lamszus K, Binder M
ONCOIMMUNOLOGY. 2019;8(11):e1644110.

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias
Simnica D, Schliffke S, Schultheiß C, Bonzanni N, Fanchi L, Akyüz N, Gösch B, Casar C, Thiele B, Schlüter J, Lohse A, Binder M
FRONT IMMUNOL. 2019;10:1897.

Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes
Mohme M, Schliffke S, Maire C, Rünger A, Glau L, Mende K, Matschke J, Gehbauer C, Akyüz N, Zapf S, Holz M, Schaper M, Martens T, Schmidt N, Peine S, Westphal M, Binder M, Tolosa E, Lamszus K
CLIN CANCER RES. 2018;24(17):4187-4200.

Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy
Schliffke S, Sivina M, Kim E, Wenserski L, Thiele B, Akyüz N, Falker-Gieske C, Statovci D, Oberle A, Thenhausen T, Krohn-Grimberghe A, Bokemeyer C, Jain N, Estrov Z, Ferrajoli A, Wierda W, Keating M, Burger J, Binder M
ONCOIMMUNOLOGY. 2018;7(4):e1417720.

MALT1 sequencing analyses in marginal zone B-cell lymphomas reveal mutations in the translocated MALT1 allele in an IGH-MALT1-positive MALT lymphoma
Akyüz N, Albert-Konetzny N, Pott C, Callet-Bauchu E, Bokemeyer C, Murga Penas E, Dierlamm J
LEUKEMIA LYMPHOMA. 2017;58(10):2480-2484.

T-cell diversification reflects antigen selection in the blood of patients on immune checkpoint inhibition and may be exploited as liquid biopsy biomarker
Akyüz N, Brandt A, Stein A, Schliffke S, Mährle T, Quidde J, Goekkurt E, Loges S, Haalck T, Ford C, Asemissen A, Thiele B, Radloff J, Thenhausen T, Krohn-Grimberghe A, Bokemeyer C, Binder M
INT J CANCER. 2017;140(11):2535-2544.

Monitoring multiple myeloma by next-generation sequencing of V(D)J rearrangements from circulating myeloma cells and cell-free myeloma DNA
Oberle A, Brandt A, Voigtländer M, Thiele B, Radloff J, Schulenkorf A, Alawi M, Akyüz N, März M, Ford C, Krohn-Grimberghe A, Binder M
HAEMATOLOGICA. 2017;102(6):1105-1111.

Clinical response to ibrutinib is accompanied by normalization of the T-cell environment in CLL-related autoimmune cytopenia
Schliffke S, Akyüz N, Ford C, Mährle T, Thenhausen T, Krohn-Grimberghe A, Knop S, Bokemeyer C, Binder M
LEUKEMIA. 2016;30(11):2232-2234.

Efficient transformation of primary human mesenchymal stromal cells by adenovirus early region 1 oncogenes
Speiseder T, Hofmann-Sieber H, Rodríguez E, Schellenberg A, Akyüz N, Dierlamm J, Spruss T, Lange C, Dobner T
J VIROL. 2016;91(1):e01782-16.

Germline ablation of dermatan-4O-sulfotransferase1 reduces regeneration after mouse spinal cord injury
Rost S, Akyüz N, Martinovic T, Huckhagel T, Jakovcevski I, Schachner M
NEUROSCIENCE. 2015;312:74-85.

Dermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration.
Akyüz N, Rost S, Mehanna A, Bian S, Loers G, Oezen I, Mishra B, Hoffmann K, Guseva D, Laczynska E, Irintchev A, Jakovcevski I, Schachner M
EXP NEUROL. 2013;247:517-530.

Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells.
Bian S, Akyüz N, Bernreuther C, Loers G, Laczynska E, Jakovcevski I, Schachner M
J CELL SCI. 2011;124(Pt 23):4051-4063.

Proof of principle: detection of genotoxicity by a fluorescence-based recombination test in mammalian cells
Akyüz N, Wiesmüller L
ALTEX-ALTERN ANIM EX. 2003;20(2):77-84.

p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair
Boehden G, Akyüz N, Roemer K, Wiesmüller L
ONCOGENE. 2003;22(26):4111-7.

Structure of the murine tenascin-R gene and functional characterisation of the promoter
Putthoff P, Akyüz N, Kutsche M, Zardi L, Borgmeyer U, Schachner M
BIOCHEM BIOPH RES CO. 2003;308(4):940-9.

DNA substrate dependence of p53-mediated regulation of double-strand break repair
Akyüz N, Boehden G, Süsse S, Rimek A, Preuss U, Scheidtmann K, Wiesmüller L
MOL CELL BIOL. 2002;22(17):6306-17.

Potential roles of p53 in recombination.
Akyüz N, Boehden G, Janz C, Süße S, Süße S, Wiesmüller L
GENE THER MOL BIOL. 2000;5:63-79.

Letzte Aktualisierung aus dem FIS: 21.12.2024 - 23:36 Uhr